Download or read book The Roles of the Elm1 and Swe1 Kinases in the Cell Cycle of the Budding Yeast Saccharomyces Cerevisiae written by Aparna Sreenivasan and published by . This book was released on 2000 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Swe1 and Clb2 cdc28 in the Coordination of Cell Growth and Cell Division in Saccharomyces Cerevisiae written by Alyson I. Eimerl and published by . This book was released on 2001 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regulation of Budding Yeast Morphogenesis by the Elm1 Kinase written by Wei Wei and published by . This book was released on 2003 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2001 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book American Doctoral Dissertations written by and published by . This book was released on 2000 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Emerging Functions of Septins written by Manoj B. Menon and published by Frontiers Media SA. This book was released on 2017-10-10 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together with the microfilament, microtubule and intermediate-filament networks, septins constitute an integral part of the eukaryotic cytoskeleton. Historically identified as proteins critical for septum formation in the budding yeast Saccharomyces cerevisiae, septin family GTPases are expressed and participate in the process of cytokinesis in most eukaryotes except higher plants. More than a dozen septin genes in mammals, together with various splice variants displaying tissue-specific expression patterns and flexible hetero-polymeric higher-order assembly achieve an unfathomable complexity superior to the other cytoskeletal components. Even though the initial studies in the septin field was restricted to their evolutionarily conserved role in cell division, strong expression of septins in the non-dividing cells of the brain generated great interest in understanding their role in neuronal morphogenesis and other aspects of cellular function. On one hand, recent developments indicate complex non-canonical roles for septins in diverse processes ranging from neuronal development to immune response and calcium signaling. On the other hand several lines of data including those from knockout models question the universal role for septins in animal cell cytokinesis. Mammalian hematopoietic cells seem to proliferate and efficiently undergo cytokinesis in the absence of pivotal septin proteins in a context-dependent manner. The lack of septin-dependence of hematopoiesis also opens the possibility of safely targeting septin-dependent cytokinesis for solid-tumor therapy. Thus the septin field is perfectly poised with novel roles for septins being discovered and the basic understanding on septin assembly and its canonical functions constantly revisited. The objective of this research topic was to provide an exclusive platform for discussing these rapid advances in the septin field. With a mixture of reviews and research articles encompassing diverse areas of septin research, ranging from the humble yeast model to human cancer, this ebook will be an interesting reading material for both experts as well as new comers to the septin field.

Download or read book The Septins written by Peter A. Hall and published by John Wiley & Sons. This book was released on 2008-11-20 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The authors represent most of the key figures and the work and the book as a whole is an essential reference for the newcomer or specialist in this area and for any student of eukaryotic cell structure and function. This is an important and wonderful reference." –Microbiology Today, May 2009 Septins are an evolutionarily conserved group of GTP-binding and filament-forming proteins that were originally discovered in yeast. Once the preserve of a small band of yeast biologists, the field has grown rapidly in the past few years and now encompasses the whole of animal and fungal biology. Furthermore, septins are nowadays recognized to be involved in a variety of disease processes from neoplasia to neurodegenerative conditions. This book comprehensively examines the septin gene family and their proteins, providing those new to this research area with a detailed and wide ranging introduction to septin biology. It starts with a unique historical perspective on the development of the field, from its beginnings in the screen for cell division mutants by the Nobel Laureate Lee Hartwell. The evolution of the septin gene family then forms a basis for consideration of the biochemistry and functions of septins in yeast and other model organisms including C. elegans and Drosophila. A major part of the book considers the diversity of septins in mammals, their functions and properties as well as their involvement in normal and abnormal cellular states, followed by a speculative overview from the editors of the key questions in septin research and of where the field may be headed. In addition, several appendices summarise important information for those in, or just entering, the field, e.g. nomenclature and septin and septin-like sequences. This book is an essential source of reference material for researchers in septin biology, cell biology, genetics and medicine, in particular pathology, including areas of neurobiology, oncology, infectious disease and developmental biology.

Download or read book Emerging Functions of Septins Volume II written by Manoj B. Menon and published by Frontiers Media SA. This book was released on 2022-07-12 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Function and Regulation of Mitogen activated Protein Kinases in the Yeast Saccharomyces Cerevisiae written by Raymond Eric Chen and published by . This book was released on 2008 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regulation of the Morphogenesis Checkpoint in the Budding Yeast Saccharomyces Cerevisiae written by Lee Szkotnicki and published by . This book was released on 2008 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to cytoskeletal perturbations Saccharomyces cerevisiae cells trigger a morphogenesis checkpoint resulting in a G2 arrest. The arrest is due to the Swe1p kinase, which phosphorylates and inhibits the CDK Cdc28p. Dephosphorylation of Cdc28p is catalyzed by the phosphatase Mih1p, and allows for cell cycle progression. Recent work on regulation of the kinase Swe1p has shown a complex pathway of localization specific degradation. Several of the components involved in Swe1p degradation appear to have conserved roles in degradation of the Wee1 family kinases in multicellular systems. Despite this little is known about the steps leading up to the initiation of Swe1p degradation. In this study we have challenged the model that activation of the Swe1p negative regulator, Hsl1p, results from relief of autoinhibition due to septin interaction. Rather, we conclude Hsl1p is subject to phosphorylation of threonine 273, promoted by the septin-associated kinase Elm1p. We identified elm1 mutants in a screen for defects in Swe1p degradation. Additionaly regulation of the morphogenesis checkpoint appears to be acting though regulation of the phophatase Mih1p. In other eukaryotes, Mih1p homologs (Cdc25-family phosphatases) are thought to be regulated by other checkpoints through control of their phosphorylation. We have shown that Mih1p is phosphorylated in response to morphogenesis checkpoint stress. We have also identified a NLS in Mih1p, mutation of which greatly reduces its in vivo activity. These data combined with data from a competing lab suggest that phosphorylation of Mih1p is indeed regulated. We have also investigated the checkpoint response of budded yeast cells. Specifically we have shown that environmental stresses that depolarize the actin cytoskeleton result in a Swe1p mediated G2 delay.

Download or read book The Role of the Dual specificity Protein Kinase Mck1 in the Budding Yeast Saccharomyces Cerevisiae written by Derrick Tremaine Brazill and published by . This book was released on 1995 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Activation of Cyclin dependent Kinases in Saccharomyces Cerevisiae written by Francisco Hernán Espinoza and published by . This book was released on 1998 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Establishing and Maintaining Cell Polarity written by Benjamin Lin and published by Frontiers Media SA. This book was released on 2021-12-22 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Journal of Cell Science written by and published by . This book was released on 2000 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell cycle Regulation by Cdk1 in Saccharomyces Cerevisiae written by Jeffrey A. Ubersax and published by . This book was released on 2004 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Role of PAK Family Kinases in the Cell Cycle of Budding Yeast written by Stephen Paul Holly and published by . This book was released on 1999 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Phosphorylation in Human Health written by Cai Huang and published by BoD – Books on Demand. This book was released on 2012-09-06 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: 15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.