Download or read book TiO2 Nanotubes on Titanium for Early Stage Osseointegration written by Anish Shivaram and published by . This book was released on 2017 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The results show mechanically stable TiO2 nanotubes up to 1microm length used on titanium surface were successful in improving the early stage osseointegrative properties. The use of silver coatings can provide a solution for infection control in vivo. The use of dopants and surface charge further helped enhancing the surface properties of TiO 2 nanotubes which would further enhance the early stage osseointegrative properties.

Download or read book Designing Multi Scale Functionalities in 3D Printed Titanium and Tantalum Metal Implants Toward Early Stage Osseointegration written by Indranath Mitra and published by . This book was released on 2021 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, advanced materials research in implantable metallic devices for bone tissue engineering has significantly influenced orthopedic and dental applications. However, these devices' practical usage still has several challenges concomitant to acquiring and retaining biological fixation at the implant site. An important goal of current biomaterials research is to induce and accelerate bone tissue growth around the implants. In addition to rapid wound healing at the surgery site, these implants must have adequate biomechanical characteristics. This dissertation elaborates on investigating the effect of developing surface charge on Titania (TiO2) nanotubes and assessed it's in vitro and in vivo early-stage osseointegration. Growing TiO2 nanotubes on commercially pure titanium led to the introduction of bioactivity in an otherwise bioinert material via physical anchoring surface for the bone tissue to bond. Surface charge enhances makes the surfaces more hydrophilic and better suited for cellular interactions. We have further explored the effect of compositional modifications through alloying titanium (Ti) with tantalum (Ta) to induce bioactivity. Comparisons among porous and dense Ti-Ta with and without surface modification through TiO2 nanotubes were drawn to assess the variation in cellular interactions and in vivo early-stage bone regeneration.Our results indicate a stored charge of 37.15 ℗ł 14 mC/cm2 for TNT surfaces. Histomorphometric analyses show ~40% increase in mineralized bone formation around the TNT-P implants than the TNTs at 5 weeks, indicative of accelerated bone remodeling cycle. We have shown comparable performance of porous Ta and surface-modified porous Ti64 implants towards early-stage osseointegration at 5 weeks post-implantation through seamless bone-material interlocking. However, a continued and extended efficacy of porous Ta is found in terms of higher osteoid formation at 12 weeks post-surgery. Alloying Ta with Ti during additive fabrication resulted in an overall decrease in elastic modulus of Ti (Ti: 110GPa, 25Ta: 63℗ł 5.5 GPa), helping circumvent any mechanical instability that can arise from a very high mismatch in modulus. Consequently, porous Ti-Ta alloys exhibited increased osseous tissue formation at the implant-bone interface (70% trabecular bone formation in rabbit femur), providing evidence of the superior biological performance of the material towards early-stage bone healing.

Download or read book Application of Titanium Dioxide written by Magdalena Janus and published by BoD – Books on Demand. This book was released on 2017-07-26 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium dioxide is mainly used as a pigment and photocatalyst. It is possible to find it in food, cosmetics, building materials, electric devices, and others. This book contains chapters about application of titanium dioxide in different branches of economy such as the agriculture, the food industry, the medicine, the cosmetics, the water treatment technologies, and the semiconductors.

Download or read book Titanium Dioxide written by Dongfang Yang and published by BoD – Books on Demand. This book was released on 2018-06-27 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium dioxide is currently being used in many industrial products. It provides unique photocatalytic properties for water splitting and purification, bacterial inactivation, and organics degradation. It has also been widely used as the photoanode for dye-sensitized solar cells and coatings for self-cleaning surfaces, biomedical implants, and nanomedicine. This book covers various aspects of titanium dioxide nanomaterials including their unique one-dimensional, two-dimensional, mesoporous, and hierarchical nanostructures and their synthetic methods such as sol-gel, hydrothermal, anodic oxidation, and electrophoretic deposition, as well as its key applications in environmental and energy sectors. Through these 24 chapters written by experts from the international scientific community, readers will have access to a comprehensive overview of the recent research and development findings on the titanium dioxide nanomaterials.

Download or read book Processing Microstructure Characterization and Biological Performance of Hierarchical Surface Coatings for Titanium Implants written by Ellen Elizabeth Sauter and published by . This book was released on 2013 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, the lifetime of a typical orthopaedic implant is only 15-20 years, a lifetime that many patients are outliving. Therefore, implants with superior longevity need to be engineered. To improve implant longevity, much research has been focused on creating micro-scale porosity/roughness to enhance osseointegration by mechanical interlocking of bone and implant. These structures have improved osseointegration to the current 15-20 year lifespan. It has also been shown that nano-scale structures enhance osteoblast (bone cell) function. The combination of micro-scale and nano-scale structures into one hierarchical structure may further improve the osseointegrative properties of implants. A hierarchical surface modification consisting of titanium dioxide [(TiO2)] nanotubes produced by anodic oxidation of titanium in an electrolyte containing fluoride ions, [F], on a commercially pure (cp) titanium, micro-scale grid structure produced by laser powder deposition was successfully developed. [TiO2] nanotubes were characterized using field emission scanning electron microscopy (FE-SEM), while laser deposited grid structures were characterized with both FE-SEM and optical microscopy. Mouse preosteoblasts were used to evaluate the in vitro biological effects, including cell morphology and cell viability, on the four experimental groups: unanodized flat, anodized flat, unanodized laser deposition, and anodized laser deposition. All treatment groups showed good cell attachment and spreading; however, it was observed that on the samples with [TiO2] nanotubes there was a much greater density of adhesion proteins. The presence of these proteins provides a surface that cells can more readily attach to which can lead to greater cell proliferation and differentiation. Also, viability of cells on samples with nanotubes was higher than samples without nanotubes. However, viability was highest on the anodized flat surface, suggesting that the micro-scale grid on the surface of laser deposition samples did not positively affect the osteoblasts. Optimization of the micro-scale surface features, along with anodization of the micro-scale structures, could possibly further improve the bone/implant interaction and further study is needed on this topic.

Download or read book On the Tissue Response to Titanium Nanotube Modified Implants written by Garrett Cale Smith and published by . This book was released on 2012 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major emphasis in biomaterials research is the design of the implant surface because of its profound influence on the tissue response. Many clinically used implants attempt to improve the tissue response through surface treatments. These physical or chemical modifications are known to alter the biological events at the tissue-implant interface. Recent advances in nano-fabrication offer the ability to create novel 3D surface structures at the molecular scale. The nano-fabrication technique selected was electrochemical anodization. We anodized titanium (Ti) implants to form vertically aligned titanium dioxide (TiO2) nanotube arrays. The nanotubes had precisely controlled dimensions with diameters of either 30 nm or 100 nm with a 3:1 height to diameter aspect ratio. The controls used were micron-roughened titanium or chemically inert surfaces. This dissertation investigated the in vivo tissue response to these nano-modified implant surface modifications. First, the in vivo soft tissue response was measured by fibrotic capsule thickness and nitric oxide presence. These inflammatory parameters were significantly lower for TiO2 nanotubes surface compared with the titanium control. Second, the in vivo bone response was investigated histologically for bone-implant- contact area, and mechanically with a tensile pull-out test to quantify the interfacial adhesion force. TiO2 nanotubes exhibited close contact with bone, and increased the interfacial adhesion strength by approximately 9-fold compared with a Ti micron roughened control surface. Lastly, we modified the structure and chemistry of the nanotube surface to examine how these factors influence adhesion to bone. The TiO2 100 nm diameter nanotube increased bone adhesion by approximately 1-fold compared with the TiO2 30 nm diameter nanotube and by approximately 6-fold compared to the chemically inert 100 nm diameter nanotube surface. The increased bone adhesion observed on the TiO2 nanotube surfaces is thus dependent on both the nanotube structure and chemistry. These findings may be significant for the interaction between implants in soft tissue as well as bone tissue to improve future clinical implants.

Download or read book Surface Modification of Titanium Dental Implants written by Karan Gulati and published by Springer Nature. This book was released on 2023-02-27 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive technical and scientific overview of the surface modification of titanium dental implants. Coverage ranges from basic concepts of surface modification to advanced micro- and nano-engineering strategies employed to achieve augmented bioactivity to meet the needs of compromised patient conditions. A special focus of the book is advanced state-of-the-art electrochemically anodized nanostructures fabricated on implants towards enhanced bioactivity and local therapy. Surface Modification of Titanium Dental Implants will keep you current in the domain of titanium dental implants and will provide an improved understanding of their performance and application. The book will benefit engineers, clinicians, and researchers in biomaterials, biomedical engineering, dental and bone implants, nano-engineering, and technology.

Download or read book Titanium in Medicine written by D.M. Brunette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing scientific and technical in-depth information in a clear format with a homogeneous structure, this text is suited for educational and self-teaching purposes as well as a reference on titanium for biomedical applications. It covers the whole area relevant to the use of titanium for implants, devices and instruments in medicine: material and surface science, physics, chemistry, biology, medicine, quality and regulatory aspects.

Download or read book Bioceramics written by Akiyoshi Osaka and published by Elsevier. This book was released on 2020-09-13 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically functional ceramic materials have been known about for several decades, like phosphate cements and gypsum, and they are within the zeroth generation. Modern and artificially synthesized bioceramics include amorphous materials in the Bioglass® family that were developed in the early 1970’s and derivative glass ceramics such as Bioverit® and Cerabone A-W® that came in 1980’s. They are from the 2nd generation of materials, and mostly applicable to bone replacement or bone defect fillers. Since the late 1990’s, newer technologies have been introduced to the biologically functional material fields; they are the syntheses of organic-inorganic hybrids of micro- and macroscopic scales as well as nano-scales, organic fragment-covered ceramic particles of varied sizes, with light-controlling abilities to modify the frequency of light, in addition synthesis of high strength and high-tribological durability that had not been available before. With the advent of additive manufacturing technology employing lasers, electron beams, and printers, clinical materials of complicated porous structures are now easily prepared. These materials are of the 3rd generation. This book will cover almost all kinds of such 3rd generation ceramic and ceramic-related biomaterials. This book conveys the current state-of-the-art on the science and technology of bioceramics, from nano-size dots or particles to macro-scale architectures, of a wide range of constitutions including quantum dots with peptide fragments, meso-scale therapeutic particles designed to involve drugs or genes, mesoporous organic-inorganic hybrids, nano-structured oxide layers on metals and alloys. Comprehensively covers all aspects (research/experimental and commercial products) related to the latest progresses in bioceramic science, technology and applications, with emphasis on nanobioceramics Pulls together a broad range of materials, concepts, and technologies based on nanomaterials Features novel preparation procedures like additive manufacturing (3-D printing and related techniques) that have also been introduced and practiced for forming complicated architectures Features innovative 3rd generation ceramic and ceramic-related biomaterials

Download or read book Titanium Dioxide TiO2 and Its Applications written by Francesco Parrino and published by Elsevier. This book was released on 2020-11-29 with total page 735 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific interest in TiO2-based materials has exponentially grown in the last few decades. Titanium Dioxide (TiO2) and Its Applications introduces the main physicochemical properties of TiO2 which are the basis of its applications in various fields. While the basic principles of the TiO2 properties have been the subject of various previous publications, this book is mainly devoted to TiO2 applications. The book includes contributions written by experts from a wide range of disciplines in order to address titanium dioxide's utilization in energy, consumer, materials, devices, and catalytic applications. The various applications identified include: photocatalysis, catalysis, optics, electronics, energy storage and production, ceramics, pigments, cosmetics, sensors, and heat transfer. Titanium Dioxide (TiO2) and Its Applications is suitable for a wide readership in the disciplines of materials science, chemistry, and engineering in both academia and industry. Includes a wide range of current and emerging applications of titanium dioxide in the fields of energy, consumer applications, materials, and devices Provides a brief overview of titanium dioxide and its properties, as well as techniques to design, deposit, and study the material Discusses the relevant properties, preparation methods, and other apposite considerations in each application-focused chapter

Download or read book Fibroblast Growth Factors and Stem Cells in Regenerative Pharmacology and Anti Aging Intervention written by Zhouguang Wang and published by Frontiers Media SA. This book was released on 2022-05-31 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Growth and Thermal Degradation of Titanium Oxide Nanotubes on Titanium for Bone Implants written by Amit M. Sharma and published by . This book was released on 2009 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biomaterials and Engineering for Implantology written by Yoshiki Oshida and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-02-07 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials are composed of metallic materials, ceramics, polymers, composites and hybrid materials. Biomaterials used in human beings require safety regulations, toxicity, allergic reaction, etc. When used as implantable materials their biological compatibility, biomechanical compatibility, and morphological compatibility must be acessed. This book explores the design and requirements of biomaterials for the use in implantology.

Download or read book Nanostructured Titanium Dioxide Materials written by Ali Reza Khataee and published by World Scientific. This book was released on 2012 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, research and development in the area of synthesis and applications of different nanostructured titanium dioxide have become tremendous. This book briefly describes properties, production, modification and applications of nanostructured titanium dioxide focusing in particular on photocatalytic activity. The physicochemical properties of nanostructured titanium dioxide are highlighted and the links between properties and applications are emphasized. The preparation of TiO2 nanomaterials, including nanoparticles, nanorods, nanowires, nanosheets, nanofibers, and nanotubes are primarily categorized by their preparation method (sol-gel and hydrothermal processes). Examples of early applications of nanostructured titanium dioxide in dye-sensitized solar cells, hydrogen production and storage, sensors, rechargeable batteries, electrocatalysis, self-cleaning and antibacterial surfaces and photocatalytic cancer treatment are reviewed. The review of modifications of TiO2 nanomaterials is mainly focused on the research related to the modifications of the optical properties of TiO2 nanomaterials, since many applications of TiO2 nanomaterials are closely related to their optical properties. Photocatalytic removal of various pollutants using pure TiO2 nanomaterials, TiO2-based nanoclays and non-metal doped nanostructured TiO2 are also discussed.

Download or read book Bioscience and Bioengineering of Titanium Materials written by Yoshiki Oshida and published by Elsevier. This book was released on 2010-07-07 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book about bioscience and the bioengineering of titanium materials is based on more than 1,000 published articles. It bridges the gap between the medical/dental fields and the engineering/technology areas, due to the author’s unique experience in both during the last 30 years. The book covers Materials Classifications, Chemical and Electrochemical Reactions, Oxidation, Biological Reactions, Implant-related Biological Reactions, Applications, Fabri-cation Technologies, Surface Modifications, and Future Perspectives. * Provides quick access to the primary literature in this field* Reviews studies of titanium materials in medical and dental applications, as reported in nearly 1,500 articles published over last several years* Draws information from several types of studies and reports* Helps readers answer questions about the most appropriate materials and when to use them

Download or read book TiO2 Nanotube Arrays written by Craig A. Grimes and published by Springer Science & Business Media. This book was released on 2009-08-11 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: TiO2 Nanotube Arrays: Synthesis, Properties, and Applications is the first book to provide an overview of this rapidly growing field. Vertically oriented, highly ordered TiO2 nanotube arrays are unique and easily fabricated materials with an architecture that demonstrates remarkable charge transfer as well as photocatalytic properties. This volume includes an introduction to TiO2 nanotube arrays, as well as a description of the material properties and distillation of the current research. Applications considered include gas sensing, heterojunction solar cells, water photoelectrolysis, photocatalytic CO2 reduction, as well as several biomedical applications. Written by leading researchers in the field, TiO2 Nanotube Arrays: Synthesis, Properties, and Applications is a valuable reference for chemists, materials scientists and engineers involved with renewable energy sources, biomedical engineering, and catalysis, to cite but a few examples.

Download or read book Nano engineered Titanium Implants for Complex Bone Therapies written by Karan Gulati and published by . This book was released on 2015 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of bone pathologies, such as fracture, infection or cancer, require drug therapy. However, conventional systemic drug administration is inefficient, wasteful, may not reach the target bone tissue in effective concentrations, and may cause unwanted side effects in other tissues. Ideally, drug should be delivered locally at the specific site, and in an optimal therapeutic concentration. Surface modification of the titanium implants can meet these challenges effectively by enabling effective delivery of therapeutics directly at the bone site for an extended period. Among the various suggested implant modifications, titania (TiO2) nanotubes (TNTs), which can easily be fabricated on Ti surfaces via cost-effective electrochemical anodization, is emerging as a possible strategy for local drug delivery. This thesis describes advances in TNT/Ti implant technology towards achieving effective therapeutic and cellular modulating action from the surface of Ti wire implants, which have been nano-engineered to fabricate TNTs. The concept was to design and optimize novel therapeutic features of TNTs, using simple and scalable technologies that can ensure easy integration into implants currently on the market. Specifically, in order to address complex bone conditions such as infection, inflammation, and cancers of bone, TNTs were fabricated on Ti wires that could be inserted into bone for 3D in-bone therapeutic release. The main points of the thesis can be summarized as: 1. Structural engineering of TNTs: Periodic tailoring of the TNT structures using a modulated electrochemical anodization process in an attempt to enhance drug loading and releasing abilities of the TNTs. 2. Fabrication optimization of TNTs on curved surfaces: Optimization of anodization conditions was undertaken, with a special focus on defining the role of electrolyte ageing, in order to fabricate a mechanically robust anodic layer (TNTs) on complex curved surfaces such as Ti wires. The purpose of this was to enable easy integration of TNT technology into the current implant market, which includes widely varied geometries (pins, screws, plates, meshes, etc.). 3. Therapies for complex bone conditions: Demonstration of TNTs/Ti wire abilities to meet a range of therapeutic needs was modelled, by determining the effect of local release of osteoporotic drugs from TNTs, when inserted into collagen gels containing human osteoblasts. This was followed by analysis of the therapeutic effect on cells, and cell spread/migration morphology on the TNT surfaces. 4. Formation of chitosan-microtubes on TNTs in-situ: Investigation of the fate of chitosan-modified TNT/Ti implants in phosphate buffer (isotonic to human blood). Chitosan degradation into micro-tubes on the surface of TNTs was investigated to elucidate the mechanism underlying the in-situ formation of these novel structures. 5. Titanium (Ti) nanotubes vs titania (TiO2) nanotubes: Conventional titania (TiO2) nanotubes were chemically reduced into titanium while preserving the nano-topography. The converted conducting titanium nanotube implants were proposed for electrical stimulation therapy and local drug delivery. 6. TNTs on 3D printed Ti alloys: Fabrication optimization of TNTs on a unique micro-rough 3D printed Ti alloy, to enable varied surface features, including irregular micro-roughness combined with nano-topography of TNTs. Comparison was then made of cell adhesion, attachment and modulation of osteoblast function by TNTs/Ti 3D implants with conventional smooth, micro-rough and TNTs/Ti flat foil surfaces. The investigations presented in the thesis are expected to open doors towards the development of advanced in-bone therapeutic implants, in the form of easy-to-tailor nano-engineered Ti wires, with superior 3D drug releasing abilities and enhanced bone healing functionalities. The emphasis has been on designing the simplest and most cost-effective methodologies to permit easy integration into the current implant market. Applications for these implants could be in the treatment of fractures, bone infections/cancers and 'local' osteoporosis in bones.