Download or read book The Relationship of Perinatal Malnutrition to Brain Development written by E. J. Hawrylewicz and published by . This book was released on 1971 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Relationship of Perinatal Malnutrition to Brain Development Edited by E J Hawrylewicz and B Fichow written by B.F. Chow (Ed) and published by . This book was released on 1971 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Effects of Perinatal Malnutrition on Brain Development in Rats written by Ling Wang and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effects of Perinatal Malnutrition on Brain Development in Rats" by Ling, Wang, 王玲, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of the thesis entitled EFFECTS OF PERINATAL MALNUTRITION ON BRAIN DEVELOPMENT IN RATS submitted by Wang Ling for the degree of Doctor of Philosophy at The University of Hong Kong in August 2006 The perinatal period, the period around the time of birth, is critical for brain development in most mammalian species. Numerous studies reported in the literature have shown that nutritional insults during this period can cause life-long impairment in various brain functions, including learning and memory function. How perinatal malnutrition leads to impairment in brain learning and memory function is still unclear. An emerging theory suggests that nutritional factors may modulate critical gene expression and subsequently lead to the functional alteration. More resent studies have shown that brain-derived neurotrophic factor (BDNF) plays a crucial role in brain learning and memory function. The objective of the present study was to investigate the effects of perinatal malnutrition on BDNF gene expression in the brain and the effects on spatial learning and memory function. Laboratory rats (Wistar and Sprague-Dawley strains) were used as an animal model. Pregnant or lactating rats were subjected to various types of nutritional insults, including calorie restriction, protein malnutrition or n-3 fatty acid deficiency, and their offspring were evaluated for the spatial learning and memory performance using the Morris water maze test. The concentrations of BDNF and BDNF mRNA in various regions of the brain were determined using enzyme-linked immunosorbent assay (ELISA) and real-time reverse transcription polymerase chain reaction (RT-PCR) respectively. It was found that prenatal 50% calorie restriction significantly reduced the levels of BDNF and its mRNA in hippocampus. Calorie restriction also caused significant impairment in spatial learning ability in the rats. The effects appeared to be proportionate to the duration of prenatal calorie restriction. The effects of perinatal protein malnutrition on spatial learning and memory performance and BDNF gene expression varied in rats depending on the time and duration of the dietary insults. Rats fed with a low protein diet (6% vs. 20% in control) during the four weeks period after birth showed poor spatial learning and memory performance at ten weeks of age accompanied with significant decrease in BDNF and its mRNA concentrations in hippocampus. Rats subjected to the low protein diet two weeks before and four weeks after birth also showed a significantly poor learning and memory performance at four but not ten weeks of age. Moderate decrease in BDNF concentration was observed in the cerebral cortex and hippocampus. Dietary n-3 fatty acid deficiency for three generations led to significant depletion of decosahexaenoic acid (DHA) in the brain tissue. Rats with depleted brain DHA showed dramatic impairment in learning and memory ability at four and ten weeks of age. BDNF mRNA concentration was also significantly reduced in the cerebral cortex and hippocampus in DHA depleted rat pups at four weeks of age. In conclusion, results of the present study indicate that perinatal malnutrition generally reduces BDNF gene expression in the brain and causes impairment in spatial learning and memory performance. Severity of the effect increases with an increased duration of the nu
Download or read book Effects of Perinatal Malnutrition on Brain Development in Rats written by Ling Wang (Ph. D.) and published by . This book was released on 2006 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Clinical Child Psychology written by Benjamin B. Lahey and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychologists have long been interested in the problems of children, but in the last 20 years this interest has increased dramatically. The in tensified focus on clinical child psychology reflects an increased belief that many adult problems have their origin in childhood and that early treatment is often more effective than treatment at later ages, but it also seems to reflect an increased feeling that children are inherently important in their own right. As a result of this shift in emphasis, the number of publications on this topic has multiplied to the extent that even full-time specialists have not been able to keep abreast of all new developments. Researchers in the more basic fields of child psychol ogy have a variety of annual publications and journals to integrate research in their areas, but there is a marked need for such an integra tive publication in the applied segment of child and developmental psychology. Advances in Clinical Child Psychology is a serial publication designed to bring together original summaries of the most important developments each year in the field. Each chapter is written by a key figure in an innovative area of research or practice or by an individual who is particularly well qualified to comment on a topic of major contemporary importance. Each author has followed the stan dard format in which his or her area of research was reviewed and the clinical implications of the studies were made explicit.
Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Download or read book The Cambridge Handbook of Cognitive Aging written by Ayanna K. Thomas and published by Cambridge University Press. This book was released on 2020-05-28 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.
Download or read book Perinatal Nutrition and Brain Development written by and published by . This book was released on 1995 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disease Control Priorities Third Edition Volume 2 written by Robert Black and published by World Bank Publications. This book was released on 2016-04-11 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evaluation of reproductive, maternal, newborn, and child health (RMNCH) by the Disease Control Priorities, Third Edition (DCP3) focuses on maternal conditions, childhood illness, and malnutrition. Specifically, the chapters address acute illness and undernutrition in children, principally under age 5. It also covers maternal mortality, morbidity, stillbirth, and influences to pregnancy and pre-pregnancy. Volume 3 focuses on developments since the publication of DCP2 and will also include the transition to older childhood, in particular, the overlap and commonality with the child development volume. The DCP3 evaluation of these conditions produced three key findings: 1. There is significant difficulty in measuring the burden of key conditions such as unintended pregnancy, unsafe abortion, nonsexually transmitted infections, infertility, and violence against women. 2. Investments in the continuum of care can have significant returns for improved and equitable access, health, poverty, and health systems. 3. There is a large difference in how RMNCH conditions affect different income groups; investments in RMNCH can lessen the disparity in terms of both health and financial risk.
Download or read book Neurological Psychiatric and Developmental Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain disordersâ€"neurological, psychiatric, and developmentalâ€"now affect at least 250 million people in the developing world, and this number is expected to rise as life expectancy increases. Yet public and private health systems in developing countries have paid relatively little attention to brain disorders. The negative attitudes, prejudice, and stigma that often surround many of these disorders have contributed to this neglect. Lacking proper diagnosis and treatment, millions of individual lives are lost to disability and death. Such conditions exact both personal and economic costs on families, communities, and nations. The report describes the causes and risk factors associated with brain disorders. It focuses on six representative brain disorders that are prevalent in developing countries: developmental disabilities, epilepsy, schizophrenia, bipolar disorder, depression, and stroke. The report makes detailed recommendations of ways to reduce the toll exacted by these six disorders. In broader strokes, the report also proposes six major strategies toward reducing the overall burden of brain disorders in the developing world.
Download or read book Disease Control Priorities Third Edition Volume 8 written by Donald A. P. Bundy and published by World Bank Publications. This book was released on 2017-11-20 with total page 977 pages. Available in PDF, EPUB and Kindle. Book excerpt: More children born today will survive to adulthood than at any time in history. It is now time to emphasize health and development in middle childhood and adolescence--developmental phases that are critical to health in adulthood and the next generation. Child and Adolescent Health and Development explores the benefits that accrue from sustained and targeted interventions across the first two decades of life. The volume outlines the investment case for effective, costed, and scalable interventions for low-resource settings, emphasizing the cross-sectoral role of education. This evidence base can guide policy makers in prioritizing actions to promote survival, health, cognition, and physical growth throughout childhood and adolescence.
Download or read book Handbook of Nutrition Diet and Epigenetics written by Vinood B. Patel and published by Springer. This book was released on 2019-02-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.
Download or read book Developmental Disabilities Abstracts written by and published by . This book was released on 1977 with total page 1374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Africa s Future Africa s Challenge written by Marito H. Garcia and published by World Bank Publications. This book was released on 2008-01-18 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early childhood, from birth through school entry, was largely invisible worldwide as a policy concern for much of the twentieth century. Children, in the eyes of most countries, were 'appendages' of their parents or simply embedded in the larger family structure. The child did not emerge as a separate social entity until school age (typically six or seven). 'Africa's Future, Africa's Challenge: Early Childhood Care and Development in Sub-Saharan Africa' focuses on the 130 million children south of the Sahel in this 0-6 age group. This book, the first of its kind, presents a balanced collection of articles written by African and non-African authors ranging from field practitioners to academicians and from members of government organizations to those of nongovernmental and local organizations. 'Africa's Future, Africa's Challenge' compiles the latest data and viewpoints on the state of Sub-Saharan Africa's children. Topics covered include the rationale for investing in young children, policy trends in early childhood development (ECD), historical perspectives of ECD in Sub-Saharan Africa including indigenous approaches, new threats from HIV/AIDS, and the importance of fathers in children's lives. The book also addresses policy development and ECD implementation issues; presents the ECD programming experience in several countries, highlighting best practices and challenges; and evaluates the impact of ECD programs in a number of countries.
Download or read book Perinatal Biochemistry written by Emilio Herrera and published by CRC Press. This book was released on 2020-10-28 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrauterine development and birth constitute an uninterrupted sequence of events that have a molecular physiologic background. Perinatal Biochemistry presents a comprehensive review of this subject. Specific topics addressed include maternal metabolism during pregnancy, maternal insulin resistance, embryonic and fetal metabolism and fuel consumption, the fetal pancreas, growth factors, brain metabolism, and biochemical adaptations to early extrauterine life. The book will be useful to biochemists and physiologists interested in perinatology; clinicians working in areas related to maternal health, gestational development, and delivery; gynecologists, neonatologists; pediatricians; endocrinologists; and internists.
Download or read book Preterm Birth written by Institute of Medicine and published by National Academies Press. This book was released on 2007-05-23 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasing prevalence of preterm birth in the United States is a complex public health problem that requires multifaceted solutions. Preterm birth is a cluster of problems with a set of overlapping factors of influence. Its causes may include individual-level behavioral and psychosocial factors, sociodemographic and neighborhood characteristics, environmental exposure, medical conditions, infertility treatments, and biological factors. Many of these factors co-occur, particularly in those who are socioeconomically disadvantaged or who are members of racial and ethnic minority groups. While advances in perinatal and neonatal care have improved survival for preterm infants, those infants who do survive have a greater risk than infants born at term for developmental disabilities, health problems, and poor growth. The birth of a preterm infant can also bring considerable emotional and economic costs to families and have implications for public-sector services, such as health insurance, educational, and other social support systems. Preterm Birth assesses the problem with respect to both its causes and outcomes. This book addresses the need for research involving clinical, basic, behavioral, and social science disciplines. By defining and addressing the health and economic consequences of premature birth, this book will be of particular interest to health care professionals, public health officials, policy makers, professional associations and clinical, basic, behavioral, and social science researchers.
Download or read book Research Awards Index written by and published by . This book was released on with total page 1268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
