Download or read book Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI written by Belén Casas Garcia and published by Linköping University Electronic Press. This book was released on 2019-02-15 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current diagnostic tools for assessing cardiovascular disease mostly focus on measuring a given biomarker at a specific spatial location where an abnormality is suspected. However, as a result of the dynamic and complex nature of the cardiovascular system, the analysis of isolated biomarkers is generally not sufficient to characterize the pathological mechanisms behind a disease. Model-based approaches that integrate the mechanisms through which different components interact, and present possibilities for system-level analyses, give us a better picture of a patient’s overall health status. One of the main goals of cardiovascular modelling is the development of personalized models based on clinical measurements. Recent years have seen remarkable advances in medical imaging and the use of personalized models is slowly becoming a reality. Modern imaging techniques can provide an unprecedented amount of anatomical and functional information about the heart and vessels. In this context, three-dimensional, three-directional, cine phase-contrast (PC) magnetic resonance imaging (MRI), commonly referred to as 4D Flow MRI, arises as a powerful tool for creating personalized models. 4D Flow MRI enables the measurement of time-resolved velocity information with volumetric coverage. Besides providing a rich dataset within a single acquisition, the technique permits retrospective analysis of the data at any location within the acquired volume. This thesis focuses on improving subject-specific assessment of cardiovascular function through model-based analysis of 4D Flow MRI data. By using computational models, we aimed to provide mechanistic explanations of the underlying physiological processes, derive novel or improved hemodynamic markers, and estimate quantities that typically require invasive measurements. Paper I presents an evaluation of current markers of stenosis severity using advanced models to simulate flow through a stenosis. Paper II presents a framework to personalize a reduced-order, mechanistic model of the cardiovascular system using exclusively non-invasive measurements, including 4D Flow MRI data. The modelling approach can unravel a number of clinically relevant parameters from the input data, including those representing the contraction and relaxation patterns of the left ventricle, and provide estimations of the pressure-volume loop. In Paper III, this framework is applied to study cardiovascular function at rest and during stress conditions, and the capability of the model to infer load-independent measures of heart function based on the imaging data is demonstrated. Paper IV focuses on evaluating the reliability of the model parameters as a step towards translation of the model to the clinic.

Download or read book Patient Specific Modeling of the Cardiovascular System written by Roy C.P. Kerckhoffs and published by Springer Science & Business Media. This book was released on 2010-09-03 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Download or read book Automated Assessment of Blood Flow in the Cardiovascular System Using 4D Flow MRI written by Mariana Bustamante and published by Linköping University Electronic Press. This book was released on 2018-03-23 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical image analysis focuses on the extraction of meaningful information from medical images in order to facilitate clinical assessment, diagnostics and treatment. Image processing techniques have gradually become an essential part of the modern health care system, a consequence of the continuous technological improvements and the availability of a variety of medical imaging techniques. Magnetic Resonance Imaging (MRI) is an imaging technique that stands out as non-invasive, highly versatile, and capable of generating high quality images without the use of ionizing radiation. MRI is frequently performed in the clinical setting to assess the morphology and function of the heart and vessels. When focusing on the cardiovascular system, blood flow visualization and quantification is essential in order to fully understand and identify related pathologies. Among the variety of MR techniques available for cardiac imaging, 4D Flow MRI allows for full three-dimensional spatial coverage over time, also including three-directional velocity information. It is a very powerful technique that can be used for retrospective analysis of blood flow dynamics at any location in the acquired volume. In the clinical routine, however, flow analysis is typically done using two-dimensional imaging methods. This can be explained by their shorter acquisition times, higher in-plane spatial resolution and signal-to-noise ratio, and their relatively simpler post-processing requirements when compared to 4D Flow MRI. The extraction of useful knowledge from 4D Flow MR data is especially challenging due to the large amount of information included in these images, and typically requires substantial user interaction. This thesis aims to develop and evaluate techniques that facilitate the post-processing of thoracic 4D Flow MRI by automating the steps necessary to obtain hemodynamic parameters of interest from the data. The proposed methods require little to no user interaction, are fairly quick, make effective use of the information available in the four-dimensional images, and can easily be applied to sizable groups of data.The addition of the proposed techniques to the current pipeline of 4D Flow MRI analysis simplifies and expedites the assessment of these images, thus bringing them closer to the clinical routine. Medicinsk bildanalys fokuserar på extrahering av meningsfull information från medicinska bilder för att underlätta klinisk bedömning, diagnostik, och behandling. Bildbehandlingsteknik har gradvis blivit en viktig del av det moderna sjukvårdsystemet, en följd av de kontinuerliga tekniska förbättringarna och tillgången till en mängd olika medicinska bildtekniker. Magnetic resonanstomografi (MRT) är en bildteknik som är ickeinvasiv, flexibel och kan generera bilder av hög kvalitet utan joniserande strålning. MRT utförs ofta i klinisk miljö för att bedöma anatomi och funktion av hjärtat och blodkärlen. När man fokuserar på hjärt-kärlsystemet är bedömning av blodflödet viktigt för att kunna förstå och identifiera sjukdomar fullt ut. Bland de olika MRT-teknikerna som är tillgängliga för avbildning av hjärtat möjliggör 4D flödes-MRT komplett täckning av hjärtat i tre dimensioner över tid, och med hastighetsinformation i tre riktningar. 4D flödes-MRT är en mycket effektiv metod som kan användas för retrospektiv analys av blodflödesdynamik på vilken position som helst i den avbildade volymen. Till vardags görs dock blodflödesanalysen vanligtvis på bilder tagna med tvådimensionella avbildningsmetoder. Detta kan förklaras av deras kortare insamlingstider, högre spatiella upplösning, bättre signal-brusförhållandet, och att de är relativt enklare att efterbehandla jämfört med 4D flödes-MRT. Utvinningen av användbar information från 4D flödes-MRT-data är väldigt utmanande på grund av den stora mängden information som dessa bilder innehåller och kräver vanligtvis väsentlig användarinteraktion. Denna avhandling syftar till att utveckla och utvärdera metoder som underlättar efterbehandlingen av 4D flödes-MRT genom att automatisera de steg som är nödvändiga för att härleda hemodynamiska parametrarna av intresse från dessa data. De föreslagna metoderna kräver liten eller ingen användarinteraktion, är relativt snabba, använder all information som finns i de fyrdimensionella bilderna, och kan enkelt appliceras på stora datamängder. Tillägget av de i avhandlingen beskrivna metoderna till den nuvarande analysen av 4D flödes-MRT medger en avsevärd förenkling och uppsnabbad utvärdering, vilket gör att den avancerade 4D flödes MRT-tekniken kommer närmare att kunna användas i kliniskt rutinarbete.

Download or read book Patient Specific Modeling of the Cardiovascular System written by and published by . This book was released on 2011-07-11 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook on Augmenting Telehealth Services written by Sonali Vyas and published by CRC Press. This book was released on 2024-01-26 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on Augmenting Telehealth Services: Using Artificial Intelligence provides knowledge of AI-empowered telehealth systems for efficient healthcare services. The handbook discusses novel innovations in telehealth using AI techniques and also focuses on emerging tools and techniques in smart health systems. The book highlights important topics such as remote diagnosis of patients and presents e-health data management showcasing smart methods that can be used to improvise healthcare support and services. The handbook also shines a light on future trends in AI-enabled telehealth systems. Features Provides knowledge of AI-empowered telehealth systems for efficient healthcare services Discusses novel innovations in telehealth using AI techniques Covers emerging tools and techniques in smart health systems Highlights remote diagnosis of patients Focuses on e-health data management and showcases smart methods used to improvise healthcare support and services Shines a light on future trends in AI-enabled telehealth systems Every individual (patients, doctors, healthcare staff, etc.) is currently getting adapted to this new evolution of healthcare. This handbook is a must-read for students, researchers, academicians, and industry professionals working in the field of artificial intelligence and its uses in the healthcare sector.

Download or read book Image based Computational Approaches for Personalized Cardiovascular Medicine Improving Clinical Applicability and Reliability through Medical Imaging and Experimental Data written by Selene Pirola and published by Frontiers Media SA. This book was released on 2023-07-13 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mathematical Modeling of Cardiovascular Systems From Physiology to the Clinic written by Julius Guccione and published by Frontiers Media SA. This book was released on 2020-01-13 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Modeling Biomaterials written by Josef Málek and published by Springer Nature. This book was released on 2022-01-21 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The investigation of the role of mechanical and mechano-chemical interactions in cellular processes and tissue development is a rapidly growing research field in the life sciences and in biomedical engineering. Quantitative understanding of this important area in the study of biological systems requires the development of adequate mathematical models for the simulation of the evolution of these systems in space and time. Since expertise in various fields is necessary, this calls for a multidisciplinary approach. This edited volume connects basic physical, biological, and physiological concepts to methods for the mathematical modeling of various materials by pursuing a multiscale approach, from subcellular to organ and system level. Written by active researchers, each chapter provides a detailed introduction to a given field, illustrates various approaches to creating models, and explores recent advances and future research perspectives. Topics covered include molecular dynamics simulations of lipid membranes, phenomenological continuum mechanics of tissue growth, and translational cardiovascular modeling. Modeling Biomaterials will be a valuable resource for both non-specialists and experienced researchers from various domains of science, such as applied mathematics, biophysics, computational physiology, and medicine.

Download or read book Multimodality Imaging Innovations In Adult Congenital Heart Disease written by Pastora Gallego and published by Springer Nature. This book was released on 2021-06-16 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on congenital heart disease (CHD) and emerging imaging technologies. It covers all clinically relevant aspects of the fascinating new cardiac imaging technologies, including a comprehensive explanation of their basic principles, practical aspects of novel clinical applications, and detailed descriptions of specific uses in the broad spectrum of clinically important adult CHD. Innovations and emerging technologies for diagnosis and therapeutics, evaluation and treatment are continually evolving, and due to these advances in non-invasive diagnosis, there has been a significant improvement in the survival rates for CHD patient. Novel approaches to trans-catheter interventions and advances in echocardiography, MRI and CT imaging are being developed and incorporated into routine clinical practice, while emerging three-dimensional printing technologies are fundamentally affecting patient care, research, trainee education, and interactions between multidisciplinary teams, patients, and caregivers. In addition, translational technologies on the horizon promise to take this nascent field even further. Exploring the applicability of these emerging technologies in improving our understanding of complex congenital cardiac defect anatomy and physiology will provide new treatment options for this unique population. Written by experts in the field who are also involved in patient care, this book discusses the practical application of innovations in advanced multimodality imaging in the daily clinical routine and offers tips and tricks for beginners.

Download or read book Information Systems and Technologies written by Alvaro Rocha and published by Springer Nature. This book was released on 2022-05-10 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the following main topics: A) information and knowledge management; B) organizational models and information systems; C) software and systems modeling; D) software systems, architectures, applications and tools; E) multimedia systems and applications; F) computer networks, mobility and pervasive systems; G) intelligent and decision support systems; H) big data analytics and applications; I) human–computer interaction; J) ethics, computers and security; K) health informatics; L) information technologies in education; M) information technologies in radio communications; N) technologies for biomedical applications. This book is composed by a selection of articles from The 2022 World Conference on Information Systems and Technologies (WorldCIST'22), held between April 12 and 14, in Budva, Montenegro. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences, and challenges of modern information systems and technologies research, together with their technological development and applications.

Download or read book The Pathogenetic Mechanisms at the Basis of Aortopathy Associated with Bicuspid Aortic Valve Insights from Omics Models of Disease and Emergent Technologies written by Amalia Forte and published by Frontiers Media SA. This book was released on 2018-01-24 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This forum of comprehensive reviews and research studies on distinct aspects of the pathophysiology of BAV aortopathy provides both the state of the art in the knowledge on this complex disease and novel insights into its causes and consequences. The present collection of focused papers also envisions and proposes new therapeutic strategies, novel biomarkers and original risk stratification criteria, for the improvement of patient management.

Download or read book Insights in cardiovascular imaging 2022 written by Christos Bourantas and published by Frontiers Media SA. This book was released on 2023-07-21 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Statistical Atlases and Computational Models of the Heart Imaging and Modelling Challenges written by Oscar Camara and published by Springer. This book was released on 2013-04-03 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the thoroughly refereed post-conference proceedings of the Third International Workshop on Statistical Atlases and Computational Models of the Heart: Imaging and Modelling Challenges, STACOM 2012, held in conjunction with MICCAI 2012, in Nice, France, in October 2012. The 42 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on CFD challenge, DE-MRI segmentation challenge, LV landmark detection challenge, motion tracking analysis challenge, and regular papers.

Download or read book Cardiovascular Mathematics written by Luca Formaggia and published by Springer Science & Business Media. This book was released on 2010-06-27 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.

Download or read book Hemodynamic Forces and Endothelial Mechanobiology in Vascular Diseases written by Chih-Yu Yang and published by Frontiers Media SA. This book was released on 2022-08-29 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cardiovascular Biomechanics written by Peter R. Hoskins and published by Springer. This book was released on 2017-02-16 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a balanced presentation of the fundamental principles of cardiovascular biomechanics research, as well as its valuable clinical applications. Pursuing an integrated approach at the interface of the life sciences, physics and engineering, it also includes extensive images to explain the concepts discussed. With a focus on explaining the underlying principles, this book examines the physiology and mechanics of circulation, mechanobiology and the biomechanics of different components of the cardiovascular system, in-vivo techniques, in-vitro techniques, and the medical applications of this research. Written for undergraduate and postgraduate students and including sample problems at the end of each chapter, this interdisciplinary text provides an essential introduction to the topic. It is also an ideal reference text for researchers and clinical practitioners, and will benefit a wide range of students and researchers including engineers, physicists, biologists and clinicians who are interested in the area of cardiovascular biomechanics.

Download or read book Statistical Atlases and Computational Models of the Heart ACDC and MMWHS Challenges written by Mihaela Pop and published by Springer. This book was released on 2018-03-14 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the thoroughly refereed post-workshop proceedings of the 8th International Workshop on Statistical Atlases and Computational Models of the Heart: ACDC and MMWHS Challenges 2017, held in conjunction with MICCAI 2017, in Quebec, Canada, in September 2017. The 27 revised full workshop papers were carefully reviewed and selected from 35 submissions. The papers cover a wide range of topics computational imaging and modelling of the heart, as well as statistical cardiac atlases. The topics of the workshop included: cardiac imaging and image processing, atlas construction, statistical modelling of cardiac function across different patient populations, cardiac computational physiology, model customization, atlas based functional analysis, ontological schemata for data and results, integrated functional and structural analyses, as well as the pre-clinical and clinical applicability of these methods. Besides regular contributing papers, additional efforts of STACOM workshop were also focused on two challenges: ACDC and MM-WHS.