Download or read book Total Synthesis of Maoecrystal V written by Jianxian Gong and published by Springer. This book was released on 2014-07-08 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Download or read book Total Synthesis of Maoecrystal V written by Jianxian Gong and published by . This book was released on 2014-03-31 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of Maoecrystal V written by Feng Peng and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes in detail our journey toward Maoecrystal V, a potential anti-cancer diterpenoid. Maoecrsytal V was isolated in 2004 from a Chinese herbal medicine. It has a highly congested structure, in which there are three continuous quaternary carbon center embedded within a rigid pentacyclic scaffold. The first chapter of this thesis covers the isolation, bioactivity, and synthetic efforts from other groups. The second chapter discusses our first generation strategy toward Maoecrystal V. During our early studies, we successfully found the conditions for the key intramolecular Diels-Alder reaction. We also identified that the facial selectivity of this Diels-Alder reaction is a big challenge for our synthesis plan. The third chapter describes our solution to the core structure of Maoecrystal V. The exploration resulted in the discovery of a novel exo-glycal epoxide rearrangement. The last chapter describes the total synthesis of Maoecrystal V. The difficulties we met and our solution is discussed.
Download or read book Studies Toward the Total Synthesis of Maoecrystal V written by Paul John Krawczuk and published by . This book was released on 2011 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2004, Li and coworkers reported the isolation of the complex diterpenoid maoecrystal V, from the leaves of the Chinese medicinal herb Isodon eriocalyx, whose structure was verified by x-ray crystallographic analysis. It possesses a unique architecture, with five highly congested rings and seven stereocenters, two of which are adjacent all carbon quaternary centers located in its interior. In addition to the complex structure of this natural product, it also has promising biological activity, showing selective cytotoxicity towards the HeLa tumor cell line at low concentration (IC50 =40 nM), and low toxicity towards other cell lines tested. For these reasons maoecrystal V has attracted significant attention from the synthetic community. Herein we report on many of the strategies that we have pursued towards the total synthesis. One of these strategies culminated in the stereoselective synthesis of the complete carbon skeleton of the natural product. The hallmarks of this strategy are the arylation of a substituted cyclohexane ring, followed by an oxidative dearomatization, and finally by an intramolecular Diels-Alder reaction in order to construct the [2.2.2]bicyclooctane moiety.
Download or read book Studies in Natural Product Synthesis written by Irina Albrecht and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progress Towards a Total Synthesis of the Highly Selective Cytotoxic Natural Product Maoecrystal V written by Douglas D. McLeod and published by . This book was released on 2010 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang and published by John Wiley & Sons. This book was released on 2018-10-16 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals
Download or read book Asymmetric Dearomatization Reactions written by Shu-Li You and published by John Wiley & Sons. This book was released on 2016-06-03 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive account of the rapidly growing field of asymmetric dearomatization reactions with a focus on catalytic methods. It introduces the concept of dearomatization and describes recent progress in asymmetric reaction procedures with different catalyst systems, such as organocatalysts, transition metal catalysts, and enzymes. Chapters on dearomatizations of electron-deficient aromatic rings, dearomatization reactions via transition metal-catalyzed cross-couplings as well as dearomatization strategies in the synthesis of complex natural products are also included. Written by pioneers in the field, this is a highly valuable source of information not only for professional synthetic chemists in academia and industry but also for all those are interested in asymmetric methodologies and organic synthesis in general.
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Download or read book Advances in Organometallic Chemistry written by and published by Academic Press. This book was released on 2016-10-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Organometallic Chemistry contains authoritative review articles of worldwide known researchers on the field of organometallic chemistry, covering topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. The book will benefit a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies, and practical applications. Contains contributions from leading authorities in the field of organometallic chemistry Covers topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more Informs and updates readers on all the latest developments in the field Carefully edited to provide easy-to-read material
Download or read book Medicinal Plants and Mushrooms of Yunnan Province of China written by Clara Bik-San Lau and published by CRC Press. This book was released on 2021-06-17 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many texts describe plants from China, the focus of this book is to draw on the rich culture and environment of medicinal plants and fungi/mushrooms of Yunnan Province. In fact, Yunnan Province covers two global hotspots of biodiversity, with the richest biological and cultural diversity in China. In particular, the Kunming Institute of Botany (KIB) of the Chinese Academy of Sciences (founded in 1938 and located in the capital city of Yunnan Province) has made great contributions in the fields of botany and phytochemistry, earning an international reputation. This book covers those medicinal plants and fungi/mushrooms specific to Yunnan Province, and is written mainly by KIB experts in this research field. Key Features: Distinct sections cover the breadth of the topic including resource availability (wildly grown or cultivated), sustainability, and distribution Discusses plant parts used for medicinal uses (the folklore, the ancient and modern uses) Describes the important natural products and the known pharmacologically active components Presents biological activities related to medicinal uses or clinical evidence Cover image: Shilin, the stone forest (eroded vertical pinnacles of limestone), landmark of Kunming, Yunnan.
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2020-06-24 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry: Bioactive Natural Products, Volume 65, the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, provides cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products. This has opened up exciting opportunities in the field of new drug development to the pharmaceutical industry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
Download or read book Organic Synthesis written by Douglass F. Taber and published by Oxford University Press. This book was released on 2017-10-20 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic synthesis is a vibrant and rapidly evolving field; chemists can now cyclize alkenes directly onto enones. Like the first five books in this series, Organic Synthesis: State of the Art 2013-2015 will lead readers quickly to the most important recent developments in a research area. This series offers chemists a way to stay abreast of what's new and exciting in organic synthesis. The cumulative reaction/transformation index of 2013-2015 outlines all significant new organic transformations over the past twelve years. Future volumes will continue to come out every two years. The 2013-2015 volume features the best new methods in subspecialties such as C-O, C-N and C-C ring construction, catalytic asymmetric synthesis, selective C-H functionalization, and enantioselective epoxidation. This text consolidates two years of Douglass Taber's popular weekly online column, "Organic Chemistry Highlights" as featured on the organic-chemistry.org website and also features cumulative indices of all six volumes in this series, going back twelve years.
Download or read book Recent Developments Of Diazo Compounds In Organic Synthesis written by Di Qiu and published by World Scientific. This book was released on 2020-12-29 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diazo compounds are versatile substances with diverse transformations in organic synthesis and other fields. Studies of diazo compounds have been ongoing for a very long time but still attract significant attention within the organic chemistry community, with new papers related to diazo compounds appearing at a daily pace. Over the past twenty years, there have been over fifty reviews and accounts related to the reactions of diazo compounds, but most of them cover limited aspects of diazo compounds. In addition to organic synthesis, diazo compounds have found applications in interdisciplinary fields such as material sciences, chemical biology and also polymerization.In this comprehensive book, the authors cover the most recent advances in the fields related to diazo compounds, including the application of donor-acceptor carbenes, carbene-based cross-coupling reactions and polymerizations, as well as the breakthrough in catalytic asymmetric carbene O-H, S-H, and N-H bond insertions. They also cover the application of flow chemistry in diazo reactions. The authors aim to provide a contemporary and comprehensive review for investigators engaged in or with interest in diazo compounds to boost further developments in this fascinating field.
Download or read book Encyclopedia of Physical Organic Chemistry 6 Volume Set written by Zerong Wang and published by John Wiley & Sons. This book was released on 2017-04-17 with total page 4542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of 2018 PROSE Award for MULTIVOLUME REFERENCE/SCIENCE This encyclopedia offers a comprehensive and easy reference to physical organic chemistry (POC) methodology and techniques. It puts POC, a classical and fundamental discipline of chemistry, into the context of modern and dynamic fields like biochemical processes, materials science, and molecular electronics. Covers basic terms and theories into organic reactions and mechanisms, molecular designs and syntheses, tools and experimental techniques, and applications and future directions Includes coverage of green chemistry and polymerization reactions Reviews different strategies for molecular design and synthesis of functional molecules Discusses computational methods, software packages, and more than 34 kinds of spectroscopies and techniques for studying structures and mechanisms Explores applications in areas from biology to materials science The Encyclopedia of Physical Organic Chemistry has won the 2018 PROSE Award for MULTIVOLUME REFERENCE/SCIENCE. The PROSE Awards recognize the best books, journals and digital content produced by professional and scholarly publishers. Submissions are reviewed by a panel of 18 judges that includes editors, academics, publishers and research librarians who evaluate each work for its contribution to professional and scholarly publishing. You can find out more at: proseawards.com Also available as an online edition for your library, for more details visit Wiley Online Library
Download or read book Rhodium Catalysis in Organic Synthesis written by Ken Tanaka and published by John Wiley & Sons. This book was released on 2019-05-06 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference to the highly effective reactions applied to modern organic synthesis Rhodium complexes are one of the most important transition metals for organic synthesis due to their ability to catalyze a variety of useful transformations. Rhodium Catalysis in Organic Synthesis explores the most recent progress and new developments in the field of catalytic cyclization reactions using rhodium(I) complexes and catalytic carbon-hydrogen bond activation reactions using rhodium(II) and rhodium(III) complexes. Edited by a noted expert in the field with contributions from a panel of leading international scientists, Rhodium Catalysis in Organic Synthesis presents the essential information in one comprehensive volume. Designed to be an accessible resource, the book is arranged by different reaction types. All the chapters provide insight into each transformation and include information on the history, selectivity, scope, mechanism, and application. In addition, the chapters offer a summary and outlook of each transformation. This important resource: -Offers a comprehensive review of how rhodium complexes catalyze a variety of highly useful reactions for organic synthesis (e.g. coupling reactions, CH-bond functionalization, hydroformylation, cyclization reactions and others) -Includes information on the most recent developments that contain a range of new, efficient, elegant, reliable and useful reactions -Presents a volume edited by one of the international leading scientists working in the field today -Contains the information that can be applied by researchers in academia and also professionals in pharmaceutical, agrochemical and fine chemical companies Written for academics and synthetic chemists working with organometallics, Rhodium Catalysis in Organic Synthesis contains the most recent information available on the developments and applications in the field of catalytic cyclization reactions using rhodium complexes.
Download or read book Advances in Organometallic Chemistry written by Pedro J. Perez and published by Academic Press. This book was released on 2021-06-17 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Organometallic Chemistry, Volume 76, the latest release in this longstanding serial is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. It is ideal for a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies and practical applications. - Contains contributions from leading authorities in the field of organometallic chemistry - Covers topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more - Informs and updates readers on the latest developments in the field - Carefully edited to provide easy-to-read material
