Download or read book The Social Life of ABC Transporters written by Péter Mészáros and published by . This book was released on 2012 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Plant ABC Transporters written by Markus Geisler and published by Springer. This book was released on 2014-09-06 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to the fascinating superfamily of plant ATP-binding cassette (ABC) transporters and their variety of transported substrates. It highlights their exciting biological functions, covering aspects ranging from cellular detoxification, through development, to symbiosis and defense. Moreover, it also includes a number of chapters that center on ABC transporters from non-Arabidopsis species. ABC proteins are ubiquitous, membrane-intrinsic transporters that catalyze the primary (ATP-dependent) movement of their substrates through biological membranes. Initially identified as an essential aspect of a vacuolar detoxification process, genetic work in the last decade has revealed an unexpectedly diverse variety of ABC transporter substrates, which include not only xenobiotic conjugates, but also heavy metals, lipids, terpenoids, lignols, alkaloids and organic acids. The discovery that members of the ABCB and ABCG family are involved in the movement of phytohormones has further sparked their exploration and provided a new understanding of the whole family. Accordingly, the trafficking, regulation and structure-function of ABCB-type auxin transporters are especially emphasized in this book.
Download or read book The Human ATP binding Cassette ABC Transporter Superfamily written by Michael Carlton Dean and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Transporters in Drug Disposition Effects and Toxicity written by Xiaodong Liu and published by Springer Nature. This book was released on 2019-09-30 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Download or read book The Social Life of Water written by John R. Wagner and published by Berghahn Books. This book was released on 2013-08-01 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Everywhere in the world communities and nations organize themselves in relation to water. We divert water from rivers, lakes, and aquifers to our homes, workplaces, irrigation canals, and hydro-generating stations. We use it for bathing, swimming, recreation, and it functions as a symbol of purity in ritual performances. In order to facilitate and manage our relationship with water, we develop institutions, technologies, and cultural practices entirely devoted to its appropriation and distribution, and through these institutions we construct relations of class, gender, ethnicity, and nationality. Relying on first-hand ethnographic research, the contributors to this volume examine the social life of water in diverse settings and explore the impacts of commodification, urbanization, and technology on the availability and quality of water supplies. Each case study speaks to a local set of issues, but the overall perspective is global, with representation from all continents.
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Download or read book It s Complicated written by Danah Boyd and published by Yale University Press. This book was released on 2014-02-25 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surveys the online social habits of American teens and analyzes the role technology and social media plays in their lives, examining common misconceptions about such topics as identity, privacy, danger, and bullying.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Politics of Life Itself written by Nikolas Rose and published by Princeton University Press. This book was released on 2007 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: But today normality itself is open to medical modification.
Download or read book Lasso Peptides written by Yanyan Li and published by Springer. This book was released on 2014-10-21 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Download or read book Nemesis written by Philip Roth and published by Vintage. This book was released on 2011-10-04 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATIONAL BESTSELLER • Set in a close-knit Newark neighborhood during a terrifying polio outbreak in 1944, a “book [that] has the elegance of a fable and the tragic inevitability of a Greek drama” (The New Yorker)—from the Pulitzer Prize–winning author of American Pastoral. Bucky Cantor is a vigorous, dutiful twenty-three-year-old playground director during the summer of 1944. A javelin thrower and weightlifter, he is disappointed with himself because his weak eyes have excluded him from serving in the war alongside his contemporaries. As the devastating disease begins to ravage Bucky’s playground, Roth leads us through every inch of emotion such a pestilence can breed: fear, panic, anger, bewilderment, suffering, and pain. Moving between the streets of Newark and a pristine summer camp high in the Poconos, Nemesis tenderly and startlingly depicts Cantor’s passage into personal disaster, the condition of childhood, and the painful effect that the wartime polio epidemic has on a closely-knit, family-oriented Newark community and its children.
Download or read book Membrane Transport Mechanism written by Reinhard Krämer and published by Springer Science & Business Media. This book was released on 2014-03-13 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.
Download or read book Evolutionary Transitions to Multicellular Life written by Iñaki Ruiz-Trillo and published by Springer. This book was released on 2015-03-27 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book integrates our understanding of the factors and processes underlying the evolution of multicellularity by providing several complementary perspectives (both theoretical and experimental) and using examples from various lineages in which multicellularity evolved. Recent years marked an increased interest in understanding how and why these transitions occurred, and data from various fields are providing new insights into the forces driving the several independent transitions to multicellular life as well as into the genetic and molecular basis for the evolution of this phenotype. The ultimate goal of this book is to facilitate the identification of general and unifying principles and mechanisms.
Download or read book PISA The ABC of Gender Equality in Education Aptitude Behaviour Confidence written by OECD and published by OECD Publishing. This book was released on 2015-03-05 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating compilation of the recent data on gender differences in education presents a wealth of data, analysed from a multitude of angles in a clear and lively way.
Download or read book The ABC of Anarchism written by Alexander Berkman and published by Courier Corporation. This book was released on 2005-01-01 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1929, this book by one of the most gifted writers for the anarchist movement answers some of the charges made against it and presents the case for communist anarchism clearly and intelligently. Thorough and well stated, it is today regarded as a classic statement of the cause's goals and methods.
Download or read book Modified Living as a Cyborg written by Chris Hables Gray and published by Taylor & Francis. This book was released on 2020-10-07 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building off the highly successful The Cyborg Handbook, this new collection of essays, interviews, and creative pieces brings together a set of compelling personal accounts about what it means to live as a cyborg in the twenty-first century. Human integration with complex technologies goes back to clothes, cooking, and language, but has accelerated incredibly in the last few centuries, with interest spreading among scientists, coders, people with sophisticated implants, theorists, and artists. This collection includes some of the most articulate of these voices from over 25 countries, including Donna Haraway, Stelarc, Natasha Vita-More, Steve Mann, Amber Case, Michael Chorost, Moon Ribas, Kevin Warwick, Sandy Stone, Dion Farquhar, Angeliki Malakasioti, Elif Ayiter, Heesang Lee, Angel Gordo, and others. Addressing topics including race, gender, sexuality, class, conflict, capitalism, climate change, disability and beyond, this collection also explores the differences between robots, androids, cyborgs, hybrids, post-, trans-, and techno-humans, offering readers a critical vocabulary for understanding and discussing the cyborgification of culture and everyday life. Compelling, interdisciplinary, and international, the book is a perfect primer for students, researchers, and teachers of cyberculture, media and cultural theory, and science fiction studies, as well as anyone interested in the intersections between human and machine.
