Download or read book Therapeutic Rhodium Complexes written by Afzal Hussain and published by Springer Nature. This book was released on 2023-06-29 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the emergence and recent advances in the design and development of rhodium complexes as therapeutic agents. Different classes of anticancer rhodium complexes with particular emphasis on ligands containing nitrogen-oxygen donor atoms are presented. Anticancer rhodium complexes of N-heterocyclic carbenes are described, while half-sandwich, heterobimetallic, and multinuclear rhodium complexes are discussed. Therapeutic applications of rhodium complexes beyond cancer such as antibacterial agents or antiviral agents are also analyzed, among others. Their mechanism of action is overviewed in detail, and the authors thoroughly comment on the challenges and future outlooks of research in the development of rhodium metallodrugs. This title highlights the important research carried out in the development of therapeutic rhodium complexes and is of great interest to graduates and researchers working in the area of rhodium-based therapeutic drugs.

Download or read book Metal Compounds in Cancer Therapy written by S.P. Fricker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of the antitumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major international research effort investigating the potential of metal compounds in cancer therapy. Cisplatin now occupies an important place in the armamentarium of the oncologist due to its effectiveness in the treatment of testicular cancer. A second generation analogue, carbo platin, offers reduced toxicity together with therapeutic activity, which gives it a place in the front-line therapy of genitourinary cancers. These and other successes have encouraged the search for novel metal-based drugs for cancer therapy. Research has shown that metal compounds have potential for activity not only as cytotoxic antitumour agents, but also in areas such as adjuvant therapy, diagnosis and immunotherapy. The aim of this book is to review and describe the major achievements and developments arising from this international research effort. The contributing authors come from labora tories throughout Europe and America and represent the many disci plines characteristic of this research, such as clinical research, pharmacology, tumour biology and inorganic medicinal chemistry.

Download or read book DNA targeting Molecules as Therapeutic Agents written by Michael J Waring and published by Royal Society of Chemistry. This book was released on 2018-03-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.

Download or read book Synthesis and Biological Studies of Anti Cancer Rhodium ii II Carboxylates Anti Inflammatory Silver i Thiourea and Microbially Fabricated Silver Nanoparticles written by WING-SHAN. LIN and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Synthesis and Biological Studies of Anti-cancer Rhodium(II, II) Carboxylates, Anti-inflammatory Silver(I) Thiourea and Microbially Fabricated Silver Nanoparticles" by Wing-shan, Lin, 林穎珊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Discovery of cisplatin as an effective anticancer agent has stimulated the development of metal based medicine. The recent advances in research on platinum, ruthenium and gold complexes have received much attention in medicinal chemistry, and studies of other less explored metal complexes may reveal alternative mode of mechanism as novel therapeutic agents. A series of dirhodium(II, II) complexes with carboxylate and carboxamidate ligands and thiourea complexes of coinage metals have been prepared in this study. Their biological activities and mechanisms of action have been studied. Dirhodium(II, II) carboxylate complexes with variations of alkyl and benzoyl side chains were synthesized and displayed remarkable cytotoxicities to cancer cells with potency down to submicromolar level. The cytotoxicities of rhodium complexes were found to significantly correlate with the cellular uptake of the rhodium complexes. As revealed by oligonucleotide microarray and bioinformatic analysis, the mode of action of the rhodium carboxylate complexes are highly similar to that of a proteasome inhibitor. Further cellular and biochemical studies showed that rhodium carboxylate complexes induced an accumulation of ubiquitinated proteins, inhibited the proteolytic activities of purified 20S proteasome and proteasomal deubiquitinating enzyme. These results corroborate that the impairment of the ubiquitin-proteasome system is linked to the cytotoxic action of rhodium carboxylate complexes. Silver is known to be an anti-inflammatory agent for topical treatment. A silver complex of N, N''-disubstituted cyclic thiourea that is reasonably stable towards reduced glutathionewas found to potently inhibit the NF-B transcriptional activity. Treatment of cells with silver thiourea inhibited TNF-α-stimulated IκB kinase activity, IκBα phosphorylation and degradation, nuclear translocation of NF-κB p65 and eventually the stimulated gene expression of inflammatory cytokines. Suppression of IκB kinase activity was associated with modification of sensitive cysteine residues and disruption of IκB kinase assembly. These data demonstrated that the inhibitory properties of Ag+ ions on an anti-inflammatory and anti-cancer drug target could be effectively delivered via the thiourea ligand. Silver is also an antimicrobial metal, and this study was also extended to understand the silver-bacteria interaction using a silver resistant bacteria as a model. Many silver resistant bacteria often produce considerable amount of silver particles when exposed to high concentrations of silver salts but the mechanism of biosynthesis is not well understood. A silver resistant E. coli that displays active silver efflux was shown to synthesize zero-valent silver nanoparticles in the periplasmic space through reduction of silver ions under anaerobic conditions. As the microbial c-type cytochromes are known to mediate respiratory metal reduction, their role in the biosynthesis of silver nanoparticles was examined. A deletion mutant of the cytoplasmic membrane-anchored tetra-heme c-type cytochrome subunit of periplasmic nitrate reductase (NapC) showed marked reduction of accumulation of silver nanoparticles. This study identified a molecular mechanism of biosynthesis of silver nanoparticles that may have implication in bioenvironmental pro

Download or read book Supported Molecular Rhodium Complexes and Clusters written by Ann Jia-Bao Liang and published by . This book was released on 2008 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Metallotherapeutic Drugs and Metal Based Diagnostic Agents written by Marcel Gielen and published by John Wiley & Sons. This book was released on 2005-09-01 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.

Download or read book Medicinal Organometallic Chemistry written by Gérard Jaouen and published by Springer Science & Business Media. This book was released on 2010-09-14 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.

Download or read book Biological Activity of Rhodium Metalloinsertors and the Design of Bifunctional Conjugates written by Alyson Gloria Weidmann and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Barton laboratory has established that octahedral rhodium complexes bearing the sterically expansive 5,6-chrysene diimine ligand can target thermodynamically destabilized sites, such as base pair mismatches, in DNA with high affinity and selectivity. These complexes approach DNA from the minor groove, ejecting the mismatched base pairs from the duplex in a binding mode termed metalloinsertion. In recent years, we have shown that these metalloinsertor complexes also exhibit cytotoxicity preferentially in cancer cells that are deficient in the mismatch repair (MMR) machinery. Here, we establish that a sensitive structure-activity relationship exists for rhodium metalloinsertors. We studied the relationship between the chemical structures of metalloinsertors and their effect on biological activity for ten complexes with similar DNA binding affinities, but wide variation in their lipophilicity. Drastic differences were observed in the selectivities of the complexes for MMR-deficient cells. Compounds with hydrophilic ligands were highly selective, exhibiting preferential cytotoxicity in MMR-deficient cells at low concentrations and short incubation periods, whereas complexes with lipophilic ligands displayed poor cell-selectivity. It was discovered that all of the complexes localized to the nucleus in concentrations sufficient for mismatch binding; however, highly lipophilic complexes also exhibited high mitochondrial uptake. Significantly, these results support the notion that mitochondrial DNA is not the desired target for our metalloinsertor complexes; instead, selectivity stems from targeting mismatches in genomic DNA. We have also explored the potential for metalloinsertors to be developed into more complex structures with multiple functionalities that could either enhance their overall potency or impart mismatch selectivity onto other therapeutic cargo. We have constructed a family of bifunctional metalloinsertor conjugates incorporating cis-platinum, each unique in its chemical structure, DNA binding interactions, and biological activity. The study of these complexes in MMR-deficient cells has established that the cell-selective biological activity of rhodium metalloinsertors proceeds through a critical cellular pathway leading to necrosis. We further explored the underlying mechanisms surrounding the biological response to mismatch recognition by metalloinsertors in the genome. Immunofluorescence assays of MMR-deficient and MMR-proficient cells revealed that a critical biomarker for DNA damage, phosphorylation of histone H2AX (gamma-H2AX) rapidly accumulates in response to metalloinsertor treatment, signifying the induction of double strand breaks in the genome. Significantly, we have discovered that our metalloinsertor complexes selectively inhibit transcription in MMR-deficient cells, which may be a crucial checkpoint in the eventual breakdown of the cell via necrosis. Additionally, preliminary in vivo studies have revealed the capability of these compounds to traverse the complex environments of multicellular organisms and accumulate in MMR-deficient tumors. Our ever-increasing understanding of metalloinsertors, as well as the development of new generations of complexes both monofunctional and bifunctional, enables their continued progress into the clinic as promising new chemotherapeutic agents.

Download or read book Toxicity Bibliography written by and published by . This book was released on 1977 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nitric Oxide From Research to Therapeutics written by Arunabha Ray and published by Springer Nature. This book was released on 2023-03-07 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book entitled "Nitric Oxide: From Research to Therapeutics" includes the most recent information about the role of Nitric Oxide (NO) in physiology, pathophysiology and its translation to therapeutics. The Editors are vastly experienced in the field of NO research. The international panels of contributors to the various chapters of the book are all well-established researchers and health professionals who have worked in different areas of NO physiology and pathophysiology, and have made a considerable impact in the field. The book is a comprehensive collection of the most recent information on NO as a physiological regulator and its diverse potential as a therapeutic target for the treatment for a variety of disease states. This compilation is aimed at professionals and students from both academia and the industry in the areas of basic biomedical and clinical sciences.

Download or read book Current Research on Pre clinical Aspects of Cancer Therapy written by Current Cancer Research Project Analysis Center (U.S.) and published by . This book was released on 1975 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1038 references to research projects being conducted in the United States and elsewhere. Entries arranged under 5 topics, e.g., Preclinical studies of anticancer drugs, Preclinical radiation therapy, and Preclinical immunotherapy. Entriesinclude title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.

Download or read book Rhodium Catalyzed Hydroformylation written by Piet W.N.M. van Leeuwen and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade there have been numerous advances in the area of rhodium-catalyzed hydroformylation, such as highly selective catalysts of industrial importance, new insights into mechanisms of the reaction, very selective asymmetric catalysts, in situ characterization and application to organic synthesis. The views on hydroformylation which still prevail in the current textbooks have become obsolete in several respects. Therefore, it was felt timely to collect these advances in a book. The book contains a series of chapters discussing several rhodium systems arranged according to ligand type, including asymmetric ligands, a chapter on applications in organic chemistry, a chapter on modern processes and separations, and a chapter on catalyst preparation and laboratory techniques. This book concentrates on highlights, rather than a concise review mentioning all articles in just one line. The book aims at an audience of advanced students, experts in the field, and scientists from related fields. The didactic approach also makes it useful as a guide for an advanced course.

Download or read book Nucleic Acid metal Ion Interactions written by Nicholas V. Hud and published by Royal Society of Chemistry. This book was released on 2009 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a perspective on nucleic acid-metal ion interactions with an emphasis on experimental biophysical studies which will prove indispensable to biophysicists and molecular biologists.

Download or read book Comprehensive Inorganic Chemistry II written by and published by Newnes. This book was released on 2013-07-23 with total page 7694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Inorganic Chemistry II, Nine Volume Set reviews and examines topics of relevance to today’s inorganic chemists. Covering more interdisciplinary and high impact areas, Comprehensive Inorganic Chemistry II includes biological inorganic chemistry, solid state chemistry, materials chemistry, and nanoscience. The work is designed to follow on, with a different viewpoint and format, from our 1973 work, Comprehensive Inorganic Chemistry, edited by Bailar, Emeléus, Nyholm, and Trotman-Dickenson, which has received over 2,000 citations. The new work will also complement other recent Elsevier works in this area, Comprehensive Coordination Chemistry and Comprehensive Organometallic Chemistry, to form a trio of works covering the whole of modern inorganic chemistry. Chapters are designed to provide a valuable, long-standing scientific resource for both advanced students new to an area and researchers who need further background or answers to a particular problem on the elements, their compounds, or applications. Chapters are written by teams of leading experts, under the guidance of the Volume Editors and the Editors-in-Chief. The articles are written at a level that allows undergraduate students to understand the material, while providing active researchers with a ready reference resource for information in the field. The chapters will not provide basic data on the elements, which is available from many sources (and the original work), but instead concentrate on applications of the elements and their compounds. Provides a comprehensive review which serves to put many advances in perspective and allows the reader to make connections to related fields, such as: biological inorganic chemistry, materials chemistry, solid state chemistry and nanoscience Inorganic chemistry is rapidly developing, which brings about the need for a reference resource such as this that summarise recent developments and simultaneously provide background information Forms the new definitive source for researchers interested in elements and their applications; completely replacing the highly cited first edition, which published in 1973

Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1975 with total page 1276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Rhodium Complexes of Substituted Pyridine Ligands written by Jennifer Johnston Robertson and published by . This book was released on 1986 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Rhodium Catalysis in Organic Synthesis written by Ken Tanaka and published by John Wiley & Sons. This book was released on 2019-05-06 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference to the highly effective reactions applied to modern organic synthesis Rhodium complexes are one of the most important transition metals for organic synthesis due to their ability to catalyze a variety of useful transformations. Rhodium Catalysis in Organic Synthesis explores the most recent progress and new developments in the field of catalytic cyclization reactions using rhodium(I) complexes and catalytic carbon-hydrogen bond activation reactions using rhodium(II) and rhodium(III) complexes. Edited by a noted expert in the field with contributions from a panel of leading international scientists, Rhodium Catalysis in Organic Synthesis presents the essential information in one comprehensive volume. Designed to be an accessible resource, the book is arranged by different reaction types. All the chapters provide insight into each transformation and include information on the history, selectivity, scope, mechanism, and application. In addition, the chapters offer a summary and outlook of each transformation. This important resource: -Offers a comprehensive review of how rhodium complexes catalyze a variety of highly useful reactions for organic synthesis (e.g. coupling reactions, CH-bond functionalization, hydroformylation, cyclization reactions and others) -Includes information on the most recent developments that contain a range of new, efficient, elegant, reliable and useful reactions -Presents a volume edited by one of the international leading scientists working in the field today -Contains the information that can be applied by researchers in academia and also professionals in pharmaceutical, agrochemical and fine chemical companies Written for academics and synthetic chemists working with organometallics, Rhodium Catalysis in Organic Synthesis contains the most recent information available on the developments and applications in the field of catalytic cyclization reactions using rhodium complexes.