Download or read book Methods in Protein Sequence Analysis written by Brigitte Wittmann-Liebold and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Methods in Protein Sequence Analysis - 1988" - contains selected contributions on modern protein- analytical techniques as presented by speakers at the Seventh International Conference on "Methods in Protein Sequence Analysis", held from July 3rd to July 8th, 1988 in Berlin. The book contains information on new methodologies for sensitive amino acid analysis, N- and C-terminal sequence analysis, and protein and peptide purification. In addition recent mass spectrometric approaches are described, as an alter native technique to the common stepwise degradative sequence analysis of polypeptides by the Edman method. The book presents new possibilities in the design of sequencers and sophisticated equipment for the structural analysis of peptides and proteins. It describes practical approaches for the investigation of protein domains and protein complexes, and contains review chapters on the crystallization of cell organelles as well as on recent theoretical aspects of protein folding mechanisms. The nature of protein folding is not yet understood, but further advances in this area would greatly enhance our present knowledge of protein structure and function. Further, the book gives examples of the application of gene technology to protein characterization and to the design of new proteins. This enables new studies on the structure and function of proteins to be made, and opens up efficient approaches to the design of drugs.

Download or read book Alpha Keto Acid Dehydrogenase Complexes written by M.S. Patel and published by Birkhäuser. This book was released on 2012-12-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Alpha Keto Acid Dehydrogenase Complexes written by M.S. Patel and published by Nelson Thornes. This book was released on 1996-02-29 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis).

Download or read book Thiamine written by Frank Jordan and published by CRC Press. This book was released on 2003-12-11 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thiamine: Catalytic Mechanisms in Normal and Disease States brings together the most recent developments in thiamine diphosphate (TDP)-requiring enzyme research and details the mechanisms of catalysis and structure-function relationships, as well as pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing new insights into neurogenerative diseases, this volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states and offers novel aspects of thiamine enzymes in chiral synthesis as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.

Download or read book Conformational Proteomics Of Macromolecular Architecture Approaching The Structure Of Large Molecular Assemblies And Their Mechanisms Of Action With Cd rom written by R Holland Cheng and published by World Scientific. This book was released on 2004-06-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes involving large macromolecular assemblies are thought to be a dynamic consequence of cooperativity and metastability. The folding of a peptide chain creates local environments from which “activity” can emerge. In the same way, the assembly of large molecular complexes creates dynamic features that would only be feasible in a large construct. The biological implications of such adaptation are explored as it applies to the static quasisymmetry situations, as well as to the dynamics of structural transitions. The current wealth of solved high-resolution complex structures makes this an appropriate time to summarize the state of the art in structural dynamics of living architectures. With contributions by leading scientists in the fields of virology, bacterial flagellum, cytoskeleton, ribosome and giant enzymes, this important book presents cutting-edge knowledge in the various fields of structural proteomics of very large molecular assemblies, with the focus on their mechanisms of action.

Download or read book Molecular Biology of Assemblies and Machines written by Alasdair Steven and published by Garland Science. This book was released on 2016-02-18 with total page 881 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Assemblies and Machines provides a comprehensive narrative of the ways in which macromolecular structures assemble and how they interact with other complexes and organelles in the cell. Richly illustrated in full color, the text is written for advanced undergraduates, graduate students, and researchers in biochemistry, molecular biology, biophysics, cell biology, chemistry, structural biology, immunology, microbiology, and medicine.

Download or read book Bile Acids in Hepatobiliary Disease written by T.C. Northfield and published by Springer Science & Business Media. This book was released on 2000-02-29 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the Falk Workshop on `Bile Acids in Hepatobiliary Disease', which took place at the Royal Society of Medicine (RSM) in London, UK, on 29-30 March 1999, and was held in association with the Section of Measurement in Medicine at the RSM. The main interest in bile acid therapy has been recently in cholestatic liver disease. The proceedings of the workshop not only discusses this, but moves on to examine its possible use in alcoholic liver disease, and moves back to re-examine its role in biliary disease. Leading world experts attempt to define its mechanism of action, and the current role of other non-surgical treatments in biliary disease. The physiology and pathogenesis of cholestatic and alcoholic liver disease and cholesterol gallstone disease is also examined.

Download or read book Class 2 Transferases II written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 2007-10-25 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized – and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes.

Download or read book Structure and Function Relationships in Biochemical Systems written by Francesco Bossa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Annual Reports on NMR Spectroscopy written by and published by Elsevier. This book was released on 2003-11-13 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports on NMR Spectroscopy has established itself as a means for the specialist and non-specialist alike to become familiar with new applications of NMR Spectroscopy in all branches of chemistry. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicians to study the dynamics of molecules.- Includes comprehensive review articles on NMR Spectroscopy - NMR is used in all branches of science - No other technique has grown to such importance as NMR Spectroscopy in recent years

Download or read book Structure written by and published by . This book was released on 2008 with total page 1186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Macromolecular Protein Complexes V written by J. Robin Harris and published by Springer Nature. This book was released on with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Progressive Brain Disorders in Childhood written by Juan M. Pascual and published by Cambridge University Press. This book was released on 2017-04-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Download or read book Fuzzy Sets Based Heuristics for Optimization written by José-Luis Verdegay and published by Springer Science & Business Media. This book was released on 2003-05-06 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this volume is to show how Fuzzy Sets and Systems can help to provide robust and adaptive heuristic optimization algorithms in a variety of situations. The book presents the state of the art and gives a broad overview on the real practical applications that Fuzzy Sets, based on heuristic algorithms, have.

Download or read book Halophilic Microorganisms written by Antonio Ventosa and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Various groups of microorganisms - bacteria, archaea, algae and even fungi - have adapted to a life in a hypersaline environment. Halophilic Microorganisms explores the many-fold aspects of life under these extreme conditions. Several contributions analyze the microbial communities in different hypersaline environments such as salterns, soda lakes, and the Dead Sea or salt sediments. Reviews of their biodiversity, phylogeny, and genetics are given as well as of the diverse adaptation strategies of salt-tolerant or salt-requiring microorganisms. Microorganisms that have adapted to moderate salt concentrations or to habitats with drastic fluctuations are also treated in addition to the extreme halophiles. Their physiological, biochemical and molecular mechanisms developed in response to salinity and high osmotic pressure as well as current and future biotechnological applications are presented.

Download or read book Macromolecular Protein Complexes written by J. Robin Harris and published by Springer. This book was released on 2017-03-07 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the established Subcellular Biochemistry series presents 20 chapters dealing with a broad range of interesting protein complexes. It will enable researchers to readily appreciate the major contribution from both X-ray crystallography and cryo-electron microscopy in this field of study. The biological significance of these structural studies is emphasised throughout the book. The diversity of the material included here indicates the breadth of this field and the tremendous progress that has been made in recent years. The book is directed primarily to advanced students and researchers in structural biology, and others in the biochemical sciences. It will be supplemented by other related books within the Subcellular Biochemistry series. One of the Editors (JM-W) is actively involved in structural biology and the other (JRH), as a retired academic and the Series Editor of Subcellular Biochemistry, has long experience at editing multi-author books./div