Download or read book The Role of Human Papillomaviruses and Their Replication in Nonmelanoma Skin Cancer written by Lorna J. Mackintosh and published by . This book was released on 2011 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonmelanoma skin cancer (NMSC) is the commonest cancer worldwide and is a significant and increasing burden on health care resources. NMSC aetiology is fundamentally linked to sun exposure although infection with oncogenic viruses including Human Papillomaviruses (HPV) is thought to be a cofactor. Fair skinned populations residing in geographical areas with high sun exposure have an increased incidence of NMSC and an excess of NMSC is also observed in certain patient groups including immunosuppressed organ transplant recipients. This thesis describes the epidemiology of NMSC in the immunosuppressed renal transplant population in the West of Scotland. Clinical samples from this population were investigated for the presence of HPV utilising a PCR reverse hybridisation technique. This assay specifically examined for HPV of the genus Beta that have been previously linked to NMSC. The effect of presence of HPV in these samples was evaluated through an investigation of the expression of cellular biomarkers. A biomarker expression pattern specific to HPV infected lesions would add further support to the link between HPV and NMSC. Samples were probed for Ki67, p16, p53, MCM2 and MCM5 antigens in addition to novel antigen, Topoisomerase II Beta Binding Protein 1 (TopBP1). TopBP1 is a host cellular protein that is involved in the DNA damage response and is an interacting partner for HPV thus making it a likely candidate for involvement in cutaneous carcinogenesis. A biomarker expression pattern specific to HPV infected NMSC was not identified although aberrant expression of TopBP1 was identified in a subset of skin cancers. To investigate this novel observation, a molecular investigation of the interaction between TopBP1 and the viral replication factor E2 was carried out, firstly in HPV-16 before extending the work to the cutaneous virus HPV-8. A mutant of HPV-16E2 that failed to bind TopBP1 was generated. Failure to bind TopBP1 resulted in a phenotype exhibiting compromised viral replication. The equivalent mutation generated in HPV-8E2 resulted in an even more compromised replicative phenotype. In addition to this work, gene targets of TopBP1 were also identified by a microarray analysis. This was carried out using MCF7 cells untreated or damaged by ultraviolet radiation (UVR) with endogenous TopBP1 depleted by SiRNA treatment. These studies showed that TopBP1 is involved in a number of cellular processes and is likely to be involved in controlling DNA damage targets following UVR induced DNA damage. The work described in this thesis provides further evidence supporting the role of HPV in the aetiology of nonmelanoma skin cancer. Generation of an E2 mutant that fails to bind TopBP1 and exhibits a compromised replication phenotype provides further evidence to support the hypothesis that the E2-TopBP1 interaction is essential for viral replication and therefore the viral life cycle. This work may facilitate the development of anti-viral therapies for HPV-associated disease by targeting HPV DNA replication through disruption of the E2/TopBP1 interaction.

Download or read book Human Papillomaviruses and Polyomaviruses in Skin Cancer written by Herbert Johannes Pfister and published by Frontiers Media SA. This book was released on 2019-02-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonmelanoma skin cancer (NMSC), more recently defined as keratinocyte carcinoma (KC), is the most frequent malignant tumor among Caucasians. This book deals with widely distributed cutaneous papillomaviruses and polyomaviruses, which are able to establish life-long persistent infections. They are frequently clinically inapparent in the general population, but can cause skin cancer in immunocompromised hosts or in the aging skin undergoing immunosenescence, thereby leading to major medical problems. The incidence of cutaneous squamous cell carcinoma (cSCC) in immunosuppressed organ transplant recipients is 60-250 times higher than that observed in the general population, which is highly suggestive of viral etiology. The treatment of metastatic melanoma with BRAF-inhibitors can induce cSCC formation within only 8-12 weeks. The clinicopathological characteristics of these tumors led to speculations on a possible involvement of oncogenic viruses. The evidence presented in this eBook indicates that high priority should be given to the implementation of a prophylactic and/or therapeutic vaccination program against cutaneous papillomaviruses to prevent NMSC in immunosuppressed allograft recipients.

Download or read book Non melanoma skin cancer in HIV infection written by Sacha Imran Goolamali and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Study on the Potential Role of Cutaneous Human Papillomaviruses in the Development of Non melanoma Skin Cancer written by and published by . This book was released on 2005 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Papillomaviruses in Human Cancer written by Massimo Tommasino and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Papilloma Viruses written by D.J. McCance and published by Gulf Professional Publishing. This book was released on 2002-09-13 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes up-to-date information on the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic role of the viruses in epithelial cancers. Included in the book are chapters on the epidemiology of human papillomaviruses, the factors that control replication and transcription and the viral proteins, which are involved in modulating the biology of the host cell leading to cancer. Details of the immune response to the viruses and potential vaccine strategies are discussed.

Download or read book Studies on Cutaneous Human Papillomaviruses and Their Association with Non melanoma Skin Cancer written by Sarah Jackson and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Putative Role for Human Papillomaviruses in the Pathogenesis of Non melanoma Skin Cancer written by Thirunavukarasu Surentheran and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Papillomavirus and Cervical Cancer written by International Agency for Research on Cancer and published by . This book was released on 1989 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the evidence for a causal link between sexually transmitted infection with human papillomavirus (HPV) and the occurrence of cervical cancer, from a variety of different angles. Epidemiological studies and clinical, pathological, and cytological aspects of HPV infection are reviewed. Modern methods for analyzing HPV-DNA types by molecular biological techniques are described, and the statistical problems to be overcome in epidemiological work are explained. The volume was prepared by a broad team of experts from around the world, who met in Copenhagen in March 1988 to reach a consensus on the present state of understanding and to establish directions for future work.

Download or read book Non melanoma Skin Cancer in HIV Infection written by Sacha Imran Goolamali and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies on Cutaneous Human Papillomaviruses Adn Their Association with Non melanoma Skin Cancer written by S. E. Jackson and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biology of Skin Cancer excluding Melanomas written by O. D. Laerum and published by . This book was released on 1981 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Investigating the Role of Human Papillomavirus DNA Replication in the Development of Cervical Cancer written by Lauren E. King and published by . This book was released on 2010 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Human Viruses Diseases Treatments and Vaccines written by Shamim I. Ahmad and published by Springer Nature. This book was released on 2021-05-19 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.

Download or read book The Papillomaviruses written by Robert Garcea and published by Springer Science & Business Media. This book was released on 2007-08-19 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume evaluates the carcinogenic risk to humans posed by infection with human papillomaviruses (HPVs). To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies. Worldwide, cervical cancer is the second most common cancer in women. This book also considers the possible involvement of HPV infection in cancers at other sites of the human body.

Download or read book HPV and Cancer written by James A. Radosevich and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: “HPV and Cancer” is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers. While written by professionals, it design to be understandable by those that are not in the field, yet it has the technical details that professionals want to stay abreast of this changing field. The book starts out the history of HPV and progresses into the molecular biology of the virus and our current understand of the structure and functions of the proteins and genes it encodes. We then look at the dynamic trends of this infectious agent in the human population, how it interacts with human cells, and the role it plays with other organisms to produce both benign and malignant tumors. Lastly, there is a discussion about a new vaccine for HPV and the hopes that are held by many to change the trends with this virus and the associated cancers it produces.

Download or read book Human Papillomaviruses and the Molecular Pathogenesis of Non melanoma Skin Cancer Associated with Organ Transplantation written by Catherine Anne Harwood and published by . This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: