Download or read book Iodine and the Brain written by G. Robert Delong and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of a conference held at the National Institutes of Health in Bethesda on March 21-23. 1988. jointly sponsored by the International Council for Control of Iodine Deficiency Disorders (ICCIDD) and the Fogarty International Center of the National Institutes of Health. Several themes converged to make this meeting timely. The first is an increasing awareness of iodine deficiency disorders as a world-wide problem of public health and a preventable cause of mental deficiency. and as a subject of scientific effort. Increased interest in these problems owes a great deal to accessibility to remote and under developed areas of the world where iodine deficiency persists. As with any subject. greater scrutiny yields unexpected complexity and interest. It is true that provision of iodine. typically as iodized salt, is the necessary and sufficient preventative for iodine deficiency disorders. without including endemic cretinism. This provision is a governmental, economic and social problem. Apart from this, however, the scientific and medical problem of iodine deficiency and its effect on brain development and function is one of great interest and importance for developmental neurology and psychology. Even though the specific preventative agent is known, we do not totally understand the neurobiological questions raised.

Download or read book The Na K ATPase written by Jean-Daniel Horisberger and published by R. G. Landes. This book was released on 1994 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text addresses the question, How does the sodium pump pump'. A variety of primary structure information is available, and progress has been made in the functional characterization of the Na, K-pump, making the answer to this question possible, within reach of currently used techniques

Download or read book Thyroid Hormone written by N.K. Agrawal and published by BoD – Books on Demand. This book was released on 2012-07-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thyroid hormone is important for controlling metabolism and many other body functions. Changes in thyroid hormone physiology, its regulation and diseases thereof have been a concern for the mankind. Understanding of the thyroid hormone(s) has been continuously updated and revised. The contributions from different authors have been incorporated in this book for this purpose. The original work of these contributors will be especially useful in furthering the knowledge on thyroid and help in creating new vistas of research.

Download or read book Molecular Basis of Thyroid Hormone Action written by Jack H. Oppenheimer and published by . This book was released on 1983 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Basis of Thyroid Hormone Action focuses on the actions of thyroid hormones in eukaryotic cells. This book discusses the profound effects of thyroid hormones on the growth, development, and metabolism of practically all tissues of higher organisms. Organized into 15 chapters, this volume starts with an overview of the kinetic interrelationships of hormone bound to specific receptors and hormone associated with other tissue and plasma pools in living animals. This book then discusses the thyroid hormone receptor, a chromatin-associated protein that appears to mediate the actions of the ...

Download or read book Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters written by M. Morad and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

Download or read book Hormones Brain and Behavior written by and published by Academic Press. This book was released on 2016-11-09 with total page 2494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Comprehensive and updated coverage of a rapidly growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior

Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Download or read book Progress in Nucleic Acid Research and Molecular Biology written by and published by Academic Press. This book was released on 1990-04-02 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Nucleic Acid Research and Molecular Biology

Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Academic Press. This book was released on 2011-11-02 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. - Completely updated text with new authors and material, and many entirely new chapters - Over 400 fully revised figures in splendid color - 61 chapters covering the range of cellular, molecular and medical neuroscience - Translational science boxes emphasizing the connections between basic and clinical neuroscience - Companion website at http://elsevierdirect.com/companions/9780123749475

Download or read book Thyroid Hormone Metabolism written by Georg Hennemann and published by Marcel Dekker. This book was released on 1986 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pediatric Nephrology written by Ellis D. Avner and published by Springer Science & Business Media. This book was released on 2009-08-20 with total page 2059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.

Download or read book Regulation of Membrane Na K ATPase written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-16 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of α-β subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.

Download or read book Control of Membrane Function short term and long term written by J.M. Ritchie and published by Elsevier. This book was released on 2012-12-02 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: A critical factor in cell-to-cell interactions is the presence in the cell membrane of highly specific ion channels controlled by specific receptors that are bound to, and activated by, a gamut of external hormones and neurotransmitters. Through both this action on ion channels, and action on other membrane components (such as G-proteins), extracellular signals alter intracellular events, usually through the mediation of second messengers, and so provide the basis for the transduction mechanism connecting extracellular signals with intracellular effectors. This volume deals with the various ways that such membrane function is controlled.

Download or read book Na K ATPase and Related ATPases written by Kazuya Taniguchi and published by . This book was released on 2000 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1997, J.C. Skou was awarded the Nobel Prize in Chemistry for his discovery of Na/K-ATPase, which has led to widespread appreciation of this enzyme in the scientific community. This volume contains the latest findings and insights in the field and acts as a reference source containing a comprehensive overview of the present state of knowledge. It includes a proposal that Na/K-ATPase plays a role as a tranducer of signal transduction, and, amongst other topics, covers the oligomericity of the enzyme, the site directed mutagenesis of P-type ATPases and the role of g-subunit. The book will serve as an important resouce, not only for work on Na/K-ATPase, but also for the investigation of other P-type ATPases.

Download or read book Nutrition and Brain written by John D. Fernstrom and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a survey of the links between nutrition and the brain. It examines many of the mechanisms by which diet and individual nutrients are known to modify brain development, biochemistry and function, and evaluates current practices in the use of the diet for the prevention and treatment of disorders affecting brain function. It also highlights the need to consider issues related to brain function in the development and evolution of national policies for treating nutritional deficiencies and excesses. Written by leading investigators and clinicians, this publication will help practitioners, clinical investigators and scientists appreciate the broad opportunities awaiting investigation, and ultimately, clinical applications, in this dynamic and expanding area of investigation.

Download or read book Sensing the Environment Regulation of Local and Global Homeostasis by the Skin s Neuroendocrine System written by Andrzej T. Slominski and published by Springer Science & Business Media. This book was released on 2012-06-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt: