Download or read book The SCCS S Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation written by Union européenne. Scientific Committee on Consumer Safety and published by . This book was released on 2010 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present update, the state-of-the-art with respect to the validated methods of the 3Rs (Refinement, Reduction and Replacement) strategy of Russell et al. (1959), is incorporated with emphasis on New Approach Methodologies (NAMs). In view of the testing and marketing bans in the cosmetic regulation, the SCCS gives special attention to those alternative methods that are suitable for the safety testing of cosmetic substances. New methodologies for risk assessment of chemicals without using animal experimentation are worldwide being explored. Attention is given here to Next-Generation Risk Assessment (NGRA) as a possible framework for the safety evaluation of cosmetic ingredients and the NAMs that would fit into this structure (Rogiers et al., 2020). Risk assessment of cosmetics and their ingredients is shifting towards a strategic combination of NAMs and new technology with historical animal data, if available, to come to a Weight of Evidence (WoE) decision making approach. Although the "Notes of Guidance" are concerned with the testing and safety evaluation of the cosmetic substances listed in the Annexes of Regulation (EC) No 1223/2009 and those for which safety concerns have been expressed, they could be also of interest for all substances intended to be incorporated in a cosmetic product. Even though the "Notes of Guidance" have not been written for the latter purpose, they can indeed be of practical use in making a Product Information File (PIF) for a finished cosmetic product as currently required by Regulation (EC) No 1223/2009.
Download or read book The SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since July 2013, Regulation (EC) No 1223/2009 applies for cosmetic products. Their safety-in-use is, as was also the case for Directive 76/768/EEC, established by controlling the safety of the ingredients. For those ingredients for which some concern exists with respect to human health (e.g. colourants, preservatives, UV-filters, hair dyes), safety evaluation is done at the Commission level by the Scientific Committee on Consumer Safety (SCCS). These substances are addressed in the Annexes of Regulation (EC) No 1223/2009. For the safety evaluation of cosmetic ingredients, all available scientific data are considered, taking into account the testing and marketing bans in force under Regulation (EC) No 1223/2009. This includes the physical and chemical properties of the compounds under investigation, in silico data such as results obtained from (Q)SAR {(Quantitative) Structure Activity Relationship} modelling, chemical categories, grouping, read-across, Physiologically-Based PharmacoKinetics (PBPK) / ToxicoKinetics (PBTK) modelling, in vitro and ex vivo experimental results and data obtained from animal studies (in vivo) that have been carried out for the purpose of cosmetics before the testing and marketing bans. The animal testing ban on finished cosmetic products applies since 11 September 2004; the testing ban on ingredients or combination of ingredients applies since 11 March 2009. The marketing ban applies since 11 March 2009 for all human health effects with the exception of repeated-dose toxicity, reproductive toxicity, and toxicokinetics. For these specific health effects, the marketing ban applies since 11 March 2013, irrespective of the availability of alternative non-animal methods. In addition, clinical data, epidemiological studies, information derived from accidents, data from Post-Marketing Surveillance (PMS) or other human data are also taken into consideration. In the present update, the state-of-the-art with respect to the validated methods of the 3Rs (Refinement, Reduction and Replacement) strategy of Russell et al. (1959), is incorporated with emphasis on New Approach Methodologies (NAMs). In view of the testing and marketing bans in the cosmetic regulation, the SCCS gives special attention to those alternative methods that are suitable for the safety testing of cosmetic substances. Although the "Notes of Guidance" are concerned with the testing and safety evaluation of the cosmetic substances listed in the Annexes of Regulation (EC) No 1223/2009 and those for which safety concerns have been expressed, they could be also of interest for all substances intended to be incorporated in a cosmetic product. Even though the "Notes of Guidance" have not been written for the latter purpose, they can indeed be of practical use in making a Product Information File (PIF) for a finished cosmetic product as currently required by Regulation (EC) No 1223/2009. The "Notes of Guidance" should not be seen as a prescriptive procedure, but rather as an approach that may need to be adapted on a case-by-case basis when evaluating the safety of the Annex substances. However, when major deviations from standardised protocols/procedures in the safety evaluation process have been adopted, it is essential that Applicants provide scientific justification. The "Notes of Guidance" will be revised as scientifically required on the basis of scientific advances in toxicology and validated alternative methods or legislative changes.
Download or read book Addendum to the SCCS s Notes of Guidance NoG for the Testing of Cosmetic Ingredients and Their Safety Evaluation 8th Revision SCCS written by and published by . This book was released on 2014 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation written by and published by . This book was released on 2016 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "Notes of Guidance for Testing of Cosmetic Ingredients and Their Safety Evaluation by the SCCS" is a document compiled by the members of the Scientific Committee on Consumer Safety (SCCS, replacing the former SCCP, SCCNFP and SCC). The document contains relevant information on the different aspects of testing and safety evaluation of cosmetic substances in Europe. The emphasis of this guidance is on cosmetic ingredients, although some guidance is also given for the safety assessment of finished products. It is designed to provide guidance to public authorities and to the cosmetic industry in order to improve harmonised compliance with the current cosmetic EU legislation. An important development was the 2009 legislative recast, which transformed the cosmetic Directive 76/768/EEC into a Regulation. It is emphasised that from 11 July 2013 onwards this Regulation (2009/1223/EC) was fully applicable. The European cosmetic legislation prohibits the marketing of finished products containing ingredients or combinations of ingredients that have been subject to animal testing after 2013. Therefore the SCCS has closely followed the progress made with regard to the development and validation of alternative methods.
Download or read book Cosmetics Legislation Notes of guidance for testing of cosmetic ingredients for their safety evaluation written by European Commission. Enterprise DG. Pharmaceuticals and Cosmetics and published by . This book was released on 2000 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Guidelines written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Notes of Guidance for Testing of Cosmetic Ingredients for Their Safety Evaluation written by Commission of the European Communities, Scientific Committee for Cosmetology and published by . This book was released on 1990 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory Toxicology in the European Union written by Tim Marrs and published by Royal Society of Chemistry. This book was released on 2018-02-21 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consumer and environmental protection depend on the careful regulation of all classes of chemicals. Toxicology is the key science used to evaluate safety and so underpins regulatory decisions on chemicals. With the growing body of EU legislation involved in chemical regulation, there is a concomitant need to understand the toxicological principles underlying safety assessments Regulatory Toxicology in the European Union is the first book to cover regulatory toxicology specifically in Europe. It addresses the need for a wider understanding of the principles of regulatory toxicology and their application and presents the relationship between toxicology and legislative processes in regulating chemical commodities across Europe. This title has a broad scope, covering historical and current chemical regulation in Europe, the role of European agencies and institutions, and also the use of toxicology data for important classes of chemicals, including human and veterinary medicines, animal feed and food additives, biocides, pesticides and nanomaterials. This book is therefore extremely pertinent and timely in the toxicology field at present. This book is an essential reference for regulatory authorities, industrialists, academics, undergraduates and postgraduates working within safety and hazards, toxicology, the biological sciences, and the medicinal and pharmaceutical sciences across the European Union.
Download or read book Notes of Guidance for Testing of Cosmetic Ingredients for Their Safety Evaluation written by and published by . This book was released on 1999 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Rules Governing Cosmetic Products in the European Union written by European Commission and published by . This book was released on 2000 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Silico Toxicology written by Mark T. D. Cronin and published by Royal Society of Chemistry. This book was released on 2010 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book defines the use of computational approaches to predict the environmental toxicity and human health effects of organic chemicals.
Download or read book Cosmetic Creams written by Wilfried Rähse and published by John Wiley & Sons. This book was released on 2020-01-13 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to cosmetic creams that focuses on formulation, production, and safety concerns Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products puts the focus on the structure and formulation of a cosmetic cream, the production process, the effect of each ingredient, as well as safety considerations. Comprehensive in scope, the book contains a basic definition of cosmetics and describes the types of skin creams currently on the market, the major ingredients used, and example compositions. The author, Wilfried Rähse?a noted expert on the topic?offers guidelines for estimating manufacturing costs and includes procedures for an effective safety assessment. The book contains information on various aspects of skin penetration and production and covers issues like materials used and hygienic packaging. In addition, Rähse reviews legal regulations with an emphasis on the European market. He discusses GMP and EHEDG directives. This important book: -Offers a comprehensive resource that explores all aspects of cosmetic cream manufacturing and marketing -Provides valuable guidelines for practitioners in the field -Covers the underlying technologies of cosmetic creams -Includes a review of raw material and manufacturing costs, hygiene and safety, and legal regulations -Written by an author with more than 30 years? experience in the industry Written for cosmetic chemists, chemists in industry, chemical engineers, dermatologists, Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products, offers a unique industrial perspective of the topic that is comprehensive in scope.
Download or read book The Rules Governing Cosmetics Products in the European Union written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Safety and Efficacy Testing of Cosmetics written by William Waggoner and published by CRC Press. This book was released on 1989-11-27 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contact Dermatitis written by Peter J. Frosch and published by Springer Science & Business Media. This book was released on 2006-06-07 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is an unusual event for a textbook covering such a national and international networks and the use of highly specialized field as contact dermatitis to be standardized methodology, a highly differentiated published in its fourth edition within a time period picture can now be painted; we know the major p- of 13 years. When the European and Environmental fessions at risk, as well as the influences of age and Contact Dermatitis Research Group was founded in various cofactors. This is a solid basis for preventive 1985,one of the major goals was to edit a textbook of measures. A new allergen, described in one center, high scientific standard written by renown experts can now be tested on a large scale in a short time and keep it regularly updated. The greatest danger period. If the data evaluation shows an unacceptably for a textbook is to become outdated – then it stays high rate of sensitization in the exposed population, on the bookshelf and is rarely consulted. The contin- regulatory measures will be undertaken to protect uous flow of new medicaments, the fascinating the consumer. A recent example is the “methyldib- improvements in diagnostic image analysis and ever- mo glutaronitrile story. ” changing operative procedures are the reasons for These and other issues of importance are covered considerable knowledge deficits in old textbooks, in depth in the newest edition of this textbook.
Download or read book Challenges in Sun Protection written by Christian Surber and published by . This book was released on 2021 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 20th century, tanned skin was associated with good health. However, people began to protect themselves against potential overexposure to avoid sunburns. Around 1945, the first sunscreen products became available. In the years to follow, a vast number of different sunscreen filters and frameworks regulating filter substances and preparations, and methods characterizing sunscreen products were developed. The perception regarding the tasks of sunscreen products changed several times - initially it was promoted as a lifestyle product, then as a skin cancer preventive means, and more recently also for anti-aging. Different purposes and the widespread use of these products have led to myriad studies and a wealth of information. In this volume, the editors present a current collection of information analyzing and discussing issues related to sunscreen products and their use. These include challenges regarding the ideal sunscreen product including filter selection and formulation issues, measurement methods, performance characterization, safety, and regulatory issues. Further papers address topics related to the use of sunscreen products in everyday life, in vulnerable cohorts and outdoor workers. Controversial topics such as environmental effects of sunscreen products and the risks and benefits of UV radiation in the context of skin cancer, vitamin D and cardiovascular and metabolic health are also covered.
