Download or read book Handbook of Transcription Factor NF kappaB written by Sankar Ghosh and published by CRC Press. This book was released on 2006-10-20 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent evidence proving the molecular link between unchecked, chronic inflammation and cancer has implicated the transcription factor NF-kB as a key factor in both inhibiting apoptosis and promoting cell proliferation. Since its initial identification 20 years ago as a simple regulating factor in one small part of the immune response, NF-kB is prov
Download or read book NF kB Rel Transcription Factor Family written by Hsiou-Chi Liou and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.
Download or read book Controlled DNA binding of Transcription Factor NF kappa B P50 for Gene Therapy written by Yasmina Day and published by . This book was released on 2000 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Transcription Factor NF 0 B written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Audio-visual presentation: NF-kappa B activation and function -- Signal transduction pathway -- Mechanism of post-transcriptional induction -- Gene activation -- Role of NF-kappa B in physiological processes -- Initiation of the immune system -- Cell survival.
Download or read book The Transcription Factor NF B written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcription Factor NF k B in the Colonic Epithelium written by Mehmet Sait Inan and published by . This book was released on 2000 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of the NF kappa B Transcription Factor in T Lymphocytes written by Parham A. Ganchi and published by . This book was released on 1993 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of the Transcription Factor NF kappa B microform Induction Function and Associating Proteins written by Jamieson, Christina A. M. (Christina Agnes Margaret) and published by Ann Arbor, Mich. : University Microfilms International. This book was released on 1992 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of the Transcription Factors Oct 2 and NF kappa B During Pre B Cell Differentiation written by Christopher A. Klug and published by . This book was released on 1993 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tissue Targeted Inhibition of Transcription Factor NF kappa B in T Lymphocytes of Transgenic Mice written by Christoph Esslinger (Biologe.) and published by . This book was released on 1997 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Transcriptional Regulation of Memory written by Benedict C. Albensi and published by Frontiers Media SA. This book was released on 2016-09-06 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of various forms of memory involves a series of distinct cellular and molecular mechanisms, many of which are not fully understood. There are highly conserved pathways that are involved in learning, memory, and synaptic plasticity, which is the primary substrate for memory storage. The formation of short-term (across minutes) memory is mediated by local changes in synapses, while long-term (across hours to days) memory storage is associated with activation of transcription and synthesis of proteins that modify synaptic function. Transcription factors, which can either repress or activate transcription, play a vital role in driving protein synthesis underlying synaptic plasticity and memory, whereby protein synthesis provides the necessary building blocks to accommodate structural changes at the synapse that foster memory formation. Recent data implicate several families of transcription factors that appear critically important in the regulation of memory. In this Topic we will focus on the families of transcription factors thus far found to be critically involved in synaptic plasticity and memory formation. These include cAMP response element binding protein (CREB), Rel/nuclear factor B (Rel/NFB), CCAAT enhancer binding protein (C/EBP), and early growth response factor (Egr). In recent years, numerous studies have implicated epigenetic mechanisms, changes in gene activity and expression that occur without alteration in gene sequence, in the memory consolidation process. DNA methylation and chromatin remodeling are critically involved in learning and memory, supporting a role of epigenetic mechanisms. Here we provide more evidence of the importance of DNA methylation, histone posttranslational modifications and the role of histone acetylation and HDAC inhibitors in above mentioned processes.
Download or read book Activation of Transcription Factor NF KAPPA B by Tumour Necrosis Factor and Lymphotoxin alpha written by Sree Devi Menon and published by . This book was released on 1994 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Factor B written by R. Beyaert and published by Springer Science & Business Media. This book was released on 2003-10-31 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included.
Download or read book The Molecular Mechanisms of Regulatory T cell Immunosuppression written by Kendall A. Smith and published by Frontiers E-books. This book was released on with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever since Regulatory T cells (T-Regs) were first defined as peripheral CD4+ T cells that express the interleukin-2 (IL-2) receptor alpha chain (IL-2Ra), there have been intensive efforts to determine the molecular mechanisms whereby this minor subset of CD4+ T cells (~ 5-10%) nonspecifically suppresses all potential effector T cells, whether reactive to self or non-self antigens. Multiple possible molecular mechanisms have been implicated, including the scavenging of IL-2 via the expression of high densities of IL-2Rs, the inhibition of antigen presentation via CTLA-4 molecules leading to decreased IL-2 production, the activation of intracellular cAMP thereby suppressing both IL-2 production and action, and the production of suppressive cytokines such as IL-10 and Tumor Growth Factor-beta, to list a few. However, the field has thus far failed to come to a consensus, such that some investigators have now asserted that many molecular mechanisms may be operative, in fact that perhaps all of the described mechanisms may account for the suppressive effects of these cells, acting either simultaneously or sequentially. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for T-Reg immunosuppression.
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Essential Kinases and Transcriptional Regulators and Their Roles in Autoimmunity written by Raffi Gugasyan and published by Frontiers Media SA. This book was released on 2020-08-06 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Medical Subject Headings written by National Library of Medicine (U.S.) and published by . This book was released on 1995 with total page 1552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
