Download or read book Natural Products Isolation written by G.H. Wagman and published by Elsevier. This book was released on 1988-12-01 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book encompasses, in great detail, the most recent progress made in the isolation and separation of natural products. It covers antibiotics, marine and plant-derived substances, enzyme inhibitors and interferons. The most recent separation methodology is described. Although there is a bias toward antibiotics, it was done because this is still the largest natural products area of research.The fourteen chapters are written by experts in their respective fields. The first two chapters are largely devoted to new methodology applied to purification of a variety of compounds. They include an extensive review and new applications of counter-current chromatography and the newly emerging HPLC-photodiode array technology. Chapter 3 provides a review of affinity chromatography applied to the separation of antibiotics for the first time. Next are chapters on antimicrobials with an update on all the most recent &bgr;-lactam (after 1976) discoveries. A comprehensive review of a very important class of antiparasitic agents - the avermectins - follows. An update of isolation and purification of a variety of marine-derived compounds is next. The succeeding chapter is a comprehensive review of the most recent developments in isolation and purification of interferons. This is followed by a discussion of enzyme inhibitors and their isolation and purification and ties in with a chapter on plant-derived natural products, some of which are also in this same category. The final chapter is a futuristic essay indicating the isolation of minute amounts of natural products and the fascinating biological properties which they possess.The book has extensive isolation schemes, tables, figures and chemical structures. In many instances a short summary of the producing organism, brief chemical description and structure and biological activity of the compounds is presented. Detailed information of extraction, separation and purification techniques follow. Each chapter has an extensive bibliography and, where applicable, an appendix showing sources of materials and equipment. A detailed index to the subject matter is included at the end of the book.The book thus offers the reader: up-to-date reviews (including 1988) of specific topics in the natural products field not to be found elsewhere; information on new chromatographic methods and techniques described in sufficient detail to be utilized by investigators in this area of research; and extensive references to enable the serious researcher to pursue particular information. It will appeal to pharmaceutical and natural products researchers and is a valuable acquisition for university chemistry and biochemistry departments.

Download or read book An Approach to the Synthesis of thienamycin written by James Densmore Copp and published by . This book was released on 1981 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book From Bench to Market written by Walter Cabri and published by Oxford University Press, USA. This book was released on 2000 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: '... a unique book... I highly recommendthis book to process chemists not only in the pharmaceutical industry but in the fine chemical, agrochemical, and colour chemical industries, too ... It is refreshing to see the book in paperback at a low cost. Highly recommended- I will certainly use it as a teaching aid' Chemistry in BritainWho wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule to its entry in the marketplace as a drug. Using real case histories of drug development from several therapeutic areas, they discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms.

Download or read book Biodiversity written by Ewan J T Chrystal and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continuing quest for new drugs and agrochemicals has seen researchers looking to the natural world for potential products. Plants and microorganisms have long been investigated as sources of new lead compounds, but the scope of this book has been widened to include substances derived from marine organisms. Advances in genetic engineering, high throughput screening and structure elucidation have also opened up further avenues for exploration. Competitive pressure from the field of combinatorial chemistry has expedited new approaches to natural product analysis and stimulated debate on the industrial utilization of natural products. Biodiversity: New Leads for the Pharmaceutical and Agrochemical Industries reviews and discusses aspects of modern natural products research. The central theme of many articles is the sustainable use of global biodiversity. Microbial, plant and marine products are presented as the sources of new drugs, including antifungal products, antibiotics, anticancer agents and animal health products. There is also coverage of the biosynthesis of polyketides and the chemical synthesis of natural products and their derivatives. A unique blend of industrial and academic perspectives on the importance of biodiversity and natural products, this book will prove an important source of state-of-the-art information for researchers, teachers and graduates in the chemical and biological sciences.

Download or read book Biosynthesis of Heterocycles written by Patrizia Diana and published by John Wiley & Sons. This book was released on 2015-02-06 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles. • Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification • Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance • Explains the role of natural products in chemistry and their formation • Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application

Download or read book Hallelujah Moments written by Eugene H. Cordes and published by Oxford University Press. This book was released on 2020-04-20 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of novel drugs that fill unmet medical needs is important for the health and well-being of people everywhere. However, the general public knows too little about the pathways through which basic research discoveries are translated into products that protect or restore human health. In the second edition of Hallelujah Moments, Eugene H. Cordes reveals the processes and pitfalls on the route from the laboratory bench to the bedside. These are adventure stories in which wit and grit created several of the most important drugs in human medicine. This new edition adds four new tales of drug discovery: for therapy of cancer, hepatitis C, HIV/AIDS, and for weight control. The stories emphasize the integration of basic research in academe and applied research in the pharmaceutical industry and introduce the key scientists. In each case, success resulted from imagination, risk-taking, problem solving, and perseverance. Cordes shares his firsthand knowledge of the drug-discovery world, having spent a long and distinguished career in both academic and industrial settings. The eleven drug discovery tales take the reader from concept to clinic for some of the most important drugs in human health including the statins, ACE inhibitors, antibiotics, avermectins, Januvia, and Taxol. These stories offer exciting insights into the fascinating world of drug discovery.

Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Download or read book Antibiotics written by Arnold L. Demain and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Imipenem written by and published by . This book was released on 1985 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Antibiotics and Antibiotic Resistance written by Ola Sköld and published by John Wiley & Sons. This book was released on 2011-10-07 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in various antibacterial agents and explanations of how resistances to those develop. Methods for counteracting resistance development in bacteria are discussed as well.

Download or read book International Union of Pharmacology written by Paul Turner and published by Springer. This book was released on 2015-12-31 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Chirality written by and published by Newnes. This book was released on 2012-12-31 with total page 5635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Download or read book Progress in Medicinal Chemistry written by and published by Elsevier. This book was released on 1996-04-24 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Medicinal Chemistry

Download or read book Roald Hoffmann on the Philosophy Art and Science of Chemistry written by Roald Hoffmann and published by Oxford University Press. This book was released on 2012-01-23 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book Kovac and Weisberg bring together twenty-eight of Hoffmann' s most philosophically significant and interesting pieces, many of which are not easily found in print.

Download or read book Organic Reactions Volume 114 written by P. Andrew Evans and published by John Wiley & Sons. This book was released on 2024-04-02 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: A carefully curated review of the scientific literature, Volume 114 of Organic Reactions presents critical discussions of widely used organic reactions or particular steps of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method. Launched in 1942, the Organic Reactions series today is a leading secondary- and tertiary-level source for organic chemists across the world.

Download or read book The Complete Book on Biotechnology Based Bulk Drugs written by NPCS Board of Consultants & Engineers and published by NIIR PROJECT CONSULTANCY SERVICES. This book was released on 2007-01-01 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnology has played an essential role in the development of the healthcare chemical industries. The range of product includes diagnostic, prophylactic and therapeutic agents. The discovery of a potentially active compound starts a sequence of exhaustive chemical and biological testing that may culminate in manufacture of the agent or an improved analog. The role of biotechnology in this complex path to regulatory approval and marketing is diverse. Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bio products. Biotechnology also utilizes these products for manufacturing purpose. Some of the examples of drugs produced through biotechnology are penicillin, lincomycin, streptomucin, tylosin, peptide antibiotics, cephalosporins, etc. Modern use of similar terms includes genetic engineering as well as cell and tissue culture technologies. Biotechnology draws on the pure biological sciences and in many instances is also dependent on knowledge and methods from outside the sphere of biology. Conversely, modern biological sciences are intimately entwined and dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry. The development of biotechnology is taking place in almost all fields of human life. The recent advances in the field of basic genetics have opened up new vistas, potentials and possibilities. Some of the fundamentals of the book are the pharmaceutical industries, marketing strategy, common features in the evolution of products and processes, process technology fermentation, product recovery, new trends in biotechnology, penicillins, biosynthesis and regulation of thienamycin, olivanic acids and epithienamycins, aminoglycoside antibiotics, streptidine and deoxystreptamine, streptomycin, neomycin, paromomycin, ribostamycin and,butirosin gentamicin, micronomicin and sisomicin, tylosin, peptide antibiotics, current applications of peptides, blasticidin S: an agricultural antibiotic bleomycin and bestatin: peptides used in anticancer therapy etc. The present book contains process of biotechnology based bulk drugs like penicillin, B lactam antibiotics, aminoglycoside antibiotics, peptide antibiotics, anti cancer agents, lincomycin etc. This is very resourceful book for entrepreneurs, technocrats, research scholars, libraries etc. TAGS Process for Production of Penicillin, Biotechnology in Bulk Drug Production, Manufacturing of Bulk Drugs, Bulk Drugs Production, Manufacturing Process of Penicillins, Fermentation Process, Novel Fermentation Process, Manufacture Aminoglycoside, Manufacturing Process of Tylosin, Production of Peptides, Production of Streptomycin, Fermentation Process of Cephalosporins, Cephamycin Production, Production of Lincomycin, Drug Development Process, Fermentation Process for Production of Anthracylines, Batch Fermentation Process, Fermentation Process for Production of Nucleosides, Batch Production Process, Interferon Production, Leukocyte Process, Lymphoblastoid Process, Immune Interferon Process, Production of Siderophores, Production of Cloning and Expression, Production of Penicillin, Process of Fermentation, Production of Fermentation, Novel Fermentation Processes for Manufacturing, Novel Fermentation Production, Manufacture of Aminoglycoside, Production of Tylosin, Manufacturing of Peptides, Production of Peptides, Process for Production of Streptomycin, Production of Cephalosporin, Fermentation for Cephalosporin Production, Production of Cephamycin, Lincomycin Production, Anthracycline Production, Process for Production of Anthracycline, Producing Nucleotide by Fermentation, Production of Nucleotides, Batch Production, Production of Interferon, Cloning And Expression of Antibiotic Production, How to Start Anthracycline Processing Industry, Production Of Cephamycin Industry, Most Profitable Novel Fermentation Production Ideas, Cloning and Expression Processing Projects, Small Scale Nucleosides Production Projects, Starting Penicillin Production Business, How to Start Anthracylines Production Business, Bulk Drugs Based Small Scale Industries Projects, NPCS, Niir, Process Technology Books, Business Consultancy, Business Consultant, Project Identification and Selection, Preparation of Project Profiles, Startup, Business Guidance, Business Guidance to Clients, Startup Project for Aminoglycoside Manufacture, Startup Project, Startup Ideas, Project for Startups, Startup Project Plan, Business Start-Up, Business Plan for Startup Business, Great Opportunity for Startup, Small Start-Up Business Project, Start-Up Business Plan for Peptides Production, Start Up India, Stand Up India, Modern Small and Cottage Scale Industries, Profitable Small and Cottage Scale Industries, Setting Up and Opening Your Bulk Drugs Business, How To Start Production of Nucleosides ?, Best Small and Cottage Scale Industries, Bulk Based Business, Profitable Small Scale Manufacturing,

Download or read book Synthesis of Bioactive Scaffolds written by Rakesh Kumar Sharma and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-08-22 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon and carbon-heteroatom bond-forming reactions are the backbone of synthetic organic chemistry. Scientists are constantly developing and improving these techniques in order to maximize the diversity of synthetically available molecules. These techniques must be developed in a sustainable manner in order to limit their environmental impact. This book highlights green bond forming reactions for bioactive scaffolds.