Download or read book The Molecular Biology of Poliovirus written by F. Koch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Years ago when we were asked to write a book on the present-day knowledge of the molecular biology of poliovirus, we did not expect that such an apparently simple task could involve so much time and effort. Our writing was hampered by the fact that both of us are full time "workers", so that this monograph is mainly a spare time expedience. The main attention of this book focuses on a detailed review of the molecular biology of poliovirus and especially on the advances of the last decade; medical and environmental aspects are only briefly mentioned. Observations from older studies are considered in view of more recent information. Some of the older ob servations provided fundamental insights and paved the way for present day research; too often such data has been neglected or independently rediscovered. Today, poliovirus research has again attracted considerable interest. High points gained within the last few years were the elucidation of the complete nucleotide sequences of the RNAs of the three poliovinls serotypes and the corresponding vaccine strains, the demonstration of genome evolution during transmission of poliovirus in an epidemic, further characterization of the antigenic sites on the virus particle and of the antigenic drift, characterization of alternate conforma tional states of the virion capsid, the development of monoclonal antibodies against some of the virus proteins, observations on the role of the plasma membrane, cytoskeleton, and cytoplasmic membranes as mediators in the virus induced redirection of the synthetic machinery of the host cell, and characteriza

Download or read book Poliovirus written by Javier Martín and published by Humana. This book was released on 2016-03-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the most common laboratory procedures for isolation, identification and characterization of polioviruses used in clinical and research laboratories. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Poliovirus: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Download or read book The Biochemistry of Poliomyelitis Viruses written by Ernest Kovács and published by Elsevier. This book was released on 2014-05-16 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research. This volume presents a general introduction to viruses as to their descriptions and biological, biochemical, and epidemiological aspects. Clinical poliomyelitis, test measurements in the cerebrospinal fluid, and the actions of the poliomyelitis virus are explained. The isolation of the poliomyelitis virus and some aspects of its immunology and serology through refinements of serologic tools and special techniques, plus the state of poliovirus purification, are noted. This book also gives assumptions about the virus' synthetic activities in vivo based on experiments conducted in other viral diseases other than the polio virus. This text also notes that important discoveries such as those made by Gierer and Schramm or Fraenkel-Conrat provide updated poliomyelitis research. Other research studies are taken into consideration and emphasis is given to the biochemical concept of the polio infection and the related features induced during infection such as the presence of tumors. The most promising trend in research is in the study of enzymes of infected cells leading to an understanding of the biochemistry of viral diseases. The use of inference microscopy and X-ray analysis of cell mass is recommended. This book will prove invaluable for microbiologists, disease investigators, clinical workers, and research scientists.

Download or read book Molecular Biology of Picornaviruses written by Bert L. Semler and published by . This book was released on 2002 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of Picornaviruses written by Bert L. Semler and published by . This book was released on 2002 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: -- Up-to-date and in-depth analysis.

Download or read book The Molecular Biology of Viruses written by John Colter and published by Elsevier. This book was released on 2012-12-02 with total page 747 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Biology of Viruses is a collection of manuscripts presented at the Third Annual International Symposium of the Molecular Biology of Viruses, held in the University of Alberta, Canada on June 27-30, 1966, sponsored by the Faculty of Medicine of the University of Alberta. This book is organized into eight parts encompassing 36 chapters that emphasize the biosynthetic steps involved in polymer duplication. The first two parts explore the specialized processes of the cycle of virulent and temperate bacteriophage multiplication. These parts also deal with the production, regulation of development, and selectivity of these bacteriophages. The subsequent two parts look into the heterozygosity, mutation, structure, function, and mode of infection of single-stranded DNA and RNA bacteriophages. The discussions then shift to the biological and physicochemical aspects, biosynthesis, translation, genetics, and replication of mammalian DNA and RNA viruses. The concluding parts describe the homology, interaction, functions, mechanism of transformation, metabolism, and carcinogenic activity of oncogenic viruses. This book is of great benefit to biochemists, biophysicists, geneticists, microbiologists, and virologists.

Download or read book Molecular and Cellular Biology of Viruses written by Phoebe Lostroh and published by Garland Science. This book was released on 2019-05-06 with total page 971 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as HIV, influenza, and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. Key selling feature: Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors Extensive questions and answers for each chapter

Download or read book The Molecular Biology of Picornaviruses written by R. Perez-Bercoff and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: vi The intent, therefore, was to provide for a fresh and original review of all relevant topics and issues in the field, following a comprehensive and coherent programme. Such an ambitious goal could only be reached thanks to the unlimited collaboration of the lecturers: They were requested to produce nothing less than "freer, broader, speculative and personal "considerations of the subjects" they had to cover ••• And so they did: their presentations unfolded a fantastic picture, a most fascinating and meaningful identification of the field, its present problems and trends. But participants at this conference contributed many valuable observations while discussing specific points. Unfortunately, more often than not, it proved impossible to identify them in the records. Accordingly, we incorporated here and there some of these "anonymous" contributions as part of the edited version of the texts. To all of the participants, I would like to express my gratitude for their actively taking part in all the scientific (and social ••• ) activities (lectures, round tables, posters, encounters) of this N.A.T.O. ASl. The result was a stimulating atmosphere, conducive to authentic scientific exchanges. Hence, the success of this meeting should be credited only to them. Finally, on behalf of all participants, I would like to thank Professor Sissini, the Mayor of Maratea, and Mr. B. Vitolo, the Chairman of its Tourist Office: their enthusiastic support greatly contributed to make of our time in their wonderful seaside resort an unforgettable one.

Download or read book A History of Poliomyelitis written by John Rodman Paul and published by . This book was released on 1971 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Essential Human Virology written by Jennifer Louten and published by Academic Press. This book was released on 2022-05-28 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays. Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology. - Focuses on human diseases and the cellular pathology that viruses cause - Highlights current and cutting-edge technology and associated issues - Presents real case studies and current news highlights in each chapter - Features dynamic illustrations, chapter assessment questions, key terms, and a summary of concepts, as well as an instructor website with lecture slides, a test bank and recommended activities - Updated and revised, with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses

Download or read book Exploring the Role of Antiviral Drugs in the Eradication of Polio written by National Research Council and published by National Academies Press. This book was released on 2006-05-04 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the Role of Antiviral Drugs in the Eradication of Polio: Workshop Report, is a report of a workshop in which experts evaluated whether an antiviral drug against poliovirus would be helpful in the final stages of the global polio eradication campaign. The World Health Organization currently plans to stop using oral polio vaccine three years after the detection of the last case of transmission of wild polio virus. This is because the vaccine contains live, weakened polio viruses that can spread and revert to virulence in populations that have not been immunized. Under this plan, an antiviral drug could be useful to control any polio outbreaks caused by a vaccine-derived virus that might occur after vaccination ends and the number of unimmunized people in the world steadily increases. The report recommends that planning and development of such drugs should be initiated now. It identifies several promising targets for drug development and outlines the steps needed for planning for clinical trials and regulatory approval.

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Progress in Polio Eradication written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2001 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 105 of Developments in Biologicals reports scientific presentations on the latest progress in polio eradication and vaccination given at an international symposium held in June 2000. The following topics are covered: - the highly impressive progress towards global eradication and the role of the WHO Polio Eradication Program - the efficiency and reliability of virological surveillance and the scientific basis for certification of eradication, including perspectives from countries in the developing world as well as from the developed - updates on the molecular biology and genetics of poliovirus and poliovaccines, including the molecular basis for attenuation and reversion to virulence and the interesting area of receptor specificity for polio and other enteroviruses - the advantages and disadvantages of current poliovaccines and immunization strategies, reviewed by participants from industry and public health organizations - the role of inactivated poliovaccines in the end game and the vexed question of when and how vaccination against polio can be safely suspended as well as the risks of re-introduction of polio post-eradication and post-vaccination - gaps in scientific knowledge in the fields of virology, immunology and epidemiology relevant to the end game of polio eradication and priorities for future scientific research This volume will remain a key reference on polio eradication and vaccination for many years to come, not only for academic researchers but also for members of public health organizations, vaccine manufacturers and managers of immunization programs.

Download or read book Fundamentals of Molecular Virology written by Nicholas H. Acheson and published by Wiley Global Education. This book was released on 2012-04-13 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for students learning about viruses for the first time at the undergraduate or graduate level, Fundamentals of Molecular Virology is presented in a style which relates to today's students and professors. This book is also a valuable, up-to-date source of information for graduate students, postdoctoral fellows and research scientists working with viruses. Chapters contributed by prominent virologists were edited to conform to a clear and accessible style. The text provides a thorough presentation of basic and contemporary concepts in virology for a student's first exposure to the field.

Download or read book Immunization Safety Review written by Institute of Medicine and published by National Academies Press. This book was released on 2003-12-26 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immunization Safety Review Committee was established by the Institute of Medicine (IOM) to evaluate the evidence on possible causal associations between immunizations and certain adverse outcomes, and to then present conclusions and recommendations. The committee's mandate also includes assessing the broader societal significance of these immunization safety issues. While all the committee members share the view that immunization is generally beneficial, none of them has a vested interest in the specific immunization safety issues that come before the group. The committee reviews three immunization safety review topics each year, addressing each one at a time. In this fifth report in a series, the committee examines the hypothesis that exposure to polio vaccine contaminated with simian virus 40 (SV40), a virus that causes inapparent infection in some monkeys, can cause certain types of cancer.

Download or read book The Machinery of Life written by David S. Goodsell and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: A journey into the sub-microscopic world of molecular machines. Readers are first introduced to the types of molecules built by cells: proteins, nucleic acids, lipids, and polysaccharides. Then, in a series of distinctive illustrations, the reader is guided through the interior world of cells, exploring the ways in which molecules work in concert to perform the processes of living. Finally, the author shows us how vitamins, viruses, poisons, and drugs each have their effects on the molecules in our bodies. David Goodsell, author and illustrator, has prepared a fascinating introduction to biochemistry for the non-specialist. His book combines a lucid text with an abundance of drawings and computer graphics that present the world of cells and their components in a truly unique way.

Download or read book Molecular Virology of Human Pathogenic Viruses written by Wang-Shick Ryu and published by Academic Press. This book was released on 2016-03-30 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author's more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. - Presents viruses within their family structure - Contains recommended journal articles with perspectives to put primary literature in context - Includes integrated recommended reading references within each chapter - Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor's manual, study guide, and test bank