Download or read book Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor written by I. Yamamoto and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nicotinoids are the most important new class of pesticides, joining the organophosphorus compounds, methylcarbamates, and pyrethroids as the major insecticides. Recently, imidacloprid and related nicotinoids have begun replacing organophosphorus and methylcarbamate compounds as insecticides to control insect pests on major crops. Nicotinoids act on the nicotinic acetylcholine receptor, as does naturally occurring nicotine, but with remarkable effectiveness against insects while being safe for mammals; they are quickly degraded and do not persist in the environment. This volume describes the relationship of nicotinoids to botanical insecticidal alkaloids, their discovery and development as insecticides, and the prospects for their expanded use and for the development of resistance. This book is the first to provide concise, comprehensive information on nicotinoids, their chemistry, mode of action, metabolism, and application in agriculture.
Download or read book Insect Nicotinic Acetylcholine Receptors written by Steeve Hervé Thany and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.
Download or read book Nicotinic Receptors written by Robin A.J. Lester and published by Springer. This book was released on 2014-11-11 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.
Download or read book Neuronal Nicotinic Receptors written by F. Clementi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 837 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.
Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Download or read book Cellular and Molecular Neurophysiology written by Constance Hammond and published by Elsevier. This book was released on 2024-06-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
Download or read book Nicotinic Acetylcholine Receptors in the Nervous System written by Francesco Clementi and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acetylcholine nicotinic receptor is an ionic channel whose aperture is directly controlled by acetylcholine. It is a key molecule in the chemical communication between nerve cells and between nerve cell and muscle. The structure and function of muscular nicotinic receptors have been unraveled in recent years and its beauty and mysteries were reviewed in the Santorini NATO ARW organized by Dr. Maelicke in 1986. The neat, linear structure of this molecule and its conservation throughout evolution, from bacteria to humans, have led to the suggestion that it has reached the optimal structure for performing its function. But when scientists began to look at the nicotinic receptor in the nervous system, they found several surprises. From the beginning, pharmacological and physiological experiments, have made it clear that the functional characteristics of neuronal nicotinic receptors are substantially different from those of muscle receptors. Furthermore, recent sophisticated techniques such as patch clamp and gene cloning have revealed that the nicotinic receptor in the nervous system is not a single molecule but (although there are some important exceptions) a large family of similar molecules, which have in common the property of binding nicotinic agonists or antagonists. Over the last few years, the physiological implications of nicotinic receptors have been reevaluated on the basis of more precise behavioural and pharmacological techniques. Moreover, the involvement of nicotinic receptors in degenerative pathologies of the eNS, such as Parkinson's and Alzheimer's disease, has also been discovered very recently.
Download or read book Nicotinic Acetylcholine Receptor written by Alfred Maelicke and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Research Workshop on Mechanism of Action of the Nicotinic Acetylcholine Receptors held on the Island of Santorini, Greece, May 19-23, 1986
Download or read book The Nicotinic Acetylcholine Receptor written by Francisco Jose Barrantes and published by Springer. This book was released on 2013-12-17 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nicotinic Acetylcholine Receptors in Health and Disease written by R. Thomas Boyd and published by Academic Press. This book was released on 2023-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer's, Parkinson's, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders. - Describes the roles, expression and function of nicotinic receptors - Includes receptor involvement, both inside and outside the nervous system - Details nicotinic receptor involvement in Alzheimer's, Parkinson's, Cancer, Schizophrenia, and more - Emphasizes future treatment prospects of disorders via modulation of nAChR signaling
Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
Download or read book Conn s Translational Neuroscience written by P. Michael Conn and published by Academic Press. This book was released on 2016-09-28 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
Download or read book Nicotinic Acetylcholine Receptors written by Jean-Pierre Changeux and published by ODILE JACOB PUBLISHING CORP. This book was released on 2005-09-08 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they reveal the complete scientific trajectory of that research. They begin with a historical perspective, describing how several fields converged around a single receptor and then explain the initial receptor purification and characterization. Subsequent chapters trace the investigations into various aspects of receptor structure and function, including the chemical structure of the binding site, the identity and properties of the ion channel, and the mechanism of signal transmission. In the final portion of the book, Changeux and Edelstein discuss recent studies on the three-dimensional structure of the receptor molecule and share their novel understanding of inherited diseases such as congenital myasthenia and epilepsy. They also address the integration of the receptor into its synaptic membrane environment and its distribution, physiology, and regulation in brain functions and cognition. Richly illustrated and lucidly written, this book provides an exceptional opportunity for scientists and students to follow a historic advance in our knowledge of molecular mechanisms and the workings of the brain.
Download or read book Understanding Drug Action written by Peter J. Rice and published by Amer Pharmacists Assn. This book was released on 2013-11-11 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Drug Action: An Introduction to Pharmacology provides readers with a survey of the scientific understanding of drug action. This readable introduction to pharmacology is simple enough to be understood without having to take a class to follow the material, but can also be used to complement a course in pharmacology. The approach to pharmacology is at a basic scientific level to build a framework of how drugs work supplemented with information on some representative drugs that are used clinically. Each chapter includes review questions and many chapters include tables of important drugs with brand and generic names.
Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
Download or read book Lung Cancer and Personalized Medicine written by Aamir Ahmad and published by Springer. This book was released on 2015-12-14 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.
Download or read book Neuroscientific Foundations of Anesthesiology written by George A. Mashour and published by Oxford University Press. This book was released on 2011-10-05 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and neuroscience provide a novel and invaluable resource.
