Download or read book The Role of Copper and Its Chelation by Tetrathiomolybdate in Inflammation and Atherosclerosis written by Hao Wei and published by . This book was released on 2010 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these processes. The goals of my studies were to investigate the role of copper in systemic and vascular inflammation, endothelial activation, and atherosclerotic lesion development, using tetrathiomolybdate (TTM), a clinically-used copper chelator, as a specific means to manipulate cellular copper levels in vitro and in vivo. Incubation of human aortic endothelial cells (HAEC) with copper induced activation of the redox-sensitive transcription factors, nuclear factor kappa B (NF-kB) and activator protein-1 (AP-1) and up-regulation of mRNA and protein levels of adhesion molecules and the chemokine, monocyte chemotactic protein-1 (MCP-1), in a dose- and time-dependent manner. Furthermore, TTM inhibited TNF[alpha]-induced increases of mRNA and protein levels of adhesion molecules and MCP-1 in a dose-dependent manner. TNF[alpha]-induced activation of NF-kB and AP-1 also was dose-dependently attenuated by TTM, and inhibition of NF-kB activity was associated with decreased phosphorylation and degradation of its cytosolic inhibitory subunit, IkBa. In an in vivo model of systemic inflammation using of C57BL mice, oral TTM administration for three weeks significantly reduced bioavailable copper and inhibited lipopolysaccharide (LPS)-induced upregulation of inflammatory gene expression in aorta and heart. Tetrathiomolybdate also significantly inhibited LPS-induced increases of serum levels of soluble adhesion molecules, MCP-1, and pro-inflammatory cytokines. Similar inhibitory effects of TTM were observed on NF-kB and AP-1 activation in the heart and lungs. In apolipoprotein E-deficient (apoE-/-) mice, a well established animal model of human atherosclerosis, dietary supplementation with TTM for ten weeks significantly reduced bioavailable copper and attenuated atherosclerotic lesion development, which was particularly pronounced in the descending aorta. This anti-atherogenic outcome of TTM supplementation was accompanied by several anti-inflammatory effects, such as significantly declined serum levels of soluble adhesion molecules, reduced aortic gene expression of inflammatory mediators, and less aortic macrophage accumulation. Importantly, TTM supplementation for ten weeks did not cause liver toxicity or anemia. In conclusion, my studies provide the proof of concept that copper plays an important role in systemic and vascular inflammation and the pathogenesis of atherosclerosis, and demonstrate that tetrathiomolybdate exerts anti-inflammatory and anti-atherogenic effects in preclinical animal models. The possible implications of these findings for cardiovascular and inflammatory diseases in humans remain to be investigated.

Download or read book Atherosclerosis New Insights for the Healthcare Professional 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Atherosclerosis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Atherosclerosis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Foundations of Naturopathic Nutrition written by Fay Paxton and published by Routledge. This book was released on 2020-07-16 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition is a vital part of the complementary approach to health. This uniquely comprehensive and evidence-based text provides a detailed and systematic guide to the principles of clinical nutrition from a naturopathic perspective. The text begins with an overview of basic physiological principles and the body's protective systems, such as the antioxidant, detoxification and immune systems. The focus then moves to an in-depth examination of food components, including essential nutrients, such as protein, lipids, carbohydrates, vitamins, minerals and trace elements, as well as nutritional bioactives, such as coenzyme Q10, alpha-lipoic acid, phytochemicals, digestive enzymes and probiotics. There is detailed information on how each food component is digested and metabolised in the body, and guidance on its impact on health, including an explanation of the effects of inadequate and excessive intake. The types of supplements available together with dietary sources are also explored. Discussions of important nutritional topics are featured - for example, water as therapy, obesity, anorexia nervosa, high-protein diets, hypoglycaemia, diabetes, phytosterols, gamma-tocopherol, vitamin E and mortality, vitamin C and cancer, infantile scurvy, acid-forming and alkaline-forming diets, hair analysis, sodium and blood pressure, and coenzyme Q10 and cancer. Summary boxes, case studies and quizzes will help readers consolidate their knowledge. Foundations of Naturopathic Nutrition is an essential reference for everyone studying nutrition from a complementary health perspective. 'I thoroughly recommend this book as a learning aid for students, and as an excellent reference guide for experienced practitioners.' - Jackie Day, President, Naturopathic Nutrition Association (UK) 'A fabulous resource, not only for practitioners but also all those with an interest in nutrition.' - Professor Alan Bensoussan, Director, National Institute of Complementary Medicine, University of Western Sydney 'The foundation nutrition text we've all been waiting for. Fay Paxton has drawn from her many years of clinical nutrition experience, combining it with relevant research-based evidence, to produce an exhaustive body of work that is unique in its specific relevance to naturopathic and complementary medicine students and practitioners.' - David Stelfox, Associate Program Leader, Naturopathy, Endeavour College of Natural Health

Download or read book Textbook of Hepatology written by Juan Rodés and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 2360 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE encyclopedic guide to hepatology – for consultation by clinicians and basic scientists Previously the Oxford Textbook of Clinical Hepatology, this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: Symptoms and signs in liver disease Industrial diseases affecting the liver The effects of diseases of other systems on the liver The effects of liver diseases on other systems It's bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD ROM of the entire content. Click here to view a sample chapter on the liver and coagulation

Download or read book Chelation Therapy in the Treatment of Metal Intoxication written by Jan Aaseth and published by Academic Press. This book was released on 2016-04-18 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Download or read book Copper in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2000-04-12 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.

Download or read book Biomedical Applications of Metals written by Mahendra Rai and published by Springer. This book was released on 2018-02-24 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.

Download or read book Tietz Fundamentals of Clinical Chemistry Passcode Only written by Carl A. Burtis and published by W B Saunders Company. This book was released on 2007-11-06 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Pageburst digital textbook; the product description may vary from the print textbook. A condensed, student-friendly version of Tietz Textbook of Clinical Chemistry, this text uses a laboratory perspective to provide you with the chemistry fundamentals you need to work in a real-world, clinical lab. Accurate chemical structures are included to explain the key chemical features of relevant molecules. Offering complete, accurate coverage of key topics in the field, it's everything that you expect from the Tietz name! More than 500 illustrations and easy-to-read tables help you understand and remember key concepts. Key words, learning objectives, and other student-friendly features reinforce important material. Chapter review questions are included in an appendix to test your knowledge. A two-color design makes it easier to read and easy to find important topics. In-depth, reader-friendly content is appropriate for MT/CLS and MLT/CLT students and may also be used by laboratory practitioners, pathology residents, and others. A new chapter on newborn screening discusses the basic principles, screening recommendations, inborn errors, methods, and interpretation of results. A comprehensive glossary provides easy-to-find definitions of key terms. An Evolve website provides regular updates of content, answers to review questions, and web links to related sites for further research and study.

Download or read book Medicinal Inorganic Chemistry written by Jonathan L. Sessler and published by . This book was released on 2005 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.

Download or read book Present Knowledge in Nutrition written by John W. Erdman, Jr. and published by John Wiley & Sons. This book was released on 2012-05-30 with total page 2062 pages. Available in PDF, EPUB and Kindle. Book excerpt: Present Knowledge in Nutrition, 10th Edition provides comprehensive coverage of all aspects of human nutrition, including micronutrients, systems biology, immunity, public health, international nutrition, and diet and disease prevention. This definitive reference captures the current state of this vital and dynamic science from an international perspective, featuring nearly 140 expert authors from 14 countries around the world. Now condensed to a single volume, this 10th edition contains new chapters on topics such as epigenetics, metabolomics, and sports nutrition.The remaining chapters have been thoroughly updated to reflect recent developments. Suggested reading lists are now provided for readers wishing to delve further into specific subject areas. An accompanying website provides book owners with access to an image bank of tables and figures as well as any updates the authors may post to their chapters between editions. Now available in both print and electronic formats, the 10th edition will serve as a valuable reference for researchers, health professionals, and policy experts as well as educators and advanced nutrition students.

Download or read book Progressive Brain Disorders in Childhood written by Juan M. Pascual and published by Cambridge University Press. This book was released on 2017-04-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Download or read book Trace Elements in Abiotic and Biotic Environments written by Alina Kabata-Pendias and published by CRC Press. This book was released on 2015-04-07 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book helps readers understand the fundamental principles and phenomena that control the transfer of trace elements. It describes the occurrence and behavior of trace elements in rocks, soil, water, air, and plants, and also discusses the anthropogenic impact to the environment. In addition, the book covers the presence of trace elements in feeds, as either contaminants or as nutritional or zootechnical additives, and their transfer across the food chain to humans. All trace elements are covered-from aluminum to zirconium-as well as rare-earth elements (actinides and lanthanides).

Download or read book The Eye in Pediatric Systemic Disease written by Alex V. Levin and published by Springer. This book was released on 2017-06-20 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​This book is the first of its kind to describe ocular manifestations of systemic diseases in the pediatric population. Written and edited by experts in areas of pediatric ophthalmology and genetics, this new text covers a multitude of topics in a comprehensive and cataloged fashion. The Eye in Pediatric Systemic Disease is designed as an in-depth and up-to-date reference work that is heavily referenced, thus allowing the reader ready access to the international supporting literature. Everything from ocular manifestations of hematologic disease, child abuse, psychiatric diseases, renal disorders, and vitamin disorders are covered, allowing readers to know what to look for in the eyes of children with a given systemic disorder. The Eye in Pediatric Systemic Disease is written in language that is accessible to ophthalmologists and pediatricians, as well as allied health care professionals.

Download or read book Cerebellar Disorders written by Mario Ubaldo Manto and published by Cambridge University Press. This book was released on 2010-03-25 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.

Download or read book Laboratory Evaluations for Integrative and Functional Medicine written by Richard S. Lord and published by Metametrix Institute. This book was released on 2008 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Naturopathic Oncology written by Neil McKinney and published by . This book was released on 2012-10 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated for 2012, this book, Dr. Neil McKinney's fourth on naturopathic oncology, is updated with the rewards of clinical practice, study, research and reader feedback over the last several years. Patients and integrative physicians will find it easier to navigate, more complete, and of real service. DO: use this book to be informed about your best options, and what to expect them to accomplish. THEN: get expert guidance from a licensed, accountable, health professional team experienced in treating cancer. Cancer is a life-threatening disease in most cases. You do not have the objectivity, experience or knowledge to make critical medical decisions alone. This is not just a legal disclaimer! Cancer is unforgiving of delays and poor choices.

Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).