Download or read book Theoretical and Experimental Insights into Immunology written by Alan S. Perelson and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology is largely a science of observation and experimentation, and these approaches have lead to great increases in our knowledge of the genes, molecules and cells of the immune system. This book is an up-to-date discussion of the current state of modelling and theoretical work in immunology, of the impact of theory on experiment, and of future directions for theoretical research. Among the topics discussed are the function and evolution of the immune system, computer modelling of the humoral immune response and of idiotypic networks and idiotypic mimicry, T-cell memory, cryptic peptides, new views and models of AIDS and autoimmunity, and the shaping of the immune repertoire by early presented antigens and self immunoglobulin.
Download or read book Immunology The Making of a Modern Science written by Richard B. Gallagher and published by Elsevier. This book was released on 1995-07-14 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology has progressed in spectacular fashion in the last four decades. Studies of the response to infectious agents, transplanted organs and tumours (and the potential to manipulate that response), and the study of the immune system as a model system in molecular cell biology have yielded dramatic advances in our understanding of the mechanisms of immunity. The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein. Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective.
Download or read book MATHEMATICAL MODELS OF LIFE SUPPORT SYSTEMS Volume II written by Valeri I. Agoshko and published by EOLSS Publications. This book was released on 2009-10-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical Models of Life Support Systems is a component of Encyclopedia of Mathematical Sciences in which is part of the global Encyclopedia of Life Support Systems (EOLSS), an integrated compendium of twenty one Encyclopedias. The Theme is organized into several topics which represent the main scientific areas of the theme: The first topic, Introduction to Mathematical Modeling discusses the foundations of mathematical modeling and computational experiments, which are formed to support new methodologies of scientific research. The succeeding topics are Mathematical Models in - Water Sciences; Climate; Environmental Pollution and Degradation; Energy Sciences; Food and Agricultural Sciences; Population; Immunology; Medical Sciences; and Control of Catastrophic Processes. These two volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
Download or read book A Historical Perspective on Evidence Based Immunology written by Edward J. Moticka and published by Newnes. This book was released on 2015-11-25 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
Download or read book Environmental Radiation Effects on Mammals written by Olga A. Smirnova and published by Springer. This book was released on 2016-10-14 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Smirnova's updated text is devoted to the theoretical studies of radiation effects on mammals. It summarizes 35 years of results the author obtained from analyzing dose rate equivalents for the Galactic Cosmic Rays (GCR) and for Solar Particles Events (SPE). This edition also includes two new chapters on skin epidermal epithelium and risk assessment for myeloid leukemia, as well as extended revisions addressing the radiation effects on the blood-forming system. Mathematical models are used to explain the effects of both acute and chronic irradiation on the dynamics of vital body systems, like the hematopoietic system, the development of autoimmune diseases, and the mortality dynamics in homogeneous and nonhomogeneous mammalian populations. The proposed methodology of these studies, the models themselves, and the obtained results are of a great theoretical significance and can find wide practical use.
Download or read book Theory And Control Of Dynamical Systems Applications To Systems In Biology written by Stig I Andersson and published by World Scientific. This book was released on 1992-05-26 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the mathematical modeling of complex system behavior, dynamical systems play an increasing role. The flexibility and very rich phenomenology exhibited by such systems make them indispensible in this context. Control theory for dynamical systems is also a highly active field of research where a number of important results have been achieved recently.This combined course and workshop deals with recent results regarding dynamical systems and control theory, primarily in differential geometric terms as well as the applications of these fields to biological systems, with an emphasis on various aspects of the immune system and on neural networks.
Download or read book Handbook of Research on Artificial Immune Systems and Natural Computing Applying Complex Adaptive Technologies written by Mo, Hongwei and published by IGI Global. This book was released on 2009-04-30 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book offers new ideas and recent developments in Natural Computing, especially on artificial immune systems"--Provided by publisher.
Download or read book Mathematical Modeling of the Immune System in Homeostasis Infection and Disease written by Gennady Bocharov and published by Frontiers Media SA. This book was released on 2020-02-24 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171).
Download or read book Mathematical Modelling of Immune Response in Infectious Diseases written by Guri I. Marchuk and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning his work on the monograph to be published in English, this author tried to present more or less general notions of the possibilities of mathematics in the new and rapidly developing science of infectious immunology, describing the processes of an organism's defence against antigen invasions. The results presented in this monograph are based on the construc tion and application of closed models of immune response to infections which makes it possible to approach problems of optimizing the treat ment of chronic and hypertoxic forms of diseases. The author, being a mathematician, had creative long-Iasting con tacts with immunologists, geneticist, biologists, and clinicians. As far back as 1976 it resulted in the organization of a special seminar in the Computing Center of Siberian Branch of the USSR Academy of Sci ences on mathematical models in immunology. The seminar attracted the attention of a wide circle of leading specialists in various fields of science. All these made it possible to approach, from a more or less united stand point, the construction of models of immune response, the mathematical description of the models, and interpretation of results.
Download or read book Artificial Immune Systems written by Leandro N. de Castro and published by Springer. This book was released on 2007-08-28 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 6th International Conference on Artificial Immune Systems, ICARIS 2007, held in Santos, Brazil, August 2007. The papers are organized in topical sections on search and optimization, classification and clustering, anomaly detection and negative selection, robotics, control and electronics. Modeling papers, conceptual papers, and technical papers and general applications are also included.
Download or read book Recent Developments in Biologically Inspired Computing written by Leandro N. De Castro and published by IGI Global. This book was released on 2005-01-01 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Developments in Biologically Inspired Computing is necessary reading for undergraduate and graduate students, and researchers interested in knowing the most recent advances in problem solving techniques inspired by nature. This book covers the most relevant areas in computational intelligence, including evolutionary algorithms, artificial neural networks, artificial immune systems and swarm systems. It also brings together novel and philosophical trends in the exciting fields of artificial life and robotics. This book has the advantage of covering a large number of computational approaches, presenting the state-of-the-art before entering into the details of specific extensions and new developments. Pseudocodes, flow charts and examples of applications are provided so as to help newcomers and mature researchers to get the point of the new approaches presented.
Download or read book Design Principles for the Immune System and Other Distributed Autonomous Systems written by Lee A. Segel and published by Oxford University Press. This book was released on 2001-06-14 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design Principles for the Immune System and Other Distributed Autonomous Systems is the first book to examine the inner workings of such a variety of distributed autonomous systems--from insect colonies to high level computer programs to the immune system. It offers insight into the fascinating world of these systems that emerge from the interactions of seemingly autonomous components and brings us up-to-date on the state of research in these areas. Using the immune system and certain aspects of its functions as a primary model, this book examines many of the most interesting and troubling questions posed by complex systems. How do systems choose the right set of agents to perform appropriate actions with appropriate intensities at appropriate times? How in the immune system, ant colonies and metabolic networks does the diffusion and binding of a large variety of chemicals to their receptors permit coordination of system action? What advantages drive the various systems to complexity, and by what mechanisms do the systems cope with the tendency toward unwieldiness and randomness of large complex systems?
Download or read book Advances in Artificial Intelligence IBERAMIA 2002 written by Francisco J. Garijo and published by Springer. This book was released on 2003-06-30 with total page 974 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 8th Ibero-American Conference on Artificial Intelligence, IBERAMIA 2002, took place in Spain for the second time in 14 years; the first conference was organized in Barcelona in January 1988. The city of Seville hosted this 8th conference, giving the participants the opportunity of enjoying the richness of its historical and cultural atmosphere. Looking back over these 14 years, key aspects of the conference, such as its structure, organization, the quantity and quality of submissions, the publication policy, and the number of attendants, have significantly changed. Some data taken from IBERAMIA’88 and IBERAMIA 2002 may help to illustrate these changes. IBERAMIA’88 was planned as an initiative of three Ibero-American AI associations: the Spanish Association for AI (AEPIA), the Mexican Association for AI (SMIA), and the Portuguese Association for AI (APIA). The conference was organized by the AEPIA staff, including the AEPIA president, José Cuena, the secretary, Felisa Verdejo, and other members of the AEPIA board. The proceedings of IBERAMIA’88 contain 22 full papers grouped into six areas: knowledge representation and reasoning, learning, AI tools, expert systems, language, and vision. Papers were written in the native languages of the participants: Spanish, Portuguese, and Catalan. Twenty extended abstracts describing ongoing projects were also included in the proceedings.
Download or read book Artificial Immune Systems and Their Applications written by Dipankar Dasgupta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a pioneering work on the emerging field of artificial immune systems-highly distributed systems based on the principles of the natural system. Like artificial neural networks, artificial immune systems can learn new information and recall previously learned information. This book provides an overview of artificial immune systems, explaining its applications in areas such as immunological memory, anomaly detection algorithms, and modeling the effects of prior infection on vaccine efficacy.
Download or read book Self organization and Emergence in Life Sciences written by Bernard Feltz and published by Springer Science & Business Media. This book was released on 2006-01-13 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-organization constitutes one of the most important theoretical debates in contemporary life sciences. The present book explores the relevance of the concept of self-organization and its impact on such scientific fields as: immunology, neurosciences, ecology and theories of evolution. Historical aspects of the issue are also broached. Intuitions relative to self-organization can be found in the works of such key western philosophical figures as Aristotle, Leibniz and Kant. Interacting with more recent authors and cybernetics, self-organization represents a notion in keeping with the modern world's discovery of radical complexity. The themes of teleology and emergence are analyzed by philosophers of sciences with regards to the issues of modelization and scientific explanation. The implications of self-organization for life sciences are here approached from an interdisciplinary angle, revealing the notion as already rewarding and full of promise for the future.
Download or read book Immunology of HIV Infection written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts provide the only comprehensive book examining all aspects of immune response and immune-based treatments for HIV infection. Contributions, divided into three sections, discuss basic mechanisms, immunopathogenesis of HIV infection, and immune-based therapies. Researchers thoroughly review vaccine-including prospects of T cell vaccine-and gene therapy for HIV infection. Additional topics include organization of HIV genes, the role of co-receptors in signaling of lymphocytes, and biological response modifiers. This reference is designed for basic and clinical researchers, internists, pediatricians, infectious disease specialists, neuropathologists, oncologists, and rheumatologists.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1993 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
