Download or read book Thyroid Systems Engineering written by Simon Goede and published by CRC Press. This book was released on 2022-09-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a considerable amount of effort has been devoted, both in industry and academia, towards the behavioral modeling, evaluation and prediction of the hypothalamus pituitary thyroid system.Thyroid Systems Engineering targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology. Leveraging on the insights emerging from the unique combination of an electrical engineer working with a clinical thyroidologist, and both being scientists skilled in mathematics, the authors introduce this new discipline and field of scientific investigation aptly designated as Thyroid Systems Engineering.Readers will discover that mathematics can indeed model the behavior of the hypothalamus-pituitary-thyroid (HPT) axis. Focused on modeling, each of the eighteen chapters gives the reader a notion of the application of relevant mathematics to pertinent issues encountered in mainstream thyroidology. Many cellular processes resemble the flux of variables and states in a complex multi-parameter space through time analogous to current flow in electrical networks. It is then logical to apply the principles and physical laws of electrodynamics, electrical network theory, control systems theory and signal theory to many of the biological phenomena encountered in endocrinology. Such an approach is used liberally throughout the book and successfully yields elegant solutions to a number of models presented within.This book can serve as a reference to mathematical modeling in other aspects of endocrine physiology, and as the starting point for a fundamental course in medical modeling. It will appeal to postgraduates in electrical engineering, academic physicians and biomedical researchers. Further, readers equipped with advanced calculus, electrical network theory, control theory and signal theory should be able to follow the mathematical expositions that describe thyrotropic control. They represent a new discipline based on mathematical modeling in physiology applicable to medical diagnostics, measurement and treatment to cooperate in the clinical team and realize an optimized treatment for patients.
Download or read book Inherited Disorders of the Thyroid System written by Geraldo Medeiros-Neto and published by CRC Press. This book was released on 2019-06-04 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1994, Inherited Disorders of the Thyroid System presents a thorough and comprehensive study of the biology of varied thyroid disorders illustrated by numerous tables and figures. This monograph begins with the initial step in thyroid hormone production and concludes with the interaction of the thyroid hormones with their target cells. The authors have been involved in research in this field for many years and help to bring together, in a single text, the widely scattered literature relevant to the disorders of the thyroid system.
Download or read book Engineering Principles in Physiology written by J. H. U. Brown and published by Academic Press. This book was released on 2014-05-10 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering Principles in Physiology, Volume I covers the various aspects of biomedical engineering. This volume is organized into three parts encompassing 12 chapters that consider a holistic approach to physiology and the principles of communication and control, including energy input and output. The first part deals with the physiological information and related concepts, as well as the overall integration in the living body. The second part highlights the communication integration of the central nervous system as a whole with the body's various sense organs. The third part focuses on the diversity of function and modeling of various glandular functions of the endocrine system. This part briefly deals with the cardiovascular system as a system of communication and control. This book will prove useful to physiologists, biomedical engineers, and workers in the related fields.
Download or read book Homeostasis and Allostasis of Thyroid Function written by Johannes W. Dietrich and published by Frontiers Media SA. This book was released on 2018-08-29 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
Download or read book Principles and Practices of Thyroid Gland Disorders written by Subhash Kumar Wangnoo and published by JP Medical Ltd. This book was released on 2017-05-31 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive resource providing the latest information on the diagnosis and management of thyroid disorders. Beginning with an overview of thyroid physiology and symptoms and evaluation of thyroid problems, the following chapters discuss many benign and malignant disorders and their medical and surgical management. Complete chapters are dedicated to ‘special circumstances’ including neonatal and junvenile thyrotoxicosis, and hyper and hypo-thyroidism in pregnancy. In depth coverage of topics such as Graves Disease, Hashimoto Disease, paediatric Graves, and sick euthyroid syndrome, is also provided. Key points Comprehensive resource providing latest information on diagnosis and management of thyroid disorders Covers numerous benign and malignant conditions Explains both medical and surgical management techniques Complete chapters dedicated to ‘special circumstances’
Download or read book Applied Systems Engineering written by Adrian V. Gheorghe and published by John Wiley & Sons. This book was released on 1982 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine.
Download or read book Werner Ingbar s the Thyroid written by Sidney C. Werner and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely updated for its Ninth Edition, this classic text provides comprehensive coverage of every aspect of thyroid anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. This edition has a more international group of contributors and new chapters on mortality in thyroid disease, oncogenes, radioiodine treatments for carcinoma, trophoblastic tumors, and subacute and acute infectious thyroiditis. Chapters address clinical controversies regarding subclinical hypothyroidism and hyperthyroidism. The section on laboratory assessment of thyroid function has been reorganized for easier look-up of function tests.
Download or read book Werner Ingbar s The Thyroid written by Lewis E. Braverman and published by Lippincott Williams & Wilkins. This book was released on 2012-07-12 with total page 925 pages. Available in PDF, EPUB and Kindle. Book excerpt: Werner & Ingbar’s The Thyroid: A Fundamental and Clinical Text, 10th Edition has been extensively revised and streamlined to deliver the most comprehensive coverage of the thyroid including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Entirely new chapters on the surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs are in this edition. New authors and an international group of contributors elevate this classic text that includes extensive clinical coverage of thyroid dysfunction’s effects on other organ systems. Also addressed are clinical controversies regarding the ageing thyroid, subclinical hypothyroidism and hyperthyroidism and thyroid disease in pregnancy. New to this edition: · Twenty-three chapters authored by new contributors and international experts · A companion website with fully searchable text for quick reference · Three new chapters discuss surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs to keep you up-to-date on the latest advances in the field
Download or read book Homeostasis and Allostasis of Thyroid Function written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite "normal" TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of "non-canonical" mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic "Homeostasis and Allostasis of Thyroid Function", which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
Download or read book Advances in Computing and Data Sciences written by Mayank Singh and published by Springer. This book was released on 2019-07-19 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume set (CCIS 1045 and CCIS 1046) constitutes the refereed proceedings of the Third International Conference on Advances in Computing and Data Sciences, ICACDS 2019, held in Ghaziabad, India, in April 2019. The 112 full papers were carefully reviewed and selected from 621 submissions. The papers are centered around topics like advanced computing, data sciences, distributed systems organizing principles, development frameworks and environments, software verification and validation, computational complexity and cryptography, machine learning theory, database theory, probabilistic representations.
Download or read book Index Medicus written by and published by . This book was released on 2002 with total page 1404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Advanced Network Technologies and Intelligent Computing written by Isaac Woungang and published by Springer Nature. This book was released on 2022-02-17 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume constitutes the selected papers presented at the First International Conference on Advanced Network Technologies and Intelligent Computing, ANTIC 2021, hed in Varanasi, India, in December 2021. Due to the COVID-19 pandemic the conference was held online. The 61 papers presented were thoroughly reviewed and selected from 593 submissions. They are organized in topical sections on advanced network technologies and intelligent computing. ;
Download or read book The Thyroid Paradox written by James K. Rone and published by ReadHowYouWant.com. This book was released on 2010-01-07 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Don't be satisfied with business-as-usual health care. If you suffer low thyroid - or think you might - and want to learn more, especially if you're unsatisfied with the answers you're getting from your doctor, this book is for you. An estimated 5.8% of women and 3.4% of men in the United States are hypothyroid. Low thyroid is common, yet, paradoxically, may be rampantly overlooked. Why? As you'll discover in The Thyroid Paradox, there is a pervasive oversimplification of thyroid science and mainstream treatment of thyroid patients today. Current thyroid testing has weaknesses and should be interpreted, not in a vacuum, but as part of a diagnostic process based on all the evidence. Too often, doctors simply stick to test results and miss patients suffering with subtle hypothyroidism. The Thyroid Paradox is for the person who's been told ''It's not your thyroid, '' without then being told convincingly what it is. Maybe you've been told nothing is wrong but know there must be some reason for your chronic fatigue, body aches, weight gain, dry skin, constipation, ''brain fog, '' depression, or menstrual irregularity. This book provides the answers for you. You'll learn about: The loopholes in current thyroid testing; Hidden forms of hypothyroidism and how to detect them; The best strategies for thyroid replacement. The path out of the thyroid paradox is engaged teamwork involving both doctor and patient. This book should provide you with the knowledge you need to communicate and work with your doctor to get the treatment you deserve.
Download or read book Thyroid and Endocrine System Investigations with Radionuclides and Radioessays written by Fuad S. Ashkar and published by . This book was released on 1979 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Real Time Applications of Machine Learning in Cyber Physical Systems written by Easwaran, Balamurugan and published by IGI Global. This book was released on 2022-03-11 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advancements of recent decades have reshaped the way people socialize, work, learn, and ultimately live. The use of cyber-physical systems (CPS) specifically have helped people lead their lives with greater control and freedom. CPS domains have great societal significance, providing crucial assistance in industries ranging from security to healthcare. At the same time, machine learning (ML) algorithms are known for being substantially efficient, high performing, and have become a real standard due to greater accessibility, and now more than ever, multidisciplinary applications of ML for CPS have become a necessity to help uncover constructive solutions for real-world problems. Real-Time Applications of Machine Learning in Cyber-Physical Systems provides a relevant theoretical framework and the most recent empirical findings on various real-time applications of machine learning in cyber-physical systems. Covering topics like intrusion detection systems, predictive maintenance, and seizure prediction, this book is an essential resource for researchers, machine learning professionals, independent researchers, scholars, scientists, libraries, and academicians.
Download or read book Biomedical Engineering Fundamentals written by Joseph D. Bronzino and published by CRC Press. This book was released on 2006-04-14 with total page 1570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last century,medicine has come out of theblack bag and emerged as one of the most dynamic and advanced fields of development in science and technology. Today, biomedical engineering plays a critical role in patient diagnosis, care, and rehabilitation. As such, the field encompasses a wide range of disciplines, from biology and physiolog
Download or read book Knowledge Based Systems for Multiple Environments written by Ladislav J. Kohout and published by Routledge. This book was released on 2019-01-15 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1992, this volume identifies the problems facing the designer of multi-environmental knowledge-based systems, and explains the principles that must be followed in order to obtain successful results. Systems called upon to function in a variety of widely differing cultural and natural environments can only do so satisfactorily if from the very beginning they have been designed with this versatility in mind. For the first time, the know-how for this often formidable design task has been gathered together and presented here. This study was written to an overall plan, with chapters commissioned from a group of research of quite diversified back-grounds who had deeply explored their subjects. Each topic was thus covered in close connection with the others, so as to form a coherent whole. While primarily aimed at workers in Artificial Intelligence and Expert Systems, as well as designers of other kinds of sophisticated software, the contents of the book are of wider validity, just as the multi-environmental demands are of wider incidence. Manufactures, exporters and importers of computing technology with a large knowledge component will also find their concerns addressed.
