Download or read book The Regulation of Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1991 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Seventh Conference on [title] held in Airlie, Virginia, September 1990, and sponsored by the National Institute of Diabetes, Digestive and Kidney Diseases and the National Heart, Lung, and Blood Institute. Contributors address hemoglobin switching in transgenic animals, the locus control region of the globin gene domain, other Cis sequences, transcriptional control of switching, and of erythropoiesis, manipulation of hemoglobin switching in vivo, molecular and cellular biology of hematopoiesis, and gene transfer. (c) by Book News, Inc., Portland, OR.
Download or read book The Regulation of Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular and Molecular Regulation of Hemoglobin Switching written by George Stamatoyannopoulos and published by Grune & Stratton, Incorporated. This book was released on 1979 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1989 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Approaches for the Study of Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1985 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disorders of Hemoglobin written by Martin H. Steinberg and published by Cambridge University Press. This book was released on 2009-08-17 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the definitive reference on disorders of hemoglobin.
Download or read book Cellular and Molecular Regulation of Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Developmental Control of Globin Gene Expression written by George Stamatoyannopoulos and published by . This book was released on 1987 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hemoglobin Switching Part A written by George Stamatoyannopoulos and published by . This book was released on 1989 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Haemoglobin Synthesis written by J. Neuwirt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haemoglobin is one of the most important molecules in the animal kingdom. Its function is to carry oxygen to tissues. In lower invertebrates the blood pigment is present in the haemolymph and is not bound in cells. Later in the course of phylo genesis haemoglobin remains associated with cells which produce it and in this form it reaches the peripheral circulation. In higher organisms the haemoglobin production is thus determined by two main factors: haemoglobin synthesis in erythroid cells and the formation of these erythroid cells which depends on cell proliferation in haematopoietic organs. Human haemoglobin is made up of two chains which combine from four different polypeptide chains formed in varying ratios in different periods of the life cycle. During the life span of humans the following haemoglobins are formed: embryonic haemoglobins Gower 1 and 2, foetal haemoglobin F and two adult haemoglobins A and A . E-and IX-chains are part of the embryonic haemoglobins Gower 1 (E4) and 2 Gower 2 (1X2E2). These haemoglobins predominate in embryos during the second month of pregnancy and at the end of the first trimester they are completely re placed by foetal haemoglobin F (~Y2). Adult haemoglobin A consists of two IX and two ~-chains and is the main component of red cells in adults. A relatively small component of red cells accounting for less than 2 % of the total haemo globin, is haemoglobin A2 (1X0).
Download or read book Regulators of Hemoglobin Switching in Zebrafish and Human Models written by Jared Jason Ganis and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemoglobin switching is a developmental process involving the dynamic transcriptional regulation of multiple globin genes. This molecular process involves multiple layer of complexity, and elucidating new mechanisms in this process will result in a more complete understanding of general gene regulation and will likely have direct clinical implications for hemoglobinopathies, such as sickle cell anemia. In this dissertation, I develop and characterize a new model for hemoglobin switching, the zebrafish. I defined and fully annotated the two zebrafish globin loci, termed major and minor loci. Both loci contain [alpha]- and [beta]- genes oriented in a head-to-head fashion. Characterization of the globin expression pattern precisely defined the timing of normal switching and demonstrated that zebrafish, like humans, have two globin switches. The locus control region for the major locus was identified and in conjunction with a proximal promoter was able to generate robust, erythroid-specific expression in a transgenic line.
Download or read book Hemoglobin Switching written by George Stamatoyannopoulos and published by John Wiley & Sons. This book was released on 1989-08 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcriptional Regulation written by George Stamatoyannopoulos and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hemoglobins in Development and Differentiation written by George Stamatoyannopoulos and published by . This book was released on 1981 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Molecular Basis of Blood Diseases written by George Stamatoyannopoulos and published by Saunders. This book was released on 2001 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: The superb Third Edition of this popular text covers all the recent groundbreaking developments which have taken place in this field. Comprehensively revised, it presents all the latest findings on the molecular bases of blood cell functions and disease mechanisms and the impact of these discoveries on the state of medicine. This edition includes new chapters such as signaling and antigen presentation by B-lymphocytes, molecular oncogenesis and more!
Download or read book Regulation of Tissue Oxygenation Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Download or read book Hemoglobin Switching Cellular and molecular mechanisms written by George Stamatoyannopoulos and published by . This book was released on 1989 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
