Download or read book The Quantification of Dynamic Parameters that Affect Eccentric Contraction Induced Injury in an in Vivo Rodent Model written by Robert Gregory Cutlip and published by . This book was released on 1995 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Quantification of Oscillatory Force Parameters that Affect Eccentric Contraction Induced Injury in an in Vivo Rodent written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ECCENTRIC CONTRACTION INDUCED written by Wai Ella Yeung and published by Open Dissertation Press. This book was released on 2017-01-27 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Eccentric Contraction-induced Injury in Mammalian Skeletal Muscle" by Wai, Ella, Yeung, 楊慧, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Eccentric contraction-induced injury in mammalian skeletal muscle " submitted by Ella Wai YEUNG for the degree of Doctor of Philosophy at the University of Hong Kong in February, 2003 Eccentric contractions, in which muscles are lengthened during contraction, may injure skeletal muscle but the mechanism(s) for this remain uncertain. The hypothesis tested is that alterations in intracellular concentrations + + of ions such as Na or H may underlie some of the functional impairment. The initial phase of eccentric contraction-induced injury was investigated: the influence of eccentric contraction on developed force, intracellular pH, Na homeostasis and T-tubule morphology was examined; the roles of these changes in the development of muscle damage are discussed. Single fibres from the flexor brevis muscle of mice or small bundles of fibres from the soleus or extensor digitorum longus muscle of rats were dissected. Muscles underwent either 10 isometric tetani (controls) or 10 eccentric tetani, during which a 30 or 40 % stretch of the optimal length (L ) was applied. Eccentrically-contracted muscles showed 3 characteristic features of stretch- induced damage: (i) reduced maximal force, (ii) greater reduction of force at low stimulation frequencies, (iii) shift in L to a longer muscle length. Ten isometric o tetani or stretches of resting fibres reproduced none of these features. Intracellular pH ( pH ) was determined in rat soleus muscle with the fluorescent indicator BCECF. The resting pH was more acidic after eccentric contractions (6.80 0.06) than after isometric contractions (6.97 0.04). The rate of pH recovery following an acid load was reduced from 0.022 + 0.003 units i -1 -1 min following isometric contractions to 0.013 + 0.002 units min following eccentric contractions. The results suggested that the ability of the muscle to regulate pH was impaired after eccentric contractions, which may partially explain the reduction in force. T-tubule morphology and function were studied in single mouse muscle fibres with confocal microscopy. Following eccentric contractions, vacuoles connected to the T-tubules appeared, and the diffusion of an extracellular marker (sulforhodamine B) from the T-tubules was slowed to a half time 6.3 2.4 min, compared to 18 1 s in isometric controls. [Na ] measurements were performed with the fluorescent indicator SBFI or sodium green. Isometric tetani had no detectable effect on [Na ] (7.2 0.5 mM), whereas eccentric contraction increased [Na ] to 16.3 1.6 mM. Confocal i images showed a uniform increase in [Na ] after eccentric tetani with no localized elevations of [Na ]. Gadolinium, a blocker of stretch-sensitive channels prevented the rise of [Na ] and reduced the force deficit after eccentric damage. The slow extrusion of intracellular protons following eccentric contractions may be explained by the rise in [Na ] which would be expected to + + reduce the inward Na gradient and hence slow proton efflux. The Na may enter by very small and widely distributed membrane tears, or alternatively through stretch-sensitive channels which remain open for many minutes after eccentric contractions. The vacuoles may result from osmotic stresses involved in pumping out the excess Na . Th
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1995 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Gait Analysis written by Jacquelin Perry and published by CRC Press. This book was released on 2024-06-01 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extensive and ground-breaking work of Dr. Jacquelin Perry is encompassed and detailed in the world renowned text, Gait Analysis: Normal and Pathological Function. The medical, healthcare, and rehabilitation professions key text for over 18 years on gait.... Now available in a much anticipated New Second Edition Dr. Jacquelin Perry is joined by Dr. Judith Burnfield to present today's latest research findings on human gait. Gait Analysis, Second Edition has been updated and expanded to focus on current research, more sophisticated methods, and the latest equipment available to analyze gait. What is New: • A new chapter covering running • Synergy of motion between the two limbs • A new chapter covering pediatrics • A new chapter covering stair negotiation • New and updated clinical examples • A section on power inside each chapter covering normal gait • New methods and equipment to analyze gait This Second Edition to Gait Analysis offers a re-organization of the chapters and presentation of material in a more user-friendly, yet comprehensive format. Essential information is provided describing gait functions, and clinical examples to identify and interpret gait deviations. Learning is further reinforced with images and photographs. Features: • Six sections cover the fundamentals, normal gait, pathological gait, clinical considerations, advanced locomotor functions, and gait analysis systems • Clinical significance of the most common pathological gait patterns • Over 470 illustrations and photographs, as well as 40 tables • Patient examples to illustrate elements of normal and pathological gait Tens of thousands of orthopedic, orthotic and prosthetic, physical therapy, and other rehabilitation professionals have kept a copy of Gait Analysis by their side for over 18 years...join the thousands more who will bring the Second Edition into their clinics, classrooms, and personal collections.
Download or read book Skeletal Muscle Regeneration in the Mouse written by Michael Kyba and published by Springer. This book was released on 2016-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the cell biology and physiology of skeletal muscle regeneration. This Book is a collection of classic and cutting edge protocols optimized for mice, but in most cases adaptable to rat or other mammalian models, that will allow an investigator to develop and implement a research study on skeletal muscle regeneration. Chapters address the three major areas of study: provoking regeneration by inducing damage to muscle, analyzing the progenitor cells of skeletal muscle, and quantifying overall muscle function. Subjects discussed include: inducing skeletal muscle injury by eccentric contraction; volumetric muscle loss; single myofiber isolation and culture; satellite cell transplantation; muscle clearing for whole mount immunostaining; luciferase tracking of muscle stem cells; mitochondrial and mitophagy flux analysis; in vivo assessment of muscle contractility; force measurements on single isolated myofibers; and analysis of aerobic respiration in intact skeletal muscle tissue by microplate respirometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to each respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Skeletal Muscle Regeneration in the Mouse: Methods and Protocols is an essential laboratory reference for research in skeletal muscle growth, damage, repair, degeneration, and regenerative therapy in the mouse model system.
Download or read book Skeletal Muscle Damage and Repair written by Peter M. Tiidus and published by Human Kinetics. This book was released on 2008 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempts to cover a wide range of both basic research and applied clinical topics related to skeletal muscle damage and repair mechanisms and their application. This book examines muscle damage and repair mechanisms and issues in specific populations including older adults and special populations.
Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.
Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Download or read book Handbook of Sports Medicine and Science written by Dennis J. Caine and published by John Wiley & Sons. This book was released on 2013-07-18 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Handbook of Sports Medicine and Science series, published in conjunction with the Medical Commission of the International Olympic Committee, offers comprehensive and practical guidance on the training and medical care of competitive gymnasts. Written and edited by leading trainers, team doctors, coaches and other professionals with unparalleled experience in elite gymnastics, this book covers all the key aspects of caring for gymnasts, minimizing the unique risks these athletes face, and treating injuries when they happen. The book is organized into 4 sections covering: The evolution of gymnastics Growth and development Training and performance Sports medicine Individual chapters cover key topics such as energy needs and body weight management; biomechanics; psychology; the epidemiology of gymnastic injuries; treatment and rehabilitation of common injuries; injury prevention; and more. Endorsed by the International Gymnastics Federation (FIG), no other book offers such an in-depth look at the unique considerations and challenges that affect the growth, performance, training, and medical care of athletes in this demanding sport.
Download or read book Muscle Gene Therapy written by Dongsheng Duan and published by Springer Science & Business Media. This book was released on 2009-11-26 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscle disease represents an important health threat to the general population. There is essentially no cure. Gene therapy holds great promise to correct the genetic defects and eventually achieve full recovery in these diseases. Significant progresses have been made in the field of muscle gene therapy over the last few years. The development of novel gene delivery vectors has substantially enhanced specificity and efficiency of muscle gene delivery. The new knowledge on the immune response to viral vectors has added new insight in overcoming the immune obstacles. Most importantly, the field has finally moved from small experimental animal models to human patients. This book will bring together the leaders in the field of muscle gene transfer to provide an updated overview on the progress of muscle gene therapy. It will also highlight important clinical applications of muscle gene therapy.
Download or read book Cephalopod Cognition written by Anne-Sophie Darmaillacq and published by Cambridge University Press. This book was released on 2014-07-10 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on comparative cognition in cephalopods, this book illuminates the wide range of mental function in this often overlooked group.
Download or read book Recapturing a Future for Space Exploration written by National Research Council and published by National Academies Press. This book was released on 2012-01-30 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than four decades have passed since a human first set foot on the Moon. Great strides have been made in our understanding of what is required to support an enduring human presence in space, as evidenced by progressively more advanced orbiting human outposts, culminating in the current International Space Station (ISS). However, of the more than 500 humans who have so far ventured into space, most have gone only as far as near-Earth orbit, and none have traveled beyond the orbit of the Moon. Achieving humans' further progress into the solar system had proved far more difficult than imagined in the heady days of the Apollo missions, but the potential rewards remain substantial. During its more than 50-year history, NASA's success in human space exploration has depended on the agency's ability to effectively address a wide range of biomedical, engineering, physical science, and related obstacles-an achievement made possible by NASA's strong and productive commitments to life and physical sciences research for human space exploration, and by its use of human space exploration infrastructures for scientific discovery. The Committee for the Decadal Survey of Biological and Physical Sciences acknowledges the many achievements of NASA, which are all the more remarkable given budgetary challenges and changing directions within the agency. In the past decade, however, a consequence of those challenges has been a life and physical sciences research program that was dramatically reduced in both scale and scope, with the result that the agency is poorly positioned to take full advantage of the scientific opportunities offered by the now fully equipped and staffed ISS laboratory, or to effectively pursue the scientific research needed to support the development of advanced human exploration capabilities. Although its review has left it deeply concerned about the current state of NASA's life and physical sciences research, the Committee for the Decadal Survey on Biological and Physical Sciences in Space is nevertheless convinced that a focused science and engineering program can achieve successes that will bring the space community, the U.S. public, and policymakers to an understanding that we are ready for the next significant phase of human space exploration. The goal of this report is to lay out steps and develop a forward-looking portfolio of research that will provide the basis for recapturing the excitement and value of human spaceflight-thereby enabling the U.S. space program to deliver on new exploration initiatives that serve the nation, excite the public, and place the United States again at the forefront of space exploration for the global good.
