Download or read book The Synthesis and Use of Phosphine Ligands in Asymmetric Catalysis written by and published by . This book was released on 1998 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phosphorus Ligands in Asymmetric Catalysis written by Armin Börner and published by . This book was released on 2008 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of New Chiral Phosphine Ligands and Their Applications in Asymmetric Catalysis written by Murthy Narasimha Cheemala and published by . This book was released on 2007 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phosphorus III Ligands in Homogeneous Catalysis written by Paul C. J. Kamer and published by John Wiley & Sons. This book was released on 2012-05-09 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last 60 years the increasing knowledge of transition metal chemistry has resulted in an enormous advance of homogeneous catalysis as an essential tool in both academic and industrial fields. Remarkably, phosphorus(III) donor ligands have played an important role in several of the acknowledged catalytic reactions. The positive effects of phosphine ligands in transition metal homogeneous catalysis have contributed largely to the evolution of the field into an indispensable tool in organic synthesis and the industrial production of chemicals. This book aims to address the design and synthesis of a comprehensive compilation of P(III) ligands for homogeneous catalysis. It not only focuses on the well-known traditional ligands that have been explored by catalysis researchers, but also includes promising ligand types that have traditionally been ignored mainly because of their challenging synthesis. Topics covered include ligand effects in homogeneous catalysis and rational catalyst design, P-stereogenic ligands, calixarenes, supramolecular approaches, solid phase synthesis, biological approaches, and solubility and separation. Ligand families covered in this book include phosphine, diphosphine, phosphite, diphosphite, phosphoramidite, phosphonite, phosphinite, phosphole, phosphinine, phosphinidenene, phosphaalkenes, phosphaalkynes, P-chiral ligands, and cage ligands. Each ligand class is accompanied by detailed and reliable synthetic procedures. Often the rate limiting step in the application of ligands in catalysis is the synthesis of the ligands themselves, which can often be very challenging and time consuming. This book will provide helpful advice as to the accessibility of ligands as well as their synthesis, thereby allowing researchers to make a more informed choice. Phosphorus(III) Ligands in Homogeneous Catalysis: Design and Synthesis is an essential overview of this important class of catalysts for academic and industrial researchers working in catalyst development, organometallic and synthetic chemistry.
Download or read book Fundamentals of Asymmetric Catalysis written by Patrick J. Walsh and published by University Science Books. This book was released on 2009-01-02 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.
Download or read book Synthesis and Applications of Chiral Phosphine Ligands to Catalytic Asymmetric Hydrogenation written by Antonio Belmiro Gil da Silva Fortes and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lanthanides in Organic Synthesis written by Tsuneo Imamoto and published by . This book was released on 1994 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic synthesis with lanthanides has experienced enormous growth in the last ten years. Numerous synthetic reactions have been explored by the use of lanthanide reagents, and some of these have become indispensablein modern organic synthesis. This book describes the remarkable scope and potential of these reagents, addressing this rapidly growing area from a practical point-of-view. The author has summarized synthetically useful and novel organic transformations, emphasizing the characteristic properties of lanthanide reagents. These transformations are concisely and skillfully presented in many schemes and tables, with actual illustrative preparations. The coverage includes the use of lanthanide metals, the powerful divalent reagents such as samarium (II) iodide, the key trivalent reagents and their particular role as catalysts in selective reductions and cycloadditions, and the tetravalent lanthanides as oxidants. Describes the remarkable scope and potential of lanthanide reagents from a practical point-of-view Presents actual experimental procedures Provides a concise presentation of useful and novel organic transformations in table format
Download or read book Chiral Diazaligands for Asymmetric Synthesis written by Marc Lemaire and published by Springer. This book was released on 2010-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of phosphine derivatives has historically induced the tremendous development of catalysis (both non-asymmetric and asymmetric). Although the chemistry of amines is more documented, the use of nitrogen-containing ligands only appeared recently. Nevertheless, during the last ten years, the results describing chiral diamine preparations and their uses in asymmetric catalysis and synthesis are increasing faster than their phosphorus counterparts. The reader will find in this volume the most recent methods for the synthesis of chiral diamines as well as their applications in asymmetric catalysis of CC bond formation. Particular attention will be given to spartein and derivatives of such diamines. Recently, the particular properties and the chemistry of amines allowed to obtain catalysts easy to separate and recycle and new types of ligands such as diaminocarbenes, ureas and thioureas. Finally, the complexing properties of some diamines allowed the formation of complexes with chirality "at the metal " which is of major theoretical interest and presents numerous potential applications.
Download or read book Phosphorus Compounds written by Maurizio Peruzzini and published by Springer Science & Business Media. This book was released on 2011-06-10 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each chapter of Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences have been carefully selected by the editors in order to represent a state-of-the-art overview of how phosphorus chemistry can provide solutions in various fields of applications. The editors have assembled an international array of world-renowned scientists and each chapter is written by experts in the fields of synthetic chemistry, homogeneous catalysis, dendrimers, theoretical calculations, materials science, and medicinal chemistry with a special focus on the chemistry of phosphorus compounds. Phosphorus Compounds: Advanced Tools in Catalysis and Material Sciences is of interest to a general readership ranging from advanced university course students to experts in academia and industry.
Download or read book Chiral Phosphorous Based Ligands in Earth Abundant Transition Metal Catalysis written by Junliang Zhang and published by Elsevier. This book was released on 2023-05-27 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis summarizes the most significant progress in the field of chiral phosphine ligand chemistry and a broad range of earth-abundant transition metal/chiral phosphine ligand-catalyzed enantioselective transformations. The book provides an authoritative and in-depth understanding of important topics about asymmetric catalysis based on earth-abundant transition metals/chiral phosphine ligands, making it ideal for organic chemistry researchers working in the field of asymmetric catalysis, synthetic methodologies and total synthesis.The development of new chiral phosphine ligands to achieve precise stereo control in many earth-abundant transition metal-catalyzed reactions is a very important field in organic synthesis, materials science and medicinal chemistry. The asymmetric synthesis promoted by transition metal/chiral phosphine ligands provides one of the most ideal ways to produce valuable optically active chemicals. Includes a discussion of state-of-the-art asymmetric organic reactions mediated by earth-abundant transition metals and chiral phosphine ligands Features the progress and the prospect of chiral phosphine ligands in asymmetric transition metal catalysis Covers the asymmetric reactivity modes of earth-abundant transition metals and phosphine ligands
Download or read book Asymmetric Catalysis from a Chinese Perspective written by Shengming Ma and published by Springer Science & Business Media. This book was released on 2011-07-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Qi-Lin Zhou and Jian-Hua Xie: Chiral Spiro Catalysts.- Fuk Loi Lam, Fuk Yee Kwong and Albert S. C. Chan: Chiral Phosphorus Ligands with Interesting Properties and Practical Applications.- Jiang Pan, Hui-Lei Yu, Jian-He Xu, Guo-Qiang Lin: Advances in Biocatalysis: Enzymatic Reactions and Their Applications.- Mei-Xiang Wang: Enantioselective Biotransformations of Nitriles.- Man Kin Wong, Yiu Chung Yip and Dan Yang: Asymmetric Epoxidation Catalyzed by Chiral Ketones.- W. J. Liu, N. Li and L. Z. Gong: Asymmetric Organocatalysis.- Qing-Hua Fan and Kuiling Ding: Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts.- Chang-Hua Ding, Xue-Long Hou: Transition Metal-Catalyzed Asymmetric Allylation.- Jian Zhou and Yong Tang: Enantioselective Reactions with Trisoxazolines.- Xiang-Ping Hu, Duo-Sheng Wang, Chang-Bin Yu, Yong-Gui Zhou, and Zhuo Zheng: Adventure in Asymmetric Hydrogenation: Synthesis of Chiral Phosphorus Ligands and Asymmetric Hydrogenation of Heteroaromtics.
Download or read book Catalytic Synthesis of Asymmetric Phosphine Ligands written by Gale Wesley Starkey and published by . This book was released on 1998 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Homogeneous Catalysis with Metal Phosphine Complexes written by Louis M. Pignolet and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of transition metal catalysis has experienced incredible growth during the past decade. The reasons for this are obvious when one considers the world's energy problems and the need for new and less energy demanding syntheses of important chemicals. Heterogeneous catalysis has played a major industrial role; however, such reactions are generally not selective and are exceedingly difficult to study. Homogeneous catalysis suffers from on-site engineering difficulties; however, such reactions usually provide the desired selectivity. For example, Monsanto's synthesis of optically-active amino acids employs a chiral homogeneous rhodium diphosphine catalyst. Industrial uses of homogeneous catalyst systems are increasing. It is not by accident that many homogeneous catalysts contain tertiary phosphine ligands. These ligands possess the correct steric and electronic properties that are necessary for catalytic reactivity and selectivity. This point will be emphasized throughout the book. Thus the stage is set for a comprehensive be treatment of the many ways in which phosphine catalyst systems can designed, synthesized, and studied.
Download or read book Catalytic Methods in Asymmetric Synthesis written by Michelangelo Gruttadauria and published by John Wiley & Sons. This book was released on 2011-07-05 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.
Download or read book N Heterocyclic Carbenes in Organocatalysis written by Akkattu T. Biju and published by John Wiley & Sons. This book was released on 2019-01-07 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.
Download or read book C2 and C3 Symmetric Chiral Bis and Tris phosphines in Asymmetric Catalysis written by Zhiming Xu and published by . This book was released on 2017 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1. Effect of linker length on selectivity and cooperative reactivity in platinum-catalyzed asymmetric alkylation of bis(phenylphosphino)alkanes. The selectivity of catalytic asymmetric transformations of bifunctional symmetrical substrates often depends on the linker between the two reactive sites. If the catalyst controls the selectivity of reactions at both sites, the rac product will be formed in high enantiomeric ratio (er) via asymmetric amplification. Substrate control may augment this selectivity (positive cooperativity) or detract from it (negative cooperativity). We investigated the effect of linker length on the selectivity of catalytic asymmetric alkylation of the bis(secondary phosphines) PhHP-(CH2)[subscript n]PHPh (n = 2-6, 1a-e) with benzyl bromide using the base NaOSiMe3 and the catalyst precursor Pt((R,R)-Me-DuPhos)(Ph)(Cl). The two alkylations of bis(secondary phosphines) 1b-e with longer linker lengths (n = 3-6) showed identical selectivity, within experimental error. This catalyst control resulted in asymmetric amplification of rac-2. In contrast, the selectivity of the first alkylation of ethano-bridged 1a was lower than that in 1b-e (negative cooperativity), but the selectivity of the second alkylation increased due to positive cooperativity. I developed an efficient synthesis of the intermediate PhHP(CH2)2PPh(CH2Ph) (3a), which was required for determination of the selectivity of both steps in Pt-catalyzed alkylation of 1a. Possible mechanistic explanations for the observed dependence of selectivity on linker length are discussed in this chapter. Chapter 2. Selective formation of a C3-symmetric P-stereogenic tris(phosphine) via platinum-catalyzed asymmetric alkylation of a tris(secondary phosphine). C2-symmetric bis(phosphines) are the most common and successful ligands for metal-catalyzed reactions. Considering the great success of C2-symmetric ligands in asymmetric catalysis, C3-symmetric chiral tris(phosphines) were proposed to be useful in octahedral complexes, creating three homotopic sites. However, very little is known about C3-symmetric tris(phosphines) and their applications, mostly because of the lack of synthetic routes. We used Pt-catalyzed asymmetric alkylation to prepare enantiomerically enriched C3-symmetric, P-stereogenic tripodal tris(phosphines) from the tris(secondary phosphine) MeC(CH2PHPh)3 (5 a racemic mixture of C1- and C3-symmetric diastereomers) and a benzl bromide, utilizing the Pt((R,R)-Me-Duphos)(Ph)(Cl) catalyst precursor and a base. Pt-catalyzed alkylation of MeC(CH2PHPh)3 (5) with 2-cyanobenzyl bromide gave a mixture of tris(phosphines) MeC(CH2PPh(CH2Ar))3 (6) enriched in C3-6; oxidation of 6 by sulfur or H2O2 formed phosphine sulfide S-6 and oxide O-6. Hydrogen bonding between O-6 and the chiral amino acid (S)-Fmoc-Trip(BOC)-OH leads to the formation of new diastereomers. By integrating the 31P NMR spectra, I measured the dr and er values. Tris(phosphine) 6 was formed with a disatereomeric ratio (dr - C3/C1) of 2.1(2) and enantiomeric ratios of 54(10) and 3.8(7) for C3-3 and C1-3 respectively, which showed that the selectivity of the triple alkylation was not the same at each site (substrate control). Chapter 3. Screening racemic catalysts provides information on selectivity and mechanism in platinum-mediated asymmetric alkylation of bis- and tris(secondary phosphines). Screening racemic catalysts for transformations of symmetrical bifunctional substrates can provide information on the selectivity of an enantiopure catalyst. This idea was extended to Pt-catalyzed asymmetric alkylation of the bis(secondary phosphines) PhHP(CH2)3PHPh and PhHPCH2CMe2CH2PHPh and the tris(phosphine) MeC(CH2PHPh)3 with benzyl bromides using the catalyst precursors Pt(Me-DuPhos)(Ph)(CI) and Pt(BenzP*)(Ph)(CI). Depending on the catalyst and the substrate, these reactions occured under catalyst control without dissociation of the substrate, or under substrate control with or without substrate dissociation. The resulting structure-selectivity relationships provided mechanistic information. Chapter 4. Synthesis of new chiral bis(phospholane) metal-pincer complexes. Metal pincer complexes have received great attention in recent years as robust catalyst precursors. However, chiral metal pincer complexes for application in asymmetric catalysis are rare. Dialkylphospholane groups have an outstanding track record in asymmetric catalysis (commercial DuPhos and BPE ligands) and their steric properties can be easily controlled by tuning the alkyl substituents on the phospholane ring. These donors have similar steric and electronic properties to the common used bulky dialkylphosphine groups (P(t-Bu)2, P(i-Pr)2, etc.). Optimization of the synthesis of chiral PCP ligands bearing such phospholane groups and investigation of their coordination chemistry are discussed in this chapter.
Download or read book Asymmetric Catalysis written by B. Bosnich and published by Springer. This book was released on 2011-09-26 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rate of advance in areas of science is seldom constant. Usually certain fields effloresce with activity because of the ~ealization that solutions are possible to long standing important problems. So it is now with asymmetric catalysis, a field which promises to change profoundly the strategic thinking of synthetic chemists. As this Report will show, reagents which can induce catalytic enantiocontrol of chemical transformations could represent the ultimate synthetic method. Nearly all synthetic strategies of complex molecules involve steps which require enantiocontrol and, in many cases, a specific catalytic transformation embodying enan tiocontrol has enormous advantages in terms of the rate and economy of the reaction. Because asymmetric catalysis is in a formative stage, workers with different backgrounds have joined the field. This Workshop had representatives with organometallic, organic, structural, kinetic, enzymatic, microbiological and industrial backgrounds. Each had his own perspective and this Report represents a consensus of this group of eleven people. The result is probably as compre hensive and balanced a view of the subject as is possible at present. It is hoped that those who have until now had but a glancing interest in asymmetric catalysis will find this Report a useful indication of its present state. We believe that asymmetric catalysis will have an increasing impact on the development of chemistry and will eventually dominate much of synthetic and industrial chemistry.
