Download or read book The Myostatin Project written by G Robert Tait and published by Xlibris Corporation. This book was released on 2014-08-22 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Myostatin Project written by G Robert Tait and published by Xlibris Corporation. This book was released on 2014-08-22 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Julian Reichert stared in disbelief as the woman who called herself Angeline Reichert walked into the courtroom. It was as if time was moving one frame at a time; click, click, click when he watched this woman, an image from his past, walk to the plaintiff’s table and sit next to her attorneys. It was his sister Angeline, the Angeline he saw lowered into her grave more than thirty years earlier. Julian sat stunned and numb. This could not be! It was only when Gavin McGowan, the Veterinarian and friend of his father, took the witness stand that Julian learned of the bizarre chain of events that dropped this sister into his life where she would challenge his role as the heir to the Reichert empire. Conspiracy and murder, including two attempts on his own life, awaken Julian to the realization that his father has harbored a diabolical secret, a secret known only to the charismatic vet who stuns the court with his story.

Download or read book Myostatin written by Dolores Christensen and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myostatin, also known as growth and differentiation factor-8, is a member of the TGF-β family member and is mainly produced by skeletal muscle. Myostatin circulates in the serum in a latent form, whereas it acts almost exclusively on skeletal muscle. Chapter One of this book discusses the role of myostatin and related factors in muscle hypertrophy and atophy. Chapter Two concentrates on specific alterations of positive and negative regulators of muscle mass in patients with chronic kidney disease. Chapter Three examines the potential benefits of the myostatin gene polymorphisms in livestock animals. Chapter Four studies myostatin functions in fish.

Download or read book The Mutant Project written by Eben Kirksey and published by Policy Press. This book was released on 2021-03-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prologue: The World on Notice -- 1: I'm Quite Glad That I Wasn't First -- 2: A Typical Shenzhen Story -- 3: The Best Humans Haven't Been Produced Yet -- 4: Winner Takes All -- 5: Look at Those Muscles, Look at That Butt -- 6: A Moral Choice -- 7: Will I Have to Mortgage My House? -- 8: The Cancer Moonshot -- 9: Free Health Care for All -- 10: Silence = Death -- 11: Immortality Has to Be the Goal --12: I Don't Want to Walk, I Want to Fly -- 13: High-Quality Children -- 14: #Transracial -- 15: American Medicine and Only for You -- 16: He Was Busy, Busy, Always Doing Research -- 17: A Hammer, Looking for a Nail -- 18: Beautiful Lies -- 19: Two Healthy Baby Girls? -- 20: Mixed Wisdom -- 21: They Are Moving Forward -- 22: Chinese Scientists Are Creating CRISPR Babies -- 23: Bubbles Vanishing into Air -- 24: The Horse has Already Bolted -- Epilogue: We Have Never Been Human.

Download or read book The Mutant Project written by Kirksey, Eben and published by Policy Press. This book was released on 2021-03-03 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Longlisted for the Baillie Gifford Prize 2021 An anthropologist visits the frontiers of genetics, medicine, and technology to ask: whose values are guiding gene-editing experiments, and what are the implications for humanity? At a conference in Hong Kong in November 2018, Dr. Jiankui He announced that he had created the first genetically modified babies—twin girls named Lulu and Nana—sending shockwaves around the world. A year later, a Chinese court sentenced Dr. He to three years in prison for “illegal medical practice.” As scientists elsewhere start to catch up with China’s vast genetic research programme, gene editing is fuelling an innovation economy that threatens to widen racial and economic inequality. Fundamental questions about science, health, and social justice are at stake. Who gets access to gene-editing technologies? As countries loosen regulations around the globe, can we shape research agendas to promote an ethical and fair society? Professor Eben Kirksey takes us on a groundbreaking journey to meet the key scientists, lobbyists, and entrepreneurs who are bringing cutting-edge genetic modification tools like CRISPR to your local clinic. He also ventures beyond the scientific echo chamber, talking to doctors, hackers, chronically ill patients, disabled scholars, and activists and who have alternative visions of a genetically modified future for humanity. The Mutant Project empowers us to ask the right questions, uncover the truth, and navigate this new era of scientific enquiry.

Download or read book Project Superhero written by E. Paul Zehr and published by ECW Press. This book was released on 2014-09-01 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Superheroes, science, and one ordinary girl's quest for greatness. Join 13-year-old Jessie as she keeps a diary of her class's yearlong research project on superheroes, which culminates in the Superhero Slam: a head-to-head debate battle! It's shy, comics-obsessed Jessie's dream come true . . . and worst nightmare. She decides to champion Batgirl, a regular person (albeit with major talent and training under her utility belt), and soon Jessie wonders what it would take to be Batgirl. Will she prove to her best friends, Cade and Audrey, that she's more than a sidekick? Can she take down archenemy Dylan at the Slam? Combining science facts, lively illustrations, and comic-book trivia with actual correspondence from superhumans such as NYPD Sergeant Mike Bruen, Olympian Clara Hughes, and Captain Marvel writer Kelly Sue DeConnick, Project Superhero is a celebration of the heroes among us and of one girl's super-secret identity: herself.

Download or read book Equine Science written by Zoe Davies and published by John Wiley & Sons. This book was released on 2017-09-14 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: From genetics to functional anatomy, cell biology to the equine digestive system, Equine Science, Third Edition covers all the essential scientific knowledge you need for your equine programme. Thoroughly updated, this new edition features a clear, systematic presentation, stunning full-colour photographs and illustrations, chapter summary points and self-assessment questions throughout. Describes the structure and function of the various body systems of the horse Explains the scientific rationale behind modern equine training practices Features new chapters on exercise physiology and the evolution of the horse Reflects the latest scientific advances and changes in the student curriculum Includes new information on circadian rhythms and sleep patterns, the immune system, and hindgut microbiology. A powerful teaching and learning aid, Equine Science, Third Edition is an essential text for students on higher education equine studies and equine science programmes, as well as those studying for BHS qualifications up to BHSII Stage 4 Horse Knowledge and Care.

Download or read book Osteosarcopenia Bone Muscle and Fat Interactions written by Gustavo Duque and published by Springer Nature. This book was released on 2019-11-06 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Download or read book Genome Editing and Biological Weapons written by Katherine Paris and published by Springer Nature. This book was released on 2022-12-15 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph introduces current genome editing technologies—clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)—and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleases—including CRISPR, TALEN, and ZFN—allow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers.

Download or read book Progress in Drug Research written by and published by Birkhäuser. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: S. Ren and E.J. Lien: CaCo-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.- J.C.G. Halford and J.E. Blundell: Pharmacology of appetite suppression.- B. Olivier, W. Soudijn and I. van Wijngaarden: Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors.- D. Poyner, H. Cox, M. Bushfield, J.M. Treherne and M.K. Demetrikopoulos: Neuropeptides in drug research.- M. Kumari and M.K. Ticku: Regulation of NMDA receptors by ethanol.- H. Horikoshi, T. Hashimoto and T. Fujiwara: Troglitazone and emerging glitazones: new avenues for potential therapeutic benefits beyond glycemic control.- Rosamund C. Smith and Simon J. Rhodes: Applications of developmental biology to medicine and animal agriculture.

Download or read book Fragility Fracture Nursing written by Karen Hertz and published by Springer. This book was released on 2018-06-15 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book aims to provide a comprehensive but practical overview of the knowledge required for the assessment and management of the older adult with or at risk of fragility fracture. It considers this from the perspectives of all of the settings in which this group of patients receive nursing care. Globally, a fragility fracture is estimated to occur every 3 seconds. This amounts to 25 000 fractures per day or 9 million per year. The financial costs are reported to be: 32 billion EUR per year in Europe and 20 billon USD in the United States. As the population of China ages, the cost of hip fracture care there is likely to reach 1.25 billion USD by 2020 and 265 billion by 2050 (International Osteoporosis Foundation 2016). Consequently, the need for nursing for patients with fragility fracture across the world is immense. Fragility fracture is one of the foremost challenges for health care providers, and the impact of each one of those expected 9 million hip fractures is significant pain, disability, reduced quality of life, loss of independence and decreased life expectancy. There is a need for coordinated, multi-disciplinary models of care for secondary fracture prevention based on the increasing evidence that such models make a difference. There is also a need to promote and facilitate high quality, evidence-based effective care to those who suffer a fragility fracture with a focus on the best outcomes for recovery, rehabilitation and secondary prevention of further fracture. The care community has to understand better the experience of fragility fracture from the perspective of the patient so that direct improvements in care can be based on the perspectives of the users. This book supports these needs by providing a comprehensive approach to nursing practice in fragility fracture care.

Download or read book Summary Study Guide A Crack in Creation written by Lee Tang and published by LMT Press. This book was released on 2017-08-01 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Power and Peril of Gene Editing CRISPR/Cas9 Technology This book is a summary of “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution” by Jennifer A. Doudna and Samuel H. Sternberg. This book tells the story of CRISPR and “gene-editing.” CRISPR is a cutting-edge gene-editing technology that mimics what happens naturally in bacteria. It enables scientists to “play god” with plant or animal DNA, with unlimited power and peril. The technology of gene editing is the most important advance in our era. The possibility of forever altering the genetic composition of humankind is frightening. Yet we can’t overlook the opportunities that may lead to inventions for cures of HIV, debilitating genetic diseases, and cancers, and end food shortages. The book will demystify this exciting area of science and inspire you to seek answers to tough moral and ethical questions on the use of this technology. Read this book and get involved in the debate on the moral and ethical issues on the use of this technology. This guide includes: * Book Summary—helps you understand the key concepts. * Online Videos—cover the concepts in more depth. Value-added from this guide: * Save time * Understand key concepts * Expand your knowledge

Download or read book Gene Doping written by Katrin Gerlinger and published by BoD – Books on Demand. This book was released on 2013-12-06 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Just like a phantom, the topic of »gene doping« keeps haunting the debates regarding the future of competitive sports for years. Very often, corresponding fantasies and visions culminate in the imagination of super athletes who are permanently manipulated with regard to their genetic disposition. However, the application scenarios to be expected will be far more unspectacular, but more probable and more obvious at the same time. Very soon, we will have to expect the use of new substances as well as of methods in gene and cell therapy for targeted manipulation of gene activity. Their use promises a highly efficient performance enhancement and will be difficult to prove, if at all. This book provides comprehensive answers to the key questions of the further development: Which scientific results could cater to the needs of potential gene doping? Where are the future gateways in top-level and popular sports? And how can prohibitions and monitoring be used in responding to this? Another question will be which individual behavioural patterns of athletes and which social contexts will play a role with regard to the potential »career« of gene doping.

Download or read book Muscle Development of Livestock Animals written by M. F. W. te Pas and published by Cabi. This book was released on 2004-01-01 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Number and size of muscle fibres in relation to meat production. Fibre type identification and functional characterization in adult livestock animals. Manipulation of muscle fibre number during prenatal development. The effect of growth and exercise on muscle characteristics in relation to meat quality. Nutrition, hormone receptor expression and gene interactions: implications for development and disease. The impact of minerals and micronutrients on growth control. Na+ K+-ATPase in skeletal muscle: significance of exercise and thyroid hormones for development and performance. local and ystemic regulation of muscle growth. Proteolytic systems and the regulation of muscle remodelling and breakdown. Themuscle regulatory factors gene family in relation to meat production.The muscle transcriptome. Genome analysis of QTL for muscle tissue development and meat quality. Functional genomics and proteomics in relation to muscle tissue. Role of myostatin in muscle growth. The callipyge mutation for sheep muscular hypertrophy genetics, physiology and meat quality. Genetic control of intramuscular fat accretion, Post-mortem muscle proteolysis and meat tenderness.Water-holding capacity of meat.

Download or read book The Common Marmoset in Captivity and Biomedical Research written by Robert P. Marini and published by Academic Press. This book was released on 2018-11-19 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Download or read book The Sports Gene written by David Epstein and published by Penguin. This book was released on 2014-04-29 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New York Times bestseller – with a new afterword about early specialization in youth sports – from the author of Range: Why Generalists Triumph in a Specialized World. The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training? In this controversial and engaging exploration of athletic success and the so-called 10,000-hour rule, David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving it. Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.

Download or read book Stereological Methods Practical methods for biological morphometry written by Ewald R. Weibel and published by . This book was released on 1979 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: