Download or read book Transcription Induction Integrated by Nuclear Receptor Coregulators written by Eric Dammer and published by . This book was released on 2009-02-01 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies carried out during the past decade have shown that transcription of inducible eukaryotic genes involves sequential chromatin modifications by promoter-specific transcription factors and a class of proteins called transcription coregulators. First, this work identifed important chromatin modifications and modifying complexes at the CYP17 transcription start site and nearby steroidogenic factor-1 (SF-1) binding site. Post translational modifications (PTMs) to SF-1 also occur as this transcription factor interacts with the promoter. In addition, ACTH/cAMP signaling in adrenal cortex alters SF-1-containing chromatin- modifying complexes during the early phase of transcriptional induction of CYP17. Chromatin IP (ChIP) and mammalian two hybrid experiments identified complexes which are cAMP-inducible, but sensitive to the SF-1 antagonist sphingosine. SF-1 PTMs at the ligand binding pocket opening were found to be required for CYP17 transcription. Last, certain corepressors are protein kinase A (PKA) targets and are functionally sensitive to PKA- dependent NADH accumulation. Thus, signaling, metabolism, and transcription are integrated.
Download or read book Nuclear Receptors Coregulators And Human Diseases written by Rakesh Kumar and published by World Scientific. This book was released on 2008-03-14 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the “classic” papers as well as perspectives on future directions for the field.
Download or read book NR Coregulators and Human Diseases written by Rakesh Kumar (Ph. D.) and published by World Scientific. This book was released on 2008 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the OC classicOCO papers as well as perspectives on future directions for the field. Sample Chapter(s). Chapter 1: Nuclear Receptor Coregulators in Human Diseases (839 KB). Contents: Nuclear Receptor Coregulators in Human Diseases (R B Lanz et al.); p160 Coactivators: Critical Mediators of Transcriptional Activation by Nuclear Receptors (J H Kim & M R Stallcup); Regulation of Nuclear Hormone Receptor Functions by Ubiquitin-Proteasome Pathway (A Ismail et al.); Coregulators as Oncogenes and Tumor Suppressors (R Kumar & A E Gururaj); A Central Role of SRC-3/AIB1 in Tumorigenesis (J Yan et al.); Thyroid Hormone Receptors, Coregulators, and Disease (M L Privalsky); Androgen Receptor Coactivators in Prostate Cancer (N L Weigel & I U Agoulnik); PGC-1 and Metabolic Control in Skeletal and Cardiac Muscle (Z Arany & B M Spiegelman); Coregulators in Metabolic and Neurodegenerative Diseases (J N Feige et al.); Role of the RIP140 Corepressor in Metabolic Regulation (M G Parker et al.); Nuclear Receptor Corepressors and Metabolism (T Alenghat & M A Lazar); Coregulators in CNS Function and Disease (O C Meijer & E R de Kloet); Tissue Repair and Cancer Control Through PPARs and Their Coregulators (L Michalik & W Wahli); Coregulators and Inflammation (S Ghisletti & W Huang); Nuclear Receptor Coactivators in the Cardiovascular System (J-M Xu); Coregulators as Determinants of Selective Receptor Modulator (SRM) Activity (M C Pace & C L Smith); Coregulators in Toxicology (J Regg et al.); Nuclear Receptor Coactivators Co-ordinate Metabolic Responses to Hormonal and Environmental Stimuli (R M Evans et al.); Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery (L L Grasfeder & D P McDonnell). Readership: Academic, medical students, residents, fellow and biomedical research students."
Download or read book The Interaction of Transcriptional Coregulators and Nuclear Receptors written by Oliver Hirsch and published by . This book was released on 2007 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Receptors and Coregulators in Metabolism and Immunity written by Rongrong Fan and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Receptor Coregulators written by and published by Academic Press. This book was released on 2004-08-11 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. *First published in 1943, Vitamins and Hormones is AP's longest running serial *Each volume contains cutting edge reviews by leading contributors
Download or read book Nuclear Receptors as Drug Targets written by Eckhard Ottow and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
Download or read book The Role of Coregulator Proteins in Nuclear Receptor Transcriptional Activity written by Ramji Ramaswamy Rajendran and published by . This book was released on 2003 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Download or read book Nuclear Receptors in Human Health and Disease written by Moray J. Campbell and published by Springer Nature. This book was released on 2022-09-15 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
Download or read book The Nuclear Receptor FactsBook written by Vincent Laudet and published by Gulf Professional Publishing. This book was released on 2002 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure, Isolation, DNA binding properties, Ligands, Expression, Target genes, Knockouts, Disease association, Gene structure, promoter and isoforms, Chromosomal location, Amino acid sequences, Key references
Download or read book Transcription Factors written by Joseph Locker and published by Garland Science. This book was released on 2003-12-16 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the DNA-binding transcription factors and the proteins with which they directly interact. It examines the regulatory systems that modulate gene expression in all cells and the more specialized systems that regulate localized gene expression throughout the mammalian organism.
Download or read book The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and published by Humana Press. This book was released on 2008-12-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Download or read book Transcriptional Regulation of Cellular Co regulators of Nuclear Receptors written by Zhongming Zhang and published by . This book was released on 2003 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neurosteroids written by Hubert Vaudry and published by Frontiers E-books. This book was released on with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thirty years ago, the group of Baulieu and colleagues discovered that certain steroid hormones were present in higher amounts in the brain than in the plasma, and also found that suppression of circulating steroids by adrenalectomy and castration did not affect the concentration of pregnenolone, dehydroepiandrosterone and their sulfate esters in the rat brain. These seminal observations led to the concept that the brain, in very much the same way as the adrenal cortex, testis, ovary and placenta, was capable of synthesizing steroids. These brain born steroids, called neurosteroids, have been found to exert a vast array of biological activities. A number of steroidogenic enzymes have now been identified in the central nervous system by immunohistochemistry and in situ hybridization, and the neuronal and hormonal mechanisms regulating the biosynthesis of neurosteroids have been partially elucidated. The aim of this Research Topic is to celebrate three decades of research on neurosteroids by gathering a bouquet of review papers and original articles from leading scientists in the flourishing field of neurosteroids.
Download or read book Nuclear Receptors written by Mostafa Z. Badr and published by Springer Nature. This book was released on 2021-09-28 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
