Download or read book The Subchondral Bone Plate written by Magdalena Müller-Gerbl and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigations on anatomical specimens have demonstrated that the subchondral mineralization does indeed show regular distribution patterns from which conclusions about the mechanical situation within an individual joint may be drawn. Since radiographical densitometry and histological methods are only available for determining the adaptive reaction of the bone to the mechanical situation in a joint after death, the information obtained applies only to an end situation and tells us nothing about the development of the changes with time. Furthermore, investigations carried out on human specimens by radiographical densitometry mostly apply to samples of a particular age, since such specimens can be acquired only from departments of pathology, forensic medicine or anatomy.
Download or read book The Subchondral Bone Plate written by Magdalena Muller-Gerbl and published by . This book was released on 1998-02-19 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Soft Hard Tissue Junction written by Neil D. Broom and published by Cambridge University Press. This book was released on 2018-11-29 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Richly illustrated throughout with actual tissue images, this innovative book shows that the soft-hard tissue junction is best understood in a biomechanical context. The authors describe their pioneering experimental methods, providing an essential structure-function framework for computational modelling, and thereby encouraging the development of more realistic, predictive models of this important tissue junction. Covering the three main musculoskeletal junctions of cartilage-bone, disc-vertebra, and ligament/tendon-bone, the relevant soft tissues are examined with respect to both their own inherent structure and their mode of integration with the hard tissue. The soft-hard tissue interface is explored with a focus on structural damage resulting from overloading, and its associated pathologies. Adopting a multiscale approach, ranging in structural resolution from the macro to fibril levels, this is a must-have guide to the field and an ideal resource for researchers seeking new and creative approaches for studying the joint and spine tissues.
Download or read book Joint Function Preservation written by Alberto Gobbi and published by Springer Nature. This book was released on 2021-11-03 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user-friendly, pragmatic book discusses the normal and pathological conditions of the appendicular skeleton, with a focus on the preservation of joint function, providing a detailed overview of strategies for both common and complex joint preservation. The first section covers basic topics, ranging from joints homeostasis and biomechanics, to genetics, bio-orthopedics, tissue engineering and 3D bioprinting. The following sections are each dedicated to a specific joint – its functional anatomy, pathologic conditions, diagnostics and treatment. This book is of interest to orthopedists and sports medicine specialists treating common and complex injuries of the joints.
Download or read book Correlation Between Mineralization and Mechanical Strength of the Subchondral Bone Plate of the Humeral Head written by Valentin Zumstein and published by . This book was released on 2013 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Musculoskeletal Diseases 2021 2024 written by Juerg Hodler and published by Springer Nature. This book was released on 2021 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty.
Download or read book Biomarkers in Bone Disease written by Victor R. Preedy and published by Springer. This book was released on 2017-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.
Download or read book Mineralisation and Mechanical Strength of the Glenoid Cavity Subchondral Bone Plate written by and published by . This book was released on 2013 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Biomechanics written by Kozaburo Hayashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combination of readily available computing power and progress in numerical techniques has made nonlinear systems - the kind that only a few years ago were ignored as too complex - open to analysis for the first time. Now realistic models of living systems incorporating the nonlinear variation and anisotropic nature of physical properties can be solved numerically on modern computers to give realistically usable results. This has opened up new and exciting possibilities for the fusing of ideas from physiology and engineering in the burgeoning new field that is biomechanics. Computational Biomechanics presents pioneering work focusing on the areas of orthopedic and circulatory mechanics, using experimental results to confirm or improve the relevant mathematical models and parameters. Together with two companion volumes, Biomechanics: Functional Adaptation and Remodeling and the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.
Download or read book Structural Deterioration of Human Articular Cartilage and Subchondral Plate written by Neil Chang and published by . This book was released on 2016 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articular cartilage and underlying subchondral plate, comprised of calcified cartilage and a continuous plate of subchondral bone, form the osteochondral unit which bears and transmits the load as well as maintains low hydraulic conductivity and permeability. Age-related degeneration transitions to osteoarthritis (OA) a disease that results in degeneration of articular cartilage and abnormality of the subchondral plate. The mechanism of this transition is not well known, and likely involves interplay between both the bone and the cartilage. This dissertation aims to delineate the biological and structural changes that occur in the osteochondral interface with age-related degeneration and disease, to help gain a better understanding of the pathogenesis. 3-D morphometric analyses of the subchondral plate in microCT indicated that the tidemark was disrupted and roughened in the early stage of degeneration. Investigating the subchondral plate in histology and with Digital Volumetric Imaging revealed that the disruptions were often caused by penetrating vascular channels that are involved in bone remodeling, which become larger and more abnormal in morphology in early degeneration stages. The penetration and disruption of the tidemark was found to occur in an earlier stage than large changes in the chondrocyte organization and fissuring of the articular cartilage matrix, known hallmarks of OA. Because the disrupted interface can potentially compromise the subchondral plate's ability to act as a barrier to water and solutes, there is the potential of a mechanism where remodeling of the subchondral plate leads to more catabolism and fluid depressurization in the cartilage. These studies provide new technical developments in the ability to analyze three-dimensional datasets computationally, and reduce them to morphometric parameters, allowing a multiscale assessment of the tissue depending on the region of focus and size of targeted objects. They provide quantitative confirmation of known histological hallmarks of degeneration and OA in both the cartilage and subchondral plate. Additionally, they provide novel 3-D information about the structure of the human subchondral plate in degeneration and OA, which has been mostly limited to studies of normal tissue in the past.
Download or read book Cartilage Repair and Joint Preservation of the Knee written by Tom Minas and published by Elsevier Health Sciences. This book was released on 2021-10-01 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated with recent technologies, current scientific knowledge, and the latest techniques, A Primer in Cartilage Repair and Joint Preservation of the Knee, 2nd Edition, presents the full range of treatment options for a changing, increasingly younger patient population. Using an easy-to-follow, step-by-step approach, Dr. Thomas Minas clearly teaches how to meet the new challenges of cartilage repair by utilizing the latest techniques and technologies, including advances in orthobiologics. Surgical photographs, abundant illustrations, and procedural videos provide detailed visual guidance. Details the systematic approach to diagnosis, patient management, surgical techniques, and rehabilitation for a variety of problems. Covers current scientific knowledge of cartilage properties, the etiology of damage and the intrinsic repair and regeneration processes. Helps you select the best treatment course for each patient through extensive coverage of options from non-surgical to mini-incision total knee arthroplasty. Discusses the latest evidence, research and challenges associated with new techniques such as MACI, ACI, HTO, DFO, and more. Features new and expanded coverage of the latest advances in orthobiologics including platelet-rich plasma, bone marrow stem cells, fat stem cells, scaffolds and much more. Includes key topics such as printed 3-D cartilage structures and the management of secondary cartilage lesions. Contains high-quality illustrations and surgical photos, as well as new videos that provide clear instructions on how to perform key procedures. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Download or read book Subchondral Bone Loss and Articular Cartilage Damages in Patients with Knee Osteoarthritis written by Yan Chen and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Subchondral Bone Loss and Articular Cartilage Damages in Patients With Knee Osteoarthritis" by Yan, Chen, 陳炎, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Subchondral bone loss and articular cartilage damages in patients with knee osteoarthritis" Submitted by CHEN Yan for the degree of Doctor of Philosophy at the University of Hong Kong in August 2015. Osteoarthritis (OA) is the most prevalent form of arthritis, and characterized by articular cartilage damage and subchondral bone sclerosis. Subchondral bone sclerosis has been demonstrated to lead to cartilage degradation. However, clinical studies showed that treatment of antiresorptive drugs enhance subchondral bone quality, and thus attenuate OA cartilage degeneration. These results suggest a role of subchondral bone loss in OA pathogenesis. Thus, the changes of subchondral bone in OA are still unclear. We aimed to examine subchondral bone changes and their role in human knee OA. Firstly, we examined the effect of risk factors, i.e., hypertension and type 2 diabetes mellitus (T2DM) which are associated with knee OA, and further, with bone loss, on OA subchondral bone. We found significant lower bone mineral density (BMD) and higher porosity at subchondral plate in OA patients with hypertension and T2DM. Furthermore, hypertensive patients had significantly lower bone volume fraction (BV/TV), trabecular number (Tb.N) and higher structure model index (SMI) than non-hypertensive patients. In addition, hypertensive patients showed higher Osteoarthritis Research Society International + (OARSI) score, higher number of Tartrate-resistant acid phosphatase (TRAP) + osteoclasts and lower Osteocalcin osteoblasts. These findings suggest that subchondral bone loss occurs in knee OA patients with hypertension and T2DM, and is associated with exuberated articular cartilage damage. Secondly, because subchondral bone cyst (SBC), a hallmark of OA, is characterized by focal bone loss and surrounding bone sclerosis, we investigated changes in bone and articular cartilage localized in cyst regions in knee OA. We found that cyst group presented higher BV/TV, Tb.N and SMI at subchondral bone than non-cyst group. OARSI score, the numbers of TRAP osteoclasts, + + Osterix osteoprogenitors, Osteocalcin osteoblasts and expression of SOX9, were higher in cyst group. These findings further support the association between subchondral bone loss (associated with SBCs) and articular cartilage damage in knee OA. Finally, to differentiate subchondral bone loss from bone sclerosis, we evaluated subchondral trabecular plate and rod microstructural changes in human OA knees, based on the individual trabecula segmentation technique. We found that in Lateral, Anterior and Posterior subvolumes on lateral condyle, OARSI score, BV/TV, trabecular plate number and volume fraction (pBV/TV), and elastic moduli did not differ between OA and normal control groups. However, OA group had significantly lower trabecular rod number and volume, and increased rod thickness, increased trabecular plate thickness and axial volume fraction, lower plate-plate, plate-rod and rod-rod junction density. These changes occurred similarly in all subvolumes on medial condyle and Medial and Central subvolumes on lateral condyle, excepted that OARSI score, BV/TV, pBV/TV and elastic moduli were higher in OA group. These results suggest that subchondral trabecular rod loss and plate stiffening precedes OA changes in cartilage, and that trabecular rod loss probably precedes trabecular plat
Download or read book Joint Disease in the Horse written by C. Wayne McIlwraith and published by Elsevier Health Sciences. This book was released on 2015-09-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. McIlwraith's Joint Disease in the Horse, 2nd Edition is the only book to give you a full account of equine joint disease, combining a thorough, up-to-date survey of scientific advances with a practical guide to both medical and surgical treatments. With contributions from nationally and internationally recognized pioneers in the field, this groundbreaking text offers an overview of joint structure and function and translates the latest information on basic joint pathobiology into practical application for the clinician. Step-by-step guidance on injection techniques and medications, along with a survey of practical arthroscopic surgery and developments, make it a truly indispensable reference for all equine veterinarians treating sports and racing horses. UNIQUE! Unprecedented, state-of-the-art coverage of the pathology, pathogenesis, and clinical diagnosis of traumatic and degenerative joint disease, so you stay in the know. Section on general principles of joint pathobiology provides the background to evaluate and interpret the diagnostic and surgical aspects of disease. Explores treatments for traumatic arthritis and osteoarthritis and other joint entities, offering a broad range of options and up-to-date recommendations for problematic decisions. Addresses recent advances and results in arthroscopic surgery for the acute injury and results including fragment removal, fragment fixation, and synovectomy. Discussion of current research provides insight for difficult cases and calls out the directions in which future arthritis research is headed. More than 325 photographs and line drawings help engage and guide you through procedures and treatments. NEW! Full color throughout with new artwork and a range of new images including radiographs showing both the normal and the disease progression. NEW! Practical step-by-step approach demonstrates the authors' preferred injections methods and shows underlying anatomic correlations. NEW and UPDATED! Restructured and substantially revised to emphasize treatment options, making it a practical, concise, and accessible reference and text. NEW! All-new chapters on drugs and new biological therapies, including stem cells, IRAP, and PRP and thoroughly updated coverage of HA and corticosteroids. NEW! Covers advanced imaging, giving you the latest information available. NEW! Expert advice from Dr. McIlwraith, three new co-editors, and new contributors - all distinguished specialists in the field of joint disease in the horse. Lameness and surgical clinicians describe how to approach the various, specific disease conditions. Equine specific radiologists provide their opinions on the best imaging techniques for defining the disease and making interpretations.
Download or read book Cartilage Restoration written by Jack Farr and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempting to bridge the gap between the science and art of cartilage restoration, Cartilage Restoration: Practical Clinical Applications combines an overview of clinical research and methodologies with clinical cases to help guide the orthopedic treatment and care of patients presenting with cartilage issues. With chapters written by internationally-renowned orthopedic surgeons, topics include an overview of current surgical options, debridement and marrow stimulation, autograft plug transfer, allografts, cell therapy, and meniscal issues. Cartilage Restoration is a valuable resource for orthopedic surgeons, residents, and fellows.
Download or read book Pathology of Bone and Joint Disorders Print and Online Bundle written by Edward F. McCarthy and published by Cambridge University Press. This book was released on 2014-11-20 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated new edition covering all aspects of bone and joint diseases in one easily readable volume. Color illustrations throughout.
Download or read book Imaging of the Knee written by A. Mark Davies and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date and comprehensive review of the discipline of imaging of the knee. The first part discusses the various techniques employed when imaging the knee. Individual chapters are devoted to radiography, arthrography, computed tomography and CT arthrography, magnetic resonance imaging and MR arthrography, and ultrasonography. The second part then documents the application of these techniques to the diverse clinical problems and diseases encountered in the knee. Among the many topics addressed are: congenital and developmental abnormalities, trauma, meniscal pathology, and others. Each chapter is written by an acknowledged expert in the field.
Download or read book Healing of Full Thickness Chondral Defects Treated with Arthroscopic Subchondral Bone Plate Microfracture and IL 1ra IGF 1 Delivered Through Gene Transfer written by Sophie Morisset and published by . This book was released on 2003 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
