Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Download or read book Therapeutics of Nervous Diseases written by Charles Porter Hart and published by . This book was released on 1889 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disease and Mortality in Sub Saharan Africa written by Dean T. Jamison and published by World Bank Publications. This book was released on 2006-01-01 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current data and trends in morbidity and mortality for the sub-Saharan Region as presented in this new edition reflect the heavy toll that HIV/AIDS has had on health indicators, leading to either a stalling or reversal of the gains made, not just for communicable disorders, but for cancers, as well as mental and neurological disorders.
Download or read book Diseases of the Nervous System written by Harald Sontheimer and published by Elsevier. This book was released on 2021-05-20 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations. 2016 PROSE Award winner of the Best Textbook Award in Biological and Life Sciences Provides a focused tutorial introduction to the core diseases of the nervous system Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous system Covers more than 40 diseases from the foundational science to the best treatment protocols Includes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience New Edition features two new chapters on Pain and Addiction
Download or read book The Right Therapy for Neurological Disorders written by E. Beghi and published by Karger Medical and Scientific Publishers. This book was released on 2016-07-26 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most neurological disorders are chronic and aging-related. With the increase of life expectancy their incidence and prevalence will grow in the decades to come, which in turn will increase the load on medical and social systems worldwide. There is thus a desperate need for successful preventive and therapeutic measures based on randomized clinical trials (RTCs) conducted by independent organizations. This book provides a compendium relating most of the principles of reliable RTCs to specific neurological diseases. Contributed by specialized neurologists, the articles touch on important aspects of RCTs with a clear critical approach, highlighting their limitations as well as giving recommendations for their planning and conducting to address the variable genotypic and phenotypic aspects of neurological conditions. Consideration is also given to combining the clinical impact of the study results with patients’ values and the interests of pharmaceutical companies. Neurologists involved in clinical trials will certainly benefit from this book, which should become a basic text for all neurological courses dealing with evidence-based neurology.
Download or read book Neurological Disorders written by Thomas Brandt and published by Gulf Professional Publishing. This book was released on 2003-01-03 with total page 1606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This single-volume reference covers the natural course, treatment, and management of all neurological diseases affecting the brain, spinal cord nerves and muscles. This comprehensive text reference seeks to assist physicians with treatment by providing an easy-to-use compendium covering the treatment and management of all neurological diseases along with details on the natural course of these diseases. Organized for ease of use and quick reference, each chapter presents a neurological disorder or key symptoms and systematically discusses the clinical syndrome and differential diagnosis, natural course, principles of therapy, and practical management of each. Covers wide range of neurological conditions and potential treatments, including the evidence for and against each treatment Describes the spontaneous course of neurological diseases along with discussion of the management of different stages and variants of a disorder Presents special situations and exceptional cases in which alternative therapies should be considered
Download or read book Nervous Diseases and Magnetic Therapeutics written by James Edwin Briggs and published by BoD – Books on Demand. This book was released on 2024-05-03 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reprint of the original, first published in 1881.
Download or read book Therapeutics of Neural Stimulation for Neurological Disorders written by Yuping Wang and published by Springer Nature. This book was released on 2023-11-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book mainly focuses on diversity of brain diseases, such as sleep disorders, major depression disorder, anxiety disorders, epilepsy, cognitive disorders, etc. It introduces the current pathological mechanisms of various diseases from the perspective of basic theories and research; it introduces the clinical evaluation and treatment of the above diseases from the clinical perspective. In addition, the current frontier research on therapeutics of neural stimulation for the above brain disorder was introduced, such as Transcranial electrical stimulation, magnetic stimulation, ultrasonic stimulation, etc., and the therapeutic strategy and stimuli parameters for reference were proposed. This book is aimed at clinical students, doctors and researchers in the field of neurology. Based on major brain diseases, this book systematically proposed the maneuverability, safety and effectiveness of neural stimulation technologies in the treatment of major brain diseases.
Download or read book Disease Control Priorities Third Edition Volume 4 written by Vikram Patel and published by World Bank Publications. This book was released on 2016-03-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.
Download or read book Gene Therapy of the Central Nervous System From Bench to Bedside written by Michael G. Kaplitt and published by Gulf Professional Publishing. This book was released on 2006 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.
Download or read book Neuronal Networks in Brain Function CNS Disorders and Therapeutics written by Carl Faingold and published by Academic Press. This book was released on 2013-12-26 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available
Download or read book Clinical Therapeutics written by Dujardin-Beaumetz and published by . This book was released on 1885 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Therapy Approaches in Neurological Disorders written by Mario Bernardo-Filho and published by BoD – Books on Demand. This book was released on 2021-07-14 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological disorders are conditions affecting the central or peripheral nervous system, with undesirable consequences for the quality of life. This book highlights and discusses several approaches for managing these conditions and improving the functional capacity and quality of life of patients, including whole-body vibration exercise, biofeedback, sagittal plane spine alignment, allopathic and non-allopathic medications, phytotherapy, and more.
Download or read book Therapeutics of Nervous Diseases written by Charles Porter Hart and published by . This book was released on 198? with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Modern Treatment of Nervous and Mental Diseases written by William Alanson White and published by . This book was released on 1913 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, devoted to the treatment of nervous and mental diseases, is designed to meet the needs which the rapid advances in knowledge of neurology and psychiatry have created. The nervous system is here regarded as a whole and as inclusive of the mind, and it is maintained that disturbances of any and all of its functions, mental as well as physical, are proper subjects for therapeutics. The present work lays emphasis upon the psychical side of life as being worth quite as much consideration as the physical. It sets forth doctrines of nervous and mental hygiene, reconstructive factors in social organization as applied to human ills, and endeavors to present a broad front to the pessimistic nihilism in therapeutics that has been too long current in these fields, because the doctor's eyes have been too closely focused on the individual examples and results of human accidents. Neurology and psychiatry offer the widest possible opportunities for preventive medicine as well as for therapeutic optimism. The program here presented is essentially therapeutic. Planned as it has been on a broad scale, the more practical issues confronting the clinician have, nevertheless, been fully met. The editors have sacrificed philosophical views for more definite guideposts wherever, in the present state of our knowledge, such a course seemed wiser. (PsycINFO Database Record (c) 2005 APA, all rights reserved).
Download or read book The Modern Treatment of Nervous and Mental Diseases written by William A. White and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, devoted to the treatment of nervous and mental diseases, is designed to meet the needs which the rapid advances in knowledge of neurology and psychiatry have created. The nervous system is here regarded as a whole and as inclusive of the mind, and it is maintained that disturbances of any and all of its functions, mental as well as physical, are proper subjects for therapeutics. The present work lays emphasis upon the psychical side of life as being worth quite as much consideration as the physical. It sets forth doctrines of nervous and mental hygiene, reconstructive factors in social organization as applied to human ills, and endeavors to present a broad front to the pessimistic nihilism in therapeutics that has been too long current in these fields, because the doctor's eyes have been too closely focused on the individual examples and results of human accidents. Neurology and psychiatry offer the widest possible opportunities for preventive medicine as well as for therapeutic optimism. The program here presented is essentially therapeutic. Planned as it has been on a broad scale, the more practical issues confronting the clinician have, nevertheless, been fully met. The editors have sacrificed philosophical views for more definite guideposts wherever, in the present state of our knowledge, such a course seemed wiser. (PsycINFO Database Record (c) 2005 APA, all rights reserved).
Download or read book Nerves in Disorder written by Alfred Taylor Schofield and published by . This book was released on 1903 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
