Download or read book The Tissue Renin angiotensin System and Its Role in the Pathogenesis of Major Human Diseases Quo Vadis written by Babak Ebrahimzadeh Saravi and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Renin Angiotensin System in Cancer Lung Liver and Infectious Diseases written by Sukhwinder K. Bhullar and published by Springer Nature. This book was released on 2023-03-14 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
Download or read book Frontiers in Research of the Renin Angiotensin System on Human Disease written by Po Sing Leung and published by Springer Science & Business Media. This book was released on 2007-10-16 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of renin-angiotensin system (RAS) research that is expanding rapidly. In this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the RAS and their implications in human disease. This book is an indispensable tool tailor-made for specialists, non-specialists and the novice.
Download or read book Renin Angiotensin System and the Heart written by Walmor C. De Mello and published by John Wiley & Sons. This book was released on 2005-10-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone. Contains the most recent findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research
Download or read book Angiotensin 1 7 written by Robson Augusto Souza Santos and published by Springer Nature. This book was released on 2019-08-21 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of angiotensin-(1-7) and its receptor Mas, comprising the historical background, enzymatic pathways for generation, functions, integrative aspects of its protective profile, and its therapeutic potential. It also encompasses a comprehensive presentation of current knowledge about its widespread biological actions on several tissues, as well as the most recent scientific achievements, emerging from preclinical and clinical trials. Dr. Santos is a renowned researcher on the Renin-Angiontensin system, with remarkable achievements regarding the role of peptides such as alamandine and angiontensin-(1-7). He has also worked on the potential clinical applicability of angiotensin-(1-7)-related drugs for cardiovascular diseases. He has an extensive publication record in the field, including the publication of the book The Protective Arm of the Renin Angiotensin System (Academic Press, 2015). Angiotensin-(1-7) will make a unique contribution to the literature and will be an important resource for biomedical students and researchers, medical practitioners and any other professional interested in this peptide and its role in the renin-angiotensin system.
Download or read book The Renin Angiotensin System in Cardiovascular Disease written by Naranjan S. Dhalla and published by Springer Nature. This book was released on 2023-01-01 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
Download or read book Renin Angiotensin System and Cardiovascular Disease written by Walmor C. DeMello and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers the latest research into the role of the renin angiotensin system on cardiac and vascular functions and in cardiovascular diseases. It covers vital aspects such as intracellular signaling and regulation of cell volume in the failing heart.
Download or read book Renin angiotensin System written by Ayako Himura and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) is a major hormonal system that plays an essential role in regulating salt-water balance and blood pressure. In this book, the authors discuss the physiology, role in disease and health implications of RAS. Topics include the function of the renin-angiotension-aldosterone system in ISIAH rats with stress-sensitive arterial hypertension; RAS implications for eye diseases, obesity and diabetes, and cardiovascular disease; intensive blockade of renin-angiotensin systems; glomerular renin-angiotensin system activation; the role of vitamin D in RAS; the renin-angiotensin system in the pathogenesis of intracranial aneurysms; and a discussion on whether angiotensin-converting enzyme inhibitors are a contradiction for contrast-induced nephropathy prophylaxis?
Download or read book Tissue Renin Angiotensin Systems written by Amal K. Mukhopadhyay and published by Springer. This book was released on 2013-06-15 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent progress in recombinant DNA technology and the availability of a number of nonpeptide subtype-specific receptor antagonists and of specific antibodies to components of prorenin-renin-angiotensin system (PRAS) have led to rapid advances in the under standing of the multifaceted role of angiotensin II, classically known as a peptide hormone of cardiovascular homeostasis. Accumulating evidence sug responsible for the regulation gests that, in addition to its role in salt and water metabolism, PRAS may control other physiological functions including neurosecretion, cellular proliferation, hypertrophy and/or differentiation, angiogenesis and gonadal function. At the same time, it is becoming evident that the specialized functions of endocrine glands are not only regulated by trophic hormones but also by locally produced paracrine/autocrine factors. The concept is emerging that tissue PRAS is one such locally active regulatory system. With more and more reproductive and endocrine organs being added to the list of tissues that contain a local tissue PRAS, questions are being raised by the reproductive biologists and endocrinologists as to the role of such systems in the tissues of their interest. On the other hand, the cardiovascular and renovascular physiologists are wondering about the relevance of PRAS in various peripheral tissues compared to those of the classical cardiovascular organs. It appeared, therefore, that the time was ripe for a meeting to consider a merger of interest in these two important but heretofore distinct areas of physiology.
Download or read book Renin Angiotensin System written by Ayako Himura and published by . This book was released on 2014-05-14 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) is a major hormonal system that plays an essential role in regulating salt-water balance and blood pressure. In this book, the authors discuss the physiology, role in disease and health implications of RAS. Topics include the function of the renin-angiotension- aldosterone system in ISIAH rats with stress-sensitive arterial hypertension; RAS implications for eye diseases, obesity and diabetes, and cardiovascular disease; intensive blockade of renin-angiotensin systems; glomerular renin- angiotensin system activation; the role of vitamin D in RAS; the renin-angiotensin system in the pathogenesis of intracranial aneurysms; and a discussion on whether angiotensin-converting enzyme inhibitors are a contradiction for contrast-induced nephropathy prophylaxis?
Download or read book Angiotensin written by Paul M. Pilowsky and published by Elsevier. This book was released on 2023-02-20 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-aldosterone system, cover non-angiotensin II peptides, and more. The final part of the book is dedicated to angiotensin’s role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book’s complete coverage of organ systems and diseases where Angiotensin plays a key role. Covers the traditional disorders related to Angiotensin and new findings like its role in infectious diseases like COVID-19 Offers an overview of all important aspects of angiotensin, from discovery to clinical application, from physical and chemical properties to the physiological/cellular interaction Expands on the role of angiotensin beyond the individual system the researcher is focusing, providing a comprehensive coverage of the additional effects at cell, tissue, organ, and system levels
Download or read book Pulmonary Pharmacology written by and published by Elsevier. This book was released on 2023-08-02 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Pharmacology, Volume 98 provides in-depth reviews on the latest progresses about respiratory drug discovery and development. Topics covered in this volume include corticosteroids, monoclonal antibodies, tyrosine kinase inhibitors and phosphodiesterase inhibitors for the treatments of asthma, COPD or pulmonary fibrosis, with perspective on the development of novel therapeutic strategies such as renin-angiotensin system modulators, mitochondrial function modulators, and non-antibacterial macrolides. Part of the volume is devoted to senotherapy for lung ageing in respiratory diseases, and novel pulmonary delivery technologies, including inhaled biologics. Provides accurate reviews from leading experts on the topic of pulmonary pharmacology Each chapter of the volume provides consolidated graphical materials for ease of reading for the audience Provides the latest insights and future perspectives on the drug discovery and development for respiratory diseases
Download or read book Goodman and Gilman s The Pharmacological Basis of Therapeutics 14th Edition written by Laurence Brunton and published by McGraw Hill Professional. This book was released on 2022-11-04 with total page 1664 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Doody's Core Title for 2023! The landmark pharmacology reference—updated to reflect the latest research and developments in the field For more than 50 years, Goodman & Gilman’s: The Pharmacological Basis of Therapeutics has represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Fourteenth Edition features: Five NEW chapters on: -Pharmacovigilance -The blood-brain barrier -Cannabis -Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents -Gastrointestinal microbiome and drug response Expanded coverage of the use of genetic polymorphisms in designing appropriate therapies Revised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action 600+ color illustrations Drug Fact Tables summarizing clinical pharmacology Content Outline and Abbreviation List at the beginning of each chapter 50 NEW figures on mechanism of drug actions 53 NEW contributors NEW online updates
Download or read book NADPH Oxidases Revisited From Function to Structure written by Edgar Pick and published by Springer Nature. This book was released on 2023-06-22 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.
Download or read book Handbook of Sepsis written by W. Joost Wiersinga and published by Springer. This book was released on 2018-04-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.
Download or read book Oxidative Stress and Chronic Degenerative Diseases written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2013-05-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1984 pages. Available in PDF, EPUB and Kindle. Book excerpt:
