Download or read book The Vital Question written by Nick Lane and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A game-changing book on the origins of life, called the most important scientific discovery 'since the Copernican revolution' in The Observer.
Download or read book Power Sex Suicide written by Nick Lane and published by OUP Oxford. This book was released on 2005-10-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. 'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.' Mark Ridley, Department of Zoology, University of Oxford
Download or read book Life Ascending written by Nick Lane and published by Profile Books. This book was released on 2010-10-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the 2010 Royal Society Prize for science books Powerful new research methods are providing fresh and vivid insights into the makeup of life. Comparing gene sequences, examining the atomic structure of proteins and looking into the geochemistry of rocks have all helped to explain creation and evolution in more detail than ever before. Nick Lane uses the full extent of this new knowledge to describe the ten greatest inventions of life, based on their historical impact, role in living organisms today and relevance to current controversies. DNA, sex, sight and consciousnesses are just four examples. Lane also explains how these findings have come about, and the extent to which they can be relied upon. The result is a gripping and lucid account of the ingenuity of nature, and a book which is essential reading for anyone who has ever questioned the science behind the glories of everyday life.
Download or read book What Happened to the Vital Center written by Nicholas Jacobs and published by Oxford University Press. This book was released on 2022 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gradually, the moderating influence that parties played in structuring campaigns and the policy process eroded to the point where extreme polarization dominated and decision-making power migrated to the presidency. Weakened parties were increasingly dominated by presidents and their partnerships with social activists, leading to a gridlocked system characterized by the politics of demonization and demagoguery. Executive-centered parties more easily ignore the sorts of moderating voices that had prevailed in an earlier era. While the Republican Party is more susceptible to the dangers of populism than the Democrats, both parties are animated by a presidency-led, movement-centered vision of democracy. After tracing this history, the authors dismiss calls to return to some bygone era. .
Download or read book Transformer The Deep Chemistry of Life and Death written by Nick Lane and published by W. W. Norton & Company. This book was released on 2022-07-12 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
Download or read book 3 Vital Questions written by David Emerald and published by . This book was released on 2019-03-26 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finalist, 2019 Indie Book Awards, Careers Category Transform Workplace Drama into Workforce Empowerment! If you have ever experienced infighting, such as a team or a department pitting itself against another team or department; if you have ever worked for a micromanaging and overbearing boss; if you have ever navigated the changes that come with a merger or other significant restructuring process, then you have had a front-row seat for organizational drama. 3 Vital Questions is a teaching story about transforming workplace drama and its heavy costs to organizations. Working late at night, Lucas, a middle manager in a large organization, meets a custodian named Ted. The two strike up a friendship as Ted teaches Lucas three vital questions with the power to transform the disillusionment he is experiencing at work. Readers follow Lucas as he learns how to shift from feeling like a Victim to acting as a Creator in his career. With the wise guidance of Ted and Kasey, a senior manager, Lucas applies the three vital questions and begins transforming his workplace relationships, with exciting results. At home, Lucas and his wife Sarah discover how the questions can spark creative collaboration with each other and their two young children. This long-awaited and highly enjoyable read by the author of the bestselling self-leadership title, The Power of TED* (*The Empowerment Dynamic) ushers in a new era of possibility for the world of work. This book teaches David Emerald's groundbreaking 3 Vital Questions(R) approach for empowering leaders and teams to become collaborative, engaged, and resilient in the face of the rapid changes that mark today's increasingly complex competitive environment.
Download or read book Oxygen written by Nick Lane and published by Oxford University Press, USA. This book was released on 2002 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas, following chains of evidence, the book ranges through many disciplines, from environmental sciences to molecular medicine. Damage to DNA caused by oxidative stress appears to explain aging and many of its diseases, hence the popularity in alternative health circles of antioxidants. But antioxidants alone fail to prevent aging. Lane suggests two different avenues of study: modulation of the immune system, which generates free radicals as part of its defense against infectious diseases; and ways of improving the health of our cellular mitochondria, on which many age-related ailments seem to depend. Provocative and complexly argued. Copyright ©Kirkus Reviews, used with permission.
Download or read book Tell Me How It Ends written by Valeria Luiselli and published by Coffee House Press. This book was released on 2017-03-13 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Part treatise, part memoir, part call to action, Tell Me How It Ends inspires not through a stiff stance of authority, but with the curiosity and humility Luiselli has long since established." —Annalia Luna, Brazos Bookstore "Valeria Luiselli's extended essay on her volunteer work translating for child immigrants confronts with compassion and honesty the problem of the North American refugee crisis. It's a rare thing: a book everyone should read." —Stephen Sparks, Point Reyes Books "Tell Me How It Ends evokes empathy as it educates. It is a vital contribution to the body of post-Trump work being published in early 2017." —Katharine Solheim, Unabridged Books "While this essay is brilliant for exactly what it depicts, it helps open larger questions, which we're ever more on the precipice of now, of where all of this will go, how all of this might end. Is this a story, or is this beyond a story? Valeria Luiselli is one of those brave and eloquent enough to help us see." —Rick Simonson, Elliott Bay Book Company "Appealing to the language of the United States' fraught immigration policy, Luiselli exposes the cracks in this foundation. Herself an immigrant, she highlights the human cost of its brokenness, as well as the hope that it (rather than walls) might be rebuilt." —Brad Johnson, Diesel Bookstore "The bureaucratic labyrinth of immigration, the dangers of searching for a better life, all of this and more is contained in this brief and profound work. Tell Me How It Ends is not just relevant, it's essential." —Mark Haber, Brazos Bookstore "Humane yet often horrifying, Tell Me How It Ends offers a compelling, intimate look at a continuing crisis—and its ongoing cost in an age of increasing urgency." —Jeremy Garber, Powell's Books
Download or read book The End of Energy written by Michael J. Graetz and published by MIT Press. This book was released on 2011-03-04 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forty years of energy incompetence: villains, failures of leadership, and missed opportunities. Americans take for granted that when we flip a switch the light will go on, when we turn up the thermostat the room will get warm, and when we pull up to the pump gas will be plentiful and relatively cheap. In The End of Energy, Michael Graetz shows us that we have been living an energy delusion for forty years. Until the 1970s, we produced domestically all the oil we needed to run our power plants, heat our homes, and fuel our cars. Since then, we have had to import most of the oil we use, much of it from the Middle East. And we rely on an even dirtier fuel—coal—to produce half of our electricity. Graetz describes more than forty years of energy policy incompetence and argues that we must make better decisions for our energy future. Despite thousands of pages of energy legislation since the 1970s (passed by a Congress that tended to elevate narrow parochial interests over our national goals), Americans have never been asked to pay a price that reflects the real cost of the energy they consume. Until Americans face the facts about price, our energy incompetence will continue—and along with it the unraveling of our environment, security, and independence.
Download or read book Life Itself written by Robert Rosen and published by Columbia University Press. This book was released on 1991 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why are living things alive? As a theoretical biologist, Robert Rosen saw this as the most fundamental of all questions-and yet it had never been answered satisfactorily by science. The answers to this question would allow humanity to make an enormous leap forward in our understanding of the principles at work in our world. For centuries, it was believed that the only scientific approach to the question "What is life?" must proceed from the Cartesian metaphor (organism as machine). Classical approaches in science, which also borrow heavily from Newtonian mechanics, are based on a process called "reductionism." The thinking was that we can better learn about an intricate, complicated system (like an organism) if we take it apart, study the components, and then reconstruct the system-thereby gaining an understanding of the whole. However, Rosen argues that reductionism does not work in biology and ignores the complexity of organisms. Life Itself, a landmark work, represents the scientific and intellectual journey that led Rosen to question reductionism and develop new scientific approaches to understanding the nature of life. Ultimately, Rosen proposes an answer to the original question about the causal basis of life in organisms. He asserts that renouncing the mechanistic and reductionistic paradigm does not mean abandoning science. Instead, Rosen offers an alternate paradigm for science that takes into account the relational impacts of organization in natural systems and is based on organized matter rather than on particulate matter alone. Central to Rosen's work is the idea of a "complex system," defined as any system that cannot be fully understood by reducing it to its parts. In this sense, complexity refers to the causal impact of organization on the system as a whole. Since both the atom and the organism can be seen to fit that description, Rosen asserts that complex organization is a general feature not just of the biosphere on Earth-but of the universe itself.
Download or read book What s to be Done written by Nikolay Gavrilovich Chernyshevsky and published by . This book was released on 1886 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vital Signs written by Robin Cook and published by Penguin. This book was released on 1992-02-01 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatrician Melissa Blumenthal will try any scientific method available to conceive--until the horrible secrets of an urban clinic erupt in a nightmare of staggering proportions...
Download or read book The Vital Lie written by Anthony S. Abbott and published by University of Alabama Press. This book was released on 2003-08-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vital Lie is the first book to examine the reality-illusion conflict in modern drama from Ibsen to present-day playwrights. The book questions why vital lies, lies necessary for life itself, are such an obsessive concern for playwrights of the last hundred years. Using the work of fifteen playwrights, Abbott seeks to discover if modern playwrights treat illusions as helpful or necessary to life, or as signals of sicknesses from which human beings need to be cured. What happens to characters when they are forced to face the truth about themselves and their worlds without the protection of their illusions? The author develops a three-part historical analysis of the use of the reality-illusion theme, from its origins as a metaphysical search to its current elaborations as a theatrical game.
Download or read book Seveneves written by Neal Stephenson and published by Harper Collins. This book was released on 2015-05-19 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the #1 New York Times bestselling author of Anathem, Reamde, and Cryptonomicon comes an exciting and thought-provoking science fiction epic—a grand story of annihilation and survival spanning five thousand years. What would happen if the world were ending? A catastrophic event renders the earth a ticking time bomb. In a feverish race against the inevitable, nations around the globe band together to devise an ambitious plan to ensure the survival of humanity far beyond our atmosphere, in outer space. But the complexities and unpredictability of human nature coupled with unforeseen challenges and dangers threaten the intrepid pioneers, until only a handful of survivors remain . . . Five thousand years later, their progeny—seven distinct races now three billion strong—embark on yet another audacious journey into the unknown . . . to an alien world utterly transformed by cataclysm and time: Earth. A writer of dazzling genius and imaginative vision, Neal Stephenson combines science, philosophy, technology, psychology, and literature in a magnificent work of speculative fiction that offers a portrait of a future that is both extraordinary and eerily recognizable. As he did in Anathem, Cryptonomicon, the Baroque Cycle, and Reamde, Stephenson explores some of our biggest ideas and perplexing challenges in a breathtaking saga that is daring, engrossing, and altogether brilliant.
Download or read book Vital Subjects written by Rhiannon Noel Welch and published by Liverpool University Press. This book was released on 2016-04-22 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vital Subjects examines cultural production—literature, sociology and public health discourse, and early film—from the years between Unification and the end of the First World War (ca. 1860 and 1920) in order to explore how race and colonialism were integral to modern Italian national culture, rather than a marginal afterthought or a Fascist aberration.
Download or read book Rethinking Evolution The Revolution That s Hiding In Plain Sight written by Gene Levinson and published by World Scientific. This book was released on 2019-10-17 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rethinking Evolution links Darwin's early insights to the molecular realm inside living cells. This updated evolutionary synthesis provides an accessible explanation for biological complexity that cuts through the confusion surrounding evolutionary theory in a practical way.In addition to a wide-ranging survey of proposed updates to the modern synthesis, this title provides extraordinary new insights including emergent evolutionary potential and the generative phenotype. Drawing on well-characterized empirical facts, Rethinking Evolution transcends classical Darwinian natural selection while retaining those core principles that have stood the test of time.The updated synthesis brings a broad spectrum of specialized research together to provide a more plausible naturalistic explanation for biological evolution than ever before. Perspectives ranging from the role of energy in the origin of life to the networks of protein-DNA interactions that govern multicellular development are woven together in a robust conceptual fabric consistent with 21st century cutting-edge research.Inspired in part by the surprising ways that DNA sequences change — such as his early discovery of a fundamental mispairing mechanism by which DNA sequences expand — and drawing on a career's worth of experience both as a research scientist as well as a biology and chemistry tutor — the author provides an engaging account that is essential reading — both for the public awareness and understanding of the science of evolution and for students and professionals in the biomedical sciences.Related Link(s)
Download or read book I Contain Multitudes written by Ed Yong and published by HarperCollins. This book was released on 2016-08-09 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: New York Times Bestseller New York Times Notable Book of 2016 • NPR Great Read of 2016 • Named a Best Book of 2016 by The Economist, Smithsonian, NPR's Science Friday, MPR, Minnesota Star Tribune, Kirkus Reviews, Publishers Weekly, The Guardian, Times (London) From Pulitzer Prize winner Ed Yong, a groundbreaking, wondrously informative, and vastly entertaining examination of the most significant revolution in biology since Darwin—a “microbe’s-eye view” of the world that reveals a marvelous, radically reconceived picture of life on earth. Every animal, whether human, squid, or wasp, is home to millions of bacteria and other microbes. Pulitzer Prize-winning author Ed Yong, whose humor is as evident as his erudition, prompts us to look at ourselves and our animal companions in a new light—less as individuals and more as the interconnected, interdependent multitudes we assuredly are. The microbes in our bodies are part of our immune systems and protect us from disease. In the deep oceans, mysterious creatures without mouths or guts depend on microbes for all their energy. Bacteria provide squid with invisibility cloaks, help beetles to bring down forests, and allow worms to cause diseases that afflict millions of people. Many people think of microbes as germs to be eradicated, but those that live with us—the microbiome—build our bodies, protect our health, shape our identities, and grant us incredible abilities. In this astonishing book, Ed Yong takes us on a grand tour through our microbial partners, and introduces us to the scientists on the front lines of discovery. It will change both our view of nature and our sense of where we belong in it.
