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Book Thriving with Microbes

Download or read book Thriving with Microbes written by Sputnik Futures and published by Simon and Schuster. This book was released on 2021-12-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the remarkable minds of Sputnik Futures, this visually engaging exploration of the microbes that surround us and how these unseen powerhouses are shaping our future is perfect for readers of I Contain Multitudes and 10% Human. Let’s face it, microbes rule the world! Bacteria, fungi, archaea, protozoa, algae, even viruses—these microorganisms may go unseen, but the impact they have on our lives is unmistakable. From panspermia (the bacteria dust from our galaxy) and the microbiomes of our homes and our environments, to emerging research on microbes’ role in our social emotions of love and empathy, and the realization that we are a superorganism, made up of trillions of bacteria that may be what makes us “human,” the authors take you through a fascinating revelation of how microbial populations play a crucial role in every aspect of our life. Breakthroughs in our understanding of microbes are shaping the frontier of medicine and health, technology, environmentalism, wellness, architecture, and more. Microbes are talking to us, and we are learning to speak to them in turn. For example, did you know: -That the mind and the gut talk to each other? -That your personality may be shaped by your microbiome? -That a lack of biodiversity can make you sick? -That microbes can reverse climate change and reduce plastic waste? -That our first microbes came from the universe, and we are taking our microorganisms back to space? In Thriving with Microbes, the brilliant minds of Sputnik Futures reveal cutting-edge discoveries from biologists, doctors, ecologists, technologists, and thought leaders as they explore the vast network of microorganisms around and within us. With expert voices, bold discoveries, and engaging visuals, this captivating addition to the Alice in Futureland® series is a must-read guide to the vibrant microbial world we inhabit, how it is shaping our individuality, and the miraculous future these microorganisms are showing us.

Book Thriving with Microbes

    Book Details:
  • Author : Sputnik Futures
  • Publisher : Simon and Schuster
  • Release : 2021-12-07
  • ISBN : 1982172649
  • Pages : 304 pages

Download or read book Thriving with Microbes written by Sputnik Futures and published by Simon and Schuster. This book was released on 2021-12-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the remarkable minds of Sputnik Futures, this visually engaging exploration of the microbes that surround us and how these unseen powerhouses are shaping our future is perfect for readers of I Contain Multitudes and 10% Human. Let’s face it, microbes rule the world! Bacteria, fungi, archaea, protozoa, algae, even viruses—these microorganisms may go unseen, but the impact they have on our lives is unmistakable. From panspermia (the bacteria dust from our galaxy) and the microbiomes of our homes and our environments, to emerging research on microbes’ role in our social emotions of love and empathy, and the realization that we are a superorganism, made up of trillions of bacteria that may be what makes us “human,” the authors take you through a fascinating revelation of how microbial populations play a crucial role in every aspect of our life. Breakthroughs in our understanding of microbes are shaping the frontier of medicine and health, technology, environmentalism, wellness, architecture, and more. Microbes are talking to us, and we are learning to speak to them in turn. For example, did you know: -That the mind and the gut talk to each other? -That your personality may be shaped by your microbiome? -That a lack of biodiversity can make you sick? -That microbes can reverse climate change and reduce plastic waste? -That our first microbes came from the universe, and we are taking our microorganisms back to space? In Thriving with Microbes, the brilliant minds of Sputnik Futures reveal cutting-edge discoveries from biologists, doctors, ecologists, technologists, and thought leaders as they explore the vast network of microorganisms around and within us. With expert voices, bold discoveries, and engaging visuals, this captivating addition to the Alice in Futureland® series is a must-read guide to the vibrant microbial world we inhabit, how it is shaping our individuality, and the miraculous future these microorganisms are showing us.

Book Cultured

    Book Details:
  • Author : Katherine Harmon Courage
  • Publisher : Penguin
  • Release : 2019-02-12
  • ISBN : 1101905298
  • Pages : 288 pages

Download or read book Cultured written by Katherine Harmon Courage and published by Penguin. This book was released on 2019-02-12 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A revealing look at the 300 trillion microorganisms that keep us healthy—and the foods they need to thrive These days, probiotic yogurt and other "gut-friendly" foods line supermarket shelves. But what's the best way to feed our all-important microbiome—and what is a microbiome, anyway? In this engaging and eye-opening book, science journalist Katherine Harmon Courage investigates these questions, presenting a deep dive into the ancient food traditions and the latest research for maintaining a healthy gut. Courage’s insights include: • Meet your microbiome: What it is, how it works, and why it's essential for our immune system--and overall health • Gut-friendly food traditions: A guided tour of artisanal makers of yogurt, kimchi, kefir, kombucha, olives, cocoa, and other vibrant, ancient foods from around the world that feed our microbiome (along with simple recipes for curious at-home cooks) • Cutting-edge science: A first-hand look at some of the top lab facilities where microbiologists are working to better understand the human gut and how to feed it for good health Equal parts science explainer, culinary investigation, and global roadmap for healthy eating, Cultured offers a wealth of information for anyone interested in making smart food choices in our not-so-gut-friendly modern world.

Book I Contain Multitudes

    Book Details:
  • Author : Ed Yong
  • Publisher : HarperCollins
  • Release : 2016-08-09
  • ISBN : 0062368621
  • Pages : 285 pages

Download or read book I Contain Multitudes written by Ed Yong and published by HarperCollins. This book was released on 2016-08-09 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: New York Times Bestseller New York Times Notable Book of 2016 • NPR Great Read of 2016 • Named a Best Book of 2016 by The Economist, Smithsonian, NPR's Science Friday, MPR, Minnesota Star Tribune, Kirkus Reviews, Publishers Weekly, The Guardian, Times (London) From Pulitzer Prize winner Ed Yong, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since Darwin—a “microbe’s-eye view” of the world that reveals a marvelous, radically reconceived picture of life on earth. Every animal, whether human, squid, or wasp, is home to millions of bacteria and other microbes. Pulitzer Prize-winning author Ed Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squid with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. It will change both our view of nature and our sense of where we belong in it.

Book Cheese and Microbes

    Book Details:
  • Author : Catherine W. Donnelly
  • Publisher : ASM Press
  • Release : 2014-04-30
  • ISBN : 1555818595
  • Pages : 346 pages

Download or read book Cheese and Microbes written by Catherine W. Donnelly and published by ASM Press. This book was released on 2014-04-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: A scientific overview of the association of microbes with cheese, through the lens of select cheese varieties that result due to surface mold ripening, internal mold ripening, rind washing, cave aging, or surface smear rind development. Over the past decade, there has been explosive growth in the U.S. artisan cheese industry. The editor, Ms. Donnelly, was involved in developing a comprehensive education curriculum for those new to cheese making, which focused on the science of cheese, principally to promote cheese quality and safety. Many of the chapters in this book focus on aspects of that requisite knowledge. • Explains the process of transformation of milk to cheese and how sensory attributes of cheese are evaluated. • Provides an overview of cheese safety and regulations governing cheese making, both in the US and abroad, to ensure safety. • Explores how the tools of molecular biology provide new insights into the complexity of the microbial biodiversity of cheeses. • Examines the biodiversity of traditional cheeses as a result of traditional practices, and overviews research on the stability of the microbial consortium of select traditional cheese varieties. • Key text for cheese makers, scientists, students, and cheese enthusiasts who wish to expand their knowledge of cheeses and traditional foods.

Book What You Need to Know about Infectious Disease

Download or read book What You Need to Know about Infectious Disease written by Madeline Drexler and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Never Home Alone

    Book Details:
  • Author : Rob Dunn
  • Publisher : Basic Books
  • Release : 2018-11-06
  • ISBN : 154164574X
  • Pages : 380 pages

Download or read book Never Home Alone written by Rob Dunn and published by Basic Books. This book was released on 2018-11-06 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A natural history of the wilderness in our homes, from the microbes in our showers to the crickets in our basements Even when the floors are sparkling clean and the house seems silent, our domestic domain is wild beyond imagination. In Never Home Alone, biologist Rob Dunn introduces us to the nearly 200,000 species living with us in our own homes, from the Egyptian meal moths in our cupboards and camel crickets in our basements to the lactobacillus lounging on our kitchen counters. You are not alone. Yet, as we obsess over sterilizing our homes and separating our spaces from nature, we are unwittingly cultivating an entirely new playground for evolution. These changes are reshaping the organisms that live with us -- prompting some to become more dangerous, while undermining those species that benefit our bodies or help us keep more threatening organisms at bay. No one who reads this engrossing, revelatory book will look at their homes in the same way again.

Book Bugs as Drugs

    Book Details:
  • Author : Robert A. Britton
  • Publisher : John Wiley & Sons
  • Release : 2020-07-02
  • ISBN : 1555819702
  • Pages : 514 pages

Download or read book Bugs as Drugs written by Robert A. Britton and published by John Wiley & Sons. This book was released on 2020-07-02 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

Book Microbiomes of the Built Environment

    Book Details:
  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release : 2017-10-06
  • ISBN : 0309449839
  • Pages : 318 pages

Download or read book Microbiomes of the Built Environment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-10-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: People's desire to understand the environments in which they live is a natural one. People spend most of their time in spaces and structures designed, built, and managed by humans, and it is estimated that people in developed countries now spend 90 percent of their lives indoors. As people move from homes to workplaces, traveling in cars and on transit systems, microorganisms are continually with and around them. The human-associated microbes that are shed, along with the human behaviors that affect their transport and removal, make significant contributions to the diversity of the indoor microbiome. The characteristics of "healthy" indoor environments cannot yet be defined, nor do microbial, clinical, and building researchers yet understand how to modify features of indoor environmentsâ€"such as building ventilation systems and the chemistry of building materialsâ€"in ways that would have predictable impacts on microbial communities to promote health and prevent disease. The factors that affect the environments within buildings, the ways in which building characteristics influence the composition and function of indoor microbial communities, and the ways in which these microbial communities relate to human health and well-being are extraordinarily complex and can be explored only as a dynamic, interconnected ecosystem by engaging the fields of microbial biology and ecology, chemistry, building science, and human physiology. This report reviews what is known about the intersection of these disciplines, and how new tools may facilitate advances in understanding the ecosystem of built environments, indoor microbiomes, and effects on human health and well-being. It offers a research agenda to generate the information needed so that stakeholders with an interest in understanding the impacts of built environments will be able to make more informed decisions.

Book Microbial Versatility in Varied Environments

Download or read book Microbial Versatility in Varied Environments written by Raghvendra Pratap Singh and published by Springer Nature. This book was released on 2020-04-09 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book compiles the latest studies on microorganisms thriving in extreme conditions. Microbes have been found in extremely high and low temperatures, highly acidic to saline conditions, from deserts to the Dead sea, from hot-springs to underwater hydrothermal vents- the diversity is incredible. The various chapters highlight the microbial life and describe the mechanisms of tolerance to these harsh conditions, and show how an understanding of these phenomena can help us exploit the microbes in biotechnology. The theme of the book is highly significant since life in these environments can give vital clues about the origin and evolution of life on earth, as a lot of these conditions simulate the environment present billions of years ago. Additionally, the study of adaptation and survival of organisms in such environments can be important for finding life on other planets. This book shall be useful for students, researchers and course instructors interested in evolution, microbial adaptations and ecology in varied environments.

Book Microbe Science for Gardeners

Download or read book Microbe Science for Gardeners written by Robert Pavlis and published by New Society Publishers. This book was released on 2023-09-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Your garden's little helpers – the role of microbes in growing great plants Microscopic organisms are as important to plant growth as water and light. Microbe Science for Gardeners highlights the essential role of microbes in plant biosystems and soil health, provides practical how-to gardening advice for enhancing plant microbiomes, and debunks common gardening myths. This accessible guide goes beyond soil biology to examine the crucial role of microorganisms in cultivating a productive garden. Coverage includes: The vital interrelationships in microbe populations and between microbes and plants Understanding microbes such as bacteria, yeast, mycorrhizal fungi, and protozoa, both in the rhizosphere and above ground Scientific breakthroughs about microbes that live in the leaves and roots of plants, forming symbiotic relationships How practices such as tilling, crop rotation, and mulching affect the microbe community How the savvy gardener can influence microbial colonies to encourage beneficial organisms while discouraging those that cause disease or other undesirable effects An objective, common-sense analysis of recently popularized practices such as controlling fungal-to-bacterial ratios and applying biostimulants, compost tea, or plant probiotics Prevention and cures for dozens of bacterial, viral, and fungal plant diseases. Whether you're a home gardener, market gardener, or micro-farmer, Microbe Science for Gardeners will help you leverage the incredible power of the mighty microbe to grow healthy, strong, thriving plants.

Book Microbes from Hell

    Book Details:
  • Author : Patrick Forterre
  • Publisher : University of Chicago Press
  • Release : 2016-10-07
  • ISBN : 022626582X
  • Pages : 282 pages

Download or read book Microbes from Hell written by Patrick Forterre and published by University of Chicago Press. This book was released on 2016-10-07 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patrick Forterre is a leading expert on archaea and thermophiles, and in Microbes from Hell (originally published as Microbes de l enfer by Belin, 2007) he offers an engaging, colorful overview of Archaea: single-celled microorganisms that were initially found in extreme habitats such as Yellowstone s volcanic hot springs. He starts with a history of Archaea s discovery and the conceptual revolution it sparked in our understanding of life s evolution; then, in the second chapter, he provides a personal account of his own search for thermophiles. In chapter three, Mr. Forterre discusses the challenges of living in high-temperature environments along with the ways in which thermophiles have adapted to them. In chapters four and five, he examines their relationships to other organisms as well as their role in the early evolution of life. Last, he presents the latest discoveries in thermophile research."

Book Diversity of the Microbial World

    Book Details:
  • Author : Angélica Cibrián-Jaramillo
  • Publisher : Frontiers Media SA
  • Release : 2020-07-17
  • ISBN : 2889636658
  • Pages : 86 pages

Download or read book Diversity of the Microbial World written by Angélica Cibrián-Jaramillo and published by Frontiers Media SA. This book was released on 2020-07-17 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbes, or microorganisms, are tiny living beings that cannot be seen by the naked eye. These little guys are one of the oldest living things on Earth, and are extremely diverse in how they live and what they can do. They, for example, can live in many places, from the freezing iciness of glaciers, to the insides of other organisms, like termites or humans. Since they are virtually everywhere, microorganisms are essential for the biological processes that allow plants and animals to breath, eat and thrive. But how were they able to endure, adapt and flourish constantly over millions of years? The secrets of their success are still within them, coded into their genomes, waiting for us to understand them. Now, genomes, bacterial or otherwise, are the repositories of life. These repositories store almost every bit of information that allows living beings to live in discrete units called genes. Genes are strung together like the sentences in a book, interacting with each other to create meaning, saving the story of that particular book—or that particular living organism’s genome—so it can be copied, modified, corrected or enhanced, and then passed on to new generations. After many, many years of studying these “books,” we have learned to read and understand them, thanks to the technological innovations of the last decade. Nowadays, it is possible to get the full genomic sequence of practically any organism, and compare it with thousands of genomes from other organisms, letting us peek at the secrets that make each organism who it is. With the current technical abilities, the challenge now is not to obtain the information but to interpret all those chunks of the story. Finding ways to untangle the riddles of genomic information is the work of Genomics, the science that allows us to obtain, analyze and prioritize information among the many stories that we sequence everyday. To do this, Genomics draws from many sciences, like mathematics and computing sciences, making it a truly interdisciplinary endeavor. Right now , genomics are one of the most important areas of biology, and many, if not most, of current biological studies use at least a little bit of genomics. For example, genomics can be used to identify a microbe and give it a name, to learn about what types of things it can do or places it can live, and to figure out the mechanisms that enable it to survive under particular conditions. Here, we will dwell on some of the basic questions about microbial adaptation, biodiversity, and their relationships with other living beings using a genomic approach. We will also focus on the environment, trying to understand how such tiny little creatures are capable of solving their daily problems, and how they can alter the places in which they live. Learning about these mechanisms will not only provide us with knowledge about life in general but will also help us to understand these organisms as a fundamental component of our ecosystem, including their harmful and beneficial effects in all aspects of our daily life, which can be translated into useful applications in almost any imaginable way.

Book Molecular Biology of the Cell

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Missing Microbes

    Book Details:
  • Author : Martin J. Blaser, MD
  • Publisher : Henry Holt and Company
  • Release : 2014-04-08
  • ISBN : 0805098119
  • Pages : 289 pages

Download or read book Missing Microbes written by Martin J. Blaser, MD and published by Henry Holt and Company. This book was released on 2014-04-08 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: “In Missing Microbes, Martin Blaser sounds [an] alarm. He patiently and thoroughly builds a compelling case that the threat of antibiotic overuse goes far beyond resistant infections.”—Nature Renowned microbiologist Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the equilibrium and health of our bodies. Now this invisible Eden is under assault from our overreliance on medical advances including antibiotics and caesarian sections, threatening the extinction of our irreplaceable microbes and leading to severe health consequences. Taking us into the lab to recount his groundbreaking studies, Blaser not only provides elegant support for his theory, he guides us to what we can do to avoid even more catastrophic health problems in the future. “Missing Microbes is science writing at its very best—crisply argued and beautifully written, with stunning insights about the human microbiome and workable solutions to an urgent global crisis.”—David M. Oshinsky, author of the Pulitzer Prize-winning Polio: An American Story

Book The Social Biology of Microbial Communities

Download or read book The Social Biology of Microbial Communities written by Institute of Medicine and published by National Academies Press. This book was released on 2013-01-10 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with the germ theory of disease in the 19th century and extending through most of the 20th century, microbes were believed to live their lives as solitary, unicellular, disease-causing organisms . This perception stemmed from the focus of most investigators on organisms that could be grown in the laboratory as cellular monocultures, often dispersed in liquid, and under ambient conditions of temperature, lighting, and humidity. Most such inquiries were designed to identify microbial pathogens by satisfying Koch's postulates.3 This pathogen-centric approach to the study of microorganisms produced a metaphorical "war" against these microbial invaders waged with antibiotic therapies, while simultaneously obscuring the dynamic relationships that exist among and between host organisms and their associated microorganisms-only a tiny fraction of which act as pathogens. Despite their obvious importance, very little is actually known about the processes and factors that influence the assembly, function, and stability of microbial communities. Gaining this knowledge will require a seismic shift away from the study of individual microbes in isolation to inquiries into the nature of diverse and often complex microbial communities, the forces that shape them, and their relationships with other communities and organisms, including their multicellular hosts. On March 6 and 7, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats hosted a public workshop to explore the emerging science of the "social biology" of microbial communities. Workshop presentations and discussions embraced a wide spectrum of topics, experimental systems, and theoretical perspectives representative of the current, multifaceted exploration of the microbial frontier. Participants discussed ecological, evolutionary, and genetic factors contributing to the assembly, function, and stability of microbial communities; how microbial communities adapt and respond to environmental stimuli; theoretical and experimental approaches to advance this nascent field; and potential applications of knowledge gained from the study of microbial communities for the improvement of human, animal, plant, and ecosystem health and toward a deeper understanding of microbial diversity and evolution. The Social Biology of Microbial Communities: Workshop Summary further explains the happenings of the workshop.

Book WHO Guidelines on Hand Hygiene in Health Care

Download or read book WHO Guidelines on Hand Hygiene in Health Care written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The WHO Guidelines on Hand Hygiene in Health Care provide health-care workers (HCWs), hospital administrators and health authorities with a thorough review of evidence on hand hygiene in health care and specific recommendations to improve practices and reduce transmission of pathogenic microorganisms to patients and HCWs. The present Guidelines are intended to be implemented in any situation in which health care is delivered either to a patient or to a specific group in a population. Therefore, this concept applies to all settings where health care is permanently or occasionally performed, such as home care by birth attendants. Definitions of health-care settings are proposed in Appendix 1. These Guidelines and the associated WHO Multimodal Hand Hygiene Improvement Strategy and an Implementation Toolkit (http://www.who.int/gpsc/en/) are designed to offer health-care facilities in Member States a conceptual framework and practical tools for the application of recommendations in practice at the bedside. While ensuring consistency with the Guidelines recommendations, individual adaptation according to local regulations, settings, needs, and resources is desirable. This extensive review includes in one document sufficient technical information to support training materials and help plan implementation strategies. The document comprises six parts.