Download or read book Total Synthesis of the EF Fragment of Spongistatin 1 en Route to a Spongistatin 1 Analog written by Joshua Ross Infantine and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A major goal of the Leighton group is the synthesis of biologically relevant polyketide natural products. Among the most potent and chemically intriguing member of this class is spongistatin 1. This molecule has interested biologists and chemists for more than two decades. In this thesis, we report a highly practical and efficient synthesis of the EF fragment of spongistatin 1. This relied on the rapid introduction of a complex stereochemical array using double cross-metathesis/Sharpless asymmetric dihydroxylation reactions to quickly build the F-ring of spongistatin. The six contiguous stereocenters of the F-ring were established in just five steps. A new one-pot asymmetric strained-silane mediated allylation was developed that was greatly improved over previous methods in regards to practicality and substrate scope. This methodology was used to introduce the sensitive chlorodiene side chain. Finally, completion of the EF fragment led to the synthesis of a spongistatin 1 analog, using our previously developed redesigned ABCD fragment.

Download or read book Studies Directed Towards the Total Synthesis of Spongistatin 1 and the Cyclitols written by Edward B. Holson and published by . This book was released on 2003 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Organocatalysis written by Maurizio Benaglia and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-07-19 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organocatalysis is considered today one of the three pillars in asymmetric catalysis, along with biocatalysis and organometallic catalysis. The current book gives an overview of the new reactions, the catalysts and their activation strategies reported in recent years. In addition, the applications of organocatalysis in total synthesis, radical reactions, flow chemistry and industrial practice are discussed.

Download or read book Total Synthesis of spongistatin 1 and Studies Towards the Gram scale Synthesis of spongistatin 1 written by Wenyu Zhu and published by . This book was released on 2003 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Spongistatin 1 written by D. Y.-K. Chen and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of Spongistatin 1 altohyrtin A and Pectenotoxin II written by Glenn C. Micalizio and published by . This book was released on 2001 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toward the Gram scale Total Synthesis of Spongistatin 1 written by Chris Sfouggatakis and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of Spongistatin 1 written by David Glenn Washburn and published by . This book was released on 1999 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Spongistatins 1 and 2 written by Jason David Katz and published by . This book was released on 2001 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Synthesis of the C1 C28 Fragment of Spongistatin 1 written by S. J. Bamford and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of the Protected Seco acid of Spongistatin 1 written by Mark Jeffrey Coster and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis of the C 16 C 28 CD Spiroketal Fragment of Spongistatin 1 written by D. F. Hook and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Spongistatin 1 altohyrtin A and Siphonariid Derived Marine Natural Products written by D. Y.-K. Chen and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Toward the Synthesis of the C29 C51 Fragment of Altohyrtin A Spongistatin 1 written by Il Hwan Cho and published by . This book was released on 2000 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2005 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Towards the Total Synthesis of Bryostatin 1 written by Seyed Hassan Seradj and published by . This book was released on 2009 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: