Download or read book Post translational Modifications of Proteins written by John J. Harding and published by CRC Press. This book was released on 1991-12-13 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.
Download or read book Diabetes and Protein Glycosylation written by Margo Panush Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the initial discovery that blood from diabetic patients contains increased amounts of a posttranslationally gluco sylated form of hemoglobin (hemoglobin Ale)' an impressive number of studies have clarified and expanded the use of glycohemoglobin levels to assess disease status. Many other structural proteins have been shown to undergo similar changes, including proteins from tissues most commonly affected in diabetes (e.g., lens, aorta, peripheral nerve, basement membrane). Thus, the nonenzymatic glycosylation of hemoglobin emerges as an invaluable model for the pathogenesis of certain chronic diabetes complications. In addition to reviewing a wealth of investigative possibilities in the area of these chronic complications-including eye, kidney, nerve, and vascular disease-Dr. Cohen indicates how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for maintenance of long-term euglycemia. Dr. Cohen is an endocrinologist and diabetes specialist whose research activities have largely focused on the chemistry and metabo lism of the basement membrane in diabetes. This superb monograph on nonenzymatic glycosylation clearly shows the major trends of her past and present research and clinical activities. This book is beautifully written and a pleasure to read. It provides great insight into the mechanisms of the pathogenesis of the oom- vii viii Foreword cations of diabetes and should be of immense value not only to basic and clinical investigators, but also to internists, diabetologists, and endocrinologists in clinical practice.
Download or read book Endothelial Dysfunctions in Vascular Disease written by Raffaele De Caterina and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between the laboratory and the bedside, this timely volume illuminates the connection between endothelial dysfunction and vascular disease. This comprehensive survey of atherosclerotic disease begins with biology – incorporating the latest breakthroughs in the field – then elucidates risk factors and diagnostic tools and markers. A major section on endothelium-directed prevention and therapy shows you how to apply cutting-edge research to clinical care. Under the careful editorial guidance of Drs. De Caterina and Libby, the highly-regarded contributors address: endothelial activation and the initiation of atherosclerosis mechanisms of plaque progression and complications the role of LDL in the origin and progression of atherosclerosis advanced glycation endproducts and the accelerated atherosclerosis in diabetes oxidative stress and vascular disease soluble adhesion molecules as markers of vascular disease hormone-replacement therapy and cardiovascular risk anti-oxidants and endothelial protection and more. The first book dedicated to the central role of endothelial dysfunction in vascular disease, this concise volume gathers all the latest information on the subject into one convenient and cohesive text. Make sure your patients are benefiting from current knowledge by keeping a copy of Enothelial Dysfunctions in Vascular Disease close at hand for frequent consultation. Introduction Every book has a history, this one not excepted, having emerged from intersections in professional lives of the Editors. This book bears the fruits of a collaboration between the “pupil” (RDC) and the “mentor” (PL). During an extended sabbatical of the pupil in Boston in 1994, we probed together the concept that endothelial dysfunction served as a common denominator of vascular disease, with the balance between inflammation and its inhibition as a fulcrum of the regulation of the behavior of endothelial cells. As practicing cardiologists in our clinical lives, we sought to link to endothelial function the mechanisms of action of risk factors and of pharmacologic agents used to treat and prevent vascular disease. The pupil therefore authored a few reviews on the mechanism of action of risk factors and included them in a small book, published in Italian, for which the mentor wrote a preface. The book was greeted with favor from the Italian cardiological community, and provided the nidus for the present, more ambitious endeavor, which includes updated reviews on the pathogenesis of vascular disease and on the most novel aspects of vascular biology. This enterprise was enabled by the contributions of many of our former or present collaborators and colleagues, without whose enthusiasm and engagement this work could never have seen light. We largely underestimated the devotion necessary on our own side at the beginning, but it ultimately yielded a product that we feel achieves our original goals. We are aware that we confront a continuously evolving topic, where frequent updates would be desirable - if not necessary. Yet, we believe in the value of books - such as the current one - that attempt to organize in a snapshot of time, the vast amount of literature available in a coherent and comprehensive scheme. We are aware of existing gaps, of emerging material not paid its due, and of the rapid evolution of some of the concepts highlighted within. The links between the laboratory and the clinic have never afforded more opportunity for new understanding and advances in diagnosis and treatment than today We hope that our colleagues, vascular biologists cardiologists, internists, and other physicians alike will find this compendium a useful guide to this most exciting time in vascular biology and medicine —Raffaele De Caterina and Peter Libby
Download or read book Thrombosis and Haemostasis written by and published by . This book was released on 1996 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diabetes and Cardiovascular Disease written by Michael T. Johnstone and published by Springer Science & Business Media. This book was released on 2005-05-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively updated and expanded second edition reflects new research, advances in clinical care, and the growing recognition that diabetes mellitus is a risk factor for cardiovascular disease. Written for the practicing clinician as a comprehensive review of diabetic vascular disease, the book both explains the basic pathophysiology of the disease and details the latest diagnostic and therapeutic approaches. The authors have added new chapters on percutaneous interventional therapy in cardiac and peripheral vascular disease, cardiovascular surgery in diabetes, therapeutic interventions to improve endothelial function in diabetes, PARP activation and nitrosative stress in the development of the cardiovascular system, and PPARs and their emerging role in vascular biology, inflammation, and atherosclerosis.
Download or read book Advances in Pharmacology written by and published by Academic Press. This book was released on 1992-02-24 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology
Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diabetes Mellitus written by Derek LeRoith and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 1608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, this Third Edition encompasses the most recent advances in molecular and cellular research and describes the newest therapeutic modalities for type 1 and type 2 diabetes mellitus. Chapters by leading experts integrate the latest basic science and clinical research on diabetes mellitus and its complications. The text is divided into ten major sections, including extensive sections on therapeutics, diabetes during pregnancy, and complications. New chapters cover stem cell therapy for type 1 diabetes; genetics and treatment of obesity; new therapies to promote insulin action; vasculopathy; islet cell protocols; triglycerides in muscle; hypoglycemia in the adult; and the Diabetes Prevention Program.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1980 with total page 942 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Modern Urology written by R.A.S Hemat and published by Urotext. This book was released on 1998-12-31 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Modern Urology is an authorative guide to urology and integrated urology. Principles of Modern Urology is an advanced urological textbook. This book begins by showing you how to implement your pathobiology, anatomy and physiology into practical simple approach to every client you meet. This book was written for medical student, resident and professional in medicine and especially urology. The author had adapted his proven teaching strategies into a unique approach that makes integrated urology accessible, and provides the foundations for understanding urology based upon the principles of structural pathobiology. Principles of Modern Urology presents well-integrated and practical approach to most urological condition. It is a versatile retrievable e-book. Principles of Modern Urology provides the reader with current concepts of the pathobiology and interventions for diseases. Anatomy, physiology, and radiology are also included within specific topical chapters. Principles of Modern Urology is based on the extensive international clinical and teaching experience of the author, both in traditional and integrated systems of medical schools.
Download or read book Prevention and Treatment of Diabetic Late Complications written by Carl E. Mogensen and published by Walter de Gruyter. This book was released on 2011-05-09 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prevention and Treatment of Diabetic Late Complications.
Download or read book Hyperglycemia Diabetes and Vascular Disease written by Neil Ruderman and published by Springer. This book was released on 2013-05-27 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is estimated that 1-5% ofthe world's population is affected by some form of diabetes. Patients with these disorders are highly likely to develop microvas cular pathology in the retina and glomerulus and they are at a 2--6-fold greater risk for atherosclerotic vascular disease than individuals without diabetes. In addition, hypertension is far more prevalent in patients with diabetes than in the general population. As a consequence of these complications, diabetes is a leading cause of blindness and renal failure in young and middle-aged adults and it is a major risk factor for coronary heart disease, stroke and peripheral vascular disease in the Western world. An understanding of the relationship of these vascular complications to diabetic hyperglycemia has become a critical issue for clinicians in recent years, since the prevalence of diabetes appears to be increasing dramatically world-wide. In addition, it is now possible to achieve improved glycemic control in many patients-although not without incurring other risks. This volume explores two principal hypotheses concerning these complications. One is that hyperglycemia underlies or at least contributes to the pathogenesis of both micro- and macrovascular disease in patients with diabetes. The other is that it does so by producing specific metabolic and biochemical alterations in the vascular wall that lead to abnormalities in its function and ultimately its structure.
Download or read book Journal of the Indian Medical Association written by and published by . This book was released on 2002 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diabetes and Cardiovascular Disease written by Steven P. Marso and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text thoroughly reviews the latest findings and concepts on the vascular biology of diabetes mellitus, the clinical vascular manifestations of diabetes, and the therapeutic options available for diabetic patients with vascular disease. The first section provides an in-depth understanding of fundamental principles and recent discoveries regarding diabetes mellitus and vascular biology. The second, clinically oriented section includes chapters on the economic implications of diabetes mellitus, risk profiling patients with diabetes, optimizing adjunctive therapies, and treatment strategies for diabetic patients with coronary and peripheral artery disease. Summaries of important clinical trials are included to provide an evidence-based approach to treatment.
Download or read book Diabetes and Heart Disease written by Richard John Jarrett and published by Elsevier Publishing Company. This book was released on 1984 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Clinical Chemistry written by and published by Academic Press. This book was released on 1987-08-04 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Clinical Chemistry
Download or read book International Textbook of Diabetes Mellitus written by R. A. De Fronzo and published by John Wiley & Sons. This book was released on 2004-06-25 with total page 2073 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition is the most comprehensive reference on both the clinical and scientific aspects of diabetes, and is truly global in perspective with the inclusion of epidemiology and the nature and care of diabetes in different parts of the world. Following a similar format to the previous editions, the primary philosophy of the book is to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. A valuable resource for the whole diabetes community, the new edition offers: * Fully revised, updated and expanded chapters * Comprehensive coverage of all aspects of diabetes * 116 extensively referenced chapters * Full colour throughout * Available in print and online The International Textbook of Diabetes Mellitus, Third Edition is also available online via Wiley InterScience. With the flexibility afforded by the powerful search and navigation capabilities of Wiley InterScience, you can search the Textbook by subject, article and keyword. New and revised articles added regularly ensure that both professionals and students working within diabetes are kept abreast of rapidly developing areas such as genetics, treatment and epidemiology. This excellent work is an essential reference tool for all members of diabetes and endocrine teams, medical students, medical schools and libraries, and provides a valuable resource for pharmaceutical companies and industries which have an interest in this important field. FROM REVIEWS OF THE SECOND EDITION: "The scope is extraordinarily wide and truly international...a must for all libraries and any individuals who are seriously interested in the diabetes epidemic..." (Diabetologia) "...a cornerstone in the field of diabetes..." (The European Journal of Medicine) "...This multi-authored textbook provides a wealth of information spanning virtually all aspects of diabetes..." (Trends in Endocrinology and Metabolism)
