Download or read book Compounded Topical Pain Creams written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is both a symptom and a disease. It manifests in multiple forms and its treatment is complex. Physical, social, economic, and emotional consequences of pain can impair an individual's overall health, well-being, productivity, and relationships in myriad ways. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. adults are living in pain. In terms of pain's global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. One such strategy is to expand use of topical pain medicationsâ€"medications applied to intact skin. This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. Compounding is an age-old pharmaceutical practice of combining, mixing, or adjusting ingredients to create a tailored medication to meet the needs of a patient. The aim of compounding, historically, has been to provide patients with access to therapeutic alternatives that are safe and effective, especially for people with clinical needs that cannot otherwise be met by commercially available FDA-approved drugs. Compounded Topical Pain Creams explores issues regarding the safety and effectiveness of the ingredients in these pain creams. This report analyzes the available scientific data relating to the ingredients used in compounded topical pain creams and offers recommendations regarding the treatment of patients.

Download or read book Dermatology Made Easy written by Amanda Oakley and published by Scion Publishing Ltd. This book was released on 2017-05-06 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise overview of the common dermatological conditions most likely to present in general medicine From reviews: "... a perfect solution to the constant struggle that dermatology diagnosis presents to primary care physicians and other providers... This well-formatted book covers a vast array of topics ranging from common to rare skin disorders. The pictures are immensely helpful in the understanding of various skin rashes...." Fam Med 2019;51(5):451–452. “... easy to read and informative. One cannot emphasise enough the quality and comprehensive nature of the photographic content.... As someone who was interested in dermatology even as a medical student my only regret is that this book was not around when I was a student as it would have very adequately guided me into my beloved subspecialty.” Ulster Med J 2017;86(3):1–1. “The introduction outlines dermatological conditions by symptom, morphology and body site, providing an excellent index prior to delving into greater detail in the following chapters. The logical approach and level of detail make this text perfect for medical students, interns/residents, primary care physicians and other specialists who wish to quickly identify differential diagnoses or refresh their knowledge of dermatological conditions.” A Lecturer in Dermatology Dermatology Made Easy is based on the hugely popular DermNet New Zealand website and is designed to help GPs, medical students and dermatologists diagnose skin conditions with confidence. The book starts by providing a series of comprehensive tables, complete with over 500 thumbnail photos, to aid diagnosis according to symptoms, morphology, or body site. Once you have narrowed down the diagnosis, cross-references then guide you to more detailed descriptions, and another 700 photographs, covering: common infections inflammatory rashes non-inflammatory conditions skin lesions Every section provides consistent information on the disorder: who gets it and what causes it? what are the clinical features and does it cause any complications? how do you diagnose it? how do you treat it and how long does it take to resolve? The book concludes with a comprehensive section on further investigations and treatment options. Dermatology Made Easy combines the essential focus of the Made Easy book series with the authority and knowledge base of DermNet New Zealand’s unparalleled resources. Printed in full colour throughout.

Download or read book Topical Absorption of Dermatological Products written by Robert L. Bronaugh and published by CRC Press. This book was released on 2002-01-02 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains current methods of analysis for new formulations of cosmetics, perfumes, creams, and lotions! With contributions from world-renowned experts in the field, Topical Absorption of Dermatological Products summarizes novel treatments for fungal nail infections emerging risk assessment procedures for sunscreen products

Download or read book pH of the Skin Issues and Challenges written by C. Surber and published by Karger Medical and Scientific Publishers. This book was released on 2018-08-21 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of expressing acidity as the negative logarithm of the hydrogen ion concentration was defined and termed pH in the beginning of the 20th century. The general usefulness of the pH concept for life science was recognized and later gained importance to analytical research. Reports on results of pH measurements from living skin established the term acid mantle - the skin's own protective shield that maintains a naturally acid pH. It is invisible to the eye but crucial to the overall wellbeing of skin. Chronic alkalization can throw this acid mantle out of balance, leading to inflammation, dermatitis, and atopic skin diseases. It is therefore no surprise, that skin pH shifts have been observed in various skin pathologies. It is also obvious that the pH in topically applied preparations may play an important role. Optimal pH and buffer capacity within topical preparations not only support stability of active ingredients and auxiliary materials, but may also increase absorption of the non-ionized species of an acidic or a basic active ingredient. They may even open up opportunities to modify and "correct" skin pH and hence accelerate barrier recovery and maintain or enhance barrier integrity. Further efforts are needed to standardize and improve pH measurements in biological media or pharmaceutical/cosmetic vehicles to increase and ensure quality, comparability, and relevance of research data. In this volume, we present a unique collection of papers that address past, present and future issues of the pH of healthy and diseased skin. It is hoped that this collection will foster future efforts in clinical and experimental skin research.

Download or read book Topical Drug Bioavailability Bioequivalence and Penetration written by Vinod P. Shah and published by Springer. This book was released on 2015-01-30 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Download or read book Biopharmaceutics written by Hannah Batchelor and published by John Wiley & Sons. This book was released on 2021-12-20 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the latest research in biopharmaceutics from leading contributors in the field In Biopharmaceutics - From Fundamentals to Industrial Practice, distinguished Scientists from the UK's Academy of Pharmaceutical Sciences Biopharmaceutica Focus Group deliver a comprehensive examination of the tools used within the field of biopharmaceutics and their applications to drug development. This edited volume is an indispensable tool for anyone seeking to better understand the field of biopharmaceutics as it rapidly develops and evolves. Beginning with an expansive introduction to the basics of biopharmaceutics and the context that underpins the field, the included resources go on to discuss how biopharmaceutics are integrated into product development within the pharmaceutical industry. Explorations of how the regulatory aspects of biopharmaceutics function, as well as the impact of physiology and anatomy on the rate and extent of drug absorption, follow. Readers will find insightful discussions of physiologically based modeling as a valuable asset in the biopharmaceutics toolkit and how to apply the principles of the field to special populations. The book goes on to discuss: Thorough introductions to biopharmaceutics, basic pharmacokinetics, and biopharmaceutics measures Comprehensive explorations of solubility, permeability, and dissolution Practical discussions of the use of biopharmaceutics to inform candidate drug selection and optimization, as well as biopharmaceutics tools for rational formulation design In-depth examinations of biopharmaceutics classification systems and regulatory biopharmaceutics, as well as regulatory biopharmaceutics and the impact of anatomy and physiology Perfect for professionals working in the pharmaceutical and biopharmaceutical industries, Biopharmaceutics - From Fundamentals to Industrial Practice is an incisive and up-to-date resource on the practical, pharmaceutical applications of the field.

Download or read book Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds written by Kenji Sugibayashi and published by Springer. This book was released on 2017-11-28 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 1999-05-28 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Download or read book Dermatological and Transdermal Formulations written by Kenneth A. Walters and published by CRC Press. This book was released on 2002-02-20 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing 350 illustrations, tables, and equations and covering AAPS/FDA guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption, this reference provides comprehensive coverage of the development, preparation, and application of topical and transdermal therapeutic systems. Recognized international experts di

Download or read book Pharmaceutical and Cosmetic Products for Topical Administration written by N. J. Van Abbé and published by Elsevier. This book was released on 2013-10-22 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical and Cosmetic Products for Topical Administration , Volume 9 provides the product characteristics, formulation, and rationale of topical therapeutic preparations. The book attempts to take the reader logically from the physiological and pathological aspects through to the reasoning behind topical medication. The text discusses such topics as the physiology and structure of the skin; the differential diagnosis of various skin diseases; the theoretical basis of emulsion technology; and the mechanism of percutaneous absorption. Undergraduate students and teachers of pharmacy and allied subjects will find the monograph very useful.

Download or read book Cosmetic Dermatology written by Zoe Diana Draelos and published by John Wiley & Sons. This book was released on 2015-10-14 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Back for a new edition, Zoe Draelos' outstanding resource to cosmetic dermatology again provides a highly-illustrated, clinical guide to the full range of cosmetic skin treatments. Bringing together experts from research, industry, surgery and practice, it is structured in four distinct parts for easy navigation by the busy clinician: Basic Concepts - giving an overview of the physiology pertinent to cosmetic dermatology and the delivery systems by which treatments can take effect; Hygiene Products - evaluating cleansing and moisturising products; Adornment - looking at aesthetic techniques such as cosmetics, nail protheses and hair treatment; Antiaging - ie, injectables, resurfacing and skin contouring techniques, and the rapidly growing area of Cosmeceuticals. With over 300 high-quality images and key summary boxes throughout, this new edition incorporates the newest procedural innovations in this rapidly developing field. Perfect for all dermatologists, especially those specialising in cosmetic dermatology and whether hospital-based or in private practice, it provides the complete cosmetic regimen for your patients and will be an indispensable tool to consult over and over again.

Download or read book Aromatherapy Science written by Maria Lis-Balchin and published by Pharmaceutical Press. This book was released on 2006 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aromatherapy is one of the fastest growing forms of alternative medicine in the UK and USA. Essential oils are now sold in pharmacies and aromatherapy is increasingly being used in hospitals and primary care settings.This unique book takes an analytical and scientific approach to aromatherapy practices and principles based on the scientific evidence to date.The monographs cover commonly used essential oils and their therapeutic uses, details of toxicity, bioactivity, contraindications and clinical studies. This book provides pharmacists, GPs, nurses and other healthcare professionals with reliable scientifically based information on this growing discipline.

Download or read book Topical and Transdermal Drug Delivery written by Heather A. E. Benson and published by John Wiley & Sons. This book was released on 2012-02-03 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.

Download or read book Metals and the Skin written by Richard H. Guy and published by CRC Press. This book was released on 1999-04-05 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Addresses the increase of toxic heavy metals in the environment. Sets the standard for future research in interactions between the skin and metals and metal compounds-covering the general toxicology of 35 metals and metalloids, their occurrence in the environment, significance in nutrition, skin diffusivity, occupational exposure risks, and immunotoxicity."

Download or read book Polymeric Gels written by Kunal Pal and published by Woodhead Publishing. This book was released on 2018-06-15 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Gels: Characterization, Properties and Biomedical Applications covers the fundamentals and applications of polymeric gels. Particular emphasis is given to their synthesis, properties and characteristics, with topics such as natural, synthetic, and smart polymeric gels, medical applications, and advancements in conductive and magnetic gels presented. The book covers the basics and applications of hydrogels, providing readers with a comprehensive guide on the types of polymeric gels used in the field of biomedical engineering. - Provides guidance for decisions on the suitability and appropriateness of a synthetic route and characterization technique for particular polymeric networks - Analyzes and compares experimental data - Presents in-depth information on the physical properties of polymeric gels using mathematical models - Uses an interdisciplinary approach to discuss potential new applications for both established polymeric gels and recent advances

Download or read book Dermatological Drug Development written by Tomoko Maeda-Chubachi and published by Cambridge Scholars Publishing. This book was released on 2020-09-18 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book uniquely summarizes approaches to developing dermatological drugs in a regulated environment from the perspective of the pharmaceutical industry. It brings together the insights of skilled and experienced industry experts to reveal the complexities of dermatological drug development, covering topical, oral, and biologic drugs. This book fills an important gap, as there is currently no other textbook addressing dermatological drug development, explaining and illustrating why unique nonclinical and clinical studies are necessary and how they are typically designed and conducted. The drug development process is also an evolving strategy that is characterized by communicating, negotiating, and agreeing with regulatory agencies, such as FDA (US), EMA (EU), and PMDA (Japan).

Download or read book Agache s Measuring the Skin written by Philippe Humbert and published by Springer. This book was released on 2017-05-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first edition of this book was published in 2004, to much acclaim, the pace of innovation in the field of skin metrology has increased and various new technologies have become available. This new, revised edition reflects these advances by presenting the current theory and practice of noninvasive investigation and measurement of the skin and its appendices in health and disease. The first, extensive part of this authoritative work is devoted to the physiology and metrology of the various structural components of the skin. Skin functions and their measurement are then discussed in detail, with sections on mechanical protection, photoprotection, barrier function, immune function, thermoregulation, and sensory function. In addition, careful consideration is given to skin disease rating and skin maps, and a unique list of physical and biological constants and units is provided. Not only is this new edition the first comprehensive, practical handbook in this domain – it will also serve as a manual of skin physiology and collates anatomical, functional, and physical quantitative data that would otherwise be arduous to retrieve because of their dispersal throughout the literature. It will prove a valuable resource for dermatologists, cosmetologists, bioengineers, physiologists, pharmacists, and all others who deal with the skin in their work.