Download or read book The Synthesis and Characterization of Ruthenium and Osmium Polypyridyl Coordination Complexes as Photosensitizers for Photodynamic Therapy written by Leah G. Bennett and published by . This book was released on 2016 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Ruthenium Polypyridyl Complexes for Application in Photodynamic Therapy written by Colin R. Spencer and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Eighteen polypyridyl ruthenium complexes were synthesized and characterized to test their ability to be new photodynamic compounds (PDCs). Each compound bears oxazo- or imidazo[4,5-f][1,10]phenanthroline ligands with a varying R-group and 2,2-bipyridine and 1,10-phenanthroline ancillary ligands. Biological tests were employed for the complexes to test the potential to be new PDCs, and included DNA photocleavage, DNA binding, and photocytotoxicity. Compounds containing thiophenes as the R-group showed significant DNA damage in the photocleavage assays as well as light toxicity and low dark toxicity in photocytotoxic assays. Compounds with 1,10-phenanthroline ancillary ligands generally showed more DNA photocleavage, unwinding, and binding compared to their 2,2'-bipyridine counterparts. Dinuclear compounds containing the bis(imidazo[4,5-f][1,10]phenanthroline) bridging ligand exhibited the best results for high light toxicity and low dark toxicity, the strongest binding to DNA, and the most potency for DNA photocleavage. As such these compounds are promising candidates for new PDCs and warrant further investigations.
Download or read book Photochemistry and Photophysics of Coordination Compounds written by Rakshit Ameta and published by Elsevier. This book was released on 2023-06-24 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photochemistry and Photophysics of Coordination Compounds: Fundamentals and Applications provides a systematic overview of the photochemical and photophysical properties of coordination compounds with different metal cores. Beginning with a clear introduction to the fundamentals of both photochemistry and coordination chemistry, the book goes on to outline the photochemical and photophysical properties of a large range of coordination compounds, clustering metal cores together in chapters according to their period table group, ranging across Transition metals, Lanthanides and Actinides. In addition to outlining their properties, each chapter discusses the synthesis, current applications and future potential of coordination compounds in each group. Drawing on the experience of a global team of experts, this book is an authoritative guide for all those interested in understanding and harnessing the photochemical properties and potential applications of coordination complexes for their own work. Introduces the fundamentals of both photochemistry and coordination compounds Supports learning through carefully structured content, with chapters uniquely arranged by period table group Bridges the knowledge gap between theory and practice by presenting application examples in each chapter
Download or read book Ruthenium Complexes written by Alvin A. Holder and published by John Wiley & Sons. This book was released on 2018-02-27 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.
Download or read book Synthesis and Characterization of Ruthenium Polypyridyl Complexes written by Sangsub Han and published by . This book was released on 2000 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Ruthenium Polypyridyl Complexes for Application in Photodynamic Theraoy written by Colin R. Spencer and published by . This book was released on 2012 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal Ligand Chromophores for Bioassays written by Kenneth Kam-Wing Lo and published by Springer Nature. This book was released on 2022-12-10 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Chapters “Metal Peptide Conjugates in Cell and Tissue Imaging and Biosensing”, “Luminescent Metal Complexes as Emerging Tools for Lipid Imaging” and “Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex‐Based Chemosensors” are available open access under a CC BY 4.0 License via link.springer.com.
Download or read book Synthesis and Characterization of Ruthenium II Polypyridyl Complexes written by Youxiang Wang and published by . This book was released on 1994 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Novel Ru II Dipyrrin Complexes for Use as Photodynamic Therapy Agents in Cancer Treatments written by Max Tsao and published by . This book was released on 2019 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design and Synthesis of Luminescent Metal Polypyridyl Complexes of Platinum ii Ruthenium ii and Osmium ii for Chemosensing and Biological Studies written by Wing-Suen Tang and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Design and Synthesis of Luminescent Metal Polypyridyl Complexes of Platinum(II), Ruthenium(II) and Osmium(II) for Chemosensing and Biological Studies" by Wing-suen, Tang, 鄧詠璇, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled DESIGN AND SYNTHESIS OF LUMINESCENT METAL POLYPYRIDYL COMPLEXES OF PLATINUM(II), RUTHENIUM(II) AND OSMIUM(II) FOR CHEMOSENSING AND BIOLOGICAL STUDIES Submitted by TANG WING SUEN for the degree of Doctor of Philosophy at The University of Hong Kong in November 2006 A series of platinum(II) terpyridyl alkynyl complexes derivatized with basic amino functionalities and crown ether pendants, [Pt(trpy)(C≡C-R)]X (R = - - -C H -N(CH ) -4, X = OTf; R = -C H -N(CH CH OCH ) -4, X = OTf; R = 6 4 3 2 6 4 2 2 3 2 - - -C H -NH-4, X = OTf; R = -C H -N(CH )-4, X = Cl; R = 6 4 2 6 4 3 2 - - -C H -N(CH CH OCH ) -4, X = Cl; R = -C H -NH -4, X = Cl; R = -B15C5, X 6 4 2 2 3 2 6 4 2 - - = OTf; R = -A15C5, X = OTf ) have been synthesized. The X-ray crystal structure of [Pt(trpy){C≡CC H -N(CH CH OCH )-4}](OTf) has been 6 4 2 2 3 2 determined. The lowest energy absorption of the complexes except [Pt(trpy)(C≡CB15C5)](OTf) were tentatively assigned to originate from a π(C≡C) → π*(trpy) ligand-to-ligand charge transfer (LLCT) transition mixed with some metal-to-ligand charge transfer (MLCT) contribution. The ion-binding and pH dependent properties have also been studied. Their photophysical and spectroscopic properties were shown to be dependent on pH and selected metal ions, and their colorimetric and luminescence chemosensing properties were described. Another series of platinum(II) terpyridyl alkynyl complexes, t - [Pt( Bu trpy)(C≡C-R)]X [R = -C H -NH -4, X = OTf; R = -C H -NCS-4, X = 3 6 4 2 6 4 - - - OTf; R =-C H -NHCOCH I-4, X = OTf; R = -UH-5 (UH = Uracil), X = Cl; 6 4 2 -UMe-5, X = OTf (UMe = 1,3-dimethyluracil)] have been successfully synthesized and characterized. The X-ray crystal structures of t t [Pt( Bu trpy)(C≡C-C H-NCS-4)](OTf), [Pt( Bu trpy)(C≡C-UH-5)]Cl and 3 6 4 3 [Pt( Bu trpy)(C≡C-UMe-5)](OTf) have been determined. Their photophysical and electrochemical behaviour, together with their protein labeling and DNA binding studies, have also been studied. The emission of the complexes in solution at room temperature has been tentatively assigned as originated from a dπ(Pt) → π*( Bu trpy) triplet MLCT excited state. The 77 K butyronitrile glass displayed dual luminescence which were assigned to originate from an intraligand (IL) phosphorescence of the terpyridine ligand and a dπ(Pt) → t 3 t π*( Bu trpy) MLCT phosphorescence. The [Pt( Bu trpy)(C≡C- 3 3 C H-NHCSNH-4)](OTf)-HSA and [Pt( Bu trpy)(C≡C-C H -NHCOCH S- 6 4 3 6 4 2 4)](OTf)-HSA (HSA = human serum albumin) bioconjugates were highly colored and exhibited luminescence in the visible region upon photoexcitation. A series of ruthenium(II) diimine complexes and an osmium(II) diimine complex containing extended π-conjugated ligands, [Ru(bpy) (pmra)](PF ) 2 6 2 [pmra = N-(2-pyridylmethylene)-2-fluorenamine], [Ru(bpy) (pmra)]Cl, 2 2 [Ru(bpy) (pmaa)]Cl [pmaa = N-(2-pyridylmethylene)-2-anthramine], 2 2 [Ru(bpy) (pmpa)]Cl [pmpa = N-(2-pyridylmethylene)-1-pyrenamine], 2 2 [Ru(bpy) (pmfa)]Cl [pmfa = N-(2-pyridylmethylene)-3-fluoranthenamine] 2 2 and [Os(bpy) (pmaa)](PF ), have been synthesized. The lowest energy 2 6 2 absorption bands of the ruthenium(II) complexes w
Download or read book Inorganic Chemical Biology written by Gilles Gasser and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.
Download or read book Synthesis and Characterization of Photolabile Ruthenium Polypyridyl Crosslinkers with Applications in Soft Materials and Biology written by Teresa Rapp and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its discovery in 1844, ruthenium has solidified its position as the most widely used transition metal in catalysis and excited state chemistry. Its lower toxicity and relatively low price (compared to other platinum group metals) have enabled many applications of ruthenium coordination compounds. In this dissertation I discuss ruthenium polypyridyl complexes that undergo photoinduced ligand exchange, and how this unique property can be harnessed to develop next-generation smart materials and responsive chemical biology tools. Ru(LL)2X22+ complexes, where LL is a bidentate aromatic heterocycle such as 2,2'-bipyridine, 1,10-phenanthroline, or 2,2'-biquinoline, and X is a pyridine-, nitrile-, sulfur-, or imidazole-based monodentate ligand, have the unique capability to undergo ligand exchange under visible light irradiation. We have harnessed this property to develop a series of visible-light-sensitive photodegradable crosslinkers by choosing X ligands that contain reactive moieties such as alkynes (for copper-mediated azide-alkyne cycloaddition (CuAAC)) or aldehydes (for Schiff base reaction with hydrazines). Ru(bpy)2(3-ethynylpyridine)2 (RuBEP) has been used in CuAAC reactions to circularize azide-terminated oligonucleotides important for gene regulation or transcriptome analysis. Ru(bpy)2 (3-pyridinaldehyde) 2 (RuAldehyde) alternately employed aldehydes to react with hydrazine-modified hyaluronic acid (HA-HYD). The resulting hydrogel was cytocompatible, efficiently degraded with visible light, and well adapted for the storage and delivery of active enzymes via lysine-mediated crosslinking into the hydrogel matrix. Finally, Ru(biq)2(5-hexynenitrile)2 and Ru(bpy) 2(5-hexynenitrile) 2 were developed as crosslinkers to form PEG-based hydrogel, which was subsequently degraded using two different colors of visible light, orange and blue.
Download or read book Ruthenium Chemistry written by Ajay Kumar Mishra and published by CRC Press. This book was released on 2018-01-17 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.
Download or read book Synthesis and Characterization of Polypyridyl Ligands and Ruthenium II Complexes Based on the Reactivity of 4 5 diazafluorenone in the Presence and Absence of Ruthenium II Ion written by Youxiang Wang and published by . This book was released on 1998 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Ruthenium II Complexes with Polypyridyl Ligands written by Sheau Yong Lau and published by . This book was released on 2007 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of a New Ruthenium ii Polypyridyl Compound with a Quinolate type Ligand written by Michele Lorena Folmar and published by . This book was released on 2016 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of Ruthenium II Polypyridyl Complexes Containing expansive Functional Ligands as Photosensitizers for Photodynamic Therapy written by Tariq Sainuddin Puthanveettil Maliakal and published by . This book was released on 2015 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
