Download or read book Heat Shock Proteins of Malaria written by Addmore Shonhai and published by Springer Nature. This book was released on 2021-09-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.

Download or read book Molecular Chaperones and Human Disease written by Graham Chakafana and published by Frontiers Media SA. This book was released on 2022-12-19 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Homeostasis in Growth Development and Disease written by Francesco Fazi and published by Frontiers Media SA. This book was released on 2023-03-08 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Discovery and Drug Development written by Madhu Dikshit and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India's New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR. .

Download or read book Encyclopedia of Malaria written by and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.

Download or read book D L P Yali Manisi Imbongi Entsha written by D. L. P. Yali-Manisi and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: David Livingstone Phakamile Yali-Manisi (1926-99) was a Thembu imbongi, the most powerful exponent of the art of praise poetry in the Xhosa language, in the second half of the twentieth century. His literary career, however, was blighted by circumstances beyond his control, and he died in total obscurity. A supporter of the African National Congress, he was the author of the earliest poem in praise of Nelson Mandela (1954).

Download or read book John Solilo written by John Solilo and published by University of Kwazulu Natal Press. This book was released on 2016 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: For 40 years, between 1900 and 1939, John Solilo (1864-1940) was a prolific contributor to Xhosa-language newspapers under his own name and under the pseudonyms Mde-ngelimi (Master Wordsmith) and Kwanguye (It's Still Him). He submitted letters and articles on a variety of issues, local news reports from Cradock and Uitenhage, and a considerable body of poetry. Solilo's major literary contribution was his collection of poems entitled Izala, published in 1925, the earliest volume of poetry by a single author in the history of Xhosa literature. His poetry was inspired by umoya wembongi, the spirit of the imbongi, the praise poet whose stirring declamations roused his audiences to action or contemplation. Solilo's literary reputation today, however, is at variance with his prominence as a major author in the first four decades of the twentieth century: he is hardly mentioned, if at all, by literary historians. That neglect is perhaps not surprising: Izala has long been out of print, and copies can no longer be located. The present volume is therefore an exercise in reclamation and restitution. In restoring to the public domain the 65 poems that made up Izala and adding an additional 28 that were published in newspapers both before and after the appearance of Izala, the editors hope to revive John Solilo's reputation as a poet, and to establish his status as a pre-eminent Xhosa author. Jeff Opland commenced his academic career as a medievalist, but for the past 40 years he has assembled a collection of oral and printed poetry and has devoted himself to defining and restoring the heritage of literature in the Xhosa language. Amongst other works, with Peter Mtuze he edited two anthologies of Xhosa literature, Isigodlo sikaPhalo (1983) and Izwi labantu (1994). Opland is currently Visiting Professor in the School of Languages: African Language Studies at Rhodes University. Peter T. Mtuze is the most prolific living isiXhosa writer. He has authored and co-authored no fewer than 30 books. His main contribution is in creative writing: he has produced novels, short stories, essays, drama, poetry, autobiography and language books. Mtuze's first book, UDingezweni, which appeared as far back as 1966, is regarded as a classic novel. One of his singular achievements was his translation of former President Nelson Mandela's autobiography, Long Walk to Freedom, into isiXhosa. He worked on the University of Fort Hare Xhosa Dictionary Project, at the University of South Africa and at Rhodes University, where he retired as Professor Emeritus. (Series: Publications of the Opland Collection of Xhosa Literature, Vol. 3) [Subject: Poetry, African Studies]

Download or read book Drug Discovery in Africa written by Kelly Chibale and published by Springer Science & Business Media. This book was released on 2012-08-09 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

Download or read book Human Rights and Conflict Transformation in Africa written by Laurence Juma and published by African Books Collective. This book was released on 2013 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study maps the interactions between human rights norms and values, on the one hand, and conflict resolution, post-conflict peace-building and reconstruction, on the other. It advances the view both from a theoretical and practical standpoint, that human rights have a role to play throughout the life of any conflict: from the pre-conflict to the post-conflict and reconstruction stages. Identifying entry points for human rights in the pre-conflict stage leading up to the establishment of the rule of law and societal reconstruction after the conflict, this book uses Sierra Leone and Democratic Republic of Congo experiences to illustrate the obstacles, the successes, and the significance of human rights norms to the overall peace agenda in societies afflicted by conflict.

Download or read book Exercise and Stress Response written by Marius Locke and published by CRC Press. This book was released on 2002-03-28 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 10 years, researchers have been investigating the expression, regulation, and protective nature of stress proteins (SPs) during and following exercise. Since the expression of SPs have been shown to provide protection to cells and tissues, the importance of understanding their role during exercise cannot be understated. However the terminology, the myriad of stress proteins, and their complex regulation creates a confusing arena in which to enter. Exercise and Stress Response: The Role of Stress Proteins provides an up-to-date review on topics related to exercise and health, giving investigators the necessary background to pursue stress proteins. ABOUT THE EDITORS: Marius Locke, Ph.D. is an Assistant Professor in the Faculty of Physical Education and Health at the University of Toronto in Ontario, Canada. Dr. Locke received a B.A. with honors in Physical Education (1984), a B.Sc. in Biology (1987), and a Ph.D. in Kinesiology from the University of Western Ontario (1992), where he also played varsity football. Dr. Locke was awarded a Natural Science and Engineering Research Council of Canada Post Doctoral Fellowship and studied at the Deborah Research Institute in Browns Mills, New Jersey from 1993-1996. In 1999, Dr. Locke received the American College of Sports Medicine's new investigator award. Dr. Locke is a member of American College of Sports Medicine, the Canadian Society for Exercise Physiology and the Cell Stress Society International. Earl G. Noble, Ph.D. is an Associate Professor in the School of Kinesiology at the University of Western Ontario in London, Ontario, Canada. He received his B.Sc. (1973) and M.Sc. (1975) in Kinesiology from the University of Waterloo and his Ph.D. from Washington State University (1980). Dr. Noble is a member of the Canadian Society for Exercise Physiology, the American College of Sports Medicine and the Cell Stress Society International and the Research Group on Biochemistry of Exercise of the International Council of Sport Science and Physical Education (UNESCO). The overriding theme of his research is to examine muscle plasticity and the manner in which muscle adapts to novel or stressful conditions, especially exercise.

Download or read book South Africa s Border War written by Gary Baines and published by A&C Black. This book was released on 2014-02-27 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: South Africa's 'Border War' provides a timely study of the 'war of words' waged by retired South African Defence Force (SADF) generals and other veterans against critics and detractors. The book explores the impact of the 'Border War' on South African culture and society during apartheid and in the new dispensation and discusses the lasting legacy or 'afterlife' of the war in great detail. It also offers an appraisal of the secondary literature of the 'Border War', supplemented by archival research, interviews and an analysis of articles, newspaper reports, reviews and blogs. Adopting a genuinely multidisciplinary approach that borrows from the study of history, literature, visual culture, memory, politics and international relations, South Africa's 'Border War' is an important volume for anyone interested in the study of war and memory or the modern history of South Africa.

Download or read book A Report on Ubuntu written by Leonhard Praeg and published by University of Kwazulu Natal Press. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twenty years after the end of apartheid rule, the claim that democratic South Africa is founded on the 'spirit of law' (nomos) of our shared humanity is questionable, to say the least. Some would argue that all talk of Ubuntu (or African humanism) should be dismissed as a passing fad of an exhausted nationalism. But, a different response to the present is possible; one that proceeds from a temporary suspension (epoche) of the nationalist matrix, and all the dead-end questions that have resulted from it, in order to reposition Ubuntu in the more cosmopolitan terms of a critical humanism that must always remain irreducible to the politics of the day. As discussed in this book, this is a project that has to return to, in order to retrace, the founding claim that a politics premised on our shared humanity is, after all, perhaps possible. (Series: Thinking Africa) [Subject: African Studies, Politics]

Download or read book Ubuntu written by Leonhard Praeg and published by Thinking Africa. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This collection of essays contextualises the discourse on Ubuntu within the wider historical framework of postcolonial attempts to re-articulate African humanism as a substantial philosophy and emancipatory ideology." -- Back cover.

Download or read book Oxidative Folding of Proteins written by Matthias J Feige and published by Royal Society of Chemistry. This book was released on 2018-07-30 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of disulphide bonds is probably the most influential modification of proteins. These bonds are unique among post-translational modifications of proteins as they can covalently link cysteine residues far apart in the primary sequence of a protein. This has the potential to convey stability to otherwise marginally stable structures of proteins. However, the reactivity of cysteines comes at a price: the potential to form incorrect disulphide bonds, interfere with folding, or even cause aggregation. An elaborate set of cellular machinery exists to catalyze and guide this process: facilitating bond formation, inhibiting unwanted pairings and scrutinizing the outcomes. Only in recent years has it become clear how intimately connected this cellular machinery is with protein folding helpers, organellar redox balance and cellular homeostasis as a whole. This book comprehensively covers the basic principles of disulphide bond formation in proteins and describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins. The biotechnological and pharmaceutical relevance of proteins, their variants and synthetic replicates is continuously increasing. Consequently this book is an invaluable resource for protein chemists involved in realted research and production.

Download or read book Africana Studies written by Grant Farred and published by Temple University Press. This book was released on 2022-06-24 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book showcases new and expansive possibilities for Africana studies scholarship by collecting works across disciplines that push the boundaries of the discipline into topics both broader and more specific than traditionally approached: in philosophy, literature, music, political science, and more"--