Download or read book The Quantification of Oscillatory Force Parameters that Affect Eccentric Contraction Induced Injury in an in Vivo Rodent written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Quantification of Dynamic Parameters that Affect Eccentric Contraction Induced Injury in an in Vivo Rodent Model written by Robert Gregory Cutlip and published by . This book was released on 1995 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book ECCENTRIC CONTRACTION INDUCED written by Wai Ella Yeung and published by Open Dissertation Press. This book was released on 2017-01-27 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Eccentric Contraction-induced Injury in Mammalian Skeletal Muscle" by Wai, Ella, Yeung, 楊慧, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Eccentric contraction-induced injury in mammalian skeletal muscle " submitted by Ella Wai YEUNG for the degree of Doctor of Philosophy at the University of Hong Kong in February, 2003 Eccentric contractions, in which muscles are lengthened during contraction, may injure skeletal muscle but the mechanism(s) for this remain uncertain. The hypothesis tested is that alterations in intracellular concentrations + + of ions such as Na or H may underlie some of the functional impairment. The initial phase of eccentric contraction-induced injury was investigated: the influence of eccentric contraction on developed force, intracellular pH, Na homeostasis and T-tubule morphology was examined; the roles of these changes in the development of muscle damage are discussed. Single fibres from the flexor brevis muscle of mice or small bundles of fibres from the soleus or extensor digitorum longus muscle of rats were dissected. Muscles underwent either 10 isometric tetani (controls) or 10 eccentric tetani, during which a 30 or 40 % stretch of the optimal length (L ) was applied. Eccentrically-contracted muscles showed 3 characteristic features of stretch- induced damage: (i) reduced maximal force, (ii) greater reduction of force at low stimulation frequencies, (iii) shift in L to a longer muscle length. Ten isometric o tetani or stretches of resting fibres reproduced none of these features. Intracellular pH ( pH ) was determined in rat soleus muscle with the fluorescent indicator BCECF. The resting pH was more acidic after eccentric contractions (6.80 0.06) than after isometric contractions (6.97 0.04). The rate of pH recovery following an acid load was reduced from 0.022 + 0.003 units i -1 -1 min following isometric contractions to 0.013 + 0.002 units min following eccentric contractions. The results suggested that the ability of the muscle to regulate pH was impaired after eccentric contractions, which may partially explain the reduction in force. T-tubule morphology and function were studied in single mouse muscle fibres with confocal microscopy. Following eccentric contractions, vacuoles connected to the T-tubules appeared, and the diffusion of an extracellular marker (sulforhodamine B) from the T-tubules was slowed to a half time 6.3 2.4 min, compared to 18 1 s in isometric controls. [Na ] measurements were performed with the fluorescent indicator SBFI or sodium green. Isometric tetani had no detectable effect on [Na ] (7.2 0.5 mM), whereas eccentric contraction increased [Na ] to 16.3 1.6 mM. Confocal i images showed a uniform increase in [Na ] after eccentric tetani with no localized elevations of [Na ]. Gadolinium, a blocker of stretch-sensitive channels prevented the rise of [Na ] and reduced the force deficit after eccentric damage. The slow extrusion of intracellular protons following eccentric contractions may be explained by the rise in [Na ] which would be expected to + + reduce the inward Na gradient and hence slow proton efflux. The Na may enter by very small and widely distributed membrane tears, or alternatively through stretch-sensitive channels which remain open for many minutes after eccentric contractions. The vacuoles may result from osmotic stresses involved in pumping out the excess Na . Th

Download or read book Eccentric Contraction induced Injury in Skeletal Muscle written by Tina Jitendra Patel and published by . This book was released on 1998 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mechanisms Involved in the Development of Contraction induced Injury to Single Muscle Fibres of Rats written by Peter Charles Douglas Macpherson and published by . This book was released on 1995 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 1972 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Neuromuscular Fatigue written by A. J. Sargeant and published by Royal Netherlands Academy of. This book was released on 1993-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paperback. Neuromuscular fatigue is a phenomenon of great importance in everyday life as well as being of theoretical and clinical significance. Eleven years ago there was a seminal symposium on muscle fatigue held in London. The published proceedings (Ciba Foundation Symposium 82 - Human muscle fatigue: physiological mechanisms, Pitman, London, 1981) served as an important 'state-of-the-art' reference. In the intervening period there have been many developments with respect to our understanding of fatigue of the motor output, including processes located in the skeletal muscle fibres themselves as well as problems related to various aspects of (moto) neural muscle control. However, there are still uncertainties and important questions which remain unanswered. It was felt that the time was ripe to attempt a renewed synthesis by bringing together international experts from a range of complementary research areas. In this way it was hoped that attention co

Download or read book Functional Tissue Engineering written by Farshid Guilak and published by Springer Science & Business Media. This book was released on 2003-07-09 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: -Softcover reprint of a successful hardcover reference (370 copies sold) -Price to be accessible to the rapidly increasing population of students and investigators in the field of tissue engineering -Chapters written by well-known researchers discuss issues in functional tissue engineering as well as provide guidelines and a summary of the current state of technology

Download or read book Gait Analysis written by Jacquelin Perry and published by CRC Press. This book was released on 2024-06-01 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extensive and ground-breaking work of Dr. Jacquelin Perry is encompassed and detailed in the world renowned text, Gait Analysis: Normal and Pathological Function. The medical, healthcare, and rehabilitation professions key text for over 18 years on gait.... Now available in a much anticipated New Second Edition Dr. Jacquelin Perry is joined by Dr. Judith Burnfield to present today's latest research findings on human gait. Gait Analysis, Second Edition has been updated and expanded to focus on current research, more sophisticated methods, and the latest equipment available to analyze gait. What is New: • A new chapter covering running • Synergy of motion between the two limbs • A new chapter covering pediatrics • A new chapter covering stair negotiation • New and updated clinical examples • A section on power inside each chapter covering normal gait • New methods and equipment to analyze gait This Second Edition to Gait Analysis offers a re-organization of the chapters and presentation of material in a more user-friendly, yet comprehensive format. Essential information is provided describing gait functions, and clinical examples to identify and interpret gait deviations. Learning is further reinforced with images and photographs. Features: • Six sections cover the fundamentals, normal gait, pathological gait, clinical considerations, advanced locomotor functions, and gait analysis systems • Clinical significance of the most common pathological gait patterns • Over 470 illustrations and photographs, as well as 40 tables • Patient examples to illustrate elements of normal and pathological gait Tens of thousands of orthopedic, orthotic and prosthetic, physical therapy, and other rehabilitation professionals have kept a copy of Gait Analysis by their side for over 18 years...join the thousands more who will bring the Second Edition into their clinics, classrooms, and personal collections.

Download or read book Introduction to Sports Biomechanics written by Roger Bartlett and published by Routledge. This book was released on 2002-04-12 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1996. Routledge is an imprint of Taylor & Francis, an informa company.

Download or read book Tendinopathy in Athletes written by Savio L-Y. Woo and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise volume in the Encyclopaedia of Sports Medicine series, published under the auspices of the International Olympic Committee, provides a dependable source of current knowledge available on tendinopathy and covers both the basic science and clinical aspects of the subject. Despite its high incidence, the precise etiopathogenesis and effective treatment of tendinopathy remain elusive. Tendinopathy in Athletes draws on the expertise of an international and prolific collection of contributors, both clinicians and scientists, who provide new insights into this specialized area. This book: provides a comprehensive resource for both clinicians and researchers with information organized logically, with an easy-to-follow progression from the basic scientific findings to clinical applications discusses the full range of treatment modalities, including new molecular and biological approaches, plus surgical and alternative approaches to tendinopath contains “What We Need to Know” sections that suggest future areas of research for young investigators. As tendinopathy remains one of the most common injuries encountered, both in sports and at the workplace, this essential volume is sure to be a source of frequent consultation.

Download or read book Functional Atlas of the Human Fascial System written by Carla Stecco and published by Elsevier Health Sciences. This book was released on 2014-11-05 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principally based on dissections of hundreds of un-embalmed human cadavers over the past decade, Functional Atlas of the Human Fascial System presents a new vision of the human fascial system using anatomical and histological photographs along with microscopic analysis and biomechanical evaluation. Prof. Carla Stecco – orthopaedic surgeon and professor of anatomy and sport activities – brings together the research of a multi-specialist team of researchers and clinicians consisting of anatomists, biomechanical engineers, physiotherapists, osteopaths and plastic surgeons. In this Atlas Prof. Stecco presents for the first time a global view of fasciae and the actual connections that describe the myofascial kinetic chains. These descriptions help to explain how fascia plays a part in myofascial dysfunction and disease as well as how it may alter muscle function and disturb proprioceptive input. Prof. Stecco also highlights the continuity of the fascial planes, explaining the function of the fasciae and their connection between muscles, nerves and blood vessels. This understanding will help guide the practitioner in selecting the proper technique for a specific fascial problem with a view to enhancing manual therapy methods. Functional Atlas of the Human Fascial System opens with the first chapter classifying connective tissue and explaining its composition in terms of percentages of fibres, cells and extracellular matrix. The second chapter goes on to describe the general characteristics of the superficial fascia from a macroscopic and microscopic point of view; while the third analyzes the deep fascia in the same manner. The subsequent five chapters describe the fasciae from a topographical perspective. In this part of the Atlas, common anatomical terminology is used throughout to refer to the various fasciae but it also stresses the continuity of fasciae between the different bodily regions. Over 300 unique photographs which show fascia on fresh (not embalmed) cadavers Demonstrates the composition, form and function of the fascial system Highlights the role of the deep fascia for proprioception and peripheral motor coordination Companion website – www.atlasfascial.com – with videos showing how fascia connects with ligaments

Download or read book Sports Rehabilitation and Injury Prevention written by Paul Comfort and published by John Wiley & Sons. This book was released on 2010-12-01 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive, practical, evidence-based guide to the field. It covers each stage of the rehabilitation process from initial assessment, diagnosis and treatment, to return to pre-injury fitness and injury prevention. Presenting a holistic approach, this text also addresses the nutritional and psychological aspects of the rehabilitation process for the amateur sports enthusiast as well as elite athletes. Divided into five parts, Parts I, II and III cover screening and assessment, the pathophysiology of sports injuries and healing and the various stages of training during the rehabilitation process. Part IV covers effective clinical decision making, and Part V covers joint specific injuries and pathologies in the shoulder, elbow wrist and hand, groin and knee. Key features: Comprehensive. Covers the complete process from diagnosis and treatment to rehabilitation and prevention of injuries. Practical and relevant. Explores numerous real world case studies and sample rehabilitation programmes to show how to apply the theory in practice. Cutting Edge. Presents the latest research findings in each area to provide an authoritative guide to the field.

Download or read book Rhythms of the Brain written by G. Buzsáki and published by Oxford University Press. This book was released on 2011 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of mechanisms in the brain that allow complicated things to happen in a coordinated fashion have produced some of the most spectacular discoveries in neuroscience. This book provides eloquent support for the idea that spontaneous neuron activity, far from being mere noise, is actually the source of our cognitive abilities. It takes a fresh look at the coevolution of structure and function in the mammalian brain, illustrating how self-emerged oscillatory timing is the brain's fundamental organizer of neuronal information. The small-world-like connectivity of the cerebral cortex allows for global computation on multiple spatial and temporal scales. The perpetual interactions among the multiple network oscillators keep cortical systems in a highly sensitive "metastable" state and provide energy-efficient synchronizing mechanisms via weak links. In a sequence of "cycles," György Buzsáki guides the reader from the physics of oscillations through neuronal assembly organization to complex cognitive processing and memory storage. His clear, fluid writing-accessible to any reader with some scientific knowledge-is supplemented by extensive footnotes and references that make it just as gratifying and instructive a read for the specialist. The coherent view of a single author who has been at the forefront of research in this exciting field, this volume is essential reading for anyone interested in our rapidly evolving understanding of the brain.

Download or read book Skeletal Muscle Regeneration in the Mouse written by Michael Kyba and published by Springer. This book was released on 2016-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the cell biology and physiology of skeletal muscle regeneration. This Book is a collection of classic and cutting edge protocols optimized for mice, but in most cases adaptable to rat or other mammalian models, that will allow an investigator to develop and implement a research study on skeletal muscle regeneration. Chapters address the three major areas of study: provoking regeneration by inducing damage to muscle, analyzing the progenitor cells of skeletal muscle, and quantifying overall muscle function. Subjects discussed include: inducing skeletal muscle injury by eccentric contraction; volumetric muscle loss; single myofiber isolation and culture; satellite cell transplantation; muscle clearing for whole mount immunostaining; luciferase tracking of muscle stem cells; mitochondrial and mitophagy flux analysis; in vivo assessment of muscle contractility; force measurements on single isolated myofibers; and analysis of aerobic respiration in intact skeletal muscle tissue by microplate respirometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to each respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Skeletal Muscle Regeneration in the Mouse: Methods and Protocols is an essential laboratory reference for research in skeletal muscle growth, damage, repair, degeneration, and regenerative therapy in the mouse model system.

Download or read book Oxidants and Antioxidants written by Lester Packer and published by Gulf Professional Publishing. This book was released on 1999 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Total Antioxidant Activity * Vitamin C * Polyphenols and Flavanoids * Thiols * Vitamin E and Coenzyme Q10 * Carotenoids and Retinoids.