Download or read book Towards the Total Synthesis of Spirastrellolide E written by Alexander Sokolsky and published by . This book was released on 2015 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation describes progress towards the synthesis of spirastrellolide E, a potent cytotoxic marine macrolide. In particular, the synthesis of advanced southern hemisphere fragments is reported. Chapter 1 details the isolation, structural determination, and biological activity of the spirastrellolide family, as well as synthetic efforts towards members of the family. Chapter 2 describes the evolution of the Smith group synthetic strategy towards the spirastrellolides, details the choice of target for a total synthesis effort, and describes a successful first generation approach to a relevant advanced southern hemisphere fragment. Key steps involve a convergent Type I Anion Relay Chemistry (ARC) union and a gold catalyzed directed spiroketalization. Chapter 3 then revises the overall retrosynthetic analysis by proposing a novel strategy for hemisphere union, involving a cross metathesis/epoxidation/epoxide ring opening cascade, and describes the synthesis of more than 500 mg of a revised southern hemisphere fragment. In addition, the mechanism of the key directed gold catalyzed spiroketalization is discussed in detail. A stereochemical rationale for diverging outcomes during spiroketalization is described.

Download or read book Studies Towards the Total Synthesis of spirastrellolide A written by Julien Genovino and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Spirastrellolide A Methyl Ester written by Jong Ho Lim and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Total Synthesis of spirastrellolide A Methyl Ester written by Philip James Maltas and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Toward the Total Synthesis of Spirastrellolide A written by Steven Merwin Kennedy and published by . This book was released on 2010 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter one of this dissertation describes background into the biological properties of spirastrellolide A (SA) as a potent and selective protein phosphatase inhibitor. It then goes on to provide information on the isolation, structural elucidation, and structural features of SA. Additionally, it compares SA to other natural products with similar biological activity. Finally, chapter one ends with a literature review of synthetic work on SA and the other known spirastrellolides. By highlighting the total syntheses of spirastrellolide A methyl ester by Paterson and spirastrellolide F methyl ester by Fürstner an overview of synthetic challenges, strategies, and methods is seen. Other synthetic progress on the spirastrellolides is also briefly acknowledged. Chapter two provides a detailed account of my spirastrellolide A synthetic progress. It begins by analyzing synthetic challenges inherent to SA. Then my hypothesized synthetic plan for a total synthesis of SA is outlined. Synthetic advancement toward specific fragments of the SA carbon chain is discussed. It covers strategies employed for building the carbon framework of the molecule while installing necessary stereocenters. As chapter two continues, studies toward the synthesis of four distinct fragments of SA are explored. A synthesis of the C41-C47 side chain is explained. The C33-C40 fragment synthesis is also described. Next, the synthesis of stereospecific chlorohydrin containing molecules is examined. Finally, the progress toward a synthesis of the C1-C16 fragment is described in detail. The synthesis of this fragment focuses partially on the incorporation of methodology previously developed in the Chamberlin laboratory to install a cis-tetrahydropyran ring and an anti-1,3-diol moiety. The chapter concludes with suggested work. Chapter three provides all of the necessary information and data to repeat the work reported in chapter two. It begins with experimental procedures for synthesizing each of the key intermediates mentioned in successful synthetic routes. Each experimental procedure is followed by experimental data. Finally, chapter three is followed by an appendix with 1H and 13C NMR spectra useful for identifying key molecular structures.

Download or read book Total Synthesis of the Macrolide Core of spirastrellolide A written by S. M. Dalby and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Progress in Heterocyclic Chemistry written by Gordon Gribble and published by Elsevier. This book was released on 2009-06-16 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 20th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2007. As with previous volumes in the series, Volume 20 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way. * A critical review of the heterocyclic literature published during 2007 * Presents specialized reviews * Chapters all written by leading researchers in their field

Download or read book Studies Towards the Total Synthesis of Popolohuanone E written by Ross Matthew Denton and published by . This book was released on 2005 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Toward the Total Synthesis of Pseudolarolide E written by Matthieu Barragué and published by . This book was released on 2001 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Related to the Total Synthesis of Blepharocalyxin E written by Sidika Polat Cakir and published by . This book was released on 2005 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Boron Science written by Narayan S. Hosmane and published by CRC Press. This book was released on 2016-04-19 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron has made a significant impact in our lives through its quiet use in fertilizers, fungicides, soaps, detergents, and heat-resistant glassware. Boron Science: New Technologies and Applications addresses the applications of boron in chemistry, industry, medicine, and pharmacology by explaining its role in problems such as catalysis and hydrobora

Download or read book Studies Towards the Total Synthesis of Superstolide A written by Yuichi Tateno and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Heterocycles in Natural Product Synthesis written by Krishna C. Majumdar and published by John Wiley & Sons. This book was released on 2011-06-15 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.

Download or read book Towards the Total Synthesis of Agariblazeispirol C written by Laura C. Paterson and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Towards the Total Synthesis of Bryostatin 1 written by Seyed Hassan Seradj and published by . This book was released on 2009 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Merrilactone A written by Karsten Meyer and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Merrilactone A written by Jone Iriondo-Alberdi and published by . This book was released on 2007 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: