Download or read book The Properties and Structure of Some Diethylenetriamine Cobalt Complexes written by Philip Hastings Crayton and published by . This book was released on 1956 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis Structure and Properties of Some Triazido Triammine Complexes of Cobalt III written by Frederick Dominick Sancilio and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Bis diethylenetriamine Cobalt III Complex System written by Frank Richard Keene and published by . This book was released on 1972 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Introduction to Coordination Chemistry written by Geoffrey A. Lawrance and published by John Wiley & Sons. This book was released on 2013-03-15 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the heart of coordination chemistry lies the coordinate bond, in its simplest sense arising from donation of a pair of electrons from a donor atom to an empty orbital on a central metalloid or metal. Metals overwhelmingly exist as their cations, but these are rarely met ‘naked’ – they are clothed in an array of other atoms, molecules or ions that involve coordinate covalent bonds (hence the name coordination compounds). These metal ion complexes are ubiquitous in nature, and are central to an array of natural and synthetic reactions. Written in a highly readable, descriptive and accessible style Introduction to Coordination Chemistry describes properties of coordination compounds such as colour, magnetism and reactivity as well as the logic in their assembly and nomenclature. It is illustrated with many examples of the importance of coordination chemistry in real life, and includes extensive references and a bibliography. Introduction to Coordination Chemistry is a comprehensive and insightful discussion of one of the primary fields of study in Inorganic Chemistry for both undergraduate and non-specialist readers.
Download or read book Cisplatin written by Bernhard Lippert and published by John Wiley & Sons. This book was released on 1999 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1970 with total page 1396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Preparation and Properties of Some Cobalt Complexes written by Clyde Gilpin Ford and published by . This book was released on 1960 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1980 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thermodynamic Properties of Some Cobalt III Complexes written by Robert James Lemire and published by . This book was released on 1971 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis Structure and Properties of Complexes of Chromium 3 and Cobalt 3 with Soft Donor Ligands written by A. L. Hale and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Dissertation Index 1861 1972 Chemistry written by Xerox University Microfilms and published by Ann Arbor, Mich. : Xerox University Microfilms. This book was released on 1973 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis Characterization and Electronic Properties of Some Alkylaminofluorophosphine Complexes of Cobalt II Halides written by Thomas Edward Nowlin and published by . This book was released on 1971 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis Structure and Spectroscopy of Heteropentadienyl cobalt Complexes written by Bryn Lucille Lutes and published by . This book was released on 2010 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: A heteropentadienyl ligand is a molecule in which the terminal carbon of a pentadienyl ligand has been replaced with a heteroatom (O, PR, NR, S, SiR2). The study of heteropentadienyl-transition metal complexes has been an active area of research in the last decade, and has recently received significant attention in the chemical literature. These molecules can now be synthesized by generalized methods, allowing their unique reactivity to be the focus of current research. These molecules have shown the ability to adopt and shift between a variety of bonding modes, opening coordination sites at the metal center and showing promise for use as homogeneous catalysts. This work has focused on the synthesis and spectroscopy of a new class of heteropentadienyl-transition metal-phosphine complexes. Specifically, thiapentadienyl-cobalt- and oxapentadienyl-cobalt-phosphine complexes were synthesized for comparison to the existing heteropentadienyl-iridium and -rhodium systems. Though some similarities in initial bonding modes were seen, the thiapentadienyl system showed distinctive dimeric and trimeric ground state bonding modes as a result of the small size of the cobalt metal center relative to other metals in the same group. Treatment of ClCo(PMe3)3 with potassium thiapentadienide produced the dimer [Co(PMe3)2(thiapentadienyl)]2. This dimer was reactive toward the small two-electron donor ligand, CO, forming the products (5-[eta]1-cis-5-thiapentadienyl)Co(PMe3)2(CO)2 and (5-[eta]1-trans-5-thiapentadienyl)Co(PMe3)2(CO)2. Treatment of ClCo(PMe3)3 with lithium 2,3-dimethyl-5-thiapentadienide yielded the trimer [Co(PMe3)2([eta]4-2,3-dimethylthiapentadienyl)]2[[mu]-Co(2,3-dimethylthiapentadienyl)2]. This trimer was also reactive toward the two-electron donor, CO, forming (5-[eta]1-trans-2,3-dimethyl-5-thiapentadienyl)Co(PMe3)2(CO)2, upon reaction. Some similarities to previously reported systems were seen in the initial bonding modes, though one new bonding mode was seen: [mu]2-[eta]4, [eta]1-bonding mode where one cobalt center bonds to the butadiene moiety in an [eta]4-fashion while a second cobalt coordinates the anionic sulfur atom. When ClCo(PMe3)3 was treated with potassium oxapentadienide, the monomeric product, (1,2,3-[eta]-oxapentadienyl)Co(PMe3)3 was formed. The oxapentadienyl-cobalt-phosphine system showed a remarkable stability of the all carbon [eta]3 bonding mode, losing a phosphine ligand to form (1,2,3-[eta]-oxapentadienyl)Co(PMe3)2(CO) upon exposure to carbon monoxide. The addition of methyl groups to the oxapentadienyl ligand resulted in no change to the initial reactivity. Treatment of ClCo(PMe3)3 with potassium 2,4-dimethyloxapentadienide again afforded the monomeric, [eta]3 product: (1,2,3-[eta]-2,4-dimethyloxapentadienyl)Co(PMe3)3. However, the additional steric bulk of the methyl groups, along with their electron donating properties, did affect the reaction of (1,2,3-[eta]-2,4-dimethyloxapentadienyl)Co(PMe3)3 with CO. In this case, two phosphine ligands were lost to form (1,2,3-[eta]-2,4-dimethyloxapentadienyl)Co(PMe3)(CO)2. The compounds (1,2,3-[eta]-oxapentadienyl)Co(PMe3)3 and (1,2,3-[eta]-oxapentadienyl)Co(PMe3)2(CO) were reactive toward small electrophiles, H+ and Me+, at the ligand oxygen forming stable [eta]4-butadienol-cobalt or [eta]4-butadienyl methyl ether-cobalt complexes. The compounds (1,2,3-[eta]-2,4-dimethyl oxapentadienyl)Co(PMe3)3 and (1,2,3-[eta]-2,4-dimethyl oxapentadienyl)Co(PMe3)(CO)2 were also reactive exclusively at the ligand oxygen; however, the initially formed products were not stable, resulting in the formation of Co(PMe3)4+O3SCF3- in situ which was then converted to Co(PMe3)3(CO)2+O3SCF3- by exposure to CO.
Download or read book Synthesis Structure and Chirality of Some Neutral Cobalt III Complexes written by David J. Seematter and published by . This book was released on 1974 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Preparation and Structure Determination of Some Copper Cobalt Iron and Manganese Complexes and the Study of Their Properties written by Yegao Yin and published by . This book was released on 1996 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Theory of Orientation and Stereoselection written by K. Fukui and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many organic chemists will agree with me that the old "electronic theory" has for a long time been inadequate for the interpretation of various new findings in chemistry, particularly for those of reactivity. Considering the outstanding progress which has been made during the past 20 years in the interpretation of these facts, aided by the molecular orbital theory, the time has finally come for a new book showing what is within and what is beyond the reach of quantum-chemical methods. It was therefore highly suitable that Dr. F. L. Boschke of the Springer Verlag suggested to me to make a contribution to a volume in the series "Topics in Current Chemistry" in February 1969. The article was published as Vol. 15, No 1 in June 1970. This new book is an expanded version of the article written in 1970. In this present volume several of the most up-to-date findings which have been gained in organic chemistry since then have been added. It is highly probable that a certain "theoretical" design in the experimenta lists' mind may have been the reason for these developments, whether they themselves are aware of it or not. Theory produces new experimental ideas and conversely, a host of experimental data add another vista to new theories. Due to the mutual beneficial effect of theory and experiment this book will always retain its value, although the quantum-chemical approach to the theory of reactivity is, of course, still in the develop mental stage.
Download or read book I Crystal Structures and Properties of Some 4 substituted Pyridine N oxide Copper II Complexes written by David Russell Johnson and published by . This book was released on 1970 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
