Download or read book The role of cytokines in a mouse model of allergic asthma written by Edith Margarethe Hessel and published by . This book was released on 1997 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Download or read book The Immunological Basis of Asthma written by Bart Lambrecht and published by CRC Press. This book was released on 2003-02-26 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and aller
Download or read book Immunopathogenesis in a Mouse Model of Human Asthma written by Husein Hadeiba and published by . This book was released on 2002 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Role of CD4 T cell sub populations in allergic asthma written by Shakti P. Pattanayak and published by GRIN Verlag. This book was released on 2016-07-27 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Essay from the year 2016 in the subject Medicine - Pharmacology, Pharmacy, , language: English, abstract: Asthma is a chronic disorder specifically characterized by severe inflammation and constriction, mucus hyper-secretion and hyper-responsiveness in the airway. Allergic Asthma (AA) is characterized by discontinuous airway obstruction that may cause temporary to severe asphyxiation and can consequence into death. Airway obstruction in asthma is because of rigorous inflammation concerning multi-cellular components together with eosinophils, neutrophils, CD4+T lymphocytes & mast cells, with eosinophilic infiltration being the most conspicuous feature. The multifaceted phenotype of AA suggested being elevated from multiple interactions of infiltrating and structural cells that is coordinated by T helper 2 (TH2) cells consequential in chronic airway inflammation. By extremely secreting convinced mediators like interleukin (IL)-4, IL-5, and IL-13, which grasps a key point in asthma pathogenesis cause erratic degree of broncho-obstruction, increased mucus production, and airway remodeling. There are a variety of T cell which plays a significant role in AA that is TH1, TH2, TH17, regulatory T cell, TH3 TH22, TH25, TH9 and others. There are various molecular signaling molecules such as STAT4, FOXp3, GATA-3 and T-bet which regulates CD4+T cells in AA. Nowadays the approach to manage asthma is based on inhaled bronchodilator and corticosteroids. But the research is on the mechanism of some promising phytomedicines. we summarized here with some mechanisms of some flavonoids to alleviate AA through CD4+T cells. In conclusion, we found that the CD4+T-cell subpopulations played some major contribution in regulating/modulating the AA and interestingly, the natural potent anti-oxidant & anti- inflammatory compounds such as flavonoids could able to attenuate the AA by regulating these subpopulations of CD4+T-cells or the signaling molecules involved in the pathogenesis.
Download or read book Interleukin 16 in a Mouse Model of Allergic Asthma written by Joris Johannes de Bie and published by . This book was released on 1999 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Asthma written by Celso Pereira and published by BoD – Books on Demand. This book was released on 2016-07-06 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical specificities developed in this book, particularly from those reported in the pediatric population to those reported in complex shapes at ACOS patients, emphasize the importance of identifying not only biomarkers but also critical aspects regarding the variability in pharmacogenomics responsible for the individual response to the different drugs on the therapeutic plan. The contribution of several well-known specialists with their profound knowledge inherent to this issue into different age groups and socio geographical contexts has resulted in this interesting book with relevant key contents in asthma.
Download or read book Human Eosinophils written by Gianni Marone and published by Karger Medical Scientific. This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils represent approximately 1% of peripheral blood leukocytes and play a central proinflammatory and immunoregulatory role in various immune disorders. This volume provides the reader with a comprehensive survey of the major aspects of human eosinophilic biology and immunology as well as the most clinically relevant aspects of eosinophil-related disorders. Expert contributions cover the ultrastructural and phenotypic characteristics of human eosinophils, and their fundamental biochemical features including receptors for IgE and chemokines. The production of cytokines and their role in the activation of eosinophils are reviewed. Furthermore, the classic eosinophil-related disorders such as hypereosinophilia, drug reactions, allergic disorders and some cardiovascular diseases are described. Each of the chapters is written by an investigator actively engaged in research on the topic under consideration. The well-edited and stimulating material compiled in this volume will be of interest to all those working in allergology, immunology, biochemistry and pulmonary medicine.
Download or read book The Role of Regulatory T Cells in the Development and Resolution of a Mouse Model of Ovalbumin induced Allergic Airway Disease written by William Franklin Carson and published by . This book was released on 2007 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Excellence in Otolaryngology written by T. Himi and published by Karger Medical and Scientific Publishers. This book was released on 2016-04-28 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is dedicated to the 70th anniversary of the Department of Otolaryngology of the Sapporo Medical University. It commemorates this landmark event and honors the department’s rich tradition of excellence. Chapters feature results of clinical and basic research conducted at the university. The carefully selected articles – ten clinical reviews, ten original research papers, and one case report – reflect the wide range of specialty fields within the department. Topics covered include otology, allergy and rhinology, oncology, sleep medicine, and tonsils. This book is a comprehensive, inspiring contribution to the celebration of one of the oldest departments within the Sapporo Medical University. It contains valuable information for new and experienced otolaryngologists, neurotologists, allergologists, and head and neck surgeons.
Download or read book Eosinophils in Health and Disease written by James J. Lee and published by Academic Press. This book was released on 2012-11-02 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Download or read book Role of Broncho alveolar Macrophages in Airway Eosinophilia in a Mouse Model of Asthma written by Shafiuddin Siddiqui and published by . This book was released on 2008 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book I Characterization of Type 2 Cytokine Response to Allergens in a Mouse Model of Food Allergy and II The Effect of Selected Herbal Supplements on Allergen Driven Type 2 Cytokine Response by Spleen Cells from Food Allergic Mice written by Sitaram Parvataneni and published by . This book was released on 2007 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Immune Regulation written by Richard D. Granstein and published by S. Karger AG (Switzerland). This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the topics reviewed are T and B cell tolerance, clonal deletion, suppressor cells, mechanisms of immune privileged sites and experimental models of tumor immunity. Oral tolerance, ultraviolet radiation and photosensitized effects on immunity, allograft management, T cell vaccination and regulation of immunity with T cell epitopes are discussed from the point of view of possible therapeutic application.
Download or read book IL 33 and ST2 in Allergic Asthma written by Tammie Nguyen and published by . This book was released on 2013 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although our understanding of the pathogenesis of asthma remains limited, data now indicate that most patients with asthma have an immune-mediated component. Allergic asthma is thought to involve a response to a specific antigen that triggers a specific adaptive immune response in the lung that requires time. However, new data also implicate the innate immune response, either in concert with or independent of the adaptive response. The broad goal of this project was to explore the role that the cytokine interleukin (IL) 33 and its receptor, ST2, may play in asthma. The first objective was to explore the role of ST2 in a mouse model of asthma in which ovalbumin is used to induce airway hyperresponsiveness and inflammation. We hypothesized that ovalbumin-challenged mice would show increased expression of ST2 compared to unchallenged mice. The second objective was to characterize the stimuli for expression and release of IL-33 from the human airway epithelium using the human airway epithelial cell line BEAS-2B. We hypothesized that IL-33 auto-regulates its expression in airway epithelial cells. By Western blot, we found that expression of the soluble form of ST2 (sST2) appeared higher in lung tissue from ovalbumin-challenged mice compared to lung tissue from control mice. Similarly, by immunohistochemistry, we found higher expression of ST2 in lung tissue of ovalbumin-challenged mice compared to controls. Staining with mouse anti-ST2 antibody also showed ST2 expression in mediastinal lymph node tissue from ovalbumin-challenged mice. By flow cytometry, we found that splenic tissue from ovalbumin-challenged mice had a higher proportion of CD4+ cells that expressed ST2 on the cell surface (CD4+ST2+ cells) compared to control mice. We then studied BEAS-2B cells that had been conditioned with 10 ng/ml of human recombinant IL-33 in growth media or growth media alone for 24 hours at 37°C. However, our results from RT-PCR and ELISA showed that BEAS-2B cells did not express significant IL- 33 with or without IL-33 conditioning. This result could be explained by a de-differentiated state of BEAS- 2B cells in the culture conditions we used, which did not closely approximate primary bronchial epithelial cells. Overall, our results suggest that ST2 may play a role in asthma, though the interactions of the different isoforms of ST2 are very complex and further work is required to understand exactly how they may affect the pathogenesis of allergic asthma. Our results also suggest that IL-33 may have some role in auto-regulating its own expression in human airway epithelium, though further work in primary airway epithelium or using BEAS-2B cells in different culture conditions to promote differentiation would be needed to explore this further.
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
