Download or read book The Steroid Thyroid Hormone Receptor Family and Gene Regulation written by J. Carlstedt-Duke and published by Birkhäuser. This book was released on 2013-11-21 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second International CBT (Center for Biotechnology) Synposium was held in Stockholm November 4-5 1988 and had the title "The steroid/thyroid hoITIDne receptor family and gene regulation". This meeting contained contributions from most leading laboratories within the field of steroid/thyroid hOITIDne receptors and gave a very exciting perspective on the dynamic development of this i:ntx>rt. ant research field. Today all known steroid hoITIDne receptors have been cloned and sequenced and novel members of this supergene family are constantly being discovered. Sane of these new receptors remain to be characterized regarding the nature of their ligand. Access to probes for steroid receptors has enabled studies on mechanisms of regulation of receptor gene expression. Deletion and II'Altational analysis of steroid receptor cDNAs followed by expression in cells together with suitable reporter genes has yielded a detailed knowledge about the functional significance of the various domains the receptors are composed of. In certain cases, steroid resistance in patients have been shown to be due to point mutations in the corresponding steroid receptor genes resulting in non-functional receptors. The availability of receptor cDNAs also makes it possible to express receptors at high levels in procaryotic and eucaryotic cells. It is e. g. possible to express the DNA-binding domain of the glucocorticoid receptor in E. coli as a fusion protein with protein A which interacts specifically with DNA. Such studies are necessary for production of sufficient quantities of receptors to allow crystallization and X-ray crystallography for detailed structural information.
Download or read book Transcriptional Regulation by Thyroid Hormone Receptor written by Elizabeth Bozena Helmer and published by . This book was released on 1994 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Negative and Positive Transcriptional Regulation by Thyroid Hormone Receptor Isoforms written by Anne Rentoumis and published by . This book was released on 1990 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thyroid Hormone Receptors written by Aria Baniahmad and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A panel of outstanding investigators surveys and explains the major cutting-edge methods used in thryroid receptor (TR) research and explains their practical experimental details. Described in step-by-step detail to ensure robust experimental results, the techniques presented cover a wide variety of key areas, including TR in development and knockout (mouse and Xenopus), transcriptional regulation by TRs in both cell-free systems and in living cells, and TR mutant analysis of patients. Additional methods provide powerful tools for the isolation of TR-regulated protein complexes, for studying the oncogene v-Erba in blood cell differentiation, and for target gene analysis in the brain. Microarray chip methods are also presented for analyzing the organs of transgenic mice to identify target genes in the liver.
Download or read book The Steroid Thyroid Hormone Receptor Family and Gene Regulation written by J. Carlstedt-Duke and published by Birkhäuser. This book was released on 1989-04-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second International CBT (Center for Biotechnology) Synposium was held in Stockholm November 4-5 1988 and had the title "The steroid/thyroid hoITIDne receptor family and gene regulation". This meeting contained contributions from most leading laboratories within the field of steroid/thyroid hOITIDne receptors and gave a very exciting perspective on the dynamic development of this i:ntx>rt. ant research field. Today all known steroid hoITIDne receptors have been cloned and sequenced and novel members of this supergene family are constantly being discovered. Sane of these new receptors remain to be characterized regarding the nature of their ligand. Access to probes for steroid receptors has enabled studies on mechanisms of regulation of receptor gene expression. Deletion and II'Altational analysis of steroid receptor cDNAs followed by expression in cells together with suitable reporter genes has yielded a detailed knowledge about the functional significance of the various domains the receptors are composed of. In certain cases, steroid resistance in patients have been shown to be due to point mutations in the corresponding steroid receptor genes resulting in non-functional receptors. The availability of receptor cDNAs also makes it possible to express receptors at high levels in procaryotic and eucaryotic cells. It is e. g. possible to express the DNA-binding domain of the glucocorticoid receptor in E. coli as a fusion protein with protein A which interacts specifically with DNA. Such studies are necessary for production of sufficient quantities of receptors to allow crystallization and X-ray crystallography for detailed structural information.
Download or read book Thyroid Hormone Regulation of Gene Expression written by G.R. Williams and published by Springer. This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the historical perspective and physiological background of the role of thyroid hormones. In both specific target tissues and during development, it provides clinical perspectives and physiological and developmental implications of the interactions between retinoid and vitamin D3 signalling pathways.
Download or read book Analysis of the Molecular Basis of Transcriptional Regulation by Thyroid Hormone and Estrogen Receptors written by Jeffrey Morse Holloway and published by . This book was released on 1992 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of the Molecular Mechanisms of Isoform specific Transcriptional Regulation by Thyroid Hormone Receptors written by Zhihong Yang and published by . This book was released on 2001 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Isoform specific Transcriptional Regulation in the Molecular Mechanisms of Resistance to Thyroid Hormone Syndrome RTH written by Wei Wan and published by . This book was released on 2005 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Thyroid Hormone and Retinoid Receptor Transcriptional Regulation written by Anders Michael Näär and published by . This book was released on 1995 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Steroid thyroid Hormone Receptor Family and Gene Regulation written by Jan Carlstedt-Duke and published by Birkhauser. This book was released on 1989 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Steroid Thyroid Hormone Receptor Family and Gene Regulation written by J. Carlstedt-Duke and published by Birkhäuser. This book was released on 1989-04-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second International CBT (Center for Biotechnology) Synposium was held in Stockholm November 4-5 1988 and had the title "The steroid/thyroid hoITIDne receptor family and gene regulation". This meeting contained contributions from most leading laboratories within the field of steroid/thyroid hOITIDne receptors and gave a very exciting perspective on the dynamic development of this i:ntx>rt. ant research field. Today all known steroid hoITIDne receptors have been cloned and sequenced and novel members of this supergene family are constantly being discovered. Sane of these new receptors remain to be characterized regarding the nature of their ligand. Access to probes for steroid receptors has enabled studies on mechanisms of regulation of receptor gene expression. Deletion and II'Altational analysis of steroid receptor cDNAs followed by expression in cells together with suitable reporter genes has yielded a detailed knowledge about the functional significance of the various domains the receptors are composed of. In certain cases, steroid resistance in patients have been shown to be due to point mutations in the corresponding steroid receptor genes resulting in non-functional receptors. The availability of receptor cDNAs also makes it possible to express receptors at high levels in procaryotic and eucaryotic cells. It is e. g. possible to express the DNA-binding domain of the glucocorticoid receptor in E. coli as a fusion protein with protein A which interacts specifically with DNA. Such studies are necessary for production of sufficient quantities of receptors to allow crystallization and X-ray crystallography for detailed structural information.
Download or read book Transcriptional Regulation by the Thyroid Hormone Receptor and Its Viral Counterpart the P75gag v erbA Oncoprotein written by Gunilla Wahlström and published by . This book was released on 1996 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcriptional Regulation by V ErbA the Oncogenic Counterpart of Thyroid Hormone Receptor TR written by Georgia Braliou and published by . This book was released on 2000 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcriptional and Post transcriptional Regulation of a Thyroid Hormone Responsive MRNA written by Prema Narayan and published by . This book was released on 1984 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thyroid Hormone Metabolism written by Georg Hennemann and published by Marcel Dekker. This book was released on 1986 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of Steroid and Nuclear Hormone Receptors written by Leonard Freedman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Receptors: New Instruments for a Symphony of Signals In the late eighteenth century, it was proposed on theoretical grounds that each of the body's organs, beginning with the brain, must be "a factory and laboratory of a specific humor which it returns to the blood", and that these circulating signals "are indispensable for the life of the whole" (Bordeu 1775). During the nineteenth cen tury, some remarkable physiological experiments revealed the actions of humoral factors that affected the for and function of multiple tissues, organs and organ sys tems within the body (Berthold 1849); much later, the chemical and molecular na ture of some of those factors was determined. Against this deep historical backdrop of the founding studies of intercellular signaling, molecular biology sprang into existence a mere forty years ago, rooted in the revelation of regulable gene expression in bacteria. But contemporaneous with those classical analyses of transcriptional regulation of the lactose operon, the mod em era of signal transduction was inaugurated by the identification of cAMP as a second messenger -- an intracellular mediator of hormonal activation of glycogen catabolism (Sutherland and RaIl 1960). Later in that same decade, it emerged that cAMP is a critical signal not only in metazoans, but even in bacteria, where it serves an analogous function as a critical switch that activates expression of genes re quired for catabolism of complex carbon sources, including those of the lactose operon.
