Download or read book Tin Based Antitumour Drugs written by Marcel Gielen and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas platinum compounds are already clinically used as anticancer agents, tin compounds exhibiting high enough antitumour activity have not yet been found to enter the clinical phase. This is paradoxical with the observation that 50% of the tested compounds showed some activity, which is an abnormally high percentage. This is probably due to the fact that research of this type with tin compounds started more recently than with platinum compounds and that almost exclusively known compounds coming from laboratories working in the field of organotin compounds have been blindly tested. Some research directed towards the development of organotin compounds with some biologically favourable properties, for instance derivatives with hydrophilic or lipophilic, or with increased bio-availability characteristics, has started only recently. We thought that was now the appropriate time to bring together experts from different disciplines (biochemists, pharmacologists, organotin chemists, oncologists, etc.) working in the field of tin-based antitumour drugs, to contribute to the critical assessment of existing knowledge in this new important topic, to identify the directions for future research and to promote close working relations between the different countries and professional experiences gathered in this workshop.
Download or read book Metallotherapeutic Drugs and Metal Based Diagnostic Agents written by Marcel Gielen and published by John Wiley & Sons. This book was released on 2005-09-01 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.
Download or read book Metallo Drugs Development and Action of Anticancer Agents written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-02-05 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Download or read book Metal Compounds in Cancer Therapy written by S.P. Fricker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of the antitumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major international research effort investigating the potential of metal compounds in cancer therapy. Cisplatin now occupies an important place in the armamentarium of the oncologist due to its effectiveness in the treatment of testicular cancer. A second generation analogue, carbo platin, offers reduced toxicity together with therapeutic activity, which gives it a place in the front-line therapy of genitourinary cancers. These and other successes have encouraged the search for novel metal-based drugs for cancer therapy. Research has shown that metal compounds have potential for activity not only as cytotoxic antitumour agents, but also in areas such as adjuvant therapy, diagnosis and immunotherapy. The aim of this book is to review and describe the major achievements and developments arising from this international research effort. The contributing authors come from labora tories throughout Europe and America and represent the many disci plines characteristic of this research, such as clinical research, pharmacology, tumour biology and inorganic medicinal chemistry.
Download or read book Cytotoxic Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment written by N. Hadjiliadis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity. The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.
Download or read book Ions Metalliques en Biologie Et en Medecine written by Jane Anastassopoulou and published by John Libbey Eurotext. This book was released on 1992 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions are poorly known whereas they sometimes play a role more significant than vitamins. Moreover they control many diseases, such as the zinc salts in dermatology. This book contains the proceedings of 2nd International Symposium on Metal Ions in Biology and Medicine, Athens, May 1992.
Download or read book Scorpionates II written by Claudio Pettinari and published by Imperial College Press. This book was released on 2008 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery by Swiatoslaw Trofimenko in 1967, poly(pyrazol-1-yl)borates have been considered as one of the most useful ligands in modern coordination chemistry. The term OC scorpionateOCO has been used to describe the interchange between bidentate and tridentate coordination modes by these ligands that has been employed for the synthesis of complexes with virtually every metal in the periodic table, having applications in diverse fields ranging from homogeneous catalysis to bioinorganic chemistry.This all-inclusive reference book continues where Trofimenko''s original work left off. It not only includes discussions on all new ligands reported from 1999 to date, but also introduces new ligands that have yet to be touched upon in other titles, such as scorpionates based on S donors or P donors. As such, this comprehensive volume is a OC must haveOCO for all researchers who utilize this family of molecules."
Download or read book Advances in Anticancer Agents in Medicinal Chemistry written by Michelle Prudhomme and published by Bentham Science Publishers. This book was released on 2013-06-14 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.
Download or read book A Commemorative Issue in Honor of Professor Nick Hadjiliadis Metal Complex Interactions with Nucleic Acids and or DNA written by Sotiris K Hadjikakou and published by MDPI. This book was released on 2019-02-05 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "A Commemorative Issue in Honor of Professor Nick Hadjiliadis: Metal Complex Interactions with Nucleic Acids and/or DNA" that was published in IJMS
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1990 with total page 1128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Chemistry of Tin written by P.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: In common with the editor of the first edition, my own personal involvement with tin chemistry began when I had the privilege of studying for a PhD degree under the supervision of Professor Alwyn G. Davies FRS at University College London (UCL) almost exactly 30 years ago. Then, following 21 years' service with the International Tin Research Institute, it was a great pleasure for me when the wheel turned full circle and, in 1994, Alwyn - now an Emeritus Professor - asked me to return to UCL as an Honorary Research Fellow in the Chemistry Department. One of my first tasks was when I received an invitation from Blackie A&P to edit the second edition of the Chemistry of Tin, which I was delighted to accept, since it enabled me to continued my life-long interest in tin chemistry and to maintain contact with my former friends and colleagues, many of whom have contributed to this book.
Download or read book Anticancer Agents from Natural Products written by Gordon M. Cragg and published by CRC Press. This book was released on 2005-06-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
Download or read book Biochemical and Biological Effects of Organotins Title Page pdf 02 Title Page 03 REVISED eBooks End User License Agreement Website 04 Prof Nagy memorial 05 Contents Index 06 Foreword 07 Preface 08 List of contributors 09 ABBREVIATION LIST OF ORGANOTINS 10 Chapter 1 ready KW 11 Chapter 2 ready KW revised 12 Chapter 3 ready KW 13 Chapter 4 ready KW 14 Chapter 5 ready KW 15 Chapter 6 ready KW revised 16 Chapter 7 ready KW 17 Chapter 8 ready KW revised 18 Chapter 9 ready KW 19 Chapter 10 ready KW revised 20 Chapter 11 ready KW 21 Chapter 12 ready KW 22 Index written by Alessandra Pagliarani and published by Bentham Science Publishers. This book was released on 2012 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organotins are widespread contaminants especially of water environments. Their chemically versatile structure makes organotin compounds able to bind to a variety of biomolecules thus widely affecting biological functions. Trisubstituted molecules, namely tributyltin (TBT) and triphenyltin (TPhT), have been widely employed in antifouling paints and are also exploited as plastic stabilizers that unfortunately cause harmful biological effects. Persistent bioaccumulation has resulted in organotins becoming a significant environmental threat. Chapter by chapter, the biological and biochemical effec.
Download or read book Molecular Aspects of Oxidative Drug Metabolizing Enzymes written by Emel Arinc and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.
Download or read book Medicinal Organometallic Chemistry written by Gérard Jaouen and published by Springer Science & Business Media. This book was released on 2010-09-14 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.
Download or read book Handbook of Anticancer Drugs from Marine Origin written by Se-Kwon Kim and published by Springer. This book was released on 2014-11-27 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
