Download or read book The Trapping of Adenosine Diphosphate at the Active Site of Myosin Subfragment 1 written by James Coppedge and published by . This book was released on 1980 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Myosins written by James Sellers and published by OUP Oxford. This book was released on 1999-05-13 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myosins are a diverse superfamily of molecular motor proteins, which share the ability to reversibly bind actin and hydrolyse MgATP. They are capable of either translocating actin filaments or translocating vesicles or other cargo on fixed actin filaments. There are currently 15 distinct classes in the myosins superfamily, based on sequence homology. Myosin II and myosin I proteins are familiar and well studied; while Classes III-XV are less well characterized. All myosins examined to date are multimeric and appear to possess at least three functional domains, a head, neck, and tail. Myosins (second edition) explores the structure and functional properties of myosins, their regulation, and mutational analysis. It has been thoroughly updated since the first edition was published in 1995 including sections on the three additional classes defined by new sequences, information provided by the crystal structure of seven new Dicytostelium motor domains, and data from new techniques such as molecular imaging and tagging proteins with GFP 20. The three human diseases that are now known to be linked to mutations in different myosin heavy or light chains are also covered, including more than 50 mutations associated with hyperotrophic cardiomyopathy.
Download or read book Physiology written by A. S. M. Saleuddin and published by Academic Press. This book was released on 2013-10-22 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mollusca, Volume 4: Physiology, Part 1, provides an overview of the state of knowledge in molluscan physiology. It is part of a multivolume treatise that covers the fields of biochemistry, physiology, neurobiology, reproduction and development, evolution, ecology, medical aspects, and structure. The Mollusca is intended to serve a range of disciplines: biological, biochemical, paleontological, and medical. As a source of information on the current status of molluscan research, it should prove useful to researchers of the Mollusca and other phyla, as well as to teachers and qualified graduate students. The book begins with a discussion of molluscan muscle cells and intercellular connections. Separate chapters follow on the neuromuscular transmission and excitation-contraction coupling in mollusks; the biochemical and structural aspects of molluscan muscle; molluscan locomotion; cellular mechanisms of periostracum formation; shell formation and repair; molluscan endocrinology; and physiological energetics of marine mollusks.
Download or read book Nucleoside Triphosphatases in Energy Transduction Cellular Regulation and Information Transfer in Biological Systems written by John F. Eccleston and published by Portland Press, London. This book was released on 1992 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topics covered by this work include the conformational coupling in DNA polymerase information transfer, the kinetic mechanism of the GAP-activated GTPase of p21ras, and studies on the structure and mechanism of H-ras p21.
Download or read book Index Medicus written by and published by . This book was released on 2002 with total page 1734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Cambridge Scientific Biochemistry Abstracts written by and published by . This book was released on 1992 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1981 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gastrulation From Embryonic Pattern to Form written by and published by Academic Press. This book was released on 2020-01-18 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrulation: From Embryonic Pattern to Form Volume 136 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters on D. melanogaster, Zebrafish, Chick, Mouse and Human, C. elegans, D. melanogaster Internalization, Sea urchin, Ascidians, Xenopus Internalization, Xenopus Convergent Extension, Zebrafish Epiboly, Zebrafish Internalization, Zebrafish Convergence and Extension, Chick Primitive streak formation and mesendoderm internalization, Octavian Voiculescu, Mouse Primitive streak formation and internalization, Mouse Definitive endoderm morphogenesis, Conservation of movements, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series - Includes the latest information on gastrulation from embryonic pattern to form
Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource
Download or read book Journal of Cyclic Nucleotide Research written by and published by . This book was released on 1979 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Journal of Muscle Research and Cell Motility written by and published by . This book was released on 1984 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Philosophical Transactions written by and published by . This book was released on 2004 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each issue of Transactions B is devoted to a specific area of the biological sciences, including clinical science. All papers are peer reviewed and edited to the highest standards. Published on the 29th of each month, Transactions B is essential reading for all biologists.
Download or read book Biochemistry Abstracts written by and published by . This book was released on 1983-07 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Bioenergetics written by Vladimir P. Skulachev and published by Springer Science & Business Media. This book was released on 2012-12-15 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry. Bioenergetics concerns energy transductions occurring in living systems and this book pays special attention to molecular mechanisms of these processes. The main subject of the book is the "energy coupling membrane" which refers to inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases) are also part of this membrane. Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants.
Download or read book Structural and Contractile Proteins written by Dixie W. Frederiksen and published by . This book was released on 1982 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Download or read book The Sliding Filament Theory of Muscle Contraction written by David Aitchison Smith and published by Springer. This book was released on 2019-02-05 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.
Download or read book Purinergic Signalling and the Nervous System written by Geoffrey Burnstock and published by Springer Science & Business Media. This book was released on 2012-06-05 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents. In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.
