Download or read book Transcriptional Regulation and Function of Yeast Metallothionein During Oxidative Stress written by Katherine Takako Tamai and published by . This book was released on 1993 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metallothionein IV written by Curtis D. Klaassen and published by Nelson Thornes. This book was released on 1999 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metallothionein nomenclature and structure.- Nomenclature of metallothionein: Proposal for a revision.- Metallothionein: Molecular evolution and classification.- Structural and biological studies on native bovine Cu, Zn-metallothionein-3.- Circular dichroism, emission, and exafs studies of Ag(I), Cd(II), Cu(I), and Hg(II) binding to metallothioneins and modeling the metal binding site.- Metallothionein structure update.- Simulation of Zn/Cd binding in mammalian metallothionein domains.- The growth inhibitory activity of metallothionein-3 correlates with its novel ? domain sequence rather than metal binding properties.- Recombinant synthesis and metal-binding abilities of mouse metallothionein 1 and its ?- and ?-domains.- Biochemical characterization of monomeric and dimeric cadmium-substituted metallothionein-3.- Chemical and analytical aspects of metallothionein.- Mammalian metallothionein sub-isoform separation by RP-HPLC with on-line UV and electrochemical detection.- Characterisation of mammalian Cd, Zn metallothioneins using differential pulse polarography.- Comparison of CZE and MECC separations of MT isoforms.- Synthetic peptides and domains of metallothionein for structure function studies: rabbit liver peptide MT-IIA 49-61 and lobster MT ?N ?C and ?C?N domains.- Voltammetric methods in isolation and identification of plant metallothioneins from alga Chlorella.- Characterization of isometallothioneins in Chang liver cells and the transient accumulation of metallothionein and glutathione during cell proliferation.- Quantification of cytosolic metallothionein contents by a developed assay system using immobilized antibody.- Protein engineering of metallothionein to study on the metal-binding ability.- Metal binding proteins: Molecular engineering of improvements in metal specificity.- Molecular splicing of metallothionein - study on domains of metallothionein.- Metallothionein in non-mammalian tissues.- Involvement of metallothionein in female squirrelfish reproduction.- Accumulation of untranslated metallothionein mRNA in antarctic hemoglobinless fish (icefish).- Structure and function of metallothionein isoforms in terrestrial snails.- Functional and regulatory aspects of teleost metallothionein.- Metallothionein induction in mussels exposed to a metal mixture.- Synthesis and properties of class III metallothioneins of Schizosaccharomyces pombe in response to cadmium and zinc.- Phytochelatins (class III metallothioneins) and their desglycyl peptides induced by cadmium in root cultures of Rubia tinctorum L..- Chemical and spectroscopic properties of copper metallothionein from the copper resistant fungus Beauveria bassiana.- Transcription factors.- Metallothionein facts and frustrations.- Liver degeneration and embryonic lethality in mouse null mutants for the metal-responsive transcriptional activator MTF-1.- New insights into the mechanisms of cadmium regulation of mouse metallothionein-I gene expression.- Activation of mouse metallothionein I promoter by cadmium in human neuroblastoma cells.- Transcription factors involved in heavy metal regulation of the human metallothionein-IIA gene.- Transcriptional regulation of the gene encoding mouse metallothionein-3 and its expression in the organs of the reproductive system.- Dynamic regulation of yeast metallothionein gene transcription via metalloregulatory signaling factors.- Metal regulation of mammalian metal responsive element (MRE) binding proteins.- Metallothionein and hormone responsiveness.- Synergistic activation of mouse metallothionein-I gene by interleukin-6 and glucocorticoid.- Hammerhead ribozymes mediated down-regulation of rat metallothionein mrnas expression.- Inactivation of metal-induced metallothionein gene expression by protein kinase C inhibitor.- Cadmium-induced metallothionein expression and metallothionein mRNA in mice.- Role of metallothionein in reproduction, development and cell proliferation.- The nuclear-cytoplasmic presence of metallothion..
Download or read book Metal Ions in Gene Regulation written by Simon Silver and published by Springer. This book was released on 1998 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing the subject areas of bacterial systems, animal metal metabolism, and lower eukaryotes and higher plants, 17 papers cover such topics as the role of Fur repressors, the range of gene regulators of cation metabolism in Gram-positive bacteria, metal- regulating examples of bacterial two-component regulatory systems, metal ion regulated gene expression in animals, iron regulation of animal genes, metallothionein regulation of the prokaryotic cyanobacteria, and the regulation of metal cation stress in yeast. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Oxidative Stress and Metallothionein Gene Regulation written by Mousheng Xu and published by . This book was released on 1996 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Zinc Biochemistry Physiology and Homeostasis written by W. Maret and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapters in this book review the remarkable advances in the field of zinc biology over the last decade. Zinc is essential for life, in particular for growth and development, through its role in hundreds of zinc enzymes and thousands of zinc proteins. Its catalytic, structural, and regulatory functions in these proteins impact metabolism, gene expression, and signal transduction, including neurotransmission. Among the micronutrients, zinc may rank with iron as to its importance for public health. The topics covered range from single molecules to cells and to whole organisms: the chemistry, design, and application of fluorophores for the determination of cellular zinc; the role of zinc in proliferation, differentiation, and apoptosis of cells; proteins that transport, sense, and distribute zinc and together form a cellular homeostatic system; the coordination chemistry of zinc in metalloproteins; the role of zinc in the brain as a neuromodulator/transmitter; the dependence of the immune system on zinc; zinc homeostasis in the whole human body.
Download or read book Molecular Aspects of the Stress Response Chaperones Membranes and Networks written by Peter Csermely and published by Springer Science & Business Media. This book was released on 2007-08-09 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Download or read book Metallothionein III written by Kazuo T. Suzuki and published by Birkhauser. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Eye written by John V. Forrester and published by Elsevier Health Sciences. This book was released on 2015-06-01 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before. The only all-embracing textbook of basic science suitable for trainee ophthalmologists, optometrists and vision scientists - other books concentrate on the individual areas such as anatomy. Attractive page design with clear, colour diagrams and text boxes make this a much more accessible book to learn from than many postgraduate textbooks. Presents in a readable form an account of all the basic sciences necessary for an understanding of the eye - anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology. More on molecular pathology. Thorough updating of the sections on pathology, immunology, pharmacology and immunology. Revision of all other chapters. More colour illustrations Comes with complete electronic version
Download or read book Plant Metal Interaction written by Parvaiz Ahmad and published by Elsevier. This book was released on 2016-02-02 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Metal Interaction: Emerging Remediation Techniques covers different heavy metals and their effect on soils and plants, along with the remediation techniques currently available. As cultivable land is declining day-by-day as a result of increased metals in our soil and water, there is an urgent need to remediate these effects. This multi-contributed book is divided into four sections covering the whole of plant metal interactions, including heavy metals, approaches to alleviate heavy metal stress, microbial approaches to remove heavy metals, and phytoremediation. - Provides an overview of the effect of different heavy metals on growth, biochemical reactions, and physiology of various plants - Serves as a reference guide for available techniques, challenges, and possible solutions in heavy metal remediation - Covers sustainable technologies in uptake and removal of heavy metals
Download or read book The Biosynthesis of Mycotoxins written by Pieter Steyn and published by Elsevier. This book was released on 2012-12-02 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biosynthesis of Mycotoxins: A Study in Secondary Metabolism focuses on the biosynthetic analysis of mycotoxins, which are inherently a heterogeneous group of metabolites that are formed along the terpene route and the route polyketide, as well as from amino acids. This book discusses the unique biological properties and structural complexity of the highly specialized secondary microbial metabolites. Organized into 12 chapters, this book starts with an overview of the characteristics of secondary metabolites, including their problematic function and the combination of their structural diversity with their restricted biological occurrence. This text then explains the sporadic occurrence of the mycotoxins as fungal metabolites. Other chapters explore ergochromes, which are a group of light yellow mycotoxins that are isolated from ergot, mold fungi, and lichens. The final chapter discusses the biosynthesis of several unrelated fungal metabolites for which toxicological data are reported. Biochemists, organic chemists, mycologists, enzymologists, plant pathologists, toxicologists, and graduate students will find this book useful.
Download or read book In VIVO Footprinting written by I.L. Cartwright and published by Elsevier Science. This book was released on 1997-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revolution in biological research initiated by the demonstration that particular DNA molecules could be isolated, recombined in novel ways, and conveniently replicated to high copy number in vivo for further study, that is, the recombinant DNA era, has spawned many additional advances, both methodological and intellectual, that have enhanced our understanding of cellular processes to an astonishing degree. As part of the subsequent outpouring of information, research exploring the mechanisms of gene regulation, both in prokaryotes and eukaryotes (but particularly the latter), has been particularly well represented. Although no one technical approach can be said to have brought the filed to its current level of sophistication, the ability to map the interactions of trans-acting factors with their DNA recognition sequences to a high level of precision has certainly been one of the more important advances. This "footprinting" approach has become almost ubiquitous in gene regulatory studies; however, it is in its "in vivo" application that ambiguities, confusions, and inconsistencies that may arise from a purely "in vitro"-based approach can often be resolved and placed in their proper perspective. Put more simply, that an interaction can be demonstrated to occur between purified factors and a particular piece of DNA in a test tube does not, of course, say anything regarding whether such interactions are occurring in vivo. The ability to probe for such interactions as they occur inside cells, with due attention paid to the relevant developmental stage, or to the tissue specificity of the interaction being probed, has made in vivo footprinting approach an invaluable adjunct to the "gene jockey's" arsenal of weapons.
Download or read book Metal Ions in Gene Regulation written by Simon Silver and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.
Download or read book Copper Transport and Its Disorders written by Arturo Leone and published by Springer. This book was released on 2012-10-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of presentations at the first meeting devoted to the mo lecular and cellular biology of copper transport. When we first considered the possible program for the meeting, we felt that a forum to integrate the recent advances in molecular understanding of copper transport with the older knowledge of copper metabolism was needed. In addition we wished to have a strong emphasis on the diseases of copper includ ing the genetic diseases, Menkes and Wilson, and other possible health aspects of this met al seen from a molecular perspective. Overall we were very happy with the success of the meeting, and most participants were very enthusiastic. Unfortunately we were not able to obtain manuscripts from every contributor, but the selection in this book covers most of the topics discussed. The history of biological research into copper dates from the latter half of the last century when the presence of copper as a component of living systems was first noted, but it was not until the 1920s that the essential role of copper was first recognized. l. S. McHargue found that plants and animals needed copper for optimal growth and health and proposed that copper was needed for life (McHargue, 1925). Other groups soon confirmed these observations in plants. In animals the requirement of copper for hematopoiesis was discovered in 1928 (Hart et aI.
Download or read book Yeast Stress Responses written by Stefan Hohmann and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every cell has developed mechanisms to respond to changes in its environment and to adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast has long proven as a particularly useful model system for the analysis of cellular stress responses, and the completion of the yeast genome sequence has only added to its power This volume comprehensively reviews both the basic features of the yeast genral stress response and the specific adapations to different stress types (nutrient depletion, osmotic and heat shock as well as salt and oxidative stress). It includes the latest findings in the field and discusses the implications for the analysis of stress response mechanisms in higher eukaryotes as well.
Download or read book Aging at the Molecular Level written by Thomas von Zglinicki and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 40 years, the study of the biological basis of aging has progressed tremendously, and it has now become an independent and respectable field of study and research. The essential cause of aging is molecular damage that slowly overwhelms cellular and organismic defense, repair and maintenance systems. In recent years, a wealth of highly sophisticated research has transformed this idea from a credible hypothesis not only to a major theory, but essentially to accepted knowledge. Aging at the Molecular Level examines the key elements in this transformation. Bringing together contributions from an international team of authors, this volume will be of interest to graduates and postgraduates in the fields of medicine and nursing, researchers of different aspects of biogerontology and those in the pharmaceutical, cosmeceutical, nutraceutical and health-care industry.
Download or read book Zinc Finger Proteins written by Shiro Iuchi and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.
Download or read book Stress Induced Gene Expression in Plants written by Amarjit Basra and published by CRC Press. This book was released on 1994-09-21 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers from North America and Western Europe discuss the state of the art research on gene expression in plants as affected by various stresses such as water deficit, seed dessication, anoxia, salinity, temperature extremes, heavy metals, air pollutants, and infection by pathogens. They also look at the possibilities of exploiting genes that regulate ozone resistance and the ingenious molecular strategies that have been developed by plants for dealing with pathogen attack. Annotation copyright by Book News, Inc., Portland, OR
