Download or read book SARS CoV 2 Spike Protein Convergent Evolution written by Daniele Focosi and published by Springer Nature. This book was released on 2021-10-11 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

Download or read book CDC Yellow Book 2018 Health Information for International Travel written by Centers for Disease Control and Prevention CDC and published by Oxford University Press. This book was released on 2017-04-17 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Download or read book She Has Her Mother s Laugh written by Carl Zimmer and published by Penguin. This book was released on 2018-05-29 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2019 PEN/E.O. Wilson Literary Science Writing Award Finalist "Science book of the year"—The Guardian One of New York Times 100 Notable Books for 2018 One of Publishers Weekly's Top Ten Books of 2018 One of Kirkus's Best Books of 2018 One of Mental Floss's Best Books of 2018 One of Science Friday's Best Science Books of 2018 “Extraordinary”—New York Times Book Review "Magisterial"—The Atlantic "Engrossing"—Wired "Leading contender as the most outstanding nonfiction work of the year"—Minneapolis Star-Tribune Celebrated New York Times columnist and science writer Carl Zimmer presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities... But, Zimmer writes, “Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are—our appearance, our height, our penchants—in inconceivably subtle ways.” Heredity isn’t just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors—using a word that once referred to kingdoms and estates—but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world’s best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.

Download or read book Life s Edge written by Carl Zimmer and published by Penguin. This book was released on 2021-03-09 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: FINALIST FOR THE PEN/E.O. WILSON LITERARY SCIENCE WRITING AWARD***A NEW YORK TIMES NOTABLE BOOK OF 2021***A SCIENCE NEWS FAVORITE BOOK OF 2021***A SMITHSONIAN TOP TEN SCIENCE BOOK OF 2021 “Stories that both dazzle and edify… This book is not just about life, but about discovery itself.” —Siddhartha Mukherjee, New York Times Book Review We all assume we know what life is, but the more scientists learn about the living world—from protocells to brains, from zygotes to pandemic viruses—the harder they find it is to locate life’s edge. Carl Zimmer investigates one of the biggest questions of all: What is life? The answer seems obvious until you try to seriously answer it. Is the apple sitting on your kitchen counter alive, or is only the apple tree it came from deserving of the word? If we can’t answer that question here on earth, how will we know when and if we discover alien life on other worlds? The question hangs over some of society’s most charged conflicts—whether a fertilized egg is a living person, for example, and when we ought to declare a person legally dead. Life's Edge is an utterly fascinating investigation that no one but one of the most celebrated science writers of our generation could craft. Zimmer journeys through the strange experiments that have attempted to re-create life. Literally hundreds of definitions of what that should look like now exist, but none has yet emerged as an obvious winner. Lists of what living things have in common do not add up to a theory of life. It's never clear why some items on the list are essential and others not. Coronaviruses have altered the course of history, and yet many scientists maintain they are not alive. Chemists are creating droplets that can swarm, sense their environment, and multiply. Have they made life in the lab? Whether he is handling pythons in Alabama or searching for hibernating bats in the Adirondacks, Zimmer revels in astounding examples of life at its most bizarre. He tries his own hand at evolving life in a test tube with unnerving results. Charting the obsession with Dr. Frankenstein's monster and how the world briefly believed radium was the source of all life, Zimmer leads us all the way into the labs and minds of researchers engineering life from scratch.

Download or read book National Strategy for the COVID 19 Response and Pandemic Preparedness written by Joseph R. Biden, Jr. and published by Simon and Schuster. This book was released on 2021-05-04 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate guide for anyone wondering how President Joe Biden will respond to the COVID-19 pandemic—all his plans, goals, and executive orders in response to the coronavirus crisis. Shortly after being inaugurated as the 46th President of the United States, Joe Biden and his administration released this 200 page guide detailing his plans to respond to the coronavirus pandemic. The National Strategy for the COVID-19 Response and Pandemic Preparedness breaks down seven crucial goals of President Joe Biden's administration with regards to the coronavirus pandemic: 1. Restore trust with the American people. 2. Mount a safe, effective, and comprehensive vaccination campaign. 3. Mitigate spread through expanding masking, testing, data, treatments, health care workforce, and clear public health standards. 4. Immediately expand emergency relief and exercise the Defense Production Act. 5. Safely reopen schools, businesses, and travel while protecting workers. 6. Protect those most at risk and advance equity, including across racial, ethnic and rural/urban lines. 7. Restore U.S. leadership globally and build better preparedness for future threats. Each of these goals are explained and detailed in the book, with evidence about the current circumstances and how we got here, as well as plans and concrete steps to achieve each goal. Also included is the full text of the many Executive Orders that will be issued by President Biden to achieve each of these goals. The National Strategy for the COVID-19 Response and Pandemic Preparedness is required reading for anyone interested in or concerned about the COVID-19 pandemic and its effects on American society.

Download or read book Long Island Life written by and published by . This book was released on 1915 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Rules of Contagion written by Adam Kucharski and published by Profile Books. This book was released on 2020-02-13 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Observer Book of the Year A Times Science Book of the Year A New Statesman Book of the Year A Financial Times Science Book of the Year 'Astonishingly bold' Daily Mail 'It is hard to imagine a more timely book ... much of the modern world will make more sense having read it.' The Times We live in a world that's more interconnected than ever before. Our lives are shaped by outbreaks - of disease, of misinformation, even of violence - that appear, spread and fade away with bewildering speed. To understand them, we need to learn the hidden laws that govern them. From 'superspreaders' who might spark a pandemic or bring down a financial system to the social dynamics that make loneliness catch on, The Rules of Contagion offers compelling insights into human behaviour and explains how we can get better at predicting what happens next. Along the way, Adam Kucharski explores how innovations spread through friendship networks, what links computer viruses with folk stories - and why the most useful predictions aren't necessarily the ones that come true. Now revised and updated with content on Covid-19.

Download or read book The Plague Year written by Lawrence Wright and published by Vintage. This book was released on 2021-06-08 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Pulitzer Prize–winning author of The Looming Tower, and the pandemic novel The End of October: an unprecedented, momentous account of Covid-19—its origins, its wide-ranging repercussions, and the ongoing global fight to contain it "A book of panoramic breadth ... managing to surprise us about even those episodes we … thought we knew well … [With] lively exchanges about spike proteins and nonpharmaceutical interventions and disease waves, Wright’s storytelling dexterity makes all this come alive.” —The New York Times Book Review From the fateful first moments of the outbreak in China to the storming of the U.S. Capitol to the extraordinary vaccine rollout, Lawrence Wright’s The Plague Year tells the story of Covid-19 in authoritative, galvanizing detail and with the full drama of events on both a global and intimate scale, illuminating the medical, economic, political, and social ramifications of the pandemic. Wright takes us inside the CDC, where a first round of faulty test kits lost America precious time . . . inside the halls of the White House, where Deputy National Security Adviser Matthew Pottinger’s early alarm about the virus was met with confounding and drastically costly skepticism . . . into a Covid ward in a Charlottesville hospital, with an idealistic young woman doctor from the town of Little Africa, South Carolina . . . into the precincts of prediction specialists at Goldman Sachs . . . into Broadway’s darkened theaters and Austin’s struggling music venues . . . inside the human body, diving deep into the science of how the virus and vaccines function—with an eye-opening detour into the history of vaccination and of the modern anti-vaccination movement. And in this full accounting, Wright makes clear that the medical professionals around the country who’ve risked their lives to fight the virus reveal and embody an America in all its vulnerability, courage, and potential. In turns steely-eyed, sympathetic, infuriated, unexpectedly comical, and always precise, Lawrence Wright is a formidable guide, slicing through the dense fog of misinformation to give us a 360-degree portrait of the catastrophe we thought we knew.

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book Variants The Shape Shifting Challenge of COVID 19 written by William A. Haseltine and published by Access Health International. This book was released on 2021-02-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: People live in a sea of viruses. All creatures are host to these small organisms, which are made up of small bits of genetic information. Viruses are possessed by a drive to survive, but in order to reproduce they must invade a living cell. Dr. William A. Haseltine, PhD, has spent a lifetime studying viruses and their ability to adapt and flourish within an ever-changing environment. In Variants! The Shape-Shifting Challenge of COVID-19, Dr. Haseltine turns his focus to SARS-CoV-2, the virus that causes COVID-19. The variant forms of this coronavirus risk an even greater disruption to our lives, our economy, and the health and wellbeing of hundreds of billions worldwide. Variants! is a collection of Dr. Haseltine's writings and research on COVID-19 and SARS-CoV-2 mutations and variants. The book is a Living eBook, updated regularly with new information as it unfolds. When a reader purchases a copy of the book, either in print or online, they will receive a special passcode that will give them online access to every subsequent edition of the book, as it is released.

Download or read book Globally Resilient Supply Chains for Seasonal and Pandemic Influenza Vaccines written by National Academy of Medicine and published by National Academies Press. This book was released on 2021-12-31 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Influenza viruses, both seasonal and pandemic, have the potential to disrupt the health and well-being of populations around the world. The global response to the COVID-19 pandemic and prior public health emergencies of international concern illustrate the importance of global preparedness and coordination among governments, academia, scientists, policy makers, nongovernmental organizations, the private sector, and the public to address the threat of pandemic influenza. These health emergencies have revealed opportunities to enhance global vaccine infrastructure, manufacturing, distribution, and administration. Globally Resilient Supply Chains for Seasonal and Pandemic Influenza Vaccines outlines key findings and recommendations to bolster vaccine distribution, manufacturing, and supply chains for future seasonal and pandemic influenza events. This report addresses the challenges of manufacturing and distributing vaccines for both seasonal and pandemic influenza, highlighting the critical components of vaccine manufacturing and distribution and offering recommendations that would address gaps in the current global vaccine infrastructure.

Download or read book The Variant Virus written by G. A. Mohr, PhD and published by Xlibris Corporation. This book was released on 2012-06-28 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is the fi rst on the adventures of Briti sh secret agent Simon Sinclair who works mainly for Counter Terrorism Intelligence (Operati ons), or CT3, in conjuncti on with MI5, MI6 and the CIA. The book is a ‘future threat’ scenario, the threat in questi on being technologically feasible on grand scale as far back as the mid 1980s when an accident at Vektor, one of Russia’s then 50 Biological Warfare faciliti es, infected Usti nov with Marburg fi lovirus which evolved in the 15 days it took to liquefy all his organs into ‘Marburg Variant U’ which was then put atop SS16 rockets. In this gripping tale a recombinant or ‘dual’ virus is smuggled into England by CABAL, the Confederati on Against Briti sh-American Logisti cs, an internati onal group opposed to Briti sh and American power and infl uence that CABAL sees as hegemony. CABAL gives seven days noti ce of att acks on London. Aft er a CABAL att empt on his life Sinclair follows his att acker to Colombia where he learns the identi ti es of four CABAL ‘money men’ and captures one of them, the money trail left by these fi nanciers leading to the identi ty of CABAL’s operati onal leaders. Sinclair succeeds in thwarti ng four CABAL bomb att acks and stops helicopters heading to London with the virus, but not without fallout which threatens an epidemic. First symptoms of smallpox appear, and then those of a new and highly virulent strain of Marburg fi lovirus which causes haemorrhagic fever and liquefacti on of the organs. Sinclair fi nds a cure for the recombinant virus in Russia and spread throughout London, if not England or internati onally, is avoided. Many CABAL members have been captured or killed and for good measure Sinclair captures two of the three remaining top organizers sti ll at large. Refl ecti ng on a very hecti c three weeks during which England faced the greatest threat in its history, Sinclair realizes that there is a mole in CT3, leaving him a diffi cult future assignment but, at the same ti me, giving him an idea that might, given ti me, help shut down major terrorist organizati ons such as CABAL and Al Qa’ida for good.

Download or read book The COVID 19 Pandemic and China s Global Health Leadership written by Yanzhong Huang and published by . This book was released on 2022-02-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Closer Look at the COVID 19 Variants written by Richard D. Hylton and published by Nova Snova. This book was released on 2022-09-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As viruses spread, small errors - called mutations - arise in the genetic material during replication. Many of these mutations are repaired or die off as the virus continues to move through a population. Mutations that enhance the virus's ability to replicate, transmit, or survive in a host allow the virus to spread more quickly through a population, or become more resistant to immune system defenses, thereby increasing the mutations' prevalence and creating a new strain of the virus. The purpose of this book is to discuss how variants develop, how researchers identify and sequence variants, and how this information can be utilized by public health officials, government agencies, and medical practitioners to make decisions. The book examines the ways the government can better coordinate its approach to best serve the American people through this pandemic and beyond.

Download or read book Evolution of SARS CoV 2 impact of variants on hosts COVID 19 vaccines and countermeasures written by Seshadri Vasan and published by Frontiers Media SA. This book was released on 2024-02-20 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ‘novel coronavirus disease’ (COVID-19) has caused significant global morbidity, mortality and economic damage on a scale similar to the influenza pandemic of 1918. The causative ‘severe acute respiratory syndrome virus 2’ (SARS-CoV-2) is a RNA virus which is evolving rapidly, accumulating mutations, and existing as a cloud of variants with quasispecies diversity. We have tens of thousands of variants, of which currently two are ‘variants of interest’ (Lambda, Mu) and another four ‘variants of concern’ (Alpha, Beta, Gamma, Delta, Omicron) to the World Health Organization (WHO). Variants of interest often emerge as variants under investigation in one or more countries, as seen with the Omicron (initially denoted as Nu in South Africa). They become variants of concern when there is evidence of increased transmissibility, greater case severity, loss of neutralization by antibodies, and reduced effectiveness of countermeasures. Some SARS-CoV-2 variants can infect new hosts (for instance, the Alpha, Beta and Gamma variants of concern can infect wild type mice which is a species that cannot be vaccinated or controlled easily), and/or reduce the effectiveness of vaccines and therapies (especially Beta and Delta); diagnostic tests have also been reported to be affected. Currently, we do not yet have any ‘variant of high consequence’ with confirmed attributes such as widespread diagnostic test failures, significant reduction in the effectiveness of vaccines and/or therapies, with greater disease severity and deaths. It remains to be seen if Omicron would be the first to be declared by the WHO as a variant of high consequence; more variants of concern are also likely to be declared by the WHO over the next couple of years. Therefore, our ability to control and conquer this pandemic over the long run is dependent on predicting and keeping up with the evolution of this virus, its new hosts, as well as understanding and mitigating its impact on diagnostics, vaccines and therapies.

Download or read book Variant C 19 written by Robert Dresner and published by . This book was released on 2021-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Variant is a story about becoming different, as a result of having covid-19, and not knowing why.It is a creative journal recounting one year in the life of the dreaded virus in my body and in my mind. The story is intense and far reaching-if only because this virus has affected every aspect of our lives, and because our response to this medical emergency has been so terribly mishandled. As a result, there are many symptoms of Covid-19 that are still misunderstood and grossly under-reported: Why do so many of us, who had the virus, feel different?Why don't we have a true and common sense of healing?Is it physical, emotional, psychological-or something else?

Download or read book COVID 19 New Variants and Host Demography written by Ginpreet Kaur and published by Frontiers Media SA. This book was released on 2022-05-26 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: