Download or read book Transglutaminases written by Kapil Mehta and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: As newer members of the transglutaminase family are being discovered and new functions for existing members are being described, it becomes imperative to collect all the findings in a book. This volume provides the most comprehensive single source of information and will appeal to both new investigators just entering the field and established researchers aiming to elucidate the biological relevance of these enzymes in cancer, inflammation, autoimmune diseases and related areas of research.

Download or read book Transglutaminases written by Kiyotaka Hitomi and published by Springer. This book was released on 2016-02-04 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community.

Download or read book Transglutaminases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transglutaminases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Transglutaminases in a compact format. The editors have built Transglutaminases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Transglutaminases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Transglutaminases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Transglutaminase written by Yi Zhang and published by Elsevier. This book was released on 2024-03-15 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transglutaminase: Fundamentals and Applications, a new volume in the Foundations and Frontiers in Enzymology series, stands as a comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field from the Editors, international experts discuss basic biology and structure – function relationships of transglutaminases, ongoing fundamental research, as well as new application areas, including food processing, material synthesis, biomedicine and disease treatment, and biotechnology. Approaches for sourcing transglutaminases from animals, plants, and microorganisms are considered in-depth, followed by chapters on applied uses in biomedicine, skin and bone biology and medicine, drug development, tissue engineering, seafood bioprocessing, dairy bioprocessing, synthesis of materials and polymers, and as an immobilization agent. Research protocols are also provided, including research rationale, design, substrates, assays and microassay steps for studying transglutaminases. Brings together basic knowledge and applied research on transglutaminase biology Considers a range of application areas, from biomedicine to drug development, tissue engineering, food processing, and materials synthesis Includes instructive protocols for basic and applied transglutaminase research Features chapter contributions from global leading experts in the field, across disciplines and applications

Download or read book Transglutaminase written by V.A. Najjar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Molecular and Structural Biology of Hair written by Kurt S. Stenn and published by . This book was released on 1991 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: These 32 papers and 28 poster papers offer scientific and clinical information on where research on hair currently stands. They discuss future directions which might help unravel the biological phenomena and mechanisms of the hair follicle.

Download or read book American Book Publishing Record written by and published by . This book was released on 2003 with total page 838 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medical Principles and Practice written by and published by . This book was released on 2005 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Annual Review of Biochemistry written by E. E. Snell and published by Annual Reviews. This book was released on 1980 with total page 1292 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pharmacology of Retinoids in the Skin written by Uwe Reichert and published by . This book was released on 1989 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Science written by John Michels (Journalist) and published by . This book was released on 2012 with total page 1644 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The FASEB Journal written by and published by . This book was released on 1991 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair written by Mario Barbosa and published by Woodhead Publishing. This book was released on 2017-09-25 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers

Download or read book Indian Journal of Chemistry written by and published by . This book was released on 1993 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Encyclopedia of Bioprocess Technology written by Michael C. Flickinger and published by . This book was released on 1999 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification and Characterization of Peptide Substrates of Bacterial Transglutaminases for Use in Bio conjugation and Bio catalytic Applications written by Samuel Oteng-Pabi and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Transglutaminases (protein-glutamine:amine y-glutamyl- transferase, EC 2.3.2.13) are a family of calcium-dependent enzymes which catalyze an acyl transfer between glutamine residues and a wide variety of primary amines. When lysine acts as the acyl-acceptor substrate, ?-glutamyl lysine isopeptide bond is formed. Isopeptide catalyzation results in protein cross-linkage which is prevalent throughout biological processes. Microbial transglutaminase (mTG) is a bacterial variant of the transglutaminase family, distinct by virtue of its calcium-independent catalysis of the isopeptidic bond. Furthermore, mTGs promiscuity in donor substrate preference highlights its biocatalytic potential. To realize the potential of the enzyme, a high-reactivity tag was necessary for protein labelling. To address this, an enzyme-coupled assay was developed to characterize peptides in the hopes of developing orthogonal substrates to facilitate mTG-mediated labelling and biocatalysis. The discovery of high-reactivity peptide tags allowed the realization of in vitro protein labelling- facilitated by mTG. The 7M48 peptide was fused to a test protein, where it was subsequently propargylated with propargyl amine to fluorescently label or immobilize a test protein. Although there are endless possibilities for in vitro bio-conjugation through mTG, proteolytic activation limits any in-cell labelling strategies with this enzyme. To circumvent this issue, development of an alternative bacterial enzyme, Bacillus subtilis transglutaminase (bTG), was chosen to replace mTG. bTG maintains the advantages associated with mTG but is expressed in its active form. Unlike mTG, there is limited preliminary research associated with the enzyme or its substrate scope. To better understanding substrate reactivity, a FRET-based assay was developed allows for the discovery of new high-reactivity peptides for bTG. These peptides were then used in labelling strategies to demonstrate the potential bTG-mediated bioconjugation. This strategy includes the added advantage of potential for in-cellulo labelling.

Download or read book Molecular Biology of the Skin written by Michael Darmon and published by Academic Press. This book was released on 1993-06-21 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of the Skin: The Keratinocyte comprehensively reviews the major aspects of keratinocyte and epidermal differentiation, physiology, and pathology, primarily focusing on the molecular aspects. This exciting new resource discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatological pathology. The volume also highlights areas of genetic disease, new animal models to help in understanding dermatological disorders, and gene therapy using skin as a target. W.W. Franke, a pioneer in the study of the molecular biology of keratins, has written the foreword for the book. Molecular Biology of the Skin: The Keratinocyte is intended for use by dermatologists and basic researchers in cell and developmental biology. It will also be valuable for surgeons and other clinicians as well as researchers in gene therapy, virology, and pharmacology. * * Reviews keratinocyte (and epidermal) differentiation. physiology, and pathology, focusing on the molecular aspects * -Discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatalogical pathology * -Highlights genetic disease, new animal models, and gene therapy