Download or read book Textbook of Aging Skin written by Miranda A. Farage and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.

Download or read book Medicinal Foods as Potential Therapies for Type 2 Diabetes and Associated Diseases written by Solomon Habtemariam and published by Academic Press. This book was released on 2019-06-08 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. - Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level - Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases - Examines the pharmacological findings on medicinal foods, including available clinical trials

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Download or read book Human Hemoglobins written by Howard Franklin Bunn and published by W.B. Saunders Company. This book was released on 1977 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.

Download or read book Diabetes and Protein Glycosylation written by Margo Panush Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the initial discovery that blood from diabetic patients contains increased amounts of a posttranslationally gluco sylated form of hemoglobin (hemoglobin Ale)' an impressive number of studies have clarified and expanded the use of glycohemoglobin levels to assess disease status. Many other structural proteins have been shown to undergo similar changes, including proteins from tissues most commonly affected in diabetes (e.g., lens, aorta, peripheral nerve, basement membrane). Thus, the nonenzymatic glycosylation of hemoglobin emerges as an invaluable model for the pathogenesis of certain chronic diabetes complications. In addition to reviewing a wealth of investigative possibilities in the area of these chronic complications-including eye, kidney, nerve, and vascular disease-Dr. Cohen indicates how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for maintenance of long-term euglycemia. Dr. Cohen is an endocrinologist and diabetes specialist whose research activities have largely focused on the chemistry and metabo lism of the basement membrane in diabetes. This superb monograph on nonenzymatic glycosylation clearly shows the major trends of her past and present research and clinical activities. This book is beautifully written and a pleasure to read. It provides great insight into the mechanisms of the pathogenesis of the oom- vii viii Foreword cations of diabetes and should be of immense value not only to basic and clinical investigators, but also to internists, diabetologists, and endocrinologists in clinical practice.

Download or read book Mechanisms Linking Aging Diseases and Biological Age Estimation written by Sara C. Zapico and published by CRC Press. This book was released on 2017-03-27 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Download or read book Encyclopedia of Gerontology L Z and Index written by and published by . This book was released on 1996 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive source that offers a multidisciplinary overview of all aspects of aging.

Download or read book Diabetes Mellitus written by Derek LeRoith and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 1608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.

Download or read book MAO The Mother of all Amine Oxidases written by J. P. M. Finberg and published by Springer Science & Business Media. This book was released on 1998 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinsona (TM)s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and characterization of these phenotypes, as well as the structure of MAO genes, is explored. Advances in the biochemistry of MAO subtypes and their physiological function and localization in brain and periphery is included. Other sections of the book deal with the neuroprotective action of MAO inhibitors and their pharmacology, especially the pharmacology of new MAO-B inhibitors.

Download or read book Aging of Organisms written by H.D. Osiewacz and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological aging as the time-depending general decline of biological systems associated with a progressively increasing mortality risk is a general phenomenom of great significance. The underlying processes are very complex and depending on genetic and environment factors. These factors encode or affect a network of interconnected cellular pathways. In no system this network has been deciphered in greater detail. However, the strategy of studying various biological systems has let to the identification of pathways and specific modules and makes it obvious that aging is the result of different overlapping mechanisms and pathways. Some of these appear to be conserved ("public") among species, others are specific or "private" and only of significance in one or a few organisms. This volume in the series on "Biology of aging and its modulation" specifically focuses on organismic aging. The book covers research on organisms from lower to higher complexity representing examples from very diverse taxa like photosynthetic plants, fungi, sponges, nematodes, flies, birds and mammals. Such a broad treatise of this complex topic provides a comprehensive "flavor" about the current issues dealt with in this rapidly growing scientific discipline.

Download or read book Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters written by Shuguang Ma and published by Elsevier Science. This book was released on 2020-07-24 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Download or read book Co and Post Translational Modifications of Therapeutic Antibodies and Proteins written by T. Shantha Raju and published by John Wiley & Sons. This book was released on 2019-03-15 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.

Download or read book Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and published by BoD – Books on Demand. This book was released on 2021-01-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Download or read book Diabetes written by R. D. G. Leslie and published by Cambridge University Press. This book was released on 1995-03-09 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This significant new publication provides a summary and overview of the most recent scientific advances in diabetes research, and highlights the role of these developments in advancing clinical practice. Diabetes is one of the major causes of morbidity and mortality in the developed world, and its prevalence elsewhere is on the increase. It affects in excess of 100 million people worldwide. Recent scientific advances have clarified our understanding of the causes and consequences of this devastating disease. These scientific developments are playing an increasingly important role in clinical practice and could well lead the way to the prevention of complications and even a cure for the disease. An international and authoritative team of authors draws together this knowledge and the most recent developments to provide an up to date account which will benefit researchers and clinicians.

Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Download or read book Choroidal Disorders written by Jay Chhablani and published by Academic Press. This book was released on 2017-05-31 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Choroidal Disorders provides an overview on various chorioretinal disorders with a special emphasis on choroidal imaging. As our understanding of the choroid has significantly improved with the development of advanced optical coherence tomography (OCT) and its role in posterior segment diseases is gaining new significance, this book focuses on the related improvements, diagnostic capabilities, management and prognosis of various chorioretinal disorders. It covers conventional techniques, such as ultrasonography and indocyanine green angiography as well as the most advanced techniques, including enhanced depth imaging OCT, swept source OCT, and OCT angiography. - Concise overview of various chorioretinal disorders, with special emphasis on choroidal imaging - Written for practitioners and researchers in sensory systems (vision), ophthalmologists, and retina specialists - Covers the most advanced imaging techniques in choroidal disorders, such as enhanced depth imaging OCT, swept source OCT, and OCT angiography