Download or read book The Role of the Fungal Cell Wall in Host Fungal Interactions written by Vishukumar Aimanianda and published by Frontiers Media SA. This book was released on 2020-09-17 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book The Fungal Cell Wall written by Jean-Paul Latgé and published by Springer Nature. This book was released on 2020-08-12 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.
Download or read book Clinical Mycology written by Elias J. Anaissie and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book of its kind to focus on the diagnosis, prevention, and treatment of patients with fungal infections, this definitive reference returns in a completely revised, full-color new edition. It presents specific recommendations for understanding, controlling, and preventing fungal infections based upon underlying principles of epidemiology and infection control policy, pathogenesis, immunology, histopathology, and laboratory diagnosis and antifungal therapy. More than 560 photographs, illustrations, and tables depict conditions as they appear in real life and equip you to identify clinical manifestations with accuracy. Expanded therapy content helps you implement the most appropriate treatment quickly, and a bonus CD-ROM-featuring all of the images from the text-enables you to enhance your electronic presentations. Includes specific recommendations for diagnosing, preventing, and treating fungal infections in various patient populations based upon underlying principles of epidemiology and infection control policy, pathogenesis, immunology, histopathology, and laboratory diagnosis and antifungal therapy. Covers etiologic agents of disease, fungal infections in special hosts such as pediatric patients and patients with cancer and HIV, infections of specific organ systems, and more, to make you aware of the special considerations involved in certain cases. Features clinically useful and reader-friendly practical tools-including algorithms, slides, graphs, pictorials, photographs, and radiographs-that better illustrate and communicate essential points, promote efficient use in a variety of clinical and academic settings, and facilitate slide making for lectures and presentations. Offers a CD-ROM containing all of the book's images for use in your electronic presentations. Offers more clinically relevant images-more than 300 in full color for the first time-to facilitate diagnosis. Features expanded therapy-related content, including up-to-date treatment strategies and drug selection and dosing guidelines. Includes several new sections in the chapter on fungal infections in cancer patients that reflect the formidable clinical challenges these infections continue to present. Presents the work of additional international contributors who have defined many of the key issues in the field, providing more of a global perspective on the best diagnostic and management approaches. Uses a new, full-color design to enhance readability and ease of access to information.
Download or read book The Fungal Cell Wall written by Fausto Almeida and published by Frontiers Media SA. This book was released on 2020-11-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Fungal Extracellular Vesicles written by Marcio Rodrigues and published by Springer Nature. This book was released on 2022-01-01 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth overview on the manifold functions of fungal extracellular vesicles (EV) which span from cell-to-cell communication, pathogenicity and stimulation of host’s immunity to export of hundreds of biomolecules. The book summarizes the present knowledge on the impact of extracellular vesicles on fungal biology. Extracellular vesicles participate in fundamental biological processes in all living cells but only during the last 15 years the production and functions of EVs were identified and studied in fungal species too. Up to date more than 50 independent studies have shown that extracellular vesicles are produced by at least 20 fungal species. The book addresses researchers and advanced students in Microbiology, Mycology and Biotechnology.
Download or read book Recent Advances in the Study of the Host Fungus Interaction written by Attila Gacser and published by Frontiers Media SA. This book was released on 2017-01-13 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections represent nowadays a significant burden on the healthcare system of most of the countries, and are among the infections with the highest mortality rates. This has fostered the study of the interaction of these organisms with the human host. The outer most layer of a fungal cell is the cell wall, and together with the secreted components into the extracellular compartment, are the first lines of contact with the host cells. This interaction is critical for tissue adhesion, colonization and damage. In addition, these fungal extracellular components will define the outcome of the interaction with the host immune cells, leading either to the establishment of a protective antifungal immune response or to an immune-evasive mechanism by the fungal cell. On the other hand, our immune system has effectively evolved to deal with fungal pathogens, developing strategies for cell eradication, burden control, or antigen presentation from the innate branch to the adaptive immune response. Here, we provide a series of comprehensive review papers dealing with both aspect of the interaction fungus-immune cells: the role of virulence factors and cell wall components during such interaction, and the recent advances in the study of cellular receptors in the establishment of a protective anti-fungal immune response.
Download or read book The Fungal Cell Wall written by Hector Manuel Mora-Montes and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fungal cell wall is a shield that protects the cells against changes in the extracellular environment, and from the high internal pressure generated during cell growth. These protective attributes are associated with cell wall robustness and strength, but at the same time the wall has to be plastic and dynamic to allow cell growth and communication with the external environment. The main components of the cell wall are sugars, proteins and lipids. Sugars are the most abundant components of the wall, and are mostly present as polysaccharides of glucose (alpha- and beta-glucans), N-acetylglucosamine (chitin), and glucosamine (chitosan). Most of the cell wall proteins are glycoproteins modified by a glycolipid and/or oligosaccharides covalently attached to asparagine (N-linked glycosylation) or serine/threonine residues (O-linked glycosylation). These wall proteins play important roles in cell wall integrity and structure, sensing changes in the extracellular environment, and some of them have adhesive properties and hydrolytic activities.
Download or read book Candida and Candidiasis written by Richard A. Calderone and published by American Society for Microbiology Press. This book was released on 2011-12-07 with total page 1222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment. • Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis. • Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen interactions, antifungal resistance and drug discovery, and diagnostics to foster better understanding and treatment of candidiasis. • Examines recent discoveries that have shed light on morphogenesis and the cell cycle, including how new findings on host responses may have applications for the diagnosis of blood-borne candidiasis.
Download or read book Comprehensive and Molecular Phytopathology written by Yuri Dyakov and published by Elsevier. This book was released on 2007-01-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a collection of information on successive steps of molecular ‘dialogue’ between plants and pathogens. It additionally presents data that reflects intrinsic logic of plant-parasite interactions. New findings discussed include: host and non-host resistance, specific and nonspecific elicitors, elicitors and suppressors, and plant and animal immunity. This book enables the reader to understand how to promote or prevent disease development, and allows them to systematize their own ideas of plant-pathogen interactions. * Offers a more extensive scope of the problem as compared to other books in the market* Presents data to allow consideration of host-parasite relationships in dynamics and reveals interrelations between pathogenicity and resistance factors* Discusses beneficial plant-microbe interactions and practical aspects of molecular investigations of plant-parasite relationships* Compares historical study of common and specific features of plant immunity with animal immunity
Download or read book Talaromyces Marneffei Cell Wall Glucans written by Aakash A. Gupta and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Talaromyces marneffei is human fungal pathogen that infects immunocompromised patients and is endemic to southeast Asia, but a growing number of cases have been recently reported in other parts of the globe. Infections by this pathogen are generally associated with AIDS, therefore it has been named as AIDS defining pathogen, but an increasing number of cases in non-HIV patients have been documented. The fungal cell wall represents the first line of interaction between the pathogen and the host. The cell wall protects the fungal cell and is known to modulate the interaction with the host. Given its importance to the viability of the fungus, inhibitors that affect the fungal cell wall integrity are considered ideal targets for drug development. Moreover, the general conservation in composition of fungal cell walls means that it is possible to target both animal- and plant-pathogenic fungi with these compounds. By characterising the different components of cell wall, we can move towards discovering novel targets for antifungal drugs. We are also looking into the host-pathogen interactions at molecular level which will give us an insight of the phagocytosis and killing of this pathogen in its natural environment. This mechanism can be exploited through genetic manipulation to discover more natural targets for our antifungal drugs arsenal. This project is focused on some of the major components of the cell wall such as u03b2- glucans and their role in growth and pathogenicity. Mutant strains created by deleting the genes required to produce or assemble these cell wall components were characterised at macroscopic and microscopic levels. Examination of the cell wall architecture and pattern of different cell wall components was done using field emission Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Gas chromatography-mass spectrometry (GC-MS) will be used to analyse the cell wall composition and different types of linkages inside the cell wall for wild type and deletion strains. It is known that cell wall composition is dynamic, so to assess whether the expression of genes associated with cell wall biogenesis was affected by the deletion of certain components, levels of transcription of several cell wallu2013related genes was analyzed using RT-qPCR. These results lead us to a comprehensive picture of the cell wall, the importance of the various components and how the fungus copes with changes in it cell wall. The results can then be used to identify antifungal drugs for novel targets in the cell wall and combinatorial treatment strategies that can subvert the compensatory mechanisms used the maintain cell wall integrity.
Download or read book Oxford Textbook of Medical Mycology written by Christopher C. Kibbler and published by Oxford University Press. This book was released on 2017-12-14 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.
Download or read book The Fungal Kingdom written by Joseph Heitman and published by John Wiley & Sons. This book was released on 2020-07-10 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
Download or read book Fungal Cell Wall written by José Ruiz-Herrera and published by CRC Press. This book was released on 2016-04-19 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal Cell Wall: Structure, Synthesis, and Assembly, Second Edition is a compendium of information on the chemical structure, synthesis, and organization of the cell wall of fungi. Reviewing the past 20 years of research in the field, it discusses experimental evidence that demonstrates the role of the cell wall in the growth, development, morphog
Download or read book Biology of the Fungal Cell written by Dirk Hoffmeister and published by Springer. This book was released on 2019-03-05 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a detailed look at various biochemical and developmental aspects of fungal cell biology, and offers extensive information on model organisms of filamentous fungi, such as Aspergillus, and yeasts, such as Saccharomyces, while also highlighting molecular differences between ascomycetes and basidiomycetes. The book’s seven chapters, prepared by experts in the fields of mycology, have been grouped into two closely connected sections: “Fungal Cell Growth” and “Signals and Development”. The first section addresses bio-molecular mechanisms of fungal cell division and polarized cell growth, with a special emphasis on cell-cell connections, cell wall synthesis, and directed protein transport. In turn, the second section describes the intra- and extracellular signals that set off biochemical and conformational changes of cell type during development. Here, the authors focus on the molecular signalling pathways, including their impact on plant-fungus interactions, referred to as ectomycorrhizal symbiosis. Given its scope, the book offers a valuable guide for all microbiologists, geneticists, cell biologists, biochemists and plant biologists, as well as advanced students of biology, who share an interest in the field of mycology.
Download or read book Fungal Plant Interactions written by Susan Isaac and published by Springer Science & Business Media. This book was released on 1991-12-12 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal-Plant Interactions is a synthesis of fungal physiology, plant pathology and biology for undergraduates and researchers. Interactions between higher plants and fungi at the cellular and biochemical level are covered together with their ecological importance and theories as to their evolution.
Download or read book Advances in Pectin and Pectinase Research written by A. G. J. Voragen and published by Springer Science & Business Media. This book was released on 2003-02-28 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is clearly demonstrated that significant progress has been made during the past seven years.
Download or read book Fungal Physiology and Immunopathogenesis written by Marcio L. Rodrigues and published by Springer Nature. This book was released on 2019-09-03 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers an overview of the various aspects involved in the ability of fungi to damage host cells, and discusses cutting-edge approaches to the study of fungal pathogenesis. The first chapter illustrate the key roles of glycans and pigments, the most abundant surface components in fungal cells, in their interactions with host cells. The connections between cellular physiology and fungal pathogenesis are then discussed in the following chapters. Physiology-related processes affecting pathogenesis include fungal secretion, morphological transitions, and response to light. In turn, the book illustrates mechanisms of damage to host cells using the Histoplasma capsulatum model of infection, and reviews the use of transcriptomic approaches to understand the mechanisms of interaction between fungal cells and host tissues. After a discussion of the immunological mechanisms underlying host susceptibility to fungal infections, the book’s closing contribution reviews the mechanisms of interaction between fungi and other microbes, and the impact of this association on fungal pathogenesis. Given its scope, the book will appeal to scientists in the fields of mycology, microbiology, infectious diseases, biology and medicine.
