Download or read book The Role of Progesterone Receptor Isoforms in Myometrial Contractility and Timing of Parturition in the Mouse written by Mary Carolyn Peavey and published by . This book was released on 2017 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms by which Progesterone Controls Human Pregnancy and Parturition written by Peyvand Amini and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Uterine tissue-level inflammation triggers human parturition by increasing myometrial cell contractility. Progesterone, via the progesterone receptor (PR) isoforms, PR-A and PR-B, blocks labor by inhibiting the response of myometrial cells to pro-labor/pro-inflammatory stimuli. Human parturition is induced by progesterone/PR withdrawal via changes in PR activity. The research described herein explored the factors regulating progesterone/PR anti-inflammatory activity in human myometrial cells. Two core hypotheses were tested: 1) progesterone/PR anti-inflammatory activity in myometrial cells is affected by site-specific serine phosphorylation (pSer), and 2) cross-talk between progesterone/PR signaling and 3'-5'-cyclic adenosine monophosphate (cAMP) signaling affects progesterone/PR anti-inflammatory actions in myometrial cells. The hypotheses were tested using a telomerase immortalized human myometrial cell line model, hTERT-HMA/B, and biopsies of myometrium obtained from women at the time of c-section delivery. Levels of pSer-PRs were determined by immunoblotting and response to interleukin (IL)-1ß (IL-1ß) was used to assess anti-inflammatory activity. The data show that: 1) abundance of pSer344/345-PRA in myometrial cells increased in association with the onset of labor; 2) generation of pSer344/345-PRA in myometrial cells was progesterone dependent and increased by IL-1ß through the stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK); 3) pSer344/345-PRA decreased progesterone/PR anti-inflammatory activity; 4) progesterone/PR and cAMP signaling synergistically inhibited response to IL-1ß; 5) cAMP inhibited the generation of pSer344/345-PRA by inducing expression of dual specificity protein phosphatase 1 (DUSP1) that inhibits SAPK/JNK activation; and 6) P4/PR increased cAMP-induced DUSP1 expression in myometrial cells. Taken together the data suggest that for most of human pregnancy, progesterone/PR and cAMP act synergistically to promote anti-inflammatory effects in myometrial cells to induce uterine quiescence. This interaction may be exploited therapeutically as a strategy to prevent preterm birth.
Download or read book Preterm Birth written by Institute of Medicine and published by National Academies Press. This book was released on 2007-05-23 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasing prevalence of preterm birth in the United States is a complex public health problem that requires multifaceted solutions. Preterm birth is a cluster of problems with a set of overlapping factors of influence. Its causes may include individual-level behavioral and psychosocial factors, sociodemographic and neighborhood characteristics, environmental exposure, medical conditions, infertility treatments, and biological factors. Many of these factors co-occur, particularly in those who are socioeconomically disadvantaged or who are members of racial and ethnic minority groups. While advances in perinatal and neonatal care have improved survival for preterm infants, those infants who do survive have a greater risk than infants born at term for developmental disabilities, health problems, and poor growth. The birth of a preterm infant can also bring considerable emotional and economic costs to families and have implications for public-sector services, such as health insurance, educational, and other social support systems. Preterm Birth assesses the problem with respect to both its causes and outcomes. This book addresses the need for research involving clinical, basic, behavioral, and social science disciplines. By defining and addressing the health and economic consequences of premature birth, this book will be of particular interest to health care professionals, public health officials, policy makers, professional associations and clinical, basic, behavioral, and social science researchers.
Download or read book Uterine Contractility written by Robert E. Garfield and published by Serono Symposia USA, Incorporated. This book was released on 1990 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear Receptors in Development and Disease written by and published by Academic Press. This book was released on 2017-05-17 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Receptors in Development and Disease, Volume 125, the latest volume in the Current Topics in Developmental Biology series, covers nuclear receptors in development and disease, and includes contributions from an international board of authors. New chapters in this release cover the Evolution of Nuclear Receptors and Ligand Signaling: Towards a Soft Key–Lock Model?, The Function and Evolution of Nuclear Receptors in Insect Embryonic Development, Nuclear Receptors in Skeletal Homeostasis, Estrogen Hormone Biology, and the Mechanisms of Glucocorticoid Action During Development. The book's chapters provide a comprehensive set of reviews that cover such topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural development. Covers the area of nuclear receptors in development and disease Includes contributions from an International board of authors Provides a comprehensive set of reviews on topics as nuclear differentiation and remodeling, evolution of receptors, ligand signaling and neural developments
Download or read book IASLC Thoracic Oncology E Book written by Harvey Pass and published by Elsevier Health Sciences. This book was released on 2017-04-21 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global experts, in conjunction with the International Association for the Study of Lung Cancer, bring you up to date with today’s best approaches to lung cancer diagnosis, treatment, and follow-up. IASLC Thoracic Oncology, 2nd Edition, keeps you abreast of the entire scope of this fast-changing field, from epidemiology to diagnosis to treatment to advocacy. Written in a straightforward, practical style for the busy clinician, this comprehensive, multidisciplinary title is a must-have for anyone involved in the care of patients with lung cancer and other thoracic malignancies. Offers practical, relevant coverage of basic science, epidemiology, pulmonology, medical and radiation oncology, surgery, pathology, palliative care, nursing, and advocacy. Provides authoritative guidance from the IASLC – the only global organization dedicated to the study of lung cancer. Includes new content on molecular testing, immunotherapy, early detection, staging and the IASLC staging system, surgical resection for stage I and stage II lung cancer, and stem cells in lung cancer. Features a new full-color design throughout, as well as updated diagnostic algorithms.
Download or read book A Textbook of Clinical Embryology written by Eliezer Girsh and published by Cambridge University Press. This book was released on 2021-05-06 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personnel working in assisted reproductive technology often lack the opportunities for dedicated training in the specialized techniques and technologies required for the procedures. As such, success in the form of live birth rates can range from over 50% to less than 10% per treatment cycle. This comprehensive introductory textbook is an essential resource for trainee embryologists, medical students and nurses. The recent revolutions in biotechnology and molecular biology involved in delivering assisted reproductive services are thoroughly discussed. Basic knowledge such as the development and physiology of both male and female reproductive systems is covered, with practical aspects of IVF including gamete and embryo manipulation, cryopreservation and genetic testing explained in detail. A full description of the optimal structure and management of the IVF laboratory is given, helping ensure procedures are safe and effective. Extensive and highly detailed colour illustrations bring the content to life and aids readers in their understanding.
Download or read book Smooth Muscle Spontaneous Activity written by Hikaru Hashitani and published by Springer. This book was released on 2019-06-10 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets. To facilitate understanding, the volume is divided into five parts and covers 16 organs: airways, gastrointestinal tract (phasic muscle, tonic muscle), renal pelvis, ureter, urinary bladder, urethra, corporal tissue, prostate, uterus, oviducts, seminal vesicle, artery, vein, microvasculature, and lymphatic vessels. This structure will help readers to comprehend the most up-to-date information on the similarities and differences in the contractile mechanisms driving various smooth muscles as well as their potential manipulations in particular visceral organ pathologies. The vast advancements in gene, electrical recording, and imaging technologies in this field are also discussed, with review of past achievements and consideration of likely future developments. This book will be of worldwide interest to clinicians, students, and researchers alike.
Download or read book The Human Endometrium written by Carlo Bulletti and published by . This book was released on 1994 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural, biochemical and clinical events related to menstruation, implantation, parturition, endometriosis, abnormal uterine bleeding and endometrial cancer are discussed in this comprehensive volume on the biological functions of the endometrium. New topics, such as the biochemical and molecular mechanisms regulating maternal embryonic interaction, are explored, and gynecologic endoscopy and therapeutic tools are discussed. The proceedings of the first conference is also available from the Academy, as volume 622 of The Annals of The New York Academy of Science.
Download or read book Dewhurst s Textbook of Obstetrics and Gynaecology written by Keith Edmonds and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: This time honoured classic has been re-built completely: after sixeditions the editor has decided that a radical revision isnecessary. The new edition has been developed as a result ofintensive consultation with trainees in OB/GYN as to what theywant, what they need and how they learn. The book is organised into two halves covering obstetrics andgynaecology. Within each, the chapters are structured into sectionscontaining pedagogic features such as boxes, highlights and keypoints for the first time. It contains everything the clinicianneeds to practice the art of obstetrics and gynaecology andsufficient information to help sub-specialists develop theirspecific interests. This text is recommended reading for the RoyalCollege of Obstetrics and Gynaecology membership examination. This seventh edition contains 21 new chapters: Anatomy of the Pelvis and Reproductive Tract Placenta and Fetal Membranes Antenatal Care Anaesthesia and Analgesia Recurrent Miscarriage Ectopic Pregnancy Trophoblastic Disease Genetics and Prenatal Diagnosis Drugs and Pregnancy Obstetric Emergencies Prolonged Pregnancy Renal Disease Termination of Pregnancy Imaging in Gynaecology PMS Assisted Reproduction Hysteroscopy and Laparoscopy Sexual Dysfunction Psychological Aspects of Pregnancy Domestic Violence and Sexual Assault - now on MRCOG curriculum Ethical Dilemmas This seventh edition has been significantly updated with a widerange of internationally renowned contributors who are all expertsin their field, bringing this book to the cutting edge of knowledgein obstetrics and gynaecology. "It was my favourite textbook when I was working for myexaminations and I am still using it. I can recommend this editionto current trainees wholeheartedly. It is certainly worth buying."Journal of Obstetrics and Gynaecology
Download or read book MRCOG Part One written by Alison Fiander and published by Cambridge University Press. This book was released on 2016-10-13 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
Download or read book Biomechanics of the Gravid Human Uterus written by Roustem N. Miftahof and published by Springer Science & Business Media. This book was released on 2011-07-21 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of human uterine function and regulation is one of the great wonders of nature and represents a daunting challenge to unravel. This book is dedicated to the biomechanical modeling of the gravid human uterus and gives an example of the application of the mechanics of solids and the theory of soft shells to explore medical problems of labor and delivery. After a brief overview of the anatomy, physiology and biomechanics of the uterus, the authors focus mainly on electromechanical wave processes, their origin, dynamics, and neuroendocrine and pharmacological modulations. In the last chapter applications, pitfalls and problems related to modeling and computer simulations of the pregnant uterus and pelvic floor structures are discussed. A collection of exercises is added at the end of each chapter to help readers with self-evaluation. The book serves as an invaluable source of information for researchers, instructors and advanced undergraduate and graduate students interested in systems biology, applied mathematics and biomedical engineering.
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Download or read book Precision Medicine in Gynecology and Obstetrics written by Ikuo Konishi and published by Springer. This book was released on 2017-06-13 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the scientific advances and current status of our understanding of precision medicine for common diseases in gynecology and obstetrics. Standard treatments based on clinical guidelines in the field have been established for decades, and those are essential to daily clinical practice. Meanwhile comprehensive genomic and genetic analyses have led to personalized medicine by precise clinical and genomic approaches. This book is organized into two major parts, gynecology and obstetrics, and the chapters in each part give a clear exposition of the current knowledge and the future perspectives for the treatment of various gynecological cancers, maternal disorders, and other diseases that affect female patients. Topics on novel treatment strategy with the application of molecular targeted drugs, immunotherapy, and prevention medicine are also covered. This collection benefits not only experienced gynecologists and obstetricians, but also young physicians who would like to begin clinical and basic research on diseases in women, researchers in basic medicine, and all medical oncologists who are involved in gynecological cancers.
Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Download or read book The Maternal Fetal Interface written by Anthony Carter and published by Boydell & Brewer. This book was released on 1998 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden
Download or read book The Fish Oocyte written by Patrick J. Babin and published by Springer Science & Business Media. This book was released on 2007-08-20 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the growing needs in deciphering the biological processes associated with fish reproduction, in view of the growth of aquaculture and the dwindling natural stocks of commercially important fish. It presents a comprehensive overview on egg production in fish, from the standpoint of the oocyte. With this view in mind, the book includes chapters on oocyte development (oogenesis), hormonal regulation and hormone receptors, formation of the egg envelopes, growth, accumulation of nutrients and maternal transcripts, maturation, hydration, ovulation and fertilization. A special emphasis is placed on using state-of-the-art tools including electron microscopy for discerning the ultra-structure of the follicle and genomic/proteomic tools to fully understand biological basis of fish reproduction. Studies on promoting oocyte maturation, ovulation and spawning in farmed fish and preservation of fish oocytes at low temperatures are also included. The book will appeal to University lecturers, students, research scientists and those associated with culture of fish in freshwater or marine aquaculture.
