Download or read book The Neuroscience of Cocaine written by Victor R. Preedy and published by Academic Press. This book was released on 2017-05-23 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms. Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse. Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Illustrated in full color Provides unique full coverage of all aspects of cocaine and its related pathology Provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms
Download or read book Behavioral Neuroscience of Drug Addiction written by David W. Self and published by Springer Science & Business Media. This book was released on 2009-12-18 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.
Download or read book Never Enough written by Judith Grisel and published by Anchor. This book was released on 2020-01-14 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NEW YORK TIMES BESTSELLER From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.
Download or read book Memoirs of an Addicted Brain written by Marc Lewis and published by Doubleday Canada. This book was released on 2011-10-04 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: A gripping, ultimately triumphant memoir that's also the most comprehensive and comprehensible study of the neuroscience of addiction written for the general public. FROM THE INTRODUCTION: "We are prone to a cycle of craving what we don't have, finding it, using it up or losing it, and then craving it all the more. This cycle is at the root of all addictions, addictions to drugs, sex, love, cigarettes, soap operas, wealth, and wisdom itself. But why should this be so? Why are we desperate for what we don't have, or can't have, often at great cost to what we do have, thereby risking our peace and contentment, our safety, and even our lives?" The answer, says Dr. Marc Lewis, lies in the structure and function of the human brain. Marc Lewis is a distinguished neuroscientist. And, for many years, he was a drug addict himself, dependent on a series of dangerous substances, from LSD to heroin. His narrative moves back and forth between the often dark, compellingly recounted story of his relationship with drugs and a revelatory analysis of what was going on in his brain. He shows how drugs speak to the brain - which is designed to seek rewards and soothe pain - in its own language. He shows in detail the neural mechanics of a variety of powerful drugs and of the onset of addiction, itself a distortion of normal perception. Dr. Lewis freed himself from addiction and ended up studying it. At the age of 30 he traded in his pharmaceutical supplies for the life of a graduate student, eventually becoming a professor of developmental psychology, and then of neuroscience - his field for the last 12 years. This is the story of his journey, seen from the inside out.
Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Download or read book Pathways of Addiction written by Institute of Medicine and published by National Academies Press. This book was released on 1996-11-01 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Download or read book The Effects of Drug Abuse on the Human Nervous System written by Bertha Madras and published by Elsevier. This book was released on 2013-11-15 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug use and abuse continues to thrive in contemporary society worldwide and the instance and damage caused by addiction increases along with availability. The Effects of Drug Abuse on the Human Nervous System presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs. Other chapters provide a context for drug use, with overviews of use and consequences, epidemiology and risk factors, genetics of use and treatment success, and strategies to screen populations and provide appropriate interventions. The book offers meaningful, relevant and timely information for scientists, health-care professionals and treatment providers. A comprehensive reference on the effects of drug addiction on the human nervous system Focuses on core drug addiction issues from nicotine, cocaine, methamphetamine, alcohol, and other commonly abused drugs Includes foundational science chapters on the biology of addiction Details challenges in diagnosis and treatment options
Download or read book The Addicted Brain written by Michael J. Kuhar and published by FT Press. This book was released on 2012 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Addicted Brain" explains clearly and vividly what has been learned about how and why some people become addicted and abuse drugs or other substances, the relatively long-term changes these substances can make in the brain, and the progress being made on treatments.
Download or read book The Neurobiology of Cocaine Addiction written by Herman Joseph and published by Routledge. This book was released on 2014-03-18 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the use of crack on the rise in American cities, there is more need than ever to understand the biological, environmental, and social factors behind cocaine addiction, as well as the pharmacological properties of cocaine that make it such an addictive drug. The Neurobiology of Cocaine Addiction helps clinicians and researchers analyze research findings and their relevance to the clinical treatment of cocaine dependency. To do this, it looks at the whole spectrum of cocaine use, from trends in cocaine-involved deaths, hospital emergencies, arrests, and treatment admissions to the specific impact the drug has on brain function. The book reports on important findings from positron emission tomography (PET) and a “binge” pattern cocaine administration mode. This will enable you to improve your understanding of how cocaine alters the pleasure/reward system of the brain and creates new instinctual needs that displace the inherent instinctual needs of hunger and sex. By reading The Neurobiology of Cocaine Addiction, you will sharpen your knowledge of the basic actions of cocaine, the factors related to daily cocaine use, the neurobiological basis of addictive diseases, and drug-induced alterations in normal physiology. You will also learn about: the coexistence of cocaine and heroin addiction cocaine’s disruption of the endogenous opioid system QEEG and how it can play a potentially useful role in drug development and planning hypotheses of sensitization in the pathophysiology of cocaine dependence factors that predict daily cocaine use among patients in a methadone maintenance program abnormalities in brain function that persist for up to six months after last cocaine use patterns of cocaine use the importance of prospective data analysis and the limitations of a self-selective study group Clinicians, researchers, psychiatrists, and other professionals in chemical dependency and narcotics rehabilitation will turn the last page of The Neurobiology of Cocaine Addiction with a better understanding of cocaine’s addictive qualities and the characteristics of the individuals who become addicted to it. You will see what headway has been made in research at some of the nation’s top laboratories, but you will also see what remains to be done. Hopefully, you will find where you can make a contribution either at the practical level, the research level, or both.
Download or read book The Neurobiology of Cocaine written by Ronald P. Hammer, Jr. and published by CRC Press. This book was released on 1995-07-17 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field. This volume presents current research regarding the mechanisms of cocaine's action in the brain. Recent developments of cellular, molecular, and brain imaging methods provide new evidence that chemical and molecular substrates underlie cocaine reinforcement, dependence, and withdrawal. This book explores the biological bases of such effects, describing the brain circuits affected by cocaine, neuroendocrine and neurophysiological actions of cocaine, neurochemistry and pharmacology of cocaine, and cocaine effects on signal transduction, gene expression, and protein phosphorylation. This up-to-date text also describes the recently cloned class of neurotransporters affected by cocaine and characterizes their interaction with the drug. These reports focus on the effects of chronic exposure and subsequent withdrawal, which are differentiated from acute cocaine actions. Thus, they provide information on brain mechanisms likely active during long-term use and abuse in humans. Such commonalities are illustrated by a discussion of cocaine action in the human brain as visualized by positron emission tomography. This volume is a must for anyone interested in the mechanisms underlying cocaine abuse.
Download or read book Drugs Brains and Behavior written by and published by . This book was released on 2007 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cocaine written by John C. Flynn and published by Citadel Press. This book was released on 1993 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cocaine has been on the American scene for more than a century. This book traces cocaine's long history and demystifies its effects, focusing on psychological and biochemical evidence. A fascinating scientific journey, COCAINE details how the drug activates the human brain and hooks its users. The book also examines current approaches to the drug problem, including socio-economic factors.
Download or read book Drugged written by Richard J. Miller and published by Oxford University Press, USA. This book was released on 2014 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Miller takes readers on an eye-opening tour of psychotropic drugs, describing the various kinds, how they were discovered and developed, and how they have played multiple roles in virtually every culture.
Download or read book Neural Mechanisms of Addiction written by Mary Torregrossa and published by Academic Press. This book was released on 2018-08-24 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field. Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research. Transcends multiple neural, neurochemical and behavioral domains Summarizes advances in the field of addiction research since the advent of optogenetics Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms
Download or read book Drugs Addiction and the Brain written by George F. Koob and published by Academic Press. This book was released on 2014-07-12 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle Actual data figures from original sources illustrating key concepts and findings Introduction to basic neuropharmacology terms and concepts Introduction to numerous animal models used to study diverse aspects of drug use. Thorough review of extant work on the neurobiology of addiction
Download or read book Neurobiology of Addiction written by George F. Koob and published by Elsevier. This book was released on 2005-11-11 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching
Download or read book Addiction Neuroethics written by Adrian Carter and published by Cambridge University Press. This book was released on 2011-11-17 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addiction is a significant health and social problem and one of the largest preventable causes of disease globally. Neuroscience promises to revolutionise our ability to treat addiction, lead to recognition of addiction as a 'real' disorder in need of medical treatment and thereby reduce stigma and discrimination. However, neuroscience raises numerous social and ethical challenges: • If addicted individuals are suffering from a brain disease that drives them to drug use, should we mandate treatment? • Does addiction impair an individual's ability to consent to research or treatment? • How will neuroscience affect social policies towards drug use? Addiction Neuroethics addresses these challenges by examining ethical implications of emerging neurobiological treatments, including: novel psychopharmacology, neurosurgery, drug vaccines to prevent relapse, and genetic screening to identify individuals who are vulnerable to addiction. Essential reading for academics, clinicians, researchers and policy-makers in the fields of addiction, mental health and public policy.
