Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellents AI3 37220 1 3 Cyclohexen 1 Ylcarbonyl 2 Methylpiperidine and AI3 37224 1 3 Cyclohexen 1 Ylcarbonyl 1 2 3 6 Tetrahydropyridine written by Allen W. Singer and published by . This book was released on 1980 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preliminary hazard evaluations of AI3-37220 and AI3-37224 were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. The technical grade of compounds caused mild skin and eye irritation, but no phototoxic or sensitization reactions. Neither compound proved to be acutely toxic by ingestion. (Author).
Download or read book Technical Abstract Bulletin written by and published by . This book was released on 1980 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellents AI3 37221 and AI3 37225 1 3 cyclohexen 1 ylcarbonyl 3 methylpiperidine and 1 3 cyclohexen 1 ylcarbonyl 4 methylipiperazine written by Allen W. Singer and published by . This book was released on 1980 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preliminary hazard evaluations of AI3-37221 and AI3-37225 were performed by means of laboratory animal studies using rabbits and guinea pigs. Both technical grade compounds caused moderate corneal and conjunctival irritations. AI3-37221 caused mild primary skin irritation; AI3-37225 caused no such reaction. AI3-37225 was tested for skin sensitization and found to be negative. (Author).
Download or read book Government Reports Annual Index written by and published by . This book was released on 1980 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellent AI3 36328 B 1 6 Methyl 3 Cyclohexen 1 YL Carbonyl Pyrrolidine Mar 1987 written by Maurice H. Weeks and published by . This book was released on 1987 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guidance for entomological testing of the Candidate Insect Repellent AI3-36328-b, 1-((6-methyl-3-cyclohexen-2-yl) carbonyl)pyrrolidine, irritation, skin, eye, toxic hazards, toxicity.
Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellent AI3 36329a 1 6 Methyl 3 cyclohexen 1 yl carbonyl piperidine April 1978 June 1979 written by Allen W. Singer and published by . This book was released on 1979 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: A preliminary hazard evaluation of AI3-36329a was performed by means of laboratory animal studies using rats, rabbits and guinea pigs. The technical grade compound caused mild primary skin and eye irritation in rabbits, and produced a photoirritation reaction. It did not sensitize guinea pigs or prove to be acute ingestion hazard . Ethanol solutions of AI3-36329a also produced primary skin irritation. It was recommended that AI3-36329a 1-((6-Methyl-3-cyclohexen-1-y1) carbonl)-piperidine, not be approved for further testing. (Author).
Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellents AI3 36325 1 Cyclohexylcarbonyl Hexahydro 1H Azepine AI3 36326 N N Dipropyl Cyclohexanecarboxamide and AI3 36328 1 6 Methyl 3 Cyclohexen 1 YL Carbonyl Pyrrolidine written by Allen W. Singer and published by . This book was released on 1980 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preliminary hazard evaluations of the above candidate repellents were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. None of the compounds caused any phototoxic or skin sensitization reactions, nor were they acutely toxic by ingestion. AI3-36325 and AI3-36328 caused moderate corneal and conjunctival injuries, however, AI3-36326 and AI3-36328 caused mild skin irritation. (Author).
Download or read book Government Reports Announcements Index written by and published by . This book was released on 1980 with total page 1284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Topical Hazard Evaluation of Candidate Insect Repellent AI3 36542 1 cyclohexylcarbonyl 1 2 3 6 tetrahydropyridine written by Maurice H. Weeks and published by . This book was released on 1977 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hazard evaluation of AI3-36542 was conducted using New Zealand White rabbits for skin and eye studies; Hartley guinea pigs for a skin sensitization study; and Sprague-Dawley, Wistar-derived rats for determination of acute oral toxicity. Technical grade AI3-36542 caused moderate corneal opacity and severe conjunctivitis, while ethanol solutions of this compound caused primary skin irritation.
Download or read book Topical Hazard Evaluation of Candidate Insect Repellent AI3 36537 a 1 Cyclohexylcarbonyl 3 Methylpiperidine written by Maurice H. Weeks and published by . This book was released on 1977 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hazard evaluation of AI3-36537-a was conducted using New Zealand White rabbits for skin and eye studies; Hartley guinea pigs for a skin sensitization study; and Sprague-Dawley, Wistar-derived rats for determination of acute oral toxicity. Moderate corneal opacity and conjunctivitis were observed after a single application of the technical grade compound to the eyes of rabbits.
Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellents AI3 37135 and AI3 37156 and AI3 37157 1 2 3 6 Tetrahydro 1 2 Methyl 1 Oxopentyl Pyridine 1 1 Oxobutyl 4 Phenylmethyl Piperidine and 1 2 Methyl 1 Oxopropyl 4 Phenylmethyl Piperidine written by Allen W. Singer and published by . This book was released on 1980 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preliminary hazard evaluations of AI3-37135, AI3-37156, and AI3-37157 were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. The technical grade compounds did not cause any skin or sensitization reactions, and only mild corneal irritations. AI3-37135 and AI3-37156, however, caused phototoxic reactions, and were not approved for further testing. AI3-37157 did not cause such a reaction, was not acutely toxic by ingestion, and was approved for further testing as a candidate repellent. (Author).
Download or read book Preliminary Assessment of the Relative Toxicity of the Candidate Insect Repellent 1 3 Cyclohexen 1 Ylcarbonyl piperidine AI3 35765 Acute Toxicity written by and published by . This book was released on 1990 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compound AI3-35765 is comparatively non-toxic by ingestion and by dermal absorption. It has no potential for causing dermal sensitization and does not exhibit mutagenic activity in cell culture. No hazard exists from short-term inhalation of its saturated vapors. The technical grade may cause moderate, but reversible, injury to the eye. Recommend conducting further entomological and toxicological studies with AI3-35765 to determine if candidate compound meets the requirements for an effective and safe full-spectra topical insect repellent. (TTL).
Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellent AI3 36420 1 2 3 4 Tetrahydro 2 1 oxooctyl Isoquinoline written by Maurice H. Weeks and published by . This book was released on 1977 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: AI3-36420 was evaluated on New Zealand White rabbits for its potential to cause skin and eye irritation. The data obtained serves as a basis for making a recommendation concerning its potential use on humans.
Download or read book Topical Hazard Evaluation Program of Candidate Insect Repellents AI3 16734 1 11 78 Ga AI3 37519 AI3 37521 AI3 37529a AI3 37531a and AI3 37532a US Department of Agriculture Proprietary Compounds written by Allen W. Singer and published by . This book was released on 1980 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: INSECT REPELLENT COMPOUND AI3-16734-(1, 11, 78)-Ga was tested for primary irritation by application to clipped dorsal skin and to the eyes of New Zealand White rabbits. Although it was only mildly irritating to the skin, eye applications resulted in rapid systemic absorption and sudden generalized convulsions in both rabbits used, with one of the rabbits dying overnight. This response was also seen with a chemically related candidate repellent AI3-37528a (rejected September 1979). Five additional homologs of AI3-16734-(1, 11, 78)-Ga currently await testing. With the concurrence of the originator, the Organic Synthesis Laboratory, Beltsville Research Center, Department of Agriculture, all six related compounds are recommended for withdrawal from future consideration as candidate insect repellents. These are: (1) AI3-16734(1,11,78)-Ga, (2) AI3-37519, (3) AI3-37521, (4) AI3-37529a, (5) AI3-37531a, and (6) AI3-37532a.
Download or read book Topical Hazard Evaluation of Candidate Insect Repellent AI3 36536 1 Cyclohexylcarbonyl 2 Methylpiperidine October July 1976 written by Maurice H. Weeks and published by . This book was released on 1976 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hazard evaluation of AI3-36536 was conducted using New Zealand White rabbits for skin and eye studies, Hartley guinea pigs for a skin sensitization study, and Sprague-Dawley Wistar-derived rats for determination of oral toxicity. It was recommended that AI3-36536 not be approved for further testing as a candidate insect repellent. (Author).
Download or read book Topical Hazard Evaluation of Candidate Insect Repellent AI3 36558 3 Methyl 1 2 Methylcyclohexyl carbonyl Piperidine written by Maurice H. Weeks and published by . This book was released on 1977 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hazard evaluation of AI3-36558 was conducted using New Zealand White rabbits for skin and eye studies, Hartley guinea pigs for a skin sensitization study, and Sprague-Dawley, Wistar-derived rats for determination of oral toxicity. It was found that AI3-36558 is a potential sensitizing chemical. Technical grade compound produced moderate injury to the cornea and to the conjunctiva of the rabbit and may cause similar damage if it should accidentally enter the eye of man.
Download or read book Topical Hazard Evaluation Program of Hexahydro 1 2 Methylcyclohexyl Carbonyl 1 H Azepine AI3 35770 US Department of Agriculture Candidate Insect Repellent written by J. V. Wade and published by . This book was released on 1984 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: All sample batches of hexahydro-(2-methylcyclohexyl) carbonyl)-1-H-azepine, Candidate Insect Repellent AI3-35770, produced moderate to severe primary irritation of the intact skin and of the skin surrounding an abrasion. This lesion was characterized by a palpable thickening of the skin, hyperkeratosis, with eventual sloughing of the application site. Ethanol solutions of these chemicals were moderately irritating to the intact skin, and did not produce as severe a response as the technical chemicals. Washing the skin with soap and water, 6 hours after application, of either the technical chemical or ethanol solutions did not reduce the severity of dermal irritation.
