Download or read book Analysis of Cofactor Recruitment and Transcriptional Regulation by Retinoic Acid Receptors written by Behnom Farboud and published by . This book was released on 2004 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcriptional Regulation of Retinoic Acid written by Robert Francis Gillespie and published by . This book was released on 2007 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanism of Transcriptional Regulation of Retinoic Acid Production in the Intestine Through Retinol Dehydrogenase written by Sharmistha Sarkar and published by . This book was released on 2008 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retinoic Acid Receptors written by Herborg Hauksdóttir and published by . This book was released on 2002 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of CD18 by Retinoic Acid written by Thomas Scott Bush and published by . This book was released on 2002 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Biochemistry of Retinoic Acid Receptors I Structure Activation and Function at the Molecular Level written by Mary Ann Asson-Batres and published by Springer. This book was released on 2014-06-24 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Download or read book Regulation of Retinol Binding Protein Gene Expression written by Katayoun Alavi Jessen and published by . This book was released on 1999 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Retinoids written by Michael B. Sporn and published by Academic Press. This book was released on 2012-12-02 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids, Volume 1 covers the chemistry and biology of retinoids, with an emphasis on the role of retinoids in nutrition and in vision. After briefly discussing the discovery and nomenclature of retinoids, this six-chapter volume describes the chemical and physical properties of natural and synthetic retinoids, as well as the retinoidal benzoic acid derivatives. The book goes on describing various reactions with radioisotopes for the synthesis of retinoids and related compounds. Considerable chapters explain the chemical, physical, and biological methodologies for separating and measuring retinoids. A discussion on the relationships between structure and activity of retinoids is included. The last chapter addresses the role of vitamin A in animal and human nutrition. This volume also discusses the metabolism of vitamin A in normal and disease states, as well as its interaction with hormones, micronutrients, drugs, and alcohol. This volume is an ideal source for nutritionists, clinicians, and researchers who are interested in the progressing field of retinoid research.
Download or read book Gene Regulation Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
Download or read book Regulation of Gene Expression by the Retinoic Acid Receptor Alpha Requires Synergistic Binding of Transcriptional Co factors and Response to Ligand written by Mindy L. Farris and published by . This book was released on 2008 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Involvement of Nf Kb Subunit P65 and Retinoic Acid Receptors Rarae and Rxrae in the Transcriptional Regulation of the Human Gnrh II Gene written by Kin-Yue Leung and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Involvement of NF-kB Subunit P65 and Retinoic Acid Receptors RARae and RXRae in the Transcriptional Regulation of the Human GnRH II Gene" by Kin-yue, Leung, 梁建裕, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled INVOLVEMENT OF NF-κB SUBUNIT p65 AND RETINOIC ACID RECEPTORS RARα AND RXRα IN THE TRANSCRIPTIONAL REGULATION OF THE HUMAN GnRH II GENE Submitted by Leung Kin Yue for the degree of Master of Philosophy at The University of Hong Kong in August 2005 Gonadotropin-releasing hormone I (GnRH I) is a hypothalamic decapeptide which, via the hypothalamic-pituitary-gonadal axis, plays a pivotal role in the development of reproductive competence and regulation of reproductive events. Recently, the second isoform of GnRH, designated as GnRH II, was identified in humans. The peptide structure of GnRH II is highly conserved among taxa, from bony fish to humans. It is widely expressed in various parts of the brain and peripheral tissues. These imply that GnRH II possesses multiple and crucial biological functions in our body. Contrary to GnRH I, the gene regulation, expression pattern and biological role of GnRH II are still largely unclear. In this study, the transcriptional regulation, mainly on the repression mechanisms, of human GnRH II gene was investigated. By constructing series of scanning mutants, the sequence residing -641/-636 (CATGCC, designated as GII-Sil) was identified as the element responsible for mediating the repressive effect. This motif, when mutated, led to an almost total restoration of promoter activity in TE671 medulloblastoma and JEG-3 placenta choriocarcinoma cells. Subsequent Supershift assays showed that the protein factors NF-κB subunit p65, RARα and RXR specifically interacted with the sequence. Transient transfection assays verified the functions of p65 and RARα/RXRα heterodimer in vivo. p65 acts as a potent repressor of human GnRH II promoter in both neuronal and placental cells. Nuclear receptor RARα/RXRα heterodimer is involved in the differential regulation of GnRH II gene in the two cell lines. In TE671, binding of RARα/RXRα to its ligands, ATRA and 9-cisRA, further regulated the silencer-repressed promoter activity. In JEG-3, on the other hand, ATRA-activated RARα/RXRα alleviated the gene repression, while 9-cisRA-activated RXRα alone did not involve in gene regulation. Yet, when both receptors were ligand-activated, synergistic up-regulation of the gene was observed. The effects of retinoic acids and RARα/RXRα on the endogenous expression of GnRH II gene were subsequently confirmed by quantitative real-time PCR. Finally, it is concluded that NF-κB p65 and RARα/RXRα are involved in the transcriptional regulation of the human GnRH II gene. DOI: 10.5353/th_b3636703 Subjects: Retinoids - Receptors Transcription factors Luteinizing hormone releasing hormone Genetic regulation Genetic transcription
Download or read book Retinoic acid dependent regulation of gene expression written by Maria del Mar Vivanco Ruiz and published by . This book was released on 1991 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Thyroid Hormone and Retinoid Receptor Transcriptional Regulation written by Anders Michael Näär and published by . This book was released on 1995 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retinoid Signaling Pathways written by and published by Academic Press. This book was released on 2020-04-29 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Download or read book Analysis of the Molecular Mechanisms of DNA Recognition and Transcriptional Regulation by Nuclear Hormone Receptors written by Benjamin C. Lin and published by . This book was released on 2000 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Fat Soluble Vitamins written by H. DeLuca and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first demonstration of the existence of a vitamin and the full recognition of this fact are often attributed to the work of McCollum, who found that a sub stance in butterfat and cod-liver oil was necessary for growth and health of ani mals fed purified diets. It became obvious that an organic substance present in microconcentrations was vital to growth and reproduction of animals. Following the coining of the word vitamine by Funk, McCollum named this fat-soluble sub stance vitamin A. We can, therefore, state that vitamin A was certainly one of the first known vitamins, yet its function and the function of the other fat-soluble vitamins had remained largely unknown until recent years. However, there has been an explosion of investigation and new information in this field, which had remained quiescent for at least two or three decades. It is now obvious that the fat-soluble vitamins function quite differently from their water-soluble counter parts. We have learned that vitamin D functions by virtue of its being converted in the kidney to a hormone that functions to regulate calcium and phosphorus metabolism. This new endocrine system is in the process of being elucidated in detail, and in addition, the medical use of these hormonal forms of vitamin D in the treatment of a variety of metabolic bone diseases has excited the medical com munity.
Download or read book Regulation of Surfactant associated Protein Gene Expression by Retinoic Acid written by Michael David Metzler and published by . This book was released on 1995 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
