Download or read book The Role of Hormone Replacement Therapy in Preventing Cognitive Decline in Healthy Postmenopausal Women written by Grace J. Lee and published by . This book was released on 2009 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract Hormone replacement therapy (HRT) may protect postmenopausal women from cognitive decline. The effect of HRT on the relative decline in cognitive functioning of postmenopausal women across time was examined in 104 participants (35 HRT users, 15 HRT non-users, and 54 males) who completed neuropsychological evaluations at baseline and follow-up. On language scores, HRT users demonstrated more improvement over time than did men, whereas HRT non-users performed similar to men. Additionally, more years of HRT use was associated with more improvement in HRT users' delayed verbal memory scores between baseline and follow-up, r(28) = .34,p

Download or read book Hormone Replacement Therapy and Cognition written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-06-28 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this systematic evidence review, we evaluate data on the use of hormone replacement therapy (HRT) to prevent cognitive decline and dementia in healthy postmenopausal women. Specifically, we reviewed the literature reporting effects of HRT on cognitive function in women without dementia. In addition, we conducted a review and meta-analysis of studies of HRT and dementia, focusing on Alzheimer disease. Results of this review have been recently published. This report is part of a larger project on the risks and benefits of HRT prepared for the U.S. Preventive Services Task Force to assist them in making recommendations. Between 3 and 8 million people in the United States have dementia. The most common type of dementia is Alzheimer disease, which affects 3 to 4 million people and is the fourth leading cause of death in the United States. The incidence of dementia is 1 percent per year in older individuals, although in the most elderly populations this rate may be as high as 2 to 3 percent. One community-based prevalence study in east Boston estimated that almost 50 percent of those aged 85 and over suffered from dementia. Most studies report that after accounting for differences in life expectancy, women have a 1.4 to 3-fold higher risk of Alzheimer disease than men. The life expectancy of demented patients is greatly reduced. Those with early-onset (before age 60) Alzheimer disease have a median survival of 6.7 to 8.1 years, while survival in those with late-onset disease is 4.8 to 6.0 years. In 1991, the annual cost of Alzheimer disease was estimated to be $67.3 billion. Given the expected growth of the elderly population, this financial cost, as well as the emotional and physical costs of caring for demented patients, will continue to increase. Observational data suggest a possible but inconsistent relationship between endogenous estrogen exposure and cognition. Women in the high estrogen phase of the menstrual cycle have been shown to perform better on tests of motor skills compared to when they are in the low estrogen phase of the cycle. Bone mineral density, hypothesized to be a marker of cumulative estrogen exposure, has been correlated with risk of cognitive deterioration. Because of the association between endogenous estrogen exposure and cognition, it can be hypothesized that hormone replacement therapy (HRT) after menopause may prevent cognitive decline and the development of dementia.

Download or read book Hormones Cognition and Dementia written by Eef Hogervorst and published by Cambridge University Press. This book was released on 2009-09-24 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.

Download or read book Focus on Hormone Replacement Research written by Marcus I. Portallis and published by Nova Publishers. This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone replacement therapy is now simply called hormone replacement because of research discoveries identifying possible severe risks associated with this treatment which was very favourably viewed earlier. Now the lowest effective dose and the shortest duration of treatment acceptable is advised. This new book presents state-of-the-art research from around the world in HR and its relation to endometrial cancer, cardiovascular disease, Alzheimer's disease, schizophrenia, mood and anxiety disorders, Parkinson's disease, Huntington's disease and bone mass.

Download or read book Hormone Replacement Therapy and Cognition written by Erin LeBlanc and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: CONTEXT: Although postmenopausal hormone replacement (HRT) therapy is widely used, its risks and benefits are not well understood. Some observational data suggest that HRT may reduce the risk of cognitive decline and dementia but results have been conflicting. OBJECTIVE: To review and evaluate studies of HRT for preventing cognitive decline and dementia in healthy postmenopausal women. DATA SOURCES: Studies with English-language abstracts identified in MEDLINE (1966-December 2000), HealthSTAR (1975-December 2000), PsychINFO (1984-December 2000); Cochrane Library databases; and articles listed in reference lists of key articles. STUDY SELECTION: Randomized controlled trials and cohort studies were reviewed for the effects of HRT on cognitive decline; cohort and case-control studies were reviewed for dementia risk. No randomized controlled trials regarding dementia risk were identified. DATA EXTRACTION: Twenty-nine studies met inclusion criteria and were rated. Two reviewers rated study quality independently and 100% agreement was reached on Jadad scores and 80% agreement was reached on U.S. Preventive Services Task Force quality scores. A final score was reached through consensus if reviewers disagreed. DATA SYNTHESIS: Studies of cognition were not combined quantitatively because of heterogeneous study design. Women symptomatic from menopause had improvements in verbal memory, vigilance, reasoning, and motor speed, but no enhancement of other cognitive functions. Generally, no benefits were observed in asymptomatic women. A Bayesian meta-analysis of 12 observational studies suggested that HRT was associated with a decreased risk of dementia (summary odds ratio, 0.66; 95% confidence interval, 0.53-0.82). However, possible biases and lack of control for potential confounders limit interpretation of these studies. Eight studies received a poor quality rating, 3 fair, and 1 good. Studies did not contain enough information to assess adequately the effects of progestin use, various estrogen preparations or doses, or duration of therapy. CONCLUSIONS: In women with menopausal symptoms, HRT may have specific cognitive effects, and future studies should target these effects. The meta-analysis found a decreased risk of dementia in HRT users but most studies had important methodological limitations.

Download or read book The Effects of Estrogen on Brain Function written by Natalie L. Rasgon and published by JHU Press. This book was released on 2006-05-05 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume reviews current data on the effects of estrogen on the central nervous system, highlighting clinical aspects of this topic. Experts from the fields of psychiatry, pharmacology, neurology, and geriatrics collaborate to clarify the known risks and benefits of hormone therapy and explore questions that remain to be elucidated. Among the topics discussed: " Preclinical data on estrogen's effects on cognitive performance " The short-lived effects of hormone replacement therapy on cognitive function " Structural and functional brain imaging data regarding estrogen's effects on the central nervous system " Preclinical efforts to develop effective NeuroSERMs for the brain " The effects of estrogen on mood Citing the ongoing confusion over the risks and benefits of estrogen therapy, the contributors emphasize the need for additional research on medication, doses, preparations, methods of administration, alternative therapies, and supplements. This volume educates researchers, clinicians, and students on the current knowledge—including the effects of estrogen on mood, cognition, and brain metabolism—and provides guidelines for clinical practice and future research. Contributors: Roberta Diaz Brinton, Ph.D., University of Southern California; Cheri L. Geist, B.A., David Geffen School of Medicine, University of California at Los Angeles; Robert B. Gibbs, Ph.D., University of Pittsburgh School of Pharmacy; Eva Hogervorst, Ph.D., University of Loughborough and University of Oxford; Pauline M. Maki, Ph.D., Neuropsychiatric Institute, University of Illinois–Chicago; Peter J. Schmidt, M.D., National Institute of Mental Health; Daniel H. S. Silverman, M.D., Ph.D., David Geffen School of Medicine, University of California at Los Angeles; Katherine E. Williams, M.D., Stanford University School of Medicine; Kristine Yaffe, M.D., University of California, San Francisco, and San Francisco VA Medical Center; Laurel N. Zappert, B.A., Stanford University School of Medicine; Liqin Zhao, Ph.D., University of Southern California

Download or read book Cognitive Performance and Menopause written by Paula Alhola and published by . This book was released on 2007 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Women s Health and Menopause written by Roger Lobo and published by Springer Science & Business Media. This book was released on 2002-10-31 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th International Symposium on Women's Health and Menopause, organized by the Giovanni Lorenzini Medical Foundation (Milan, Italy and Houston, Texas) focused on the new strategies to improve the quality of life of post-menopausal women. This volume illustrates the findings of this conference and includes information on the age-related degenerative processes occurring after menopause including cardiovascular disease, cancer, fractures and dementia.

Download or read book International Position Paper on Women s Health and Menopause written by and published by DIANE Publishing. This book was released on 2002 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Sex and Gender Factors Affecting Metabolic Homeostasis Diabetes and Obesity written by Franck Mauvais-Jarvis and published by Springer. This book was released on 2017-12-08 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

Download or read book Preventing Cognitive Decline and Dementia written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-10-05 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.

Download or read book Research on the Menopause in the 1990s written by and published by . This book was released on 1996 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report reviews current research on the menopause, including studies on its symptons and their treatment, and its effects on the cardiovascular and skeletal systems. It also assesses the relevance of existing data to women in developing countries.

Download or read book Women s Health and Menopause written by Rodolfo Paoletti and published by Springer Science & Business Media. This book was released on 1999-09-30 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The population structure in the world is rapidly changing, to the extent that in 75 years we will face a tripling of the elderly population. Although women are favored in terms of life expectancy, they also live with a longer period of disability (approximately twice that of aging men), as well as with the enemies of all the elderly, cardiovascular disease, cancer, and dementia. Menopause is the endocrine event that overlaps with aging, potentially worsening both the quality of life and the risks of disease in women. While the effect of hormone replacement therapy (HRT) on menopausal symptoms is generally viewed as rapid and consistent, and is thereby accepted by the scientific community, its relationship to the other aforementioned chronic conditions associated with menopause is considered variable and controversial. In analyzing these complex issues, this volume yields new and significant insights into both the study of menopause-related disorders and their treatment, by illustrating the most recent information on mechanisms of actions of new estrogen receptors and on the use of sophisticated techniques of statistical analysis for population-based studies.

Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders.KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine

Download or read book Effects of Hormone Replacement Therapy on Mood and Cognition in Healthy Postmenopausal Women written by Candace Michelle Genest and published by . This book was released on 2007 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oestrogen Matters written by Dr Avrum Bluming and published by Hachette UK. This book was released on 2018-09-04 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'I believe it is an ethical imperative for all clinicians who treat women in menopause or women with breast cancer to alert their patients to this book' Michael Baum, MD, Professor Emeritus of Surgery and visiting professor of Medical Humanities, University College London 'A thorough, careful and unbiased assessment . . . This extremely valuable message deserves to be widely disseminated' Lord Turnberg, former President of the Royal College of Physicians A compelling defence of hormone replacement therapy, exposing the faulty science behind its fall from prominence and empowering readers to make informed decisions about their health. For years, hormone replacement therapy (HRT) was hailed as a miracle. Study after study showed that HRT, if initiated at the onset of menopause, could ease symptoms ranging from hot flushes to memory loss; reduce the risk of heart disease, Alzheimer's, osteoporosis, and some cancers; and even extend a woman's overall life expectancy. But when a large study by the Women's Health Initiative announced results showing an uptick in breast cancer among women taking HRT, the winds shifted abruptly, and HRT, officially deemed a carcinogen, was abandoned. Now, sixteen years after HRT was left for dead, Dr Bluming, a medical oncologist, and Dr Tavris, a social psychologist, track its strange history and present a compelling case for its resurrection. They investigate what led the public - and much of the medical establishment - to accept the Women's Health Initiative's often exaggerated claims, while also providing a fuller picture of the science that supports HRT. A sobering and revelatory read, Oestrogen Matters sets the record straight on this beneficial treatment and provides an empowering path to wellness for women everywhere.

Download or read book Dementia in Australia written by Australian Institute of Health and Welfare and published by AIHW. This book was released on 2012 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides a comprehensive picture of dementia in Australia, illustrated by the latest available data and information on trends over time.